meropenem has been researched along with picolinic-acid* in 1 studies
1 other study(ies) available for meropenem and picolinic-acid
| Article | Year |
|---|---|
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.
The clinical effectiveness of carbapenem antibiotics such as meropenem is becoming increasingly compromised by the spread of both metallo-β-lactamase (MBL) and serine-β-lactamase (SBL) enzymes on mobile genetic elements, stimulating research to find new β-lactamase inhibitors to be used in conjunction with carbapenems and other β-lactam antibiotics. Herein, we describe our initial exploration of a novel chemical series of metallo-β-lactamase inhibitors, from concept to efficacy, in a survival model using an advanced tool compound (ANT431) in conjunction with meropenem. Topics: Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Crystallography, X-Ray; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae Infections; Inhibitory Concentration 50; Meropenem; Microbial Sensitivity Tests; Picolinic Acids; Protein Binding; Structure-Activity Relationship | 2019 |