meropenem and ebselen

meropenem has been researched along with ebselen* in 1 studies

Other Studies

1 other study(ies) available for meropenem and ebselen

Article	Year
Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1). Chemical communications (Cambridge, England), 2015, Jun-11, Volume: 51, Issue:46 We report the discovery of a promising NDM-1 inhibitor, ebselen, through a cell-based screening approach. Enzymatic kinetic study and ESI-MS analysis suggested that ebselen could bind to NDM-1 by forming a S-Se bond with the Cys(221) residue at the active site, thereby exhibiting a new inhibition mechanism with broad spectrum inhibitory potential. Topics: Ampicillin; Anti-Bacterial Agents; Azoles; beta-Lactamase Inhibitors; beta-Lactamases; Escherichia coli; Isoindoles; Meropenem; Microbial Sensitivity Tests; Organoselenium Compounds; Thienamycins	2015

Article

Year

Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1).

Chemical communications (Cambridge, England), 2015, Jun-11, Volume: 51, Issue:46

We report the discovery of a promising NDM-1 inhibitor, ebselen, through a cell-based screening approach. Enzymatic kinetic study and ESI-MS analysis suggested that ebselen could bind to NDM-1 by forming a S-Se bond with the Cys(221) residue at the active site, thereby exhibiting a new inhibition mechanism with broad spectrum inhibitory potential.

Topics: Ampicillin; Anti-Bacterial Agents; Azoles; beta-Lactamase Inhibitors; beta-Lactamases; Escherichia coli; Isoindoles; Meropenem; Microbial Sensitivity Tests; Organoselenium Compounds; Thienamycins

2015