merocyanine-dye and 4-aminobenzyl-alcohol

merocyanine-dye has been researched along with 4-aminobenzyl-alcohol* in 1 studies

Other Studies

1 other study(ies) available for merocyanine-dye and 4-aminobenzyl-alcohol

Article	Year
Activatable Near-Infrared Probe for Fluorescence Imaging of γ-Glutamyl Transpeptidase in Tumor Cells and In Vivo. Chemistry (Weinheim an der Bergstrasse, Germany), 2017, Oct-20, Volume: 23, Issue:59 γ-Glutamyl transpeptidase (GGT) is a cell-membrane-bound enzyme that is involved in various physiological and pathological processes and is regarded as a potential biomarker for many malignant tumors, precise detection of which is useful for early cancer diagnosis. Herein, a new GGT-activatable near-infrared (NIR) fluorescence imaging probe (GANP) by linking of a GGT-recognitive substrate γ-glutamate (γ-Glu) and a NIR merocyanine fluorophore (mCy-Cl) with a self-immolative linker p-aminobenzyl alcohol (PABA) is reported. GANP was stable under physiological conditions, but could be efficiently activated by GGT to generate ≈100-fold enhanced fluorescence, enabling high sensitivity (detection limit of ≈3.6 mU L Topics: Animals; Benzopyrans; Benzyl Alcohols; Cell Line, Tumor; Female; Fluorescent Dyes; gamma-Glutamyltransferase; HCT116 Cells; Humans; Indoles; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasms; Spectroscopy, Near-Infrared; Transplantation, Heterologous	2017

Article

Year

Activatable Near-Infrared Probe for Fluorescence Imaging of γ-Glutamyl Transpeptidase in Tumor Cells and In Vivo.

Chemistry (Weinheim an der Bergstrasse, Germany), 2017, Oct-20, Volume: 23, Issue:59

γ-Glutamyl transpeptidase (GGT) is a cell-membrane-bound enzyme that is involved in various physiological and pathological processes and is regarded as a potential biomarker for many malignant tumors, precise detection of which is useful for early cancer diagnosis. Herein, a new GGT-activatable near-infrared (NIR) fluorescence imaging probe (GANP) by linking of a GGT-recognitive substrate γ-glutamate (γ-Glu) and a NIR merocyanine fluorophore (mCy-Cl) with a self-immolative linker p-aminobenzyl alcohol (PABA) is reported. GANP was stable under physiological conditions, but could be efficiently activated by GGT to generate ≈100-fold enhanced fluorescence, enabling high sensitivity (detection limit of ≈3.6 mU L

Topics: Animals; Benzopyrans; Benzyl Alcohols; Cell Line, Tumor; Female; Fluorescent Dyes; gamma-Glutamyltransferase; HCT116 Cells; Humans; Indoles; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasms; Spectroscopy, Near-Infrared; Transplantation, Heterologous

2017