meridianin-a and pyrimidine

meridianin-a has been researched along with pyrimidine* in 1 studies

Other Studies

1 other study(ies) available for meridianin-a and pyrimidine

Article	Year
CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs. Bioorganic & medicinal chemistry, 2011, Oct-01, Volume: 19, Issue:19 The marine invertebrate-derived meridianin A, the originally proposed structure for psammopemmin A, and several related 3-pyrimidylindole analogs were synthesized and subsequently investigated for central nervous system, antimalarial, and cytotoxic activity. A Suzuki coupling of an indoleborate ester to the pyrimidine electrophile was utilized to form the natural product and derivatives thereof. The 3-pyrimidineindoles were found to prevent radioligand binding to several CNS receptors and transporters, most notably, serotonin receptors (<0.2 μM K(i) for 5HT(2B)). Two compounds also inhibited the human malaria parasite Plasmodium falciparum (IC(50) <50 μM). Only the natural product was cytotoxic toward A549 cells (IC(50)=15 μM). Topics: Antimalarials; Cell Line, Tumor; Central Nervous System Agents; Humans; Indole Alkaloids; Indoles; Plasmodium falciparum; Pyrimidines; Receptors, Serotonin	2011

Article

Year

CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.

Bioorganic & medicinal chemistry, 2011, Oct-01, Volume: 19, Issue:19

The marine invertebrate-derived meridianin A, the originally proposed structure for psammopemmin A, and several related 3-pyrimidylindole analogs were synthesized and subsequently investigated for central nervous system, antimalarial, and cytotoxic activity. A Suzuki coupling of an indoleborate ester to the pyrimidine electrophile was utilized to form the natural product and derivatives thereof. The 3-pyrimidineindoles were found to prevent radioligand binding to several CNS receptors and transporters, most notably, serotonin receptors (<0.2 μM K(i) for 5HT(2B)). Two compounds also inhibited the human malaria parasite Plasmodium falciparum (IC(50) <50 μM). Only the natural product was cytotoxic toward A549 cells (IC(50)=15 μM).

Topics: Antimalarials; Cell Line, Tumor; Central Nervous System Agents; Humans; Indole Alkaloids; Indoles; Plasmodium falciparum; Pyrimidines; Receptors, Serotonin

2011