mercaptopurine and acadesine

mercaptopurine has been researched along with acadesine* in 1 studies

Other Studies

1 other study(ies) available for mercaptopurine and acadesine

Article	Year
Reversal of 6-mercaptopurine and 6-methylmercaptopurine ribonucleoside cytotoxicity by amidoimidazole carboxamide ribonucleoside in Molt F4 human malignant T-lymphoblasts. Biochemical pharmacology, 1993, Aug-03, Volume: 46, Issue:3 Cytotoxicity of 6-mercaptopurine (6MP) and 6-methylmercaptopurine ribonucleoside (Me-MPR) was studied in Molt F4 human malignant lymphoblasts. Both drugs are converted into methylthioIMP (Me-tIMP), which inhibits purine de novo synthesis. Addition of amidoimidazole carboxamide ribonucleoside (AICAR) circumvented inhibition of purine de novo synthesis, and thus partly prevented 6MP and Me-MPR cytotoxicity. Purine nucleotides, and especially adenine nucleotides, were recovered by addition of AICAR. Under these conditions, Me-tIMP formation decreased. The results of this study indicate that formation of Me-tIMP may be important for 6MP cytotoxicity in Molt F4 cells. These data suggest that depletion of adenine nucleotides is the main cause for Me-tIMP cytotoxicity. Topics: Adenine Nucleotides; Aminoimidazole Carboxamide; Cell Count; Cell Death; Drug Interactions; Guanine Nucleotides; Humans; Mercaptopurine; Methylthioinosine; Ribonucleosides; Thioinosine; Thionucleosides; Thionucleotides; Time Factors; Tumor Cells, Cultured	1993

Article

Year

Reversal of 6-mercaptopurine and 6-methylmercaptopurine ribonucleoside cytotoxicity by amidoimidazole carboxamide ribonucleoside in Molt F4 human malignant T-lymphoblasts.

Biochemical pharmacology, 1993, Aug-03, Volume: 46, Issue:3

Cytotoxicity of 6-mercaptopurine (6MP) and 6-methylmercaptopurine ribonucleoside (Me-MPR) was studied in Molt F4 human malignant lymphoblasts. Both drugs are converted into methylthioIMP (Me-tIMP), which inhibits purine de novo synthesis. Addition of amidoimidazole carboxamide ribonucleoside (AICAR) circumvented inhibition of purine de novo synthesis, and thus partly prevented 6MP and Me-MPR cytotoxicity. Purine nucleotides, and especially adenine nucleotides, were recovered by addition of AICAR. Under these conditions, Me-tIMP formation decreased. The results of this study indicate that formation of Me-tIMP may be important for 6MP cytotoxicity in Molt F4 cells. These data suggest that depletion of adenine nucleotides is the main cause for Me-tIMP cytotoxicity.

Topics: Adenine Nucleotides; Aminoimidazole Carboxamide; Cell Count; Cell Death; Drug Interactions; Guanine Nucleotides; Humans; Mercaptopurine; Methylthioinosine; Ribonucleosides; Thioinosine; Thionucleosides; Thionucleotides; Time Factors; Tumor Cells, Cultured

1993