meradine and 9-benzyladenine

meradine has been researched along with 9-benzyladenine* in 1 studies

Other Studies

1 other study(ies) available for meradine and 9-benzyladenine

Article	Year
Synthesis and biological evaluation of 2,8-disubstituted 9-benzyladenines: discovery of 8-mercaptoadenines as potent interferon-inducers. Bioorganic & medicinal chemistry, 2003, Jul-03, Volume: 11, Issue:13 Recently, we have identified 9-benzyl-8-hydroxyadenines bearing an appropriate substituent (a butoxy, propylthio or butylamino group) at the 2-position as potent interferon (IFN)-inducers. Herein we report the design, synthesis, and IFN-inducing activity of 8-substituted 9-benzyladenines possessing such an appropriate substituent at the 2-position. Introduction of the appropriate substituent into the 2-position of the adenine nucleus gave rise to expression of the activity even in 9-benzyladenines bearing no hydroxyl group at the 8-position. An amino group at the 6-position and a hydroxyl or thiol group carrying an acidic proton at the 8-position are required to express excellent IFN-inducing activity. 9-Benzyl-2-butoxy-8-mercaptoadenine (9) indicated the most potent activity with MEC of 0.001 microM. Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Drug Design; Gene Expression Regulation; Hepatitis C; Immunotherapy; Interferons; Mice; Spleen; Vesicular stomatitis Indiana virus	2003

Article

Year

Synthesis and biological evaluation of 2,8-disubstituted 9-benzyladenines: discovery of 8-mercaptoadenines as potent interferon-inducers.

Bioorganic & medicinal chemistry, 2003, Jul-03, Volume: 11, Issue:13

Recently, we have identified 9-benzyl-8-hydroxyadenines bearing an appropriate substituent (a butoxy, propylthio or butylamino group) at the 2-position as potent interferon (IFN)-inducers. Herein we report the design, synthesis, and IFN-inducing activity of 8-substituted 9-benzyladenines possessing such an appropriate substituent at the 2-position. Introduction of the appropriate substituent into the 2-position of the adenine nucleus gave rise to expression of the activity even in 9-benzyladenines bearing no hydroxyl group at the 8-position. An amino group at the 6-position and a hydroxyl or thiol group carrying an acidic proton at the 8-position are required to express excellent IFN-inducing activity. 9-Benzyl-2-butoxy-8-mercaptoadenine (9) indicated the most potent activity with MEC of 0.001 microM.

Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Drug Design; Gene Expression Regulation; Hepatitis C; Immunotherapy; Interferons; Mice; Spleen; Vesicular stomatitis Indiana virus

2003