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mephobarbital and phenobarbital

mephobarbital has been researched along with phenobarbital in 91 studies

Research

Studies (91)

Timeframe	Studies, this research(%)	All Research%
pre-1990	75 (82.42)	18.7374
1990's	6 (6.59)	18.2507
2000's	8 (8.79)	29.6817
2010's	2 (2.20)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bruno-Blanch, L; Gálvez, J; García-Domenech, R	1
Abellán Guillén, A; Cordeiro, MN; Garrido Escudero, A; Morales Helguera, A; Pérez-Garrido, A	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Eadie, MJ; Lander, CM; Tyrer, JH	2
Buchthal, A	1
Hanson, JW; Smith, DW	1
Barker, JL; Macdonald, RL	2
Hattori, M; Kazamatsuri, H	1
Leuschner, U; Quednow, B; Walther, H	1
Kupferberg, HJ; Longacre-Shaw, J	1
Forsythe, A; Wolf, SM	1
Burke, DG; Halpern, B; Korth, J; Summons, R; Truscott, RJ	1
Bochner, F; Eadie, MJ; Hooper, WD; Tyrer, JH	1
Mallette, LE	1
Kitova, E; Mileva, M; Popov, P; Staneva-Stoĭcheva, D	1
Kitova, E; Krustev, L; Staneva-Stoĭcheva, D	1
Eadie, MJ; Hooper, WD; Lander, CM; Tyrer, JH	1
Anderson, RC	1
Jeremić, V; Nikolić, R	1
Friel, P; Troupin, AS	1
Blaskovics, ME; Podosin, RL; Roe, TF	1
Wehrhahn, L; Wiegrebe, W	1
Annegers, JF; Elveback, LR; Hauser, WA; Kurland, LT	2
Borrás, J; Perelló, L; Sevilla, I	1
England, TM; Mongrain, SE; Soine, PJ; Soine, WH	1
Hässler, F	1
England, TM; Merat, S; Overton, BW; Soine, PJ; Soine, WH	1
Furlan, G; Mamolo, MG; Vio, L	1
Alger, PM; Bauer, L; Lauderbaugh, D; Young, RS	1
Domínguez, A; Jiménez, H	1
Eadie, MJ; Hooper, WD; Jacobsen, NW; Philippides, A; Treston, AM	1
Burd, L; Fisher, W; Gascon, G; Kerbeshian, J	1
Dunwiddie, TV; Olsen, RW; Worth, TS	1
Fulco, AJ; Wen, LP	1
Bardou, LG; Gentric, E; Lauransan, J; Menez, JF; Saumagne, P	1
Deitrich, RA; Erwin, VG	1
Kar, PP; Matin, MA	1
Brill, PW; Leonidas, JC; Waldman, N	1
Freeman, JM; Lietman, PS	1
Saad, SF	1
Gardner-Thorpe, C; Parsonage, MJ; Toothill, C	1
Garrettson, LK	1
Tharp, BR	1
Carroll, FI; Freudenthal, RI	1
Bouché, R	1
Cooper, SD; De la Iglesia, FA; Feuer, G; Lumb, G; Miller, DR	1
Rodgers, G; Roger, JC; Soo, A	1
Hooker, ML; Vida, JA	1
Lifshitz, F; Maclaren, NK	1
Cremers, HM; Verheesen, PE	1
Alvin, J; Bush, MT	1
Greeley, RH	1
Hill, RM; Horning, MG; McCulley, LB; Morgan, NF; Verniaud, WM	1
Glazener, L; Harvey, DJ; Hill, RM; Horning, MG; Nowlin, J; Stratton, C	1
Borgstedt, AD; Bryson, MF; Forbes, GB; Young, LW	1
Fiereck, EA; Tietz, NW	1
Alicino, JF; Hess, SM; Michel, IM; Weinryb, I	1
Ferngren, H; Paalzow, L	1
MacGee, J	1
Craig, CR; Shideman, FE	1
Bush, MT; Sanders-Bush, E	1
Gmyrek, D; Grimmer, I; Gross, J; Klinger, W; Moller, R	1
Holliday, TA	1
Fukuda, H; Goto, M; Kondo, M	1
Jaffery, FN; Matin, MA; Siddiqui, RA	1
Eadie, MJ; Hooper, WD; Kunze, HE	2
Bararay, M; Wahbi, AM	1
Neighbors, SM; Paibir, SG; Soine, WH	1
Fujii-Kuriyama, Y; Kato, R; Murayama, N; Nakayama, K; Shimada, M; Sogawa, K; Yamazoe, Y	1
An, A; Black, FW; Borges, A; Nelson, A; Rice, J; Willis, J	1
Boulanger, B; Ceccato, A; Chiap, P; Crommen, J; Hubert, P	1
Luco, JM; Olsina, RA	1
El-Gindy, A; Emara, S; Hadad, GM	1
Alkhamis, KA; Wurster, DE	1
BUTLER, TC	1
KOHLHEPP, B	1
ROMIJN, HM	1
WESTERINK, D	1
LIVINGSTON, S	1
JABBOUR, JT	1
OLIVEROS, RG	1
Alkhamis, KA; Matheson, LE; Wurster, DE	1
Chiba, K; Irie, S; Ishizaki, T; Kimura, M; Kobayashi, K; Morita, J; Urae, A; Wanibuchi, A	1
Heeringa-Karreman, M; van Munster, ET	1
Bialer, M	1

Reviews

6 review(s) available for mephobarbital and phenobarbital

Article	Year
[Pharmacotherapy of epilepsy. II]. Die Medizinische Welt, 1978, Jun-02, Volume: 29, Issue:22 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; Humans; Mephenytoin; Mephobarbital; Phenobarbital; Phenytoin; Primidone; Succinimides; Thiazines; Valproic Acid	1978
A basic approach to the understanding of seizures and the mechanism of action and metabolism of anticonvulsants. Advances in pediatrics, 1973, Volume: 20, Issue:0 Topics: Acetylcholine; Aminobutyrates; Anticonvulsants; Calcium; Cell Membrane Permeability; Depression, Chemical; Diazepam; Epilepsy; Ethosuximide; Humans; Membrane Potentials; Mephobarbital; Neural Inhibition; Neurons; Phenobarbital; Phenytoin; Primidone; Seizures; Stimulation, Chemical; Synapses; Synaptic Transmission	1973
Pharmacology of anticonvulsants. Pediatric clinics of North America, 1972, Volume: 19, Issue:1 Topics: Animals; Anticonvulsants; Child; Drug Interactions; Electroencephalography; Ethosuximide; Half-Life; Humans; Liver; Mephobarbital; Phenobarbital; Phenytoin; Primidone	1972
Recent progress in epilepsy. Diagnostic procedures and treatment. California medicine, 1973, Volume: 119, Issue:1 Topics: Anticonvulsants; Brain Neoplasms; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Humans; Mephobarbital; Phenobarbital; Phenytoin; Psychosurgery; United States	1973
Metabolism of certain commonly used barbiturates. Drug metabolism reviews, 1973, Volume: 2, Issue:2 Topics: Alcohols; Amobarbital; Animals; Barbiturates; Biotransformation; Chemical Phenomena; Chemistry; Dealkylation; Dogs; Ethers, Cyclic; Humans; Hydroxylation; Kinetics; Mephobarbital; Methylation; Microsomes, Liver; Oxidation-Reduction; Pentobarbital; Phenobarbital; Stereoisomerism	1973
Seizure disorders. The Veterinary clinics of North America. Small animal practice, 1980, Volume: 10, Issue:1 Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Diazepam; Dog Diseases; Dogs; Epilepsy; Mephobarbital; Phenobarbital; Phenytoin; Primidone; Recurrence; Seizures; Succinimides	1980

Trials

2 trial(s) available for mephobarbital and phenobarbital

Article	Year
A randomized, double-blind, crossover study of phenobarbital and mephobarbital. Journal of child neurology, 1986, Volume: 1, Issue:4 Topics: Child; Child Behavior; Clinical Trials as Topic; Double-Blind Method; Epilepsy; Female; Humans; Male; Mephobarbital; Phenobarbital; Prospective Studies; Random Allocation	1986
Barbiturate anticonvulsants: a neuropsychological and quantitative electroencephalographic study. Journal of child neurology, 1997, Volume: 12, Issue:3 Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy; Humans; Hypnotics and Sedatives; Mephobarbital; Neuropsychological Tests; Phenobarbital	1997

Other Studies

83 other study(ies) available for mephobarbital and phenobarbital

Article	Year
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship	2003
Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Bioorganic & medicinal chemistry, 2009, Jan-15, Volume: 17, Issue:2 Topics: beta-Cyclodextrins; Hydrophobic and Hydrophilic Interactions; Organic Chemicals; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Interactions between anticonvulsants. Proceedings of the Australian Association of Neurologists, 1975, Volume: 12 Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Humans; Mephobarbital; Phenobarbital; Phenytoin; Primidone; Thiazines	1975
The fetal hydantoin syndrome. The Journal of pediatrics, 1975, Volume: 87, Issue:2 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Child, Preschool; Developmental Disabilities; Epilepsy; Female; Fetus; Fingers; Growth Disorders; Humans; Hydantoins; Hypertelorism; Infant; Intellectual Disability; Male; Mephobarbital; Motor Skills; Mouth Abnormalities; Myoclonus; Nails, Malformed; Phenobarbital; Pregnancy; Pregnancy Complications; Primidone; Succinimides; Syndrome; Teratogens; Toes	1975
Anticonvulsant and anesthetic barbiturates: different postsynaptic actions in cultured mammalian neurons. Neurology, 1979, Volume: 29, Issue:4 Topics: Animals; Barbiturates; Chlorides; Culture Techniques; gamma-Aminobutyric Acid; Glutamates; Ion Channels; Membrane Potentials; Mephobarbital; Mice; Neural Inhibition; Neurons; Pentobarbital; Phenobarbital; Secobarbital; Spinal Cord; Synapses; Synaptic Transmission	1979
Enhancement of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: a common mode of anticonvulsant action. Brain research, 1979, May-11, Volume: 167, Issue:2 Topics: Animals; Anticonvulsants; Chlordiazepoxide; Culture Techniques; Diazepam; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Mephobarbital; Mice; Neural Conduction; Neural Inhibition; Neurons; Penicillin G; Phenobarbital; Spinal Cord; Synapses	1979
Serum levels of phenytoin and phenobarbital in epileptic patients treated with mixture antiepileptic tablets, Comital-L or Hydantol-F. Folia psychiatrica et neurologica japonica, 1979, Volume: 33, Issue:3 Topics: Anticonvulsants; Drug Combinations; Epilepsy; Humans; Mephobarbital; Phenobarbital; Phenytoin	1979
[Studies on the separation and photometric determination of antiepileptics (author's transl)]. Die Pharmazie, 1979, Volume: 34, Issue:11 Topics: Anticonvulsants; Carbamazepine; Chromatography, Thin Layer; Humans; Mephobarbital; Methods; Phenobarbital; Phenytoin; Spectrophotometry, Ultraviolet	1979
Mephobarbital and phenobarbital plasma concentrations in epileptic patients treated with mephobarbital. Therapeutic drug monitoring, 1979, Volume: 1, Issue:1 Topics: Chromatography, Gas; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Mephobarbital; Phenobarbital	1979
Factors influencing plasma carbamazepine concentrations. Clinical and experimental neurology, 1977, Volume: 14 Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Child, Preschool; Drug Interactions; Female; Humans; Infant; Infant, Newborn; Male; Mephobarbital; Middle Aged; Phenobarbital; Phenytoin	1977
Behavior disturbance, phenobarbital, and febrile seizures. Pediatrics, 1978, Volume: 61, Issue:5 Topics: Barbiturates; Child Behavior Disorders; Humans; Hyperkinesis; Mephobarbital; Phenobarbital; Recurrence; Seizures; Seizures, Febrile	1978
Simultaneous determination of diphenylhydantoin, mephobarbital, carbamazepine, phenobarbital and primidone in serum using direct chemical ionization mass spectrometry. Biomedical mass spectrometry, 1978, Volume: 5, Issue:8 Topics: Anticonvulsants; Carbamazepine; Computers; Evaluation Studies as Topic; Humans; Mass Spectrometry; Mephobarbital; Methods; Palmitic Acids; Phenobarbital; Phenytoin; Primidone	1978
Preliminary observations on the pharmacokinetics of methylphenobarbitone. Clinical and experimental neurology, 1978, Volume: 15 Topics: Adult; Drug Combinations; Female; Humans; Kinetics; Male; Mephobarbital; Metabolic Clearance Rate; Methylation; Middle Aged; Phenobarbital; Regression Analysis	1978
Acetazolamide-accelerated anticonvulsant osteomalacia. Archives of internal medicine, 1977, Volume: 137, Issue:8 Topics: Acetazolamide; Adult; Anticonvulsants; Calcium; Epilepsy; Female; Humans; Mephobarbital; Osteomalacia; Phenobarbital; Phenytoin; Phosphates	1977
[Comparative studies of enzyme-inducing ability of phenobarbital, methylphenobarbital, glutethimide and their N-substituted morphoalkylic derivatives]. Eksperimentalna meditsina i morfologiia, 1977, Volume: 16, Issue:1 Topics: Animals; Enzyme Induction; Glutethimide; Liver; Male; Mephobarbital; Microsomes, Liver; Organ Size; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Time Factors	1977
[Morphological changes in the liver of rats treated with phenobarbital, methylphenobarbital and their N-substituted morpholinoethyl derivatives]. Eksperimentalna meditsina i morfologiia, 1977, Volume: 16, Issue:2 Topics: Animals; Hypertrophy; Liver; Male; Mephobarbital; Phenobarbital; Rats; Time Factors	1977
Factors influencing plasma phenobarbitone levels in epileptic patients. British journal of clinical pharmacology, 1977, Volume: 4, Issue:5 Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Mephobarbital; Middle Aged; Phenobarbital; Primidone; Sex Factors	1977
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy. The Journal of pediatrics, 1976, Volume: 89, Issue:2 Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadione; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Heart Defects, Congenital; Humans; Infant, Newborn; Male; Mephobarbital; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Trimethadione	1976
An improved UV-spectrophotometric method for routine barbiturate monitoring. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1976, Volume: 14, Issue:10 Topics: Humans; Mephobarbital; Phenobarbital; Primidone; Spectrophotometry, Ultraviolet	1976
Flash-heater ethylation of some antiepileptic drugs. Clinical chemistry, 1975, Volume: 21, Issue:6 Topics: Alkylation; Anticonvulsants; Evaluation Studies as Topic; Hot Temperature; Humans; Mephenytoin; Mephobarbital; Methylation; Phenobarbital; Phenytoin; Primidone; Saliva	1975
Drug interaction: diazoxide and diphenylhydantoin. The Journal of pediatrics, 1975, Volume: 87, Issue:3 Topics: Administration, Oral; Adolescent; Child, Preschool; Chromatography, Gas; Diazoxide; Drug Therapy, Combination; Ethosuximide; Humans; Hyperinsulinism; Hypoglycemia; Infant; Injections, Intramuscular; Male; Mephobarbital; Phenobarbital; Phenytoin; Primidone; Radioligand Assay; Seizures	1975
[Polarographic determination of some phenylsubstituted anticonvulsants]. Arzneimittel-Forschung, 1975, Volume: 25, Issue:4 Topics: Anticonvulsants; Chromatography, Thin Layer; Mephenytoin; Mephobarbital; Phenobarbital; Phenytoin; Polarography; Primidone	1975
Epilepsy anticonvulsants and malformations. Birth defects original article series, 1975, Volume: 11, Issue:5 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defects, Congenital; Humans; Mephobarbital; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Primidone; Teratogens	1975
Metal complexes of phenobarbituric acid. Chelating behavior of the phenobarbiturate ring. Anticonvulsant properties of the K2[Cu(N-methylphenobarbiturato)]4.8H2O. Journal of inorganic biochemistry, 1992, Volume: 45, Issue:4 Topics: Animals; Anticonvulsants; Chelating Agents; Copper; Electron Spin Resonance Spectroscopy; Electroshock; Magnetic Resonance Spectroscopy; Mephobarbital; Metals; Molecular Structure; Phenobarbital; Seizures; Structure-Activity Relationship	1992
Stereochemical characterization of the diastereomers of the phenobarbital N-beta-D-glucose conjugate excreted in human urine. Pharmaceutical research, 1990, Volume: 7, Issue:4 Topics: Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Male; Mephobarbital; Molecular Conformation; Phenobarbital; Spectrophotometry, Ultraviolet; Stereoisomerism	1990
[A barbiturate derivative-induced depressive syndrome in a 9-year-old boy with complex focal seizures and secondary generalization--a case report]. Psychiatrie, Neurologie, und medizinische Psychologie, 1989, Volume: 41, Issue:12 Topics: Anticonvulsants; Child; Depressive Disorder; Drug Combinations; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy, Temporal Lobe; Humans; Male; Mephobarbital; Phenobarbital; Phenylpropanolamine	1989
Synthesis of N-beta-D-glucopyranosyl derivatives of barbital, phenobarbital, metharbital, and mephobarbital. Carbohydrate research, 1989, Oct-31, Volume: 193 Topics: Barbital; Barbiturates; Chromatography, High Pressure Liquid; Disaccharides; Magnetic Resonance Spectroscopy; Mephobarbital; Phenobarbital	1989
Simultaneous determination of phenobarbital, phenytoin and methylphenobarbital in tablet formulations by HPLC. Il Farmaco; edizione pratica, 1988, Volume: 43, Issue:5 Topics: Chromatography, High Pressure Liquid; Mephobarbital; Phenobarbital; Phenytoin; Tablets	1988
Study of the physicochemical properties of the binary complexes FeL2(OH)1,5H2O and FeP2(OH). Measurement of the pharmacological properties for the compound FeL2(OH)1,5H2O. Pharmaceutica acta Helvetiae, 1987, Volume: 62, Issue:10-11 Topics: Animals; Chemical Phenomena; Chemistry, Physical; Ferric Compounds; Hypnotics and Sedatives; Magnetics; Mephobarbital; Phenobarbital; Rats; Spectrophotometry, Infrared	1987
Identification and synthesis of O-methylcatechol metabolites of phenobarbital and some N-alkyl derivatives. Journal of pharmaceutical sciences, 1987, Volume: 76, Issue:6 Topics: Catechols; Gas Chromatography-Mass Spectrometry; Humans; Male; Mephobarbital; Phenobarbital; Stereoisomerism	1987
Anticonvulsant medications: an iatrogenic cause of tic disorders. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1986, Volume: 31, Issue:5 Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Female; Humans; Hyperkinesis; Male; Mephobarbital; Phenobarbital; Tic Disorders	1986
Facilitation of recurrent inhibition in rat hippocampus by barbiturate and related nonbarbiturate depressant drugs. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:2 Topics: Animals; Barbiturates; Central Nervous System Depressants; Etomidate; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Mephobarbital; Neural Inhibition; Pentobarbital; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism	1986
Induction of a cytochrome P-450-dependent fatty acid monooxygenase in Bacillus megaterium by a barbiturate analog, 1-[2-phenylbutyryl]-3-methylurea. Molecular and cellular biochemistry, 1985, Volume: 67, Issue:1 Topics: Bacillus megaterium; Bacterial Proteins; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydrolysis; Mephobarbital; Methylurea Compounds; Oxygenases; Phenobarbital; Structure-Activity Relationship	1985
Heteroassociation of O- and N-isopropyl derivatives of barbital and phenobarbital with 9-ethyladenine. Chemico-biological interactions, 1985, Volume: 54, Issue:1 Topics: Adenine; Barbital; Barbiturates; Carbon Tetrachloride; Chemical Phenomena; Chemistry; Computers; Mephobarbital; Phenobarbital; Spectrophotometry, Infrared; Uracil	1985
Inhibition of bovine brain aldehyde reductase by anticonvulsant compounds in vitro. Biochemical pharmacology, 1973, Oct-15, Volume: 22, Issue:20 Topics: Aldehyde Oxidoreductases; Amobarbital; Animals; Anticonvulsants; Barbiturates; Brain; Cattle; Ethosuximide; Hydantoins; Hydrogen-Ion Concentration; In Vitro Techniques; Isomerism; Kinetics; Mephobarbital; NADP; Pentobarbital; Phenobarbital; Phenytoin; Spectrometry, Fluorescence; Spectrophotometry; Succinimides; Trimethadione	1973
Effect of barbiturates and isoniazid on cerebral hemisphere gamma-aminobutyric acid content in pp' DDT treated mice. Pharmacological research communications, 1974, Volume: 6, Issue:4 Topics: Aminobutyrates; Animals; Anticonvulsants; Barbiturates; Behavior, Animal; Brain Chemistry; DDT; Drug Synergism; gamma-Aminobutyric Acid; Isoniazid; Male; Mephobarbital; Mice; Phenobarbital; Primidone; Seizures	1974
Antiepileptic therapy and rickets in children. Radiology, 1973, Volume: 109, Issue:2 Topics: Adolescent; Anticonvulsants; Barbiturates; Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, Tonic-Clonic; Female; Humans; Infant; Male; Mephobarbital; Phenobarbital; Phenytoin; Primidone; Rickets	1973
The effect of isoniazid and some anticonvulsant drugs on the gamma-aminobutyric acid content of mouse brain in insulin hypoglycaemia. The Journal of pharmacy and pharmacology, 1970, Volume: 22, Issue:5 Topics: Aminobutyrates; Animals; Barbiturates; Brain; Brain Chemistry; Cerebral Cortex; Hypoglycemia; Insulin Antagonists; Isoniazid; Male; Mephobarbital; Mice; Phenobarbital; Primidone; Seizures	1970
Anticonvulsant drugs in idiopathic epilepsy. The Medical letter on drugs and therapeutics, 1970, Jun-26, Volume: 12, Issue:13 Topics: Acetazolamide; Anticonvulsants; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Hydantoins; Mephobarbital; Phenobarbital; Phenytoin; Primidone; Substance Withdrawal Syndrome; Succinimides; Urea	1970
A comprehensive scheme for the evaluation of anticonvulsant concentrations in blood using thin-layer chromatography. Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 35, Issue:1 Topics: Acetazolamide; Anticonvulsants; Benzazepines; Carbamazepine; Chlordiazepoxide; Chromatography, Thin Layer; Diazepam; Epilepsy; Ethosuximide; Humans; Hydantoins; Mephobarbital; Nitro Compounds; Oxazepam; Phenobarbital; Phenytoin; Primidone; Succinimides; Thiazines	1971
Do anticonvulsants have a teratogenic effect? Archives of neurology, 1974, Volume: 31, Issue:6 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital Abnormalities; Epilepsy; Female; Heart Defects, Congenital; Humans; Infant; Infant Mortality; Infant, Newborn; Intellectual Disability; Male; Mephobarbital; Minnesota; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Pregnancy Trimester, First; Primidone; Teratogens	1974
[Differentiation of phenobarbital and methylphenobarbital by Pesez's reaction]. Annales pharmaceutiques francaises, 1972, Volume: 30, Issue:10 Topics: Benzoates; Chemistry Techniques, Analytical; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mephobarbital; Methods; Nitro Compounds; Phenobarbital; Polarography; Spectrum Analysis	1972
The influence of methyl groups on toxicity and drug metabolism. International journal of clinical pharmacology, therapy and toxicology, 1973, Volume: 7, Issue:1 Topics: Administration, Oral; Amphetamine; Animals; Carbon Isotopes; Coumarins; Enzyme Induction; Female; Humans; Mephobarbital; Methylation; Microscopy, Electron; Microsomes, Liver; Nicotine; Phenobarbital; Phenols; Phospholipids; Pyrazoles; Rats; Structure-Activity Relationship; Tritium	1973
Simultaneous determination of carbamazapine ("Tegretol") and other anticonvulsants in human plasma by gas-liquid chromatography. Clinical chemistry, 1973, Volume: 19, Issue:6 Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Computers; Dibenzazepines; Humans; Hydantoins; Mephobarbital; Methods; Methylation; Microchemistry; Phenobarbital; Phenytoin; Primidone; Quaternary Ammonium Compounds	1973
Anticonvulsants. 3. Phenobarbital and mephobarbital derivatives. Journal of medicinal chemistry, 1973, Volume: 16, Issue:6 Topics: Animals; Anticonvulsants; Barbiturates; Chemical Phenomena; Chemistry; Electroshock; Hypnotics and Sedatives; Male; Mephobarbital; Methods; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Time Factors	1973
Vitamin D-dependent rickets in institutionalized, mentally retarded children receiving long-term anticonvulsant therapy. I. A survey of 288 patients. The Journal of pediatrics, 1973, Volume: 83, Issue:4 Topics: Adolescent; Alkaline Phosphatase; Anticonvulsants; Calcium; Child; Child, Preschool; Female; Humans; Infant; Intellectual Disability; Magnesium; Male; Mephobarbital; Mesoridazine; Phenobarbital; Phenytoin; Phosphorus; Potassium; Primidone; Rickets; Seizures; Sodium; Succinimides; Vitamin D	1973
A rapid method for the estimation of anti-epileptic drugs in blood serum by gas-liquid chromatography. Clinica chimica acta; international journal of clinical chemistry, 1973, Nov-15, Volume: 48, Issue:4 Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Epilepsy; Ethosuximide; Evaluation Studies as Topic; Humans; Mephobarbital; Methods; Methylation; Microchemistry; Phenobarbital; Phenytoin; Primidone; Succinimides; Temperature; Time Factors; Trimethadione	1973
The metabolic fate of N,N'-dimethoxymethyl-phenobarbital in the rat. The Journal of pharmacology and experimental therapeutics, 1974, Volume: 188, Issue:1 Topics: Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Countercurrent Distribution; Dealkylation; Feces; In Vitro Techniques; Liver; Male; Mephobarbital; Methyl Ethers; Phenobarbital; Rats; Spectrophotometry, Ultraviolet; Time Factors	1974
New approach to derivatization and gas-chromatographic analysis of barbiturates. Clinical chemistry, 1974, Volume: 20, Issue:2 Topics: Amobarbital; Barbiturates; Chromatography, Gas; Evaluation Studies as Topic; Hexobarbital; Humans; Mephobarbital; Methods; Pentobarbital; Phenobarbital; Secobarbital	1974
Infants exposed in utero to antiepileptic drugs. A prospective study. American journal of diseases of children (1960), 1974, Volume: 127, Issue:5 Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chromatography, Gas; Diazepam; Epilepsy; Ethosuximide; Female; Fetus; Growth Disorders; Humans; Hydantoins; Infant, Newborn; Mass Spectrometry; Mephobarbital; Meprobamate; Milk, Human; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Primidone; Prochlorperazine; Prospective Studies; Substance Withdrawal Syndrome; Succinimides; Time Factors	1974
Detection of a 5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-metabolite of phenobarbital and mephobarbital in rat, guinea pig and human. Research communications in chemical pathology and pharmacology, 1972, Volume: 3, Issue:3 Topics: Alcohols; Alkenes; Animals; Barbiturates; Chromatography, Gas; Cyclohexanes; Cyclohexanols; Female; Guinea Pigs; Humans; Injections, Intraperitoneal; Mass Spectrometry; Mephobarbital; Phenobarbital; Pregnancy; Rats	1972
Long-term administration of antiepileptic drugs and the development of rickets. The Journal of pediatrics, 1972, Volume: 81, Issue:1 Topics: Alkaline Phosphatase; Anticonvulsants; Calcium; Diazepam; Ethosuximide; Female; Gluconates; Humans; Infant; Mephobarbital; Osteomalacia; Phenobarbital; Phenytoin; Phosphorus; Primidone; Radiography; Rickets; Seizures; Time Factors; Trimethadione; Vitamin D	1972
A gas-chromatographic method for separating and measuring barbiturates and glutethimide in blood. Clinical chemistry, 1971, Volume: 17, Issue:10 Topics: Amobarbital; Barbiturates; Blood Chemical Analysis; Chloroform; Chromatography, Gas; Evaluation Studies as Topic; Glass; Glutethimide; Hexobarbital; Humans; Hydrogen-Ion Concentration; Mathematics; Mephobarbital; Methods; Methohexital; Methylation; Pentobarbital; Phenobarbital; Secobarbital; Solubility; Spectrophotometry; Time Factors; Ultraviolet Rays	1971
Effects of barbiturate derivatives, sulfhydryl reagents, and oxidizing agents on the activity of adenylate cyclase from guinea pig heart and lung. Archives of biochemistry and biophysics, 1971, Volume: 146, Issue:2 Topics: Adenylyl Cyclase Inhibitors; Alloxan; Amobarbital; Animals; Barbiturates; Ethacrynic Acid; Guinea Pigs; Heart Ventricles; Lung; Male; Mephobarbital; Myocardium; Organomercury Compounds; Pentobarbital; Phenobarbital; Pulmonary Alveoli; Pyrrolidinones; Secobarbital; Sulfhydryl Reagents	1971
I.F. Anticonvulsants or antiepileptics. 4. Phenobarbital. Behavioral neuropsychiatry, 1971, Volume: 3, Issue:7 Topics: Epilepsy; Humans; Mephobarbital; Phenobarbital; Seizures	1971
High frequency electro-shock seizures and their antagonism during postnatal development in the mouse. II. Effects of phenobarbital sodium, mephobarbital, trimethadione, dimethadione, ethosuximide and acetazolamide. Acta pharmacologica et toxicologica, 1969, Volume: 27, Issue:4 Topics: Acetazolamide; Age Factors; Animals; Animals, Newborn; Anticonvulsants; Electroshock; Ethosuximide; Mephobarbital; Mice; Phenobarbital; Seizures; Trimethadione	1969
Rapid identification and quantitative determination of barbiturates and glutethimide in blood by gas-liquid chromatography. Clinical chemistry, 1971, Volume: 17, Issue:7 Topics: Amobarbital; Barbiturates; Chromatography, Gas; Glutethimide; Hydroxides; Mephobarbital; Methods; Pentobarbital; Phenobarbital; Secobarbital; Tetraethylammonium Compounds; Time Factors	1971
Metabolism and anticonvulsant properties of mephobarbital and phenobarbital in rats. The Journal of pharmacology and experimental therapeutics, 1971, Volume: 176, Issue:1 Topics: Animals; Anticonvulsants; Barbiturates; Brain; Chromatography, Gas; Electroshock; Male; Mephobarbital; Phenobarbital; Rats; Seizures	1971
Diazomethane: improved analytical and distillation techniques for small quantities and some synthetic applications. Analytical biochemistry, 1980, Volume: 106, Issue:2 Topics: Barbiturates; Chemistry, Organic; Chromatography, Gas; Diazomethane; Mephobarbital; Methods; Phenobarbital	1980
Influence of drugs on the bilirubin UDP-glucuronyltransferase activity and the concentration of Y and Z acceptor proteins in rat liver. Biology of the neonate, 1981, Volume: 40, Issue:5-6 Topics: Animals; Carrier Proteins; Cytoplasm; Drug Combinations; Fatty Acid-Binding Proteins; Glucuronosyltransferase; Intracellular Signaling Peptides and Proteins; Liver; Male; Mephobarbital; Nikethamide; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism; Stimulation, Chemical	1981
Effects of barbiturates on the decerebrate rigidity in rats. Journal of pharmacobio-dynamics, 1982, Volume: 5, Issue:9 Topics: Aminooxyacetic Acid; Amobarbital; Animals; Barbiturates; Decerebrate State; Male; Mephobarbital; Muscle Rigidity; Pentobarbital; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Time Factors	1982
A possible neurochemical basis of the central stimulatory effects of pp'DDT. Journal of neurochemistry, 1981, Volume: 36, Issue:3 Topics: Acetylcholine; Aminooxyacetic Acid; Ammonia; Animals; Central Nervous System; Corpus Striatum; DDT; gamma-Aminobutyric Acid; Hydroxylamines; Male; Mephobarbital; Mice; Phenobarbital; Primidone; Pyridoxine; Seizures	1981
High performance liquid chromatographic assay of methylphenobarbital metabolites in urine. Therapeutic drug monitoring, 1981, Volume: 3, Issue:1 Topics: Chromatography, High Pressure Liquid; Humans; Hydrolysis; Mephobarbital; Phenobarbital	1981
Simultaneous assay of methylphenobarbital and phenobarbital in plasma using gas chromatography--mass spectrometry with selected ion monitoring. Journal of chromatography, 1981, May-08, Volume: 223, Issue:2 Topics: Gas Chromatography-Mass Spectrometry; Humans; Mephobarbital; Phenobarbital; Time Factors	1981
Spectrophotometric determination of phenobarbitone, methylphenobarbitone and phenytoin in tablets. The Analyst, 1980, Volume: 105, Issue:1254 Topics: Mephobarbital; Phenobarbital; Phenytoin; Spectrophotometry, Ultraviolet; Tablets	1980
Synthesis of N-beta-D-glucopyranosyluronate derivatives of barbital, phenobarbital, metharbital, and mephobarbital. Carbohydrate research, 1995, Apr-19, Volume: 269, Issue:2 Topics: Barbital; Barbiturates; Chromatography, High Pressure Liquid; Diazomethane; Glucuronates; Magnetic Resonance Spectroscopy; Mephobarbital; Phenobarbital; Stereoisomerism	1995
Distinct effects of phenobarbital and its N-methylated derivative on liver cytochrome P450 induction. Archives of biochemistry and biophysics, 1996, Apr-01, Volume: 328, Issue:1 Topics: Animals; Base Sequence; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Induction; Gene Expression Regulation, Enzymologic; Hydroxylation; Liver; Mephobarbital; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; Phenobarbital; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Testosterone	1996
Simultaneous determination of methylphenobarbital enantiomers and phenobarbital in human plasma by on-line coupling of an achiral precolumn to a chiral liquid chromatographic column. Journal of chromatography. A, 1998, Sep-11, Volume: 819, Issue:1-2 Topics: Chromatography, Liquid; Humans; Mephobarbital; Phenobarbital; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism	1998
Simultaneous spectrophotometric determination of phenobarbital, phenytoin and methylphenobarbital in pharmaceutical preparations by using partial least-squares and principal component regression multivariate calibration. Journal of pharmaceutical and biomedical analysis, 2000, Dec-15, Volume: 24, Issue:2 Topics: Least-Squares Analysis; Mephobarbital; Multivariate Analysis; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Spectrophotometry, Ultraviolet	2000
Determination of two ternary mixtures containing phenobarbitone by second derivative of the ratio spectrum-zero-crossing and HPLC methods. Farmaco (Societa chimica italiana : 1989), 2003, Volume: 58, Issue:5 Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Mephobarbital; Papaverine; Phenobarbital; Phenytoin; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Technology, Pharmaceutical; Theophylline	2003
Prediction of adsorption from multicomponent solutions by activated carbon using single-solute parameters. Part II--Proposed equation. AAPS PharmSciTech, 2002, Volume: 3, Issue:3 Topics: Adsorption; Body Fluids; Charcoal; Chromatography, High Pressure Liquid; Gastrointestinal Contents; Mephobarbital; Models, Chemical; Pancreatin; Phenobarbital; Predictive Value of Tests; Primidone; Solutions; Thermodynamics	2002
Quantitative studies of the metabolic fate of mephobarbital (N-methyl phenobarbital). The Journal of pharmacology and experimental therapeutics, 1952, Volume: 106, Issue:2 Topics: Barbiturates; Humans; Mephobarbital; Phenobarbital	1952
[Experiences with comital and comital-L]. Medizinische Monatsschrift, 1951, Volume: 5, Issue:12 Topics: Barbiturates; Drug Combinations; Epilepsy; Hydantoins; Mephobarbital; Phenobarbital; Phenytoin	1951
[A microchemical reaction of methylphenobarbital]. Pharmaceutisch weekblad, 1959, Feb-21, Volume: 94, Issue:4 Topics: Mephobarbital; Phenobarbital	1959
[Chromatographic separation and microdetermination of phenobarbital, methylphenobarbital, butobarbital and phenytoin]. Pharmaceutisch weekblad, 1962, Nov-09, Volume: 97 Topics: Barbiturates; Chromatography; Mephobarbital; Phenobarbital; Phenytoin	1962
ANTIEPILEPTIC DRUGS. The American journal of nursing, 1963, Volume: 63 Topics: Acetazolamide; Amphetamine; Amphetamines; Anticonvulsants; Barbiturates; Bromides; Epilepsy; Ethosuximide; Humans; Hydantoins; Mephobarbital; Meprobamate; Phenobarbital; Phenytoin; Primidone; Succinimides; Toxicology	1963
THE INFANT WITH EPILEPSY. Southwestern medicine, 1963, Volume: 44 Topics: Acetazolamide; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Birth Injuries; Classification; Diagnosis; Epilepsy; Epilepsy, Temporal Lobe; Female; Genetics, Medical; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Mephobarbital; Meprobamate; Metabolism; Myoclonus; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Seizures; Spasms, Infantile; Temporal Lobe; Toxicology; Wounds and Injuries	1963
[REHABILITATION OF THE EPILEPTIC. CLINICAL EXPERIENCE WITH A POTENTIALIZED ANTICONVULSANT]. Hospital (Rio de Janeiro, Brazil), 1964, Volume: 65 Topics: Anticonvulsants; Barbiturates; Epilepsy; Humans; Mephobarbital; Phenobarbital; Phenytoin	1964
Prediction of adsorption from multicomponent solutions by activated carbon using single-solute parameters. AAPS PharmSciTech, 2000, Aug-31, Volume: 1, Issue:3 Topics: Adsorption; Area Under Curve; Body Fluids; Charcoal; Gastrointestinal Contents; Mephobarbital; Models, Chemical; Molecular Structure; Phenobarbital; Predictive Value of Tests; Primidone; Solutions; Surface Properties	2000
Pharmacogenetic roles of CYP2C19 and CYP2B6 in the metabolism of R- and S-mephobarbital in humans. Pharmacogenetics, 2004, Volume: 14, Issue:8 Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Genotype; Heterozygote; Homozygote; Humans; Hydroxylation; Japan; Male; Mephobarbital; Mixed Function Oxygenases; Molecular Structure; Oxidoreductases, N-Demethylating; Pharmacogenetics; Phenobarbital; Polymorphism, Genetic; Stereoisomerism	2004
[Intoxication due to replacement of the precursor methylphenobarbital by phenobarbital]. Nederlands tijdschrift voor geneeskunde, 2006, Apr-29, Volume: 150, Issue:17 Topics: Aged, 80 and over; Anticonvulsants; Biological Availability; Female; Humans; Intestinal Absorption; Mephobarbital; Phenobarbital	2006
How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)? Epilepsia, 2012, Volume: 53 Suppl 8 Topics: Anticonvulsants; Carbamazepine; Drug Discovery; Epilepsy; Ethosuximide; History, 20th Century; Humans; Mephenytoin; Mephobarbital; Phenobarbital; Phenytoin; Primidone; Structure-Activity Relationship; Succinimides; Valproic Acid	2012