mephenytoin has been researched along with warfarin in 21 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (4.76) | 18.7374 |
1990's | 6 (28.57) | 18.2507 |
2000's | 7 (33.33) | 29.6817 |
2010's | 6 (28.57) | 24.3611 |
2020's | 1 (4.76) | 2.80 |
Authors | Studies |
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Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Boddy, AV; Levy, RH | 1 |
Branch, RA; Guengerich, FP; Hall, SD; Wilkinson, GR | 1 |
Kunze, KL; Rettie, AE; Storch, E; Trager, WF; Wienkers, LC; Wurden, CJ | 1 |
Binkley, SN; Ring, BJ; VandenBranden, M; Wrighton, SA | 1 |
Heyn, H; Stevens, JC; White, RB | 1 |
Endres, HG; Henschel, L; Hippius, M; Hoffmann, A; Merkel, U | 1 |
Inoue, K; Mimura, M; Nakamura, S; Oda, H; Ohmori, S; Shimada, T; Yamazaki, H | 1 |
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K | 1 |
Beckurts, KT; Brachtendorf, L; Fuhr, U; Hölscher, AH; Jetter, A | 1 |
Bell, AR; Crewe, HK; Graham, MJ; Lennard, MS; Moorcraft, CL; Walker, L; Whittaker, EF | 1 |
Fouda, HG; Khojasteh-Bakht, SC; Prakash, C; Rossulek, MI | 1 |
Ekman, S; Fransson-Steen, R; Hagbjörk, AL; Löfgren, S; Terelius, Y | 1 |
Ashton, M; Asimus, S; Elsherbiny, D; Hai, TN; Huong, NV; Jansson, B; Petzold, MG; Simonsson, US | 1 |
Delaporte, E; Rodrigues, AD | 1 |
Hasegawa, M; Inoue, R; Kakuni, M; Tahara, H; Tateno, C; Ushiki, J | 1 |
Doogue, MP; Jensen, BP; Patel, F; Polasek, TM; Sorich, MJ; Wiese, MD | 1 |
Kanazawa, H; Maekawa, Y; Nagase, K; Okada, Y; Okamoto, N | 1 |
2 review(s) available for mephenytoin and warfarin
Article | Year |
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DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Stereoselectivity in pharmacokinetics: a general theory.
Topics: Humans; Mephenytoin; Models, Biological; Pharmacokinetics; Propranolol; Stereoisomerism; Verapamil; Warfarin | 1991 |
2 trial(s) available for mephenytoin and warfarin
Article | Year |
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Lack of pharmacokinetic interaction between dextromethorphan, coumarin and mephenytoin in man after simultaneous administration.
Topics: Administration, Oral; Adult; Anticoagulants; Anticonvulsants; Antitussive Agents; Coumarins; Dextromethorphan; Drug Interactions; Humans; Liver Function Tests; Male; Mephenytoin; Phenotype | 1996 |
Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Caffeine; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Male; Mephenytoin; Metoprolol; Midazolam; Middle Aged | 2007 |
17 other study(ies) available for mephenytoin and warfarin
Article | Year |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; Hydantoins; Isoenzymes; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenytoin; Polymorphism, Genetic; Stereoisomerism; Warfarin | 1987 |
Formation of (R)-8-hydroxywarfarin in human liver microsomes. A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19.
Topics: Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fluconazole; Humans; Hydroxylation; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Theophylline; Tranylcypromine; Warfarin | 1996 |
Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Coumarins; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Kinetics; Liver; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Proton-Translocating ATPases; Rabbits; Rabeprazole; Recombinant Proteins; Sulfaphenazole; Theophylline | 1996 |
Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin.
Topics: Antibodies, Monoclonal; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Recombinant Proteins; Troleandomycin | 1996 |
Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans.
Topics: Adrenergic beta-Antagonists; Aniline Compounds; Animals; Antineoplastic Agents; Benzphetamine; Carcinogens; Coumarins; Cytochrome P-450 Enzyme System; Dogs; Erythromycin; Ethanolamines; Ethylmorphine; Guinea Pigs; Humans; Macaca fascicularis; Mephenytoin; Microsomes, Liver; Nifedipine; Oxazines; Oxidation-Reduction; Phenacetin; Phenytoin; Rats; Species Specificity | 1997 |
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured | 2002 |
Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.
Topics: Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzymes; Humans; Ketoconazole; Kinetics; Maprotiline; Mephenytoin; Microsomes, Liver; Models, Biological; Quinidine; Sulfaphenazole; Theophylline | 2002 |
mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates.
Topics: Algorithms; Animals; Cytochrome P-450 Enzyme System; Dextromethorphan; Dogs; Female; Humans; Isoenzymes; Kinetics; Liver; Male; Mephenytoin; Microsomes, Liver; Omeprazole; Protein Biosynthesis; RNA, Messenger; Warfarin | 2003 |
Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543.
Topics: Adolescent; Adult; Aged; Chromans; Coumarins; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Ketoconazole; Kinetics; Male; Mephenytoin; Microsomes, Liver; Middle Aged; NADP; Oxidation-Reduction; Quinidine; Receptors, Leukotriene B4; Recombinant Proteins; Sulfaphenazole; Theophylline | 2003 |
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison.
Topics: Amiodarone; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Female; Humans; Kinetics; Lauric Acids; Male; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrophenols; Oxidoreductases, N-Demethylating; Oxygen; Paclitaxel; Phenacetin; Rats; Sex Factors; Species Specificity; Substrate Specificity; Testosterone | 2004 |
Cytochrome p450 assays.
Topics: Animals; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Enzyme Inhibitors; Humans; Mephenytoin; Paclitaxel; Phenacetin; Testosterone | 2002 |
Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver.
Topics: Animals; Biological Transport; Biotransformation; Chimera; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Inactivation, Metabolic; Liver; Male; Mephenytoin; Mice; Microsomes, Liver; Models, Animal; Pioglitazone; Pregnane X Receptor; Receptors, Steroid; Rifampin; RNA, Messenger; Thiazolidinediones; Triazolam; Warfarin | 2012 |
Predicted metabolic drug clearance with increasing adult age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Computer Simulation; Desipramine; Female; Humans; Male; Mephenytoin; Metabolic Clearance Rate; Midazolam; Middle Aged; Models, Biological; Warfarin | 2013 |
Green analytical method for the simultaneous analysis of cytochrome P450 probe substrates by poly(N-isopropylacrylamide)-based temperature-responsive chromatography.
Topics: Acrylic Resins; Chlorzoxazone; Chromatography, Liquid; Coumarins; Cytochrome P-450 Enzyme System; Drug Development; Green Chemistry Technology; Mephenytoin; Molecular Structure; Phenacetin; Solvents; Substrate Specificity; Temperature; Testosterone; Tolbutamide; Water | 2020 |