mephenytoin and warfarin

mephenytoin has been researched along with warfarin in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (4.76)	18.7374
1990's	6 (28.57)	18.2507
2000's	7 (33.33)	29.6817
2010's	6 (28.57)	24.3611
2020's	1 (4.76)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Boddy, AV; Levy, RH	1
Branch, RA; Guengerich, FP; Hall, SD; Wilkinson, GR	1
Kunze, KL; Rettie, AE; Storch, E; Trager, WF; Wienkers, LC; Wurden, CJ	1
Binkley, SN; Ring, BJ; VandenBranden, M; Wrighton, SA	1
Heyn, H; Stevens, JC; White, RB	1
Endres, HG; Henschel, L; Hippius, M; Hoffmann, A; Merkel, U	1
Inoue, K; Mimura, M; Nakamura, S; Oda, H; Ohmori, S; Shimada, T; Yamazaki, H	1
Chiba, K; Kobayashi, K; Shimada, N; Urashima, K	1
Beckurts, KT; Brachtendorf, L; Fuhr, U; Hölscher, AH; Jetter, A	1
Bell, AR; Crewe, HK; Graham, MJ; Lennard, MS; Moorcraft, CL; Walker, L; Whittaker, EF	1
Fouda, HG; Khojasteh-Bakht, SC; Prakash, C; Rossulek, MI	1
Ekman, S; Fransson-Steen, R; Hagbjörk, AL; Löfgren, S; Terelius, Y	1
Ashton, M; Asimus, S; Elsherbiny, D; Hai, TN; Huong, NV; Jansson, B; Petzold, MG; Simonsson, US	1
Delaporte, E; Rodrigues, AD	1
Hasegawa, M; Inoue, R; Kakuni, M; Tahara, H; Tateno, C; Ushiki, J	1
Doogue, MP; Jensen, BP; Patel, F; Polasek, TM; Sorich, MJ; Wiese, MD	1
Kanazawa, H; Maekawa, Y; Nagase, K; Okada, Y; Okamoto, N	1

Reviews

2 review(s) available for mephenytoin and warfarin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Stereoselectivity in pharmacokinetics: a general theory. Pharmaceutical research, 1991, Volume: 8, Issue:5 Topics: Humans; Mephenytoin; Models, Biological; Pharmacokinetics; Propranolol; Stereoisomerism; Verapamil; Warfarin	1991

Trials

2 trial(s) available for mephenytoin and warfarin

Article	Year
Lack of pharmacokinetic interaction between dextromethorphan, coumarin and mephenytoin in man after simultaneous administration. Die Pharmazie, 1996, Volume: 51, Issue:1 Topics: Administration, Oral; Adult; Anticoagulants; Anticonvulsants; Antitussive Agents; Coumarins; Dextromethorphan; Drug Interactions; Humans; Liver Function Tests; Male; Mephenytoin; Phenotype	1996
Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects. Fundamental & clinical pharmacology, 2007, Volume: 21, Issue:3 Topics: Adolescent; Adult; Antimalarials; Artemisinins; Caffeine; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Male; Mephenytoin; Metoprolol; Midazolam; Middle Aged	2007

Other Studies

17 other study(ies) available for mephenytoin and warfarin

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:1 Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; Hydantoins; Isoenzymes; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenytoin; Polymorphism, Genetic; Stereoisomerism; Warfarin	1987
Formation of (R)-8-hydroxywarfarin in human liver microsomes. A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:5 Topics: Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fluconazole; Humans; Hydroxylation; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Theophylline; Tranylcypromine; Warfarin	1996
Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor. Pharmacogenetics, 1996, Volume: 6, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Coumarins; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Kinetics; Liver; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Proton-Translocating ATPases; Rabbits; Rabeprazole; Recombinant Proteins; Sulfaphenazole; Theophylline	1996
Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:9 Topics: Antibodies, Monoclonal; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Recombinant Proteins; Troleandomycin	1996
Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans. Archives of toxicology, 1997, Volume: 71, Issue:6 Topics: Adrenergic beta-Antagonists; Aniline Compounds; Animals; Antineoplastic Agents; Benzphetamine; Carcinogens; Coumarins; Cytochrome P-450 Enzyme System; Dogs; Erythromycin; Ethanolamines; Ethylmorphine; Guinea Pigs; Humans; Macaca fascicularis; Mephenytoin; Microsomes, Liver; Nifedipine; Oxazines; Oxidation-Reduction; Phenacetin; Phenytoin; Rats; Species Specificity	1997
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. Biochemical pharmacology, 2002, Mar-01, Volume: 63, Issue:5 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured	2002
Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. Pharmacology & toxicology, 2002, Volume: 90, Issue:3 Topics: Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzymes; Humans; Ketoconazole; Kinetics; Maprotiline; Mephenytoin; Microsomes, Liver; Models, Biological; Quinidine; Sulfaphenazole; Theophylline	2002
mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates. Xenobiotica; the fate of foreign compounds in biological systems, 2003, Volume: 33, Issue:3 Topics: Algorithms; Animals; Cytochrome P-450 Enzyme System; Dextromethorphan; Dogs; Female; Humans; Isoenzymes; Kinetics; Liver; Male; Mephenytoin; Microsomes, Liver; Omeprazole; Protein Biosynthesis; RNA, Messenger; Warfarin	2003
Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543. Xenobiotica; the fate of foreign compounds in biological systems, 2003, Volume: 33, Issue:12 Topics: Adolescent; Adult; Aged; Chromans; Coumarins; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Ketoconazole; Kinetics; Male; Mephenytoin; Microsomes, Liver; Middle Aged; NADP; Oxidation-Reduction; Quinidine; Receptors, Leukotriene B4; Recombinant Proteins; Sulfaphenazole; Theophylline	2003
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:9 Topics: Amiodarone; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Female; Humans; Kinetics; Lauric Acids; Male; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrophenols; Oxidoreductases, N-Demethylating; Oxygen; Paclitaxel; Phenacetin; Rats; Sex Factors; Species Specificity; Substrate Specificity; Testosterone	2004
Cytochrome p450 assays. Current protocols in pharmacology, 2002, Volume: Chapter 3 Topics: Animals; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Enzyme Inhibitors; Humans; Mephenytoin; Paclitaxel; Phenacetin; Testosterone	2002
Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:3 Topics: Animals; Biological Transport; Biotransformation; Chimera; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Inactivation, Metabolic; Liver; Male; Mephenytoin; Mice; Microsomes, Liver; Models, Animal; Pioglitazone; Pregnane X Receptor; Receptors, Steroid; Rifampin; RNA, Messenger; Thiazolidinediones; Triazolam; Warfarin	2012
Predicted metabolic drug clearance with increasing adult age. British journal of clinical pharmacology, 2013, Volume: 75, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Computer Simulation; Desipramine; Female; Humans; Male; Mephenytoin; Metabolic Clearance Rate; Midazolam; Middle Aged; Models, Biological; Warfarin	2013
Green analytical method for the simultaneous analysis of cytochrome P450 probe substrates by poly(N-isopropylacrylamide)-based temperature-responsive chromatography. Scientific reports, 2020, 06-01, Volume: 10, Issue:1 Topics: Acrylic Resins; Chlorzoxazone; Chromatography, Liquid; Coumarins; Cytochrome P-450 Enzyme System; Drug Development; Green Chemistry Technology; Mephenytoin; Molecular Structure; Phenacetin; Solvents; Substrate Specificity; Temperature; Testosterone; Tolbutamide; Water	2020