Compounds > mephenytoin

mephenytoin and sulfaphenazole

mephenytoin has been researched along with sulfaphenazole in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's3 (21.43)18.2507
2000's5 (35.71)29.6817
2010's5 (35.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Birkett, DJ; Doecke, CJ; McManus, ME; Miners, JO; Pond, SM; Sansom, LN; Veronese, ME1
Brian, WR; Guengerich, FP; Lloyd, RS; Srivastava, PK; Umbenhauer, DR1
Chiba, K; Echizen, H; Ishizaki, T; Tani, M; Yoshimoto, K1
Binkley, SN; Ring, BJ; VandenBranden, M; Wrighton, SA1
Chiba, K; Fujii, H; Kobayashi, K; Mimura, N; Minami, H; Sasaki, Y; Shimada, N1
Dunbar, D; Kaminsky, LS; Obach, RS; Zhang, QY1
Beckurts, KT; Brachtendorf, L; Fuhr, U; Hölscher, AH; Jetter, A1
Fouda, HG; Khojasteh-Bakht, SC; Prakash, C; Rossulek, MI1
Chang, SY; Cui, D; Li, W; Rodrigues, AD; Traeger, SC; Wang, B; Wen, B; Zhang, H1
Farid, NA; Hagihara, K; Ikeda, T; Ishizuka, T; Kazui, M; Kurihara, A; Nishiya, Y; Okazaki, O1
Burmistrova, OA; Poloznikov, AA; Sakharov, DA; Shkurnikov, MY; Zakhariants, AA1

Other Studies

14 other study(ies) available for mephenytoin and sulfaphenazole

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes.
    British journal of clinical pharmacology, 1991, Volume: 31, Issue:2

    Topics: Binding, Competitive; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Immunoglobulin G; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Phenytoin; Sulfaphenazole; Tolbutamide

1991
Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae.
    Biochemistry, 1989, Jun-13, Volume: 28, Issue:12

    Topics: Catalysis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Electrophoresis; Gene Expression Regulation; Genetic Vectors; Hexobarbital; Humans; Liver; Mephenytoin; Mixed Function Oxygenases; Oxidation-Reduction; Plasmids; Saccharomyces cerevisiae; Spectrophotometry, Ultraviolet; Sulfaphenazole; Tolbutamide

1989
Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2.
    British journal of clinical pharmacology, 1995, Volume: 39, Issue:4

    Topics: Aged; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Ditiocarb; Female; Humans; Hydroxylation; In Vitro Techniques; Isoenzymes; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Oxazines; Phenacetin; Propranolol; Quinidine; Recombinant Proteins; Stereoisomerism; Substrate Specificity; Sulfaphenazole; Tolbutamide; Troleandomycin

1995
Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor.
    Pharmacogenetics, 1996, Volume: 6, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Coumarins; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Kinetics; Liver; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Proton-Translocating ATPases; Rabbits; Rabeprazole; Recombinant Proteins; Sulfaphenazole; Theophylline

1996
Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:8

    Topics: Animals; Antibodies; Antineoplastic Agents, Hormonal; Baculoviridae; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Inhibitors; Humans; Insecta; Isoenzymes; Ketoconazole; Medroxyprogesterone Acetate; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Recombinant Proteins; Sulfaphenazole

2000
Metabolic characterization of the major human small intestinal cytochrome p450s.
    Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:3

    Topics: Adult; Aged; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diclofenac; Enterocytes; Female; Humans; Hydroxylation; Immunoblotting; Intestine, Small; Isoenzymes; Kinetics; Male; Mephenytoin; Microsomes; Middle Aged; Mixed Function Oxygenases; Regression Analysis; Sulfaphenazole; Testosterone; Ticlopidine

2001
Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.
    Pharmacology & toxicology, 2002, Volume: 90, Issue:3

    Topics: Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzymes; Humans; Ketoconazole; Kinetics; Maprotiline; Mephenytoin; Microsomes, Liver; Models, Biological; Quinidine; Sulfaphenazole; Theophylline

2002
Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543.
    Xenobiotica; the fate of foreign compounds in biological systems, 2003, Volume: 33, Issue:12

    Topics: Adolescent; Adult; Aged; Chromans; Coumarins; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Ketoconazole; Kinetics; Male; Mephenytoin; Microsomes, Liver; Middle Aged; NADP; Oxidation-Reduction; Quinidine; Receptors, Leukotriene B4; Recombinant Proteins; Sulfaphenazole; Theophylline

2003
Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:12

    Topics: Acetates; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Catalysis; Cyclopropanes; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Enzyme Inhibitors; Genotype; Humans; Hydroxylation; Ibuprofen; Ketoconazole; Kinetics; Mephenytoin; Microsomes, Liver; Quinolines; Recombinant Proteins; Stereoisomerism; Sulfaphenazole; Sulfides; Tandem Mass Spectrometry

2008
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:1

    Topics: Antibodies; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Biotransformation; Cell Line; Cell Line, Tumor; Clopidogrel; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Glutathione; Humans; Ketoconazole; Kinetics; Mephenytoin; Microsomes; Microsomes, Liver; NADP; Omeprazole; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Sulfaphenazole; Theophylline; Ticlopidine

2010
Development of a Specific Substrate-Inhibitor Panel (Liver-on-a-Chip) for Evaluation of Cytochrome P450 Activity.
    Bulletin of experimental biology and medicine, 2016, Volume: 162, Issue:1

    Topics: Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Humans; Ketoconazole; Lab-On-A-Chip Devices; Liver; Mass Spectrometry; Mephenytoin; Microsomes, Liver; Omeprazole; Phencyclidine; Substrate Specificity; Sulfaphenazole; Testosterone; Tolbutamide

2016