Compounds > mephenytoin

mephenytoin and metoprolol

mephenytoin has been researched along with metoprolol in 12 studies

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (16.67)	18.7374
1990's	3 (25.00)	18.2507
2000's	3 (25.00)	29.6817
2010's	4 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Horai, Y; Ishikawa, K; Ishizaki, T; Liao, CL; Nakano, M; Zhang, LM; Zhou, BI; Zhou, HH	1
Catin, T; Dayer, P; Gut, J; Kronbach, T; Meier, UT; Meyer, UA; Skoda, C	1
Chiba, K; Echizen, H; Ishizaki, T; Kim, YH; Koyama, E; Shin, JG; Shin, SG; Sohn, DR	1
Chiba, K; Darmansjah, I; Ishizaki, T; Kusaka, M; Setiabudy, R	1
Xie, HG; Xu, ZH; Zhou, HH	1
Chen, XP; He, N; Huang, SL; Ou-Yang, DS; Tan, ZR; Zhou, HH; Zhu, B	1
Chen, XP; Huang, SL; Huang, Z; Ou-Yang, DS; Tan, ZR; Zhou, HH	1
Ashton, M; Asimus, S; Elsherbiny, D; Hai, TN; Huong, NV; Jansson, B; Petzold, MG; Simonsson, US	1

Reviews

1 review(s) available for mephenytoin and metoprolol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for mephenytoin and metoprolol

Article	Year
Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects. Fundamental & clinical pharmacology, 2007, Volume: 21, Issue:3 Topics: Adolescent; Adult; Antimalarials; Artemisinins; Caffeine; Chlorzoxazone; Coumarins; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Male; Mephenytoin; Metoprolol; Midazolam; Middle Aged	2007

Other Studies

10 other study(ies) available for mephenytoin and metoprolol

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese. Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:2 Topics: Adolescent; Adult; Asian People; China; Female; Humans; Hydantoins; Japan; Male; Mephenytoin; Metoprolol; Middle Aged; Oxidation-Reduction; Polymorphism, Genetic; Stereoisomerism	1989
The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation. Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:5 Topics: Adrenergic beta-Antagonists; Cytochrome P-450 Enzyme System; Ethanolamines; Genetic Variation; Humans; Hydantoins; Hydroxylation; Isoenzymes; Kinetics; Mephenytoin; Metoprolol; Microsomes, Liver; Oxidation-Reduction; Polymorphism, Genetic; Structure-Activity Relationship; Tissue Donors	1986
Metabolic disposition of imipramine in oriental subjects: relation to metoprolol alpha-hydroxylation and S-mephenytoin 4'-hydroxylation phenotypes. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:2 Topics: Adult; Asian People; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dealkylation; Female; Humans; Hydroxylation; Imipramine; Isoenzymes; Male; Mephenytoin; Metoprolol; Mixed Function Oxygenases; Phenotype	1994
Dapsone N-acetylation, metoprolol alpha-hydroxylation, and S-mephenytoin 4-hydroxylation polymorphisms in an Indonesian population: a cocktail and extended phenotyping assessment trial. Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:2 Topics: Acetylation; Adolescent; Adult; Asian People; China; Dapsone; Female; Humans; Hydroxylation; Indonesia; Japan; Male; Mephenytoin; Metoprolol; Middle Aged; Phenotype; Polymorphism, Genetic	1994
In vivo inhibition of CYP2C19 but not CYP2D6 by fluvoxamine. British journal of clinical pharmacology, 1996, Volume: 42, Issue:4 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Fluvoxamine; Humans; Male; Mephenytoin; Metoprolol; Mixed Function Oxygenases; Reference Values	1996
Assessment of cytochrome P450 activity by a five-drug cocktail approach. Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:5 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Male; Mephenytoin; Metoprolol; Midazolam; Mixed Function Oxygenases; Omeprazole; Oxidoreductases, N-Demethylating	2001
Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects. Clinical pharmacology and therapeutics, 2003, Volume: 73, Issue:3 Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Asian People; Aspirin; Caffeine; China; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Isoenzymes; Male; Mephenytoin; Metoprolol; Midazolam; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenotype; Reference Values; Theophylline	2003