mephenytoin has been researched along with hydantoins in 172 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 161 (93.60) | 18.7374 |
| 1990's | 9 (5.23) | 18.2507 |
| 2000's | 2 (1.16) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Roger, J; Tassinari, CA | 1 |
| Canonne, MA; Hue, G; Landriau, N; Maitrot, B; Rocher, A | 1 |
| Godolphin, W | 1 |
| Lawrence, RC; Lovering, EG; Watson, JR | 1 |
| Friel, P; Lovely, MP; Troupin, AS; Wilensky, AJ | 1 |
| Bircher, J; Küpfer, A | 1 |
| Gerber, N; Lynn, RK; Smith, RG; Thompson, RM | 1 |
| Kupferberg, HJ; Yonekawa, W | 1 |
| Rosenmund, H; Wad, N | 1 |
| MacMillan, SF; Raisys, VA; Zebelman, AM | 1 |
| Bircher, J; Küpfer, A; Preisig, R | 1 |
| Sohár, P; Stájer, G; Szabó, AE; Vinkler, E | 1 |
| Dodrill, CB; Ojemann, LM; Troupin, AS | 1 |
| Ojemann, LM; Troupin, AS | 1 |
| Hayslett, J; Siegel, N; Snead, C | 1 |
| Pezeshk, A; Pezeshk, V | 1 |
| Acuff-Smith, KD; Minck, DR; Vorhees, CV | 1 |
| Aoyama, T; Gonzalez, FJ; Meyer, UA; Relling, MV | 1 |
| Kato, R; Murayama, N; Yamazoe, Y; Yasumori, T | 1 |
| Blouin, RA; Britto, M; Foster, TS; Guttendorf, RJ; John, W; Pittman, KA; Wedlund, PJ | 1 |
| Bertilsson, L; Sanz, EJ | 1 |
| Breimer, DD; Schellens, JH; van der Wart, JH | 1 |
| Andersson, T; Bertilsson, L; Dahl-Puustinen, ML; Regårdh, CG | 1 |
| Bellino, L; Black, CM; Branch, RA; Csuka, ME; May, DG; Olsen, NJ; Porter, JA; Tanner, SB; Wilkinson, GR | 1 |
| Bertilsson, L; Henthorn, TK; Sanz, E; Säwe, J; Tybring, G; Villén, T | 1 |
| Bertilsson, L; Buemi, AL; Sanz, E; Spina, E | 1 |
| Abe, A; Fukasawa, T; Kato, R; Murayama, N; Nogi, Y; Yamazoe, Y; Yasumori, T | 1 |
| Branch, RA; Guengerich, FP; Wilkinson, GR | 1 |
| Alm, C; Bertilsson, L; Sanz, EJ; Villén, T | 1 |
| Breimer, DD; Brugman, M; Schellens, JH; van der Wart, JH | 1 |
| Bathum, L; Brøsen, K; Drøhse, A; Gram, LF | 1 |
| Horai, Y; Ishikawa, K; Ishizaki, T; Liao, CL; Nakano, M; Zhang, LM; Zhou, BI; Zhou, HH | 1 |
| Atiba, JO; Blaschke, TF; Wilkinson, GR | 1 |
| Catin, T; Dayer, P; Gut, J; Kronbach, T; Meier, UT; Meyer, UA; Skoda, C | 1 |
| Branch, RA; Guengerich, FP; Hall, SD; Wilkinson, GR | 1 |
| Catin, T; Gut, J; Meier, UT; Meyer, UA | 1 |
| Poling, A; Schlinger, H | 1 |
| Poling, A; Schlinger, H; Wilkenfield, J | 1 |
| Dulac, H; Jacqz, E; Mathieu, H | 1 |
| Lee, HS; Tan, SF; Wong, PT | 1 |
| Delaney, D; Pellettiere, V; Poling, A; Schlinger, H | 1 |
| Blakely, E; Poling, A; Starin, S | 1 |
| Diwan, BA; Hu, H; Lubet, RA; Nims, RW; Rice, JM; Ward, JM | 1 |
| Arias, TD; Inaba, T; Jorge, LF | 1 |
| Baumann, P; Jonzier-Perey, M | 1 |
| Dubey, RK; Guengerich, FP; Knodell, RG; Wilkinson, GR | 1 |
| Billante, C; Jacqz, E; Mathieu, H; Moysan, F | 1 |
| Alpin, RS; Day, PA; Hall, IH; Maguire, JH; Wong, OT | 1 |
| Delaney, D; Poling, A | 1 |
| Inaba, T | 1 |
| Baumann, P; Jonzier-Perey, M; Koeb, L; Küpfer, A; Schöpf, J; Tinguely, D | 1 |
| Branch, RA; Goto, F; Jacqz, E; Nakamura, K; Ward, SA; Wilkinson, GR | 1 |
| Branch, RA; Hall, SD; Jacqz, E; Wilkinson, GR | 1 |
| Inaba, T; Jurima, M; Kalow, W | 2 |
| Akrawi, SH; Wedlund, PJ | 1 |
| Adrian, K; Balthasar, S; Gachályi, B; Káldor, A; Róna, K; Vas, A | 1 |
| Gurtner, HP; Küpfer, A; Preisig, R; Saner, H | 1 |
| Inaba, T; Jurima, M; Kadar, D; Kalow, W | 1 |
| Guengerich, FP; Shimada, T | 1 |
| Aslanian, WS; Branch, RA; Jacqz, E; McAllister, CB; Wedlund, PJ; Wilkinson, GR | 1 |
| Branch, RA; Goto, F; Jacqz, E; McAllister, CB; Nakamura, K; Ray, WA; Wilkinson, GR | 1 |
| Branch, RA; Küpfer, A | 1 |
| Dayer, P; Kronbach, T; Malè, PJ; Meier, UT; Meyer, UA | 1 |
| Kronbach, T; Meier, UT; Meyer, UA | 1 |
| Cvejn, J; Hradecký, J; Pazdera, J; Zich, V | 1 |
| Branch, RA; Küpfer, A; Lawson, J | 1 |
| Desai, BT; Kupferberg, HJ; Newmark, ME; Penry, JK; Porter, RJ; Theodore, WH; Yonekawa, WD | 1 |
| Inaba, T; Jurima, M; Kalow, W; Nakano, M | 1 |
| Küpfer, A; Preisig, R | 1 |
| Aslanian, WS; Branch, RA; McAllister, CB; Wedlund, PJ; Wilkinson, GR | 1 |
| Branch, RA; Desmond, P; Küpfer, A; Patwardhan, R; Schenker, S | 1 |
| Branch, RA; McAllister, CB; Sweetman, BJ; Wedlund, PJ; Wilkinson, GR | 1 |
| Branch, RA; Küpfer, A; Patwardhan, R; Preisig, R; Schenker, S; Ward, S | 1 |
| Dicicco, BS; Goffman, TE; Tsou, E | 1 |
| Harbison, RD; Küpfer, A; Lawson, JA; Wells, PG | 1 |
| Branch, RA; Desmond, PV; Küpfer, A; Schenker, S | 1 |
| Branch, R; Carr, K; James, R; Küpfer, A | 1 |
| Bircher, J; Preisig, R; Zysset, T | 1 |
| Branch, RA; Küpfer, A; Roberts, RK; Schenker, S | 1 |
| Buckroyd, JE | 1 |
| Roeda, D; Westera, G | 1 |
| NIELSEN, DI | 1 |
| HAYS, AL; HILL, TS; WONG, YT | 1 |
| BELSASSO, M; BONIVENTO, M | 1 |
| SWARTOUT, R | 1 |
| ANDERSSON, B | 1 |
| HOLLANDER, L; MARKS, D; SCHWARTZ, L; SNAPPER, I | 1 |
| HALLEN, O | 2 |
| KOSKINEN, P | 1 |
| BUTLER, TC | 3 |
| BJØRNSTAD, R | 1 |
| GAMMON, GD; MALLIN, AW | 2 |
| BUTLER, TC; WADDELL, WJ | 1 |
| ABBOTT, JA; SCHWAB, RS | 1 |
| FUGLSANG-FREDERIKSEN, V | 1 |
| BODART, F | 1 |
| HOLTEN, C | 1 |
| KASLARIS, E | 1 |
| BARO, WZ | 1 |
| TAYLOR, WC | 1 |
| LA GRUTTA, G | 1 |
| DREYER, R | 1 |
| KLOPP, HW | 2 |
| HEUMANN, WA; WISE, RA | 1 |
| SOLTZ, WB; SPRING, M | 1 |
| LINDQVIST, T | 1 |
| GONZALEZ GUIJA, A | 1 |
| VIGNE, JP | 1 |
| FONDARAI, JA; VIGNE, JP | 1 |
| KIORBOE, E; KROMANN, K | 1 |
| IPPEN, H | 1 |
| HOFLE, KH; SCHOOP, W | 1 |
| WILLIAMS, CM | 1 |
| JONSSON, M | 1 |
| AKSOY, M; ALPUSTUN, H; DEVRIMEL, H | 1 |
| CRAVIOTTO, C | 2 |
| LUPAS, JA | 1 |
| KETZ, E; SCHWEINGRUBER, R | 1 |
| DOYLE, AP; HELLSTROM, HR | 1 |
| GRIESSHABER, W | 1 |
| REWERTS, G | 1 |
| BURRELL, ZL | 1 |
| LEIBETSEDER, F; ZELGER, J | 1 |
| HUSBY, J | 1 |
| SOLMS, W; WALLENTIN, G | 1 |
| GABRIELSEN, LH | 1 |
| JESSERER, H | 1 |
| HAWLEY, WD; WEISS, HA | 1 |
| JONES, DP | 1 |
| BEDELL, SG; LEAVITT, D; STILLMAN, S | 1 |
| KOREY, SR | 1 |
| HOLUB, K; WILD, H | 1 |
| WEINMANN, O | 2 |
| RUSKIN, DB | 1 |
| EITINGER, L; VISLIE, H | 1 |
| SCHERGNA, E | 1 |
| DANIEL MARTINEZ, P; GOMEZ OROZCO, L | 1 |
| HERMANN, HT; HOUFEK, EE | 1 |
| STOUSLAND, H | 1 |
| BRICK, H | 1 |
| ROMPEL, H | 1 |
| HOFSTATTER, L | 1 |
| KEIBL, E; MAYR, HO; NEUHOLD, R | 1 |
| HUNTER, H; JENKINS, D | 1 |
| WAID, ME; WITKIND, E | 1 |
| LITTLE, SC; LITTLJOHN, WS; McLALLEN, CD | 1 |
| BERCEL, NA; ZISKIND, E | 1 |
| LUND, M; NØRGAARD, K | 1 |
| MacARTHUR, P | 1 |
| SCHMUTTERMEIER, E; STACHEL, I | 1 |
| WINKLER, A | 1 |
| Jones, JP; Kneller, MB; Rettie, AE; Rock, DA; Suzuki, H; Trager, WF | 1 |
| GARVIN, JS; GIBBS, FA | 1 |
| BERNHARDT, H | 1 |
| DAVIES, RR; FISCH, C; TISCHER, EP | 1 |
| GREENHOUSE, JM; LEHR, E | 1 |
| BERCEL, NA; FINESILVER, B; SOLOMON, P; SOMERFELD-ZISKIND, E; ZISKIND, E | 1 |
| METCALFE, J; WELLER, RW | 1 |
| LITTLE, SC; McAVOY, M | 1 |
| Aird, RB | 1 |
| CARTER, HR | 1 |
| HARRIS, TH; OTTO, JL | 1 |
| KOZOL, HL | 1 |
2 review(s) available for mephenytoin and hydantoins
| Article | Year |
|---|---|
Genetic polymorphism of S-mephenytoin hydroxylation.
Topics: Animals; Humans; Hydantoins; Hydroxylation; Mephenytoin; Molecular Biology; Polymorphism, Genetic | 1989 |
Genetic polymorphism of mephenytoin metabolism.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chemical Phenomena; Chemistry; China; Cytochrome P-450 CYP2C19; Debrisoquin; Dogs; Ethnicity; Humans; Hydantoins; Hydroxylation; Japan; Kinetics; Liver; Mephenytoin; Mephobarbital; Mice; Mixed Function Oxygenases; Ontario; Phenotype; Polymorphism, Genetic; Sparteine; Tennessee; White People | 1986 |
2 trial(s) available for mephenytoin and hydantoins
| Article | Year |
|---|---|
Rapid screening for polymorphisms in dextromethorphan and mephenytoin metabolism.
Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Hydantoins; Levorphanol; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Oxidation-Reduction; Phenotype; Polymorphism, Genetic | 1990 |
Effects of ketoconazole on the polymorphic 4-hydroxylations of S-mephenytoin and debrisoquine.
Topics: Adult; Debrisoquin; Humans; Hydantoins; Hydroxylation; Isoquinolines; Ketoconazole; Male; Mephenytoin; Oxidation-Reduction; Phenotype; Stereoisomerism | 1989 |
168 other study(ies) available for mephenytoin and hydantoins
| Article | Year |
|---|---|
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Prognosis and therapy of complex partial seizures with barbiturates, hydantoins, and other drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Drug Therapy, Combination; Epilepsy; Epilepsy, Temporal Lobe; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Primidone; Prognosis; Succinimides; Thiazines; Valproic Acid | 1975 |
[Determination of phenobarbital, mephenytoin and diphenylhydantoin in the surveillance of anticonvulsant treatment].
Topics: Barbiturates; Child; Chromatography, Gas; Epilepsy; Ether; Humans; Hydantoins; Mephenytoin; Methylation; Phenobarbital; Phenytoin; Solvents; Temperature | 1976 |
Literature disagreement as to identity of Nirvanol.
Topics: Hydantoins; Mephenytoin; Terminology as Topic | 1977 |
Simple GLC analysis of anticonvulsant drugs in commercial dosage forms.
Topics: Anticonvulsants; Chromatography, Gas; Glutethimide; Hydantoins; Mephenytoin; Phenytoin; Primidone; Succinimides | 1978 |
Clinical pharmacology of mephenytoin and ethotoin.
Topics: Biotransformation; Epilepsy; Half-Life; Humans; Hydantoins; Kinetics; Mephenytoin; Saliva; Time Factors | 1979 |
Stereoselectivity of differential routes of drug metabolism: the fate of the enantiomers of [14C]mephenytoin in the dog.
Topics: Animals; Breath Tests; Chromatography, Gas; Dealkylation; Dogs; Dose-Response Relationship, Drug; Female; Hydantoins; Kinetics; Mephenytoin; Stereoisomerism | 1979 |
Evidence for the epoxide-diol pathway in the biotransformation of mephenytoin.
Topics: Adult; Biotransformation; Epilepsy; Humans; Hydantoins; Male; Mephenytoin | 1979 |
Measurement of mephenytoin (3-methyl-5-ethyl-5-phenylhydantoin) and its demethylated metabolite by selective ion monitoring.
Topics: Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Hydantoins; Mephenytoin; Time Factors | 1979 |
Rapid quantitative method for the simultaneous determination of carbamazepine, carbamazepine-10,11-epoxide, diphenylhydantion, mephenytoin, phenobarbital and primidone in serum by thin-layer chromatography.
Topics: Carbamazepine; Chromatography, Thin Layer; Drug Combinations; Epoxy Compounds; Humans; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Primidone | 1978 |
Gas-chromatographic determination of mephenytoin and desmethylmephenytoin, after off-column alkylation.
Topics: Alkylation; Chromatography, Gas; Humans; Hydantoins; Mephenytoin | 1979 |
Stereoselective metabolism, pharmacokinetics and biliary elimination of phenylethylhydantoin (Nirvanol) in the dog.
Topics: Animals; Bile; Chromatography, Gas; Dogs; Female; Hydantoins; Kinetics; Mephenytoin; Stereoisomerism | 1977 |
[New reaction for the identification of mesantoin (author's transl)].
Topics: Hydantoins; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mephenytoin | 1977 |
Mephenytoin: a reappraisal.
Topics: Adolescent; Adult; Anemia, Aplastic; Anticonvulsants; Chemical Phenomena; Chemistry; Drug Evaluation; Epilepsy; Follow-Up Studies; Humans; Hydantoins; Mephenytoin | 1976 |
Paradoxical intoxication--a complication of anticonvulsant administration.
Topics: Carbamazepine; Drug Therapy, Combination; Humans; Hydantoins; Mephenytoin; Phenytoin; Seizures | 1975 |
Generalized lymphadenopathy and nephrotic syndrome as a manifestation of mephenytoin (mesantoin) toxicity.
Topics: Adolescent; Edema; Epilepsy; Humans; Hydantoins; Lymphatic Diseases; Male; Mephenytoin; Nephrotic Syndrome | 1976 |
Drug-metal interactions: spectroscopic studies of copper hydantoin complexes.
Topics: Copper; Crystallization; Electron Spin Resonance Spectroscopy; Hydantoins; Mephenytoin; Molecular Structure; Phenytoin; Pyridines; Spectrophotometry, Infrared | 1991 |
Comparison of the behavioral teratogenic potential of phenytoin, mephenytoin, ethotoin, and hydantoin in rats.
Topics: Animals; Behavior, Animal; Ear, Inner; Female; Hydantoins; Male; Mephenytoin; Phenytoin; Pregnancy; Rats; Rats, Inbred Strains; Teratogens | 1991 |
Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.
Topics: Cell Line; Cytochrome P-450 Enzyme System; DNA; Humans; Hydantoins; Hydroxylation; In Vitro Techniques; Mephenytoin; Microsomes, Liver; Polymorphism, Genetic; Tolbutamide; Vaccinia virus | 1990 |
Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2.
Topics: Cytochrome P-450 Enzyme System; Hexobarbital; Humans; Hydantoins; Hydroxylation; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Phenotype; Polymorphism, Genetic; Stereoisomerism | 1990 |
d-Propoxyphene is a potent inhibitor of debrisoquine, but not S-mephenytoin 4-hydroxylation in vivo.
Topics: Administration, Oral; Adolescent; Adult; Debrisoquin; Dextropropoxyphene; Female; Humans; Hydantoins; Hydroxylation; Isomerism; Isoquinolines; Male; Mephenytoin; Polymorphism, Genetic | 1990 |
Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects.
Topics: Adult; Female; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Oxidation-Reduction; Phenobarbital; Phenotype; Phenytoin | 1990 |
Slow omeprazole metabolizers are also poor S-mephenytoin hydroxylators.
Topics: Administration, Oral; Humans; Hydantoins; Mephenytoin; Omeprazole | 1990 |
Scleroderma is associated with differences in individual routes of drug metabolism: a study with dapsone, debrisoquin, and mephenytoin.
Topics: Acetylation; Adult; Biotransformation; Dapsone; Debrisoquin; Disease Susceptibility; Female; Humans; Hydantoins; Hydroxylation; Isoquinolines; Logistic Models; London; Male; Mephenytoin; Middle Aged; Oxidation-Reduction; Scleroderma, Systemic; Tennessee | 1990 |
Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.
Topics: Adult; Benzodiazepines; Debrisoquin; Diazepam; Female; Humans; Hydantoins; Isoquinolines; Male; Mephenytoin; Mixed Function Oxygenases; Nordazepam; Phenotype; Smoking | 1989 |
Diazepam treatment does not influence the debrisoquine or mephenytoin hydroxylation phenotyping tests.
Topics: Adult; Debrisoquin; Diazepam; Drug Interactions; Humans; Hydantoins; Hydroxylation; Isoquinolines; Male; Mephenytoin; Middle Aged; Phenotype | 1989 |
Expression of a human P-450IIC gene in yeast cells using galactose-inducible expression system.
Topics: Antigen-Antibody Reactions; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Blotting, Western; Cloning, Molecular; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; DNA; DNA, Recombinant; Galactose; Gene Expression Regulation; Genetic Vectors; Humans; Hydantoins; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Saccharomyces cerevisiae; Transcription, Genetic | 1989 |
S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin.
Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Interactions; Female; Humans; Hydantoins; Hydroxylation; Isoquinolines; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Phenotype; Sweden | 1989 |
Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design.
Topics: Adult; Antipyrine; Cimetidine; Enzyme Induction; Female; Humans; Hydantoins; Male; Mephenytoin; Metabolic Clearance Rate; Nifedipine; Oxidation-Reduction; Phenobarbital; Smoking; Sparteine | 1989 |
Mephenytoin and sparteine oxidation: genetic polymorphisms in Denmark.
Topics: Adolescent; Adult; Chromatography, Gas; Denmark; Female; Humans; Hydantoins; Male; Mephenytoin; Middle Aged; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Sparteine | 1989 |
Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese.
Topics: Adolescent; Adult; Asian People; China; Female; Humans; Hydantoins; Japan; Male; Mephenytoin; Metoprolol; Middle Aged; Oxidation-Reduction; Polymorphism, Genetic; Stereoisomerism | 1989 |
The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation.
Topics: Adrenergic beta-Antagonists; Cytochrome P-450 Enzyme System; Ethanolamines; Genetic Variation; Humans; Hydantoins; Hydroxylation; Isoenzymes; Kinetics; Mephenytoin; Metoprolol; Microsomes, Liver; Oxidation-Reduction; Polymorphism, Genetic; Structure-Activity Relationship; Tissue Donors | 1986 |
Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; Hydantoins; Isoenzymes; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenytoin; Polymorphism, Genetic; Stereoisomerism; Warfarin | 1987 |
Mephenytoin-type polymorphism of drug oxidation: purification and characterization of a human liver cytochrome P-450 isozyme catalyzing microsomal mephenytoin hydroxylation.
Topics: Animals; Cytochrome P-450 Enzyme System; Humans; Hydantoins; Hydroxylation; Isoenzymes; Kinetics; Mephenytoin; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Polymorphism, Genetic; Rats | 1986 |
Acute and chronic effects of methsuximide and mephenytoin on the delayed-matching-to-sample performance of pigeons.
Topics: Animals; Anticonvulsants; Behavior, Animal; Columbidae; Hydantoins; Memory, Short-Term; Mephenytoin; Succinimides | 1988 |
Effects of methsuximide and mephenytoin on the responding of pigeons under a fixed-consecutive-number schedule with and without an external discriminative stimulus.
Topics: Animals; Anticonvulsants; Columbidae; Conditioning, Operant; Discrimination, Psychological; Hydantoins; Mephenytoin; Reinforcement Schedule; Succinimides | 1988 |
Phenotyping polymorphic drug metabolism in the French Caucasian population.
Topics: Adult; Dextromethorphan; Female; France; Humans; Hydantoins; Levorphanol; Male; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic; White People | 1988 |
N-demethylation of methyl and dimethyl derivatives of phenytoin and their anticonvulsant activities in mice.
Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Electroshock; gamma-Aminobutyric Acid; Hydantoins; Injections, Intraperitoneal; Male; Mephenytoin; Mice; Mice, Inbred Strains; Phenytoin; Radioligand Assay | 1988 |
Effects of mephenytoin on schedule-controlled responding in the pigeon.
Topics: Animals; Columbidae; Food; Hydantoins; Mephenytoin; Reaction Time; Reinforcement Schedule | 1988 |
Effects of mephenytoin and methsuximide on the reaction time of pigeons.
Topics: Animals; Anticonvulsants; Columbidae; Dose-Response Relationship, Drug; Hydantoins; Mephenytoin; Reaction Time; Succinimides | 1988 |
P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats.
Topics: Animals; Barbital; Barbiturates; Body Weight; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Hydantoins; Liver; Liver Neoplasms, Experimental; Male; Mephenytoin; Organ Size; Phenobarbital; Rats; Rats, Inbred F344; Thyroid Neoplasms | 1988 |
Mephenytoin hydroxylation in the Cuna Amerindians of Panama.
Topics: Humans; Hydantoins; Hydroxylation; Indians, Central American; Mephenytoin; Panama; Polymorphism, Genetic; White People | 1988 |
GC and GC-MS procedures for simultaneous phenotyping with dextromethorphan and mephenytoin.
Topics: Adult; Chromatography, Gas; Dextromethorphan; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydantoins; Hydroxylation; Levorphanol; Male; Mephenytoin; Phenotype | 1988 |
Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation.
Topics: Cytochrome P-450 Enzyme System; Hexobarbital; Humans; Hydantoins; Hydroxylation; In Vitro Techniques; Liver; Male; Mephenytoin; Oxidation-Reduction; Polymorphism, Genetic | 1988 |
The non-human primate: a possible model for human genetically determined polymorphisms in oxidative drug metabolism.
Topics: Animals; Biotransformation; Debrisoquin; Female; Hydantoins; Isoquinolines; Macaca; Macaca fascicularis; Male; Mephenytoin; Oxidation-Reduction; Polymorphism, Genetic | 1988 |
A comparison of the S(+) and R(-) enantiomers of 5-ethyl-5-phenylhydantoin as hypolipidemic agents in rodents.
Topics: Administration, Oral; Animals; Cholesterol; Feces; Hydantoins; Hypolipidemic Agents; Injections, Intraperitoneal; Intestine, Small; Isomerism; Lipid Metabolism; Lipoproteins; Liver; Male; Mephenytoin; Mice; Rats; Rats, Inbred Strains; Reference Values; Structure-Activity Relationship; Triglycerides | 1987 |
Effects of methsuximide and mephenytoin on the behavior of pigeons under a repeated acquisition procedure.
Topics: Animals; Anticonvulsants; Behavior, Animal; Columbidae; Conditioning, Operant; Female; Hydantoins; Learning; Mephenytoin; Reinforcement Schedule; Succinimides | 1987 |
Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin.
Topics: Adult; Amitriptyline; Debrisoquin; Depressive Disorder; Female; Humans; Hydantoins; Hydroxylation; Isoquinolines; Kinetics; Male; Mephenytoin; Middle Aged; Nortriptyline; Phenotype; Polymorphism, Genetic | 1986 |
S-mephenytoin 4-hydroxylase is inherited as an autosomal-recessive trait in Japanese families.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Female; Humans; Hydantoins; Hydroxylation; Japan; Male; Mephenytoin; Mixed Function Oxygenases; Pedigree; Phenotype | 1987 |
Polymorphic metabolism of mephenytoin in man: pharmacokinetic interaction with a co-regulated substrate, mephobarbital.
Topics: Administration, Oral; Adult; Aged; Drug Interactions; Female; Humans; Hydantoins; Kinetics; Male; Mephenytoin; Mephobarbital; Metabolic Clearance Rate; Middle Aged; Phenotype; Polymorphism, Genetic; Stereoisomerism | 1986 |
Family studies of mephenytoin hydroxylation deficiency.
Topics: Adolescent; Adult; Female; Genes, Recessive; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Middle Aged; Pedigree; Phenotype | 1986 |
A problem with quantitation of mephenytoin enantiomers due to chiral interference from its N-demethylated metabolite.
Topics: Chromatography, Gas; Dealkylation; Hydantoins; Mephenytoin; Stereoisomerism | 1986 |
[Distribution of the mephenytoin hydroxylator phenotype in the Hungarian adult population].
Topics: Female; Genetics, Population; Humans; Hungary; Hydantoins; Hydroxylation; Male; Mephenytoin; Middle Aged; Phenotype; Roma; White People | 1986 |
Polymorphic debrisoquine and mephenytoin hydroxylation in patients with pulmonary hypertension of vascular origin after aminorex fumarate.
Topics: Adult; Aged; Aminorex; Animals; Appetite Depressants; Debrisoquin; Female; Humans; Hydantoins; Hydroxylation; Hypertension, Pulmonary; In Vitro Techniques; Isoquinolines; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Oxazoles; Phenotype; Polymorphism, Genetic; Rats; Rats, Inbred Strains | 1986 |
Genetic polymorphism of mephenytoin p(4')-hydroxylation: difference between Orientals and Caucasians.
Topics: Adolescent; Adult; Aged; Asian People; Canada; China; Chromatography, Gas; Female; Humans; Hydantoins; Hydroxylation; Japan; Male; Mephenytoin; Middle Aged; Polymorphism, Genetic; White People | 1985 |
Participation of a rat liver cytochrome P-450 induced by pregnenolone 16 alpha-carbonitrile and other compounds in the 4-hydroxylation of mephenytoin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine-N-Demethylase; Hydantoins; Hydroxylation; Isoenzymes; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Pregnenolone Carbonitrile; Rats | 1985 |
Phenotypic differences in mephenytoin pharmacokinetics in normal subjects.
Topics: Adult; Aged; Humans; Hydantoins; Hydroxylation; Kinetics; Male; Mephenytoin; Middle Aged; Phenotype; Stereoisomerism | 1985 |
Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations.
Topics: Administration, Oral; Adolescent; Adult; Debrisoquin; Female; Genotype; Humans; Hydantoins; Hydroxylation; Isoquinolines; Japan; Male; Mephenytoin; Middle Aged; Phenotype; Random Allocation; White People | 1985 |
Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation.
Topics: Administration, Oral; Chromatography, High Pressure Liquid; Humans; Hydantoins; Hydroxylation; Mephenytoin; Mephobarbital; Phenotype; Stereoisomerism | 1985 |
Mephenytoin hydroxylation polymorphism: characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo.
Topics: Adult; Aged; Cytochrome P-450 Enzyme System; Female; Humans; Hydantoins; Hydroxylation; Kinetics; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Phenotype; Polymorphism, Genetic | 1985 |
Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Hydantoins; Hydroxylation; Kinetics; Mephenytoin; Microsomes, Liver; Stereoisomerism; Structure-Activity Relationship | 1985 |
[Changes in reactivity to halothane after administration of mephenytoin].
Topics: Animals; Halothane; Hydantoins; Malignant Hyperthermia; Mephenytoin; Swine; Swine Diseases | 1983 |
Stereoselectivity of the arene epoxide pathway of mephenytoin hydroxylation in man.
Topics: Ethers, Cyclic; Glucuronidase; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Molecular Conformation; Multienzyme Complexes; Sulfatases; Urine | 1984 |
Disposition of mephenytoin and its metabolite, nirvanol, in epileptic patients.
Topics: Adolescent; Adult; Epilepsies, Partial; Female; Humans; Hydantoins; Male; Mephenytoin | 1984 |
Mephenytoin and sparteine pharmacogenetics in Canadian Caucasians.
Topics: Administration, Oral; Adult; Aged; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Middle Aged; Pharmacogenetics; Sparteine; White People | 1984 |
Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man.
Topics: Adult; Debrisoquin; Female; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Phenotype; Polymorphism, Genetic | 1984 |
Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism.
Topics: Administration, Oral; Adolescent; Adult; Chromatography, High Pressure Liquid; Debrisoquin; Female; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic; Tennessee; White People | 1984 |
Mephenytoin hydroxylation deficiency: kinetics after repeated doses.
Topics: Adult; Female; Humans; Hydantoins; Hydroxylation; Kinetics; Male; Mephenytoin; Metabolism, Inborn Errors; Middle Aged; Pedigree; Stereoisomerism; Tritium | 1984 |
Sparteine oxidation by the human liver: absence of inhibition by mephenytoin.
Topics: Binding, Competitive; Cytochrome P-450 Enzyme System; Humans; Hydantoins; In Vitro Techniques; Liver; Mephenytoin; Oxidation-Reduction; Sparteine | 1984 |
Direct enantiomeric resolution of mephenytoin and its N-demethylated metabolite in plasma and blood using chiral capillary gas chromatography.
Topics: Anticonvulsants; Chromatography, Gas; Half-Life; Humans; Hydantoins; Mephenytoin; Stereoisomerism | 1984 |
Stereoselective metabolism and pharmacogenetic control of 5-phenyl-5-ethylhydantoin (nirvanol) in humans.
Topics: Adolescent; Adult; Anticonvulsants; Half-Life; Humans; Hydantoins; Male; Mephenytoin; Stereoisomerism; Time Factors | 1984 |
Mesantoin and pulmonary changes.
Topics: Adult; Female; Humans; Hydantoins; Mephenytoin; Respiratory Hypersensitivity | 1982 |
Relation of in vivo drug metabolism to stereoselective fetal hydantoin toxicology in mouse: evaluation of mephenytoin and its metabolite, nirvanol.
Topics: Animals; Embryo, Mammalian; Female; Fetus; Hydantoins; Mephenytoin; Mice; Mice, Inbred ICR; Pregnancy; Stereoisomerism | 1982 |
Stereoselective metabolism and disposition of the enantiomers of mephenytoin during chronic oral administration of the racemic drug in man.
Topics: Administration, Oral; Adult; Biotransformation; Blood Proteins; Humans; Hydantoins; Injections, Intravenous; Kinetics; Male; Mephenytoin; Stereoisomerism; Time Factors | 1982 |
Analysis of hydroxylated and demethylated metabolites of mephenytoin in man and laboratory animals using gas-liquid chromatography and high-performance liquid chromatography.
Topics: Animals; Chromatography, Gas; Chromatography, High Pressure Liquid; Dealkylation; Dogs; Guinea Pigs; Humans; Hydantoins; Hydroxylation; Mephenytoin; Mice; Rabbits; Rats | 1982 |
Increased systemic availability of drugs during acute ethanol intoxication: studies with mephenytoin in the dog.
Topics: Administration, Oral; Alcoholic Intoxication; Animals; Biological Availability; Biotransformation; Dogs; Drug Interactions; Ethanol; Female; Humans; Hydantoins; Injections, Intravenous; Mephenytoin | 1980 |
Stereoselective metabolism of mephenytoin in man.
Topics: Adult; Biotransformation; Carbon Radioisotopes; Chromatography, Gas; Chromatography, High Pressure Liquid; Humans; Hydantoins; Isotope Labeling; Male; Mephenytoin; Middle Aged; Stereoisomerism; Tritium | 1981 |
Mesantoin (methoin)
Topics: Australia; Hydantoins; Mephenytoin; Pharmacopoeias as Topic | 1981 |
The synthesis of some 11C-labelled antiepileptic drugs with potential utility as radiopharmaceuticals: hydantoins and barbiturates.
Topics: Anticonvulsants; Barbital; Barbiturates; Carbon Radioisotopes; Hydantoins; Isotope Labeling; Mephenytoin; Phenobarbital; Phenytoin | 1981 |
Aplastic anemia following mesantoin with recovery, case report.
Topics: Anemia; Anemia, Aplastic; Biological Phenomena; Hydantoins; Mephenytoin; Physiological Phenomena | 1952 |
The control with mesantoin on convulsive seizures due to neurosyphilis; clinical and electroencephalographic studies.
Topics: Electroencephalography; Epilepsy; Humans; Hydantoins; Mephenytoin; Neurosyphilis; Seizures | 1952 |
[Granulocytopenic syndromes in mesantoin therapy].
Topics: Agranulocytosis; Epilepsy; Humans; Hydantoins; Mephenytoin; Syndrome | 1952 |
Two cases of fatal pancytopenia following mesantoin therapy.
Topics: Anemia; Anemia, Aplastic; Hydantoins; Mephenytoin; Pancytopenia; Tracheophyta | 1953 |
[Complications in mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1953 |
Hemolytic anemia secondary to mesantoin.
Topics: Anemia; Anemia, Hemolytic; Humans; Hydantoins; Mephenytoin | 1953 |
[The treatment of epilepsy with mesantoin].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1953 |
[Treatment of epilepsy with mesantoin].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1953 |
[Fatal pancytopenia caused by mesantoin therapy].
Topics: Hematologic Diseases; Humans; Hydantoins; Mephenytoin; Pancytopenia | 1953 |
Quantitative studies of the physiological disposition of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin) and 5-ethyl-5-phenyl hydantoin (nirvanol).
Topics: Anticonvulsants; Blood; Humans; Hydantoins; Imidazoles; Mephenytoin | 1953 |
Leukopenia and scarlatiniform exanthema resulting from medication with mesantoin.
Topics: Drug Eruptions; Exanthema; Humans; Hydantoins; Leukocyte Count; Leukopenia; Mephenytoin | 1953 |
A clinical evaluation of mesantoin in epilepsy.
Topics: Epilepsy; Humans; Hydantoins; Mephenytoin | 1953 |
A pharmacological comparison of the optical isomers of 5-ethyl-5-phenyl hydantoin (nirvanol) and of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin).
Topics: Anticonvulsants; Hydantoins; Imidazoles; Mephenytoin | 1954 |
Mesantoin in the treatment of epilepsy; a study of its effect on the leukocyte count in seventy-nine cases.
Topics: Epilepsy; Hydantoins; Leukocyte Count; Mephenytoin | 1954 |
[Mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1953 |
[Lymph node swellings after mesantoin medication and their cytological picture].
Topics: Disease; Humans; Hydantoins; Lymph Nodes; Lymphatic Diseases; Mephenytoin | 1953 |
[Mesantoin and severe bone marrow aplasias].
Topics: Bone Marrow; Bone Marrow Diseases; Humans; Hydantoins; Mephenytoin | 1954 |
[Experimental production of lymph node swellings by feeding of mesantoin].
Topics: Disease; Humans; Hydantoins; Lymph Nodes; Lymphatic Diseases; Mephenytoin | 1953 |
Mesantoin (methyl-phenylethyl-hydantoin) as the anticonvulsant of choice.
Topics: Anticonvulsants; Behavior; Choice Behavior; Craniocerebral Trauma; Epilepsy; Hydantoins; Imidazoles; Intellectual Disability; Mephenytoin | 1954 |
Accidental mesantoin poisoning in an infant.
Topics: Child; Humans; Hydantoins; Infant; Mephenytoin; Poisoning | 1954 |
[Action of 5-ethyl-3-methyl-5-phenylhydantoin on experimental reflex epilepsy].
Topics: Epilepsy; Epilepsy, Reflex; Hydantoins; Mephenytoin | 1954 |
[Experiences with mesantoin].
Topics: Hydantoins; Mephenytoin | 1954 |
[Additional experience with mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1954 |
Mesantoin in the treatment of epilepsy.
Topics: Epilepsy; Humans; Hydantoins; Mephenytoin | 1955 |
Fatal aplastic anemia due to methylphenylethyl hydantoin (mesantoin).
Topics: Anemia; Anemia, Aplastic; Anticonvulsants; Humans; Hydantoins; Imidazoles; Mephenytoin | 1955 |
The metabolic conversion of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin) and of 5-ethyl-5-phenyl hydantoin (nirvanol) to 5 - ethyl -5- (p-hydroxyphenyl) hydantoin.
Topics: Anticonvulsants; Hydantoins; Imidazoles; Mephenytoin | 1956 |
Lupus erythematosus disseminatus after administration of mesantoin; report of two cases.
Topics: Humans; Hydantoins; Lupus Erythematosus, Systemic; Mephenytoin | 1957 |
[Mesantoin (sedantoinal) therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1957 |
[Metabolism of an antiepileptic drug, 5-ethyl-3-methyl-5-phenylhydantoin].
Topics: Anticonvulsants; Hydantoins; Mephenytoin | 1957 |
[An example of the application of radioisotopes in the pharmacological study of an anti-epileptic drug: 5-ethyl-3-methyl-5-phenylhydantoin].
Topics: Humans; Hydantoins; Mephenytoin; Radioisotopes | 1958 |
[Regular blood counts after treatment with mesantoin & dimedione].
Topics: Agranulocytosis; Anticonvulsants; Humans; Hydantoins; Mephenytoin | 1958 |
[Mesantoin injury and infectious mononucleosis].
Topics: Humans; Hydantoins; Infectious Mononucleosis; Mephenytoin | 1959 |
[Acute nephrotic syndrome caused by mesantoin treatment].
Topics: Humans; Hydantoins; Mephenytoin; Nephrotic Syndrome | 1959 |
Aplastic anaemia due to 3-methyl-5-phenyl-5-ethyl-hydantoin ("mesantoin").
Topics: Anemia; Anemia, Aplastic; Humans; Hydantoins; Mephenytoin | 1960 |
[Mesantoin reaction simulating infection].
Topics: Hydantoins; Infections; Mephenytoin | 1961 |
[Case of generalized lymphadenopathy with high fever, diffuse dermal eruptions, eosinophilia and plasmocytosis due to the administration of an anticonvulsant (mesantoin)].
Topics: Anticonvulsants; Eosinophilia; Exanthema; Humans; Hydantoins; Leukocyte Disorders; Lymphatic Diseases; Mephenytoin | 1959 |
[Experimental ophthalmopathic syndrome in guinea pigs caused by prolonged administration of 3-methyl-5-ethylphenylhydantoin].
Topics: Animals; Cataract; Eye Diseases; Guinea Pigs; Hydantoins; Keratitis; Mephenytoin | 1961 |
Severe drug reaction with bone marrow depression due to mesantoin.
Topics: Bone Marrow; Bone Marrow Diseases; Depression; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Hydantoins; Mephenytoin | 1962 |
[Clinical experiences with new anticonvulsants similar to mesantoin (N3, N5 and N7)].
Topics: Anticonvulsants; Humans; Hydantoins; Mephenytoin | 1962 |
MESANTOIN LYMPHADENOPATHY MORPHOLOGICALLY SIMULATING HODGKIN'S DISEASE.
Topics: Drug Hypersensitivity; Epilepsy; Hodgkin Disease; Humans; Hydantoins; Hyperplasia; Hypertrophy; Lymph Nodes; Lymphatic Diseases; Mephenytoin; Toxicology | 1963 |
[CONSIDERATIONS ON THE INTRAPARENCHYMAL CORNEAL OPACITY AND VASCULARIZATIONS INDUCED IN GUINEA PIGS WITH ADMINISTRATION OF MESANTOIN AND ALLOXAN].
Topics: Alloxan; Blood Vessels; Corneal Opacity; Guinea Pigs; Hydantoins; Mephenytoin; Neovascularization, Pathologic; Pharmacology; Research; Toxicology | 1963 |
[DATA TO THE PROBLEM OF CHRONIC MESANTOIN POISONING].
Topics: Adolescent; Blood Transfusion; Electroencephalography; Epilepsy; Epilepsy, Absence; Exanthema; Hydantoins; Lymphadenitis; Mephenytoin; Prednisolone; Toxicology | 1964 |
[MESANTOIN SIDE-EFFECT AND LYMPHOID CELL REACTION WITH SPECIAL REFERENCE TO THE DIFFERENTIAL DIAGNOSIS OF TOXIC CHANGES AND INFECTIOUS MONONUCLEOSIS].
Topics: Diagnosis, Differential; Drug-Related Side Effects and Adverse Reactions; Humans; Hydantoins; Iatrogenic Disease; Infectious Mononucleosis; Lymphocytes; Lymphocytosis; Mephenytoin; Poisoning; Toxicology | 1965 |
Fatal pancytopenia as a result of improperly supervised mesantoin therapy.
Topics: Anemia; Anemia, Aplastic; Epilepsy; Hydantoins; Mephenytoin; Pancytopenia; Research Personnel; Tracheophyta | 1955 |
[Manifestations of mesantoin reactions].
Topics: Humans; Hydantoins; Hypersensitivity; Immune System Diseases; Mephenytoin | 1954 |
[Phenantoin, diphydan Leo, phenytoinum NFN on the 25th anniversary of its synthesis].
Topics: Anniversaries and Special Events; Hydantoins; Mephenytoin | 1962 |
[Hydantal and mesantoin in treatment of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1950 |
Clinical evaluation of mesantoin in treatment of epilepsy.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Manifestations of intoxication in mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1950 |
[Differentiation of methylphenylethylhydantoin's (mesantoin's) mode of action in epileptic and in tetanic convulsions].
Topics: Epilepsy; Humans; Hydantoins; Mephenytoin; Seizures; Tetany | 1950 |
Pancytopenia following the use of mesantoin and thiantoin. Report of a fatal case.
Topics: Anemia; Anemia, Aplastic; Humans; Hydantoins; Mephenytoin; Pancytopenia; Tracheophyta | 1951 |
Methoin in the treatment of epilepsy.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
Fatal aplastic anemia associated with mesantoin; report of a case with autopsy.
Topics: Anemia; Anemia, Aplastic; Autopsy; Humans; Hydantoins; Mephenytoin; Tracheophyta | 1951 |
Effect of dilantin and mesantoin on the giant axon of the squid.
Topics: Animals; Axons; Decapodiformes; Hydantoins; Mephenytoin; Phenytoin; Shellfish | 1951 |
[Toxic effects of mesantoin].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1950 |
[Another case of importance bone-marrow lesion by mesantoin].
Topics: Bone Marrow; Epilepsy; Hydantoins; Mephenytoin | 1951 |
Comparative results in seizure control using phenobarbital, dilantin, and mesantoin.
Topics: Barbital; Epilepsy; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Seizures | 1950 |
[Mesantoin premedication and electroshock therapy].
Topics: Convulsive Therapy; Electroconvulsive Therapy; Humans; Hydantoins; Mephenytoin; Premedication | 1950 |
[New antiepileptic; 3-methyl-5,5-phenylethyl-hydantoin. (mesantoin Sandoz)].
Topics: Anticonvulsants; Epilepsy; Hydantoins; Imidazoles; Mephenytoin | 1951 |
[A case of scarlatinoform dermatitis produced by mesantoin administration].
Topics: Dermatitis; Hydantoins; Mephenytoin | 1950 |
Mesantoin in difficult cases of epilepsy.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Aplastic anemia caused by the hydantoin derivative mesantoin; fatal case].
Topics: Anemia; Anemia, Aplastic; Anticonvulsants; Epilepsy; Humans; Hydantoins; Mephenytoin | 1951 |
Treatment of epilepsy with mesantoin or hydantal.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Complications of electro-convulsontherapy caused by mesantoin].
Topics: Convulsive Therapy; Hydantoins; Mephenytoin | 1951 |
Mesantoin in the management of the hospitalized psychotic epileptic; report of toxic effects and one fatality.
Topics: Disease Management; Epilepsy; Hydantoins; Mental Disorders; Mephenytoin; Psychotic Disorders | 1951 |
[Injurious effects of mesantoin].
Topics: Communicable Diseases; Hydantoins; Infectious Mononucleosis; Mephenytoin | 1951 |
Occurrence of skin pigmentation during mesantoin therapy.
Topics: Epilepsy; Hydantoins; Mephenytoin; Skin; Skin Pigmentation | 1951 |
Aplasia of the bone marrow during mesantoin therapy; report of a fatal case.
Topics: Bone Marrow; Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Another case of aplastic anemia due to mesantoin].
Topics: Anemia; Anemia, Aplastic; Hydantoins; Mephenytoin | 1951 |
Mesantoin in the treatment of convulsive disorders.
Topics: Epilepsy; Hydantoins; Mephenytoin; Seizures | 1951 |
Fast electroencephalographic activity due to mesantoin.
Topics: Electroencephalography; Fasting; Humans; Hydantoins; Mephenytoin | 1951 |
Treatment of epilepsy with mesantoin and phenantoin.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
Metabolic demethylation of 3-methyl-5-ethyl-5-phenyl hydantoin (Mesantoin).
Topics: Anticonvulsants; Hydantoins; Mephenytoin | 1952 |
Serious idiosyncrasy to methoin.
Topics: Agranulocytosis; Hydantoins; Mephenytoin | 1952 |
[Results of mesantoin therapy of epilepsy].
Topics: Epilepsy; Hydantoins; Mephenytoin | 1951 |
[Experiences with hydantal Sandoz and Mesantoin in the therapy of epilepsy of children].
Topics: Child; Epilepsy; Hydantoins; Infant; Mephenytoin | 1952 |
[Skin eruptions caused by new antiepileptics (mesantoin)].
Topics: Anticonvulsants; Drug Eruptions; Exanthema; Hydantoins; Mephenytoin | 1952 |
Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors.
Topics: Aryl Hydrocarbon Hydroxylases; Barbiturates; Binding Sites; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Design; Enzyme Activation; Hydantoins; Mephenytoin; Mixed Function Oxygenases; Models, Chemical; Models, Molecular; Phenobarbital; Phenytoin; Protein Binding | 2004 |
Mesantoin toxicity; a clinical note.
Topics: Hydantoins; Mephenytoin | 1950 |
Fatal granulocytopenia following hydantoins, mesantoin and dilantin; report of a case.
Topics: Agranulocytosis; Hydantoins; Mephenytoin; Phenytoin | 1950 |
Pancytopenia due to mesantoin: report of a case.
Topics: Anemia; Hydantoins; Mephenytoin; Pancytopenia | 1950 |
Dermatitis medicamentosa caused by mesantoin.
Topics: Drug Eruptions; Hydantoins; Mephenytoin; Pharmaceutical Preparations | 1950 |
Mesantoin in epilepsy; report of 80 cases.
Topics: Epilepsy; Hydantoins; Mephenytoin | 1950 |
Fatal pancytopenia following the use of mesantoin; report of a case.
Topics: Aged; Anemia, Aplastic; Humans; Hydantoins; Mephenytoin; Pancytopenia | 1949 |
Changes in the electroencephalogram following administration o mesantoin (methyl-phenyl-ethyl hydantoin).
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Hydantoins; Mephenytoin | 1949 |
THE TREATMENT OF EPILEPSY WITH METHYLPHENYLETHYL HYDANTOIN (MESANTOIN).
Topics: Anticonvulsants; Epilepsy; Humans; Hydantoins; Imidazoles; Mephenytoin | 1948 |
Mesantoin, a new anticonvulsant in the management of epilepsy; a preliminary report.
Topics: Anticonvulsants; Disease Management; Epilepsy; Humans; Hydantoins; Imidazoles; Mephenytoin | 1947 |
The use of hydantoin (mesantoin) as an anticonvulsive drug.
Topics: Anticonvulsants; Humans; Hydantoins; Imidazoles; Mephenytoin | 1947 |
Epilepsy; treatment with new drug; 3-methyl 5,5-phenyl-ethyl-hydantoin (phenantoin).
Topics: Anticonvulsants; Epilepsy; Hydantoins; Imidazoles; Mephenytoin | 1946 |