mephenytoin and hydantoins

mephenytoin has been researched along with hydantoins in 172 studies

Research

Studies (172)

TimeframeStudies, this research(%)All Research%
pre-1990161 (93.60)18.7374
1990's9 (5.23)18.2507
2000's2 (1.16)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Roger, J; Tassinari, CA1
Canonne, MA; Hue, G; Landriau, N; Maitrot, B; Rocher, A1
Godolphin, W1
Lawrence, RC; Lovering, EG; Watson, JR1
Friel, P; Lovely, MP; Troupin, AS; Wilensky, AJ1
Bircher, J; Küpfer, A1
Gerber, N; Lynn, RK; Smith, RG; Thompson, RM1
Kupferberg, HJ; Yonekawa, W1
Rosenmund, H; Wad, N1
MacMillan, SF; Raisys, VA; Zebelman, AM1
Bircher, J; Küpfer, A; Preisig, R1
Sohár, P; Stájer, G; Szabó, AE; Vinkler, E1
Dodrill, CB; Ojemann, LM; Troupin, AS1
Ojemann, LM; Troupin, AS1
Hayslett, J; Siegel, N; Snead, C1
Pezeshk, A; Pezeshk, V1
Acuff-Smith, KD; Minck, DR; Vorhees, CV1
Aoyama, T; Gonzalez, FJ; Meyer, UA; Relling, MV1
Kato, R; Murayama, N; Yamazoe, Y; Yasumori, T1
Blouin, RA; Britto, M; Foster, TS; Guttendorf, RJ; John, W; Pittman, KA; Wedlund, PJ1
Bertilsson, L; Sanz, EJ1
Breimer, DD; Schellens, JH; van der Wart, JH1
Andersson, T; Bertilsson, L; Dahl-Puustinen, ML; Regårdh, CG1
Bellino, L; Black, CM; Branch, RA; Csuka, ME; May, DG; Olsen, NJ; Porter, JA; Tanner, SB; Wilkinson, GR1
Bertilsson, L; Henthorn, TK; Sanz, E; Säwe, J; Tybring, G; Villén, T1
Bertilsson, L; Buemi, AL; Sanz, E; Spina, E1
Abe, A; Fukasawa, T; Kato, R; Murayama, N; Nogi, Y; Yamazoe, Y; Yasumori, T1
Branch, RA; Guengerich, FP; Wilkinson, GR1
Alm, C; Bertilsson, L; Sanz, EJ; Villén, T1
Breimer, DD; Brugman, M; Schellens, JH; van der Wart, JH1
Bathum, L; Brøsen, K; Drøhse, A; Gram, LF1
Horai, Y; Ishikawa, K; Ishizaki, T; Liao, CL; Nakano, M; Zhang, LM; Zhou, BI; Zhou, HH1
Atiba, JO; Blaschke, TF; Wilkinson, GR1
Catin, T; Dayer, P; Gut, J; Kronbach, T; Meier, UT; Meyer, UA; Skoda, C1
Branch, RA; Guengerich, FP; Hall, SD; Wilkinson, GR1
Catin, T; Gut, J; Meier, UT; Meyer, UA1
Poling, A; Schlinger, H1
Poling, A; Schlinger, H; Wilkenfield, J1
Dulac, H; Jacqz, E; Mathieu, H1
Lee, HS; Tan, SF; Wong, PT1
Delaney, D; Pellettiere, V; Poling, A; Schlinger, H1
Blakely, E; Poling, A; Starin, S1
Diwan, BA; Hu, H; Lubet, RA; Nims, RW; Rice, JM; Ward, JM1
Arias, TD; Inaba, T; Jorge, LF1
Baumann, P; Jonzier-Perey, M1
Dubey, RK; Guengerich, FP; Knodell, RG; Wilkinson, GR1
Billante, C; Jacqz, E; Mathieu, H; Moysan, F1
Alpin, RS; Day, PA; Hall, IH; Maguire, JH; Wong, OT1
Delaney, D; Poling, A1
Inaba, T1
Baumann, P; Jonzier-Perey, M; Koeb, L; Küpfer, A; Schöpf, J; Tinguely, D1
Branch, RA; Goto, F; Jacqz, E; Nakamura, K; Ward, SA; Wilkinson, GR1
Branch, RA; Hall, SD; Jacqz, E; Wilkinson, GR1
Inaba, T; Jurima, M; Kalow, W2
Akrawi, SH; Wedlund, PJ1
Adrian, K; Balthasar, S; Gachályi, B; Káldor, A; Róna, K; Vas, A1
Gurtner, HP; Küpfer, A; Preisig, R; Saner, H1
Inaba, T; Jurima, M; Kadar, D; Kalow, W1
Guengerich, FP; Shimada, T1
Aslanian, WS; Branch, RA; Jacqz, E; McAllister, CB; Wedlund, PJ; Wilkinson, GR1
Branch, RA; Goto, F; Jacqz, E; McAllister, CB; Nakamura, K; Ray, WA; Wilkinson, GR1
Branch, RA; Küpfer, A1
Dayer, P; Kronbach, T; Malè, PJ; Meier, UT; Meyer, UA1
Kronbach, T; Meier, UT; Meyer, UA1
Cvejn, J; Hradecký, J; Pazdera, J; Zich, V1
Branch, RA; Küpfer, A; Lawson, J1
Desai, BT; Kupferberg, HJ; Newmark, ME; Penry, JK; Porter, RJ; Theodore, WH; Yonekawa, WD1
Inaba, T; Jurima, M; Kalow, W; Nakano, M1
Küpfer, A; Preisig, R1
Aslanian, WS; Branch, RA; McAllister, CB; Wedlund, PJ; Wilkinson, GR1
Branch, RA; Desmond, P; Küpfer, A; Patwardhan, R; Schenker, S1
Branch, RA; McAllister, CB; Sweetman, BJ; Wedlund, PJ; Wilkinson, GR1
Branch, RA; Küpfer, A; Patwardhan, R; Preisig, R; Schenker, S; Ward, S1
Dicicco, BS; Goffman, TE; Tsou, E1
Harbison, RD; Küpfer, A; Lawson, JA; Wells, PG1
Branch, RA; Desmond, PV; Küpfer, A; Schenker, S1
Branch, R; Carr, K; James, R; Küpfer, A1
Bircher, J; Preisig, R; Zysset, T1
Branch, RA; Küpfer, A; Roberts, RK; Schenker, S1
Buckroyd, JE1
Roeda, D; Westera, G1
NIELSEN, DI1
HAYS, AL; HILL, TS; WONG, YT1
BELSASSO, M; BONIVENTO, M1
SWARTOUT, R1
ANDERSSON, B1
HOLLANDER, L; MARKS, D; SCHWARTZ, L; SNAPPER, I1
HALLEN, O2
KOSKINEN, P1
BUTLER, TC3
BJØRNSTAD, R1
GAMMON, GD; MALLIN, AW2
BUTLER, TC; WADDELL, WJ1
ABBOTT, JA; SCHWAB, RS1
FUGLSANG-FREDERIKSEN, V1
BODART, F1
HOLTEN, C1
KASLARIS, E1
BARO, WZ1
TAYLOR, WC1
LA GRUTTA, G1
DREYER, R1
KLOPP, HW2
HEUMANN, WA; WISE, RA1
SOLTZ, WB; SPRING, M1
LINDQVIST, T1
GONZALEZ GUIJA, A1
VIGNE, JP1
FONDARAI, JA; VIGNE, JP1
KIORBOE, E; KROMANN, K1
IPPEN, H1
HOFLE, KH; SCHOOP, W1
WILLIAMS, CM1
JONSSON, M1
AKSOY, M; ALPUSTUN, H; DEVRIMEL, H1
CRAVIOTTO, C2
LUPAS, JA1
KETZ, E; SCHWEINGRUBER, R1
DOYLE, AP; HELLSTROM, HR1
GRIESSHABER, W1
REWERTS, G1
BURRELL, ZL1
LEIBETSEDER, F; ZELGER, J1
HUSBY, J1
SOLMS, W; WALLENTIN, G1
GABRIELSEN, LH1
JESSERER, H1
HAWLEY, WD; WEISS, HA1
JONES, DP1
BEDELL, SG; LEAVITT, D; STILLMAN, S1
KOREY, SR1
HOLUB, K; WILD, H1
WEINMANN, O2
RUSKIN, DB1
EITINGER, L; VISLIE, H1
SCHERGNA, E1
DANIEL MARTINEZ, P; GOMEZ OROZCO, L1
HERMANN, HT; HOUFEK, EE1
STOUSLAND, H1
BRICK, H1
ROMPEL, H1
HOFSTATTER, L1
KEIBL, E; MAYR, HO; NEUHOLD, R1
HUNTER, H; JENKINS, D1
WAID, ME; WITKIND, E1
LITTLE, SC; LITTLJOHN, WS; McLALLEN, CD1
BERCEL, NA; ZISKIND, E1
LUND, M; NØRGAARD, K1
MacARTHUR, P1
SCHMUTTERMEIER, E; STACHEL, I1
WINKLER, A1
Jones, JP; Kneller, MB; Rettie, AE; Rock, DA; Suzuki, H; Trager, WF1
GARVIN, JS; GIBBS, FA1
BERNHARDT, H1
DAVIES, RR; FISCH, C; TISCHER, EP1
GREENHOUSE, JM; LEHR, E1
BERCEL, NA; FINESILVER, B; SOLOMON, P; SOMERFELD-ZISKIND, E; ZISKIND, E1
METCALFE, J; WELLER, RW1
LITTLE, SC; McAVOY, M1
Aird, RB1
CARTER, HR1
HARRIS, TH; OTTO, JL1
KOZOL, HL1

Reviews

2 review(s) available for mephenytoin and hydantoins

ArticleYear
Genetic polymorphism of S-mephenytoin hydroxylation.
    Pharmacology & therapeutics, 1989, Volume: 43, Issue:1

    Topics: Animals; Humans; Hydantoins; Hydroxylation; Mephenytoin; Molecular Biology; Polymorphism, Genetic

1989
Genetic polymorphism of mephenytoin metabolism.
    Progress in clinical and biological research, 1986, Volume: 214

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chemical Phenomena; Chemistry; China; Cytochrome P-450 CYP2C19; Debrisoquin; Dogs; Ethnicity; Humans; Hydantoins; Hydroxylation; Japan; Kinetics; Liver; Mephenytoin; Mephobarbital; Mice; Mixed Function Oxygenases; Ontario; Phenotype; Polymorphism, Genetic; Sparteine; Tennessee; White People

1986

Trials

2 trial(s) available for mephenytoin and hydantoins

ArticleYear
Rapid screening for polymorphisms in dextromethorphan and mephenytoin metabolism.
    British journal of clinical pharmacology, 1990, Volume: 29, Issue:4

    Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Hydantoins; Levorphanol; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Oxidation-Reduction; Phenotype; Polymorphism, Genetic

1990
Effects of ketoconazole on the polymorphic 4-hydroxylations of S-mephenytoin and debrisoquine.
    British journal of clinical pharmacology, 1989, Volume: 28, Issue:2

    Topics: Adult; Debrisoquin; Humans; Hydantoins; Hydroxylation; Isoquinolines; Ketoconazole; Male; Mephenytoin; Oxidation-Reduction; Phenotype; Stereoisomerism

1989

Other Studies

168 other study(ies) available for mephenytoin and hydantoins

ArticleYear
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Prognosis and therapy of complex partial seizures with barbiturates, hydantoins, and other drugs.
    Advances in neurology, 1975, Volume: 11

    Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Drug Therapy, Combination; Epilepsy; Epilepsy, Temporal Lobe; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Primidone; Prognosis; Succinimides; Thiazines; Valproic Acid

1975
[Determination of phenobarbital, mephenytoin and diphenylhydantoin in the surveillance of anticonvulsant treatment].
    Annales de biologie clinique, 1976, Volume: 34, Issue:2

    Topics: Barbiturates; Child; Chromatography, Gas; Epilepsy; Ether; Humans; Hydantoins; Mephenytoin; Methylation; Phenobarbital; Phenytoin; Solvents; Temperature

1976
Literature disagreement as to identity of Nirvanol.
    Clinical chemistry, 1977, Volume: 23, Issue:8

    Topics: Hydantoins; Mephenytoin; Terminology as Topic

1977
Simple GLC analysis of anticonvulsant drugs in commercial dosage forms.
    Journal of pharmaceutical sciences, 1978, Volume: 67, Issue:7

    Topics: Anticonvulsants; Chromatography, Gas; Glutethimide; Hydantoins; Mephenytoin; Phenytoin; Primidone; Succinimides

1978
Clinical pharmacology of mephenytoin and ethotoin.
    Annals of neurology, 1979, Volume: 6, Issue:5

    Topics: Biotransformation; Epilepsy; Half-Life; Humans; Hydantoins; Kinetics; Mephenytoin; Saliva; Time Factors

1979
Stereoselectivity of differential routes of drug metabolism: the fate of the enantiomers of [14C]mephenytoin in the dog.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 209, Issue:2

    Topics: Animals; Breath Tests; Chromatography, Gas; Dealkylation; Dogs; Dose-Response Relationship, Drug; Female; Hydantoins; Kinetics; Mephenytoin; Stereoisomerism

1979
Evidence for the epoxide-diol pathway in the biotransformation of mephenytoin.
    Epilepsia, 1979, Volume: 20, Issue:3

    Topics: Adult; Biotransformation; Epilepsy; Humans; Hydantoins; Male; Mephenytoin

1979
Measurement of mephenytoin (3-methyl-5-ethyl-5-phenylhydantoin) and its demethylated metabolite by selective ion monitoring.
    Journal of chromatography, 1979, Jun-11, Volume: 163, Issue:2

    Topics: Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Hydantoins; Mephenytoin; Time Factors

1979
Rapid quantitative method for the simultaneous determination of carbamazepine, carbamazepine-10,11-epoxide, diphenylhydantion, mephenytoin, phenobarbital and primidone in serum by thin-layer chromatography.
    Journal of chromatography, 1978, Jul-01, Volume: 146, Issue:1

    Topics: Carbamazepine; Chromatography, Thin Layer; Drug Combinations; Epoxy Compounds; Humans; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Primidone

1978
Gas-chromatographic determination of mephenytoin and desmethylmephenytoin, after off-column alkylation.
    Clinical chemistry, 1979, Volume: 25, Issue:1

    Topics: Alkylation; Chromatography, Gas; Humans; Hydantoins; Mephenytoin

1979
Stereoselective metabolism, pharmacokinetics and biliary elimination of phenylethylhydantoin (Nirvanol) in the dog.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 203, Issue:3

    Topics: Animals; Bile; Chromatography, Gas; Dogs; Female; Hydantoins; Kinetics; Mephenytoin; Stereoisomerism

1977
[New reaction for the identification of mesantoin (author's transl)].
    Archiv der Pharmazie, 1977, Volume: 310, Issue:11

    Topics: Hydantoins; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mephenytoin

1977
Mephenytoin: a reappraisal.
    Epilepsia, 1976, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Anemia, Aplastic; Anticonvulsants; Chemical Phenomena; Chemistry; Drug Evaluation; Epilepsy; Follow-Up Studies; Humans; Hydantoins; Mephenytoin

1976
Paradoxical intoxication--a complication of anticonvulsant administration.
    Epilepsia, 1975, Volume: 16, Issue:5

    Topics: Carbamazepine; Drug Therapy, Combination; Humans; Hydantoins; Mephenytoin; Phenytoin; Seizures

1975
Generalized lymphadenopathy and nephrotic syndrome as a manifestation of mephenytoin (mesantoin) toxicity.
    Pediatrics, 1976, Volume: 57, Issue:1

    Topics: Adolescent; Edema; Epilepsy; Humans; Hydantoins; Lymphatic Diseases; Male; Mephenytoin; Nephrotic Syndrome

1976
Drug-metal interactions: spectroscopic studies of copper hydantoin complexes.
    Journal of inorganic biochemistry, 1991, Volume: 42, Issue:4

    Topics: Copper; Crystallization; Electron Spin Resonance Spectroscopy; Hydantoins; Mephenytoin; Molecular Structure; Phenytoin; Pyridines; Spectrophotometry, Infrared

1991
Comparison of the behavioral teratogenic potential of phenytoin, mephenytoin, ethotoin, and hydantoin in rats.
    Teratology, 1991, Volume: 43, Issue:4

    Topics: Animals; Behavior, Animal; Ear, Inner; Female; Hydantoins; Male; Mephenytoin; Phenytoin; Pregnancy; Rats; Rats, Inbred Strains; Teratogens

1991
Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1

    Topics: Cell Line; Cytochrome P-450 Enzyme System; DNA; Humans; Hydantoins; Hydroxylation; In Vitro Techniques; Mephenytoin; Microsomes, Liver; Polymorphism, Genetic; Tolbutamide; Vaccinia virus

1990
Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2.
    Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:3

    Topics: Cytochrome P-450 Enzyme System; Hexobarbital; Humans; Hydantoins; Hydroxylation; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Phenotype; Polymorphism, Genetic; Stereoisomerism

1990
d-Propoxyphene is a potent inhibitor of debrisoquine, but not S-mephenytoin 4-hydroxylation in vivo.
    Therapeutic drug monitoring, 1990, Volume: 12, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Debrisoquin; Dextropropoxyphene; Female; Humans; Hydantoins; Hydroxylation; Isomerism; Isoquinolines; Male; Mephenytoin; Polymorphism, Genetic

1990
Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects.
    British journal of clinical pharmacology, 1990, Volume: 29, Issue:6

    Topics: Adult; Female; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Oxidation-Reduction; Phenobarbital; Phenotype; Phenytoin

1990
Slow omeprazole metabolizers are also poor S-mephenytoin hydroxylators.
    Therapeutic drug monitoring, 1990, Volume: 12, Issue:4

    Topics: Administration, Oral; Humans; Hydantoins; Mephenytoin; Omeprazole

1990
Scleroderma is associated with differences in individual routes of drug metabolism: a study with dapsone, debrisoquin, and mephenytoin.
    Clinical pharmacology and therapeutics, 1990, Volume: 48, Issue:3

    Topics: Acetylation; Adult; Biotransformation; Dapsone; Debrisoquin; Disease Susceptibility; Female; Humans; Hydantoins; Hydroxylation; Isoquinolines; Logistic Models; London; Male; Mephenytoin; Middle Aged; Oxidation-Reduction; Scleroderma, Systemic; Tennessee

1990
Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.
    Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:4

    Topics: Adult; Benzodiazepines; Debrisoquin; Diazepam; Female; Humans; Hydantoins; Isoquinolines; Male; Mephenytoin; Mixed Function Oxygenases; Nordazepam; Phenotype; Smoking

1989
Diazepam treatment does not influence the debrisoquine or mephenytoin hydroxylation phenotyping tests.
    Therapeutic drug monitoring, 1989, Volume: 11, Issue:6

    Topics: Adult; Debrisoquin; Diazepam; Drug Interactions; Humans; Hydantoins; Hydroxylation; Isoquinolines; Male; Mephenytoin; Middle Aged; Phenotype

1989
Expression of a human P-450IIC gene in yeast cells using galactose-inducible expression system.
    Molecular pharmacology, 1989, Volume: 35, Issue:4

    Topics: Antigen-Antibody Reactions; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Blotting, Western; Cloning, Molecular; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; DNA; DNA, Recombinant; Galactose; Gene Expression Regulation; Genetic Vectors; Humans; Hydantoins; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Saccharomyces cerevisiae; Transcription, Genetic

1989
S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin.
    Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:5

    Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Debrisoquin; Drug Interactions; Female; Humans; Hydantoins; Hydroxylation; Isoquinolines; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Phenotype; Sweden

1989
Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:2

    Topics: Adult; Antipyrine; Cimetidine; Enzyme Induction; Female; Humans; Hydantoins; Male; Mephenytoin; Metabolic Clearance Rate; Nifedipine; Oxidation-Reduction; Phenobarbital; Smoking; Sparteine

1989
Mephenytoin and sparteine oxidation: genetic polymorphisms in Denmark.
    British journal of clinical pharmacology, 1989, Volume: 27, Issue:5

    Topics: Adolescent; Adult; Chromatography, Gas; Denmark; Female; Humans; Hydantoins; Male; Mephenytoin; Middle Aged; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Sparteine

1989
Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese.
    Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:2

    Topics: Adolescent; Adult; Asian People; China; Female; Humans; Hydantoins; Japan; Male; Mephenytoin; Metoprolol; Middle Aged; Oxidation-Reduction; Polymorphism, Genetic; Stereoisomerism

1989
The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation.
    Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:5

    Topics: Adrenergic beta-Antagonists; Cytochrome P-450 Enzyme System; Ethanolamines; Genetic Variation; Humans; Hydantoins; Hydroxylation; Isoenzymes; Kinetics; Mephenytoin; Metoprolol; Microsomes, Liver; Oxidation-Reduction; Polymorphism, Genetic; Structure-Activity Relationship; Tissue Donors

1986
Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:1

    Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; Hydantoins; Isoenzymes; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenytoin; Polymorphism, Genetic; Stereoisomerism; Warfarin

1987
Mephenytoin-type polymorphism of drug oxidation: purification and characterization of a human liver cytochrome P-450 isozyme catalyzing microsomal mephenytoin hydroxylation.
    Biochimica et biophysica acta, 1986, Dec-10, Volume: 884, Issue:3

    Topics: Animals; Cytochrome P-450 Enzyme System; Humans; Hydantoins; Hydroxylation; Isoenzymes; Kinetics; Mephenytoin; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Polymorphism, Genetic; Rats

1986
Acute and chronic effects of methsuximide and mephenytoin on the delayed-matching-to-sample performance of pigeons.
    Psychopharmacology, 1988, Volume: 95, Issue:1

    Topics: Animals; Anticonvulsants; Behavior, Animal; Columbidae; Hydantoins; Memory, Short-Term; Mephenytoin; Succinimides

1988
Effects of methsuximide and mephenytoin on the responding of pigeons under a fixed-consecutive-number schedule with and without an external discriminative stimulus.
    Psychopharmacology, 1988, Volume: 95, Issue:2

    Topics: Animals; Anticonvulsants; Columbidae; Conditioning, Operant; Discrimination, Psychological; Hydantoins; Mephenytoin; Reinforcement Schedule; Succinimides

1988
Phenotyping polymorphic drug metabolism in the French Caucasian population.
    European journal of clinical pharmacology, 1988, Volume: 35, Issue:2

    Topics: Adult; Dextromethorphan; Female; France; Humans; Hydantoins; Levorphanol; Male; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic; White People

1988
N-demethylation of methyl and dimethyl derivatives of phenytoin and their anticonvulsant activities in mice.
    Japanese journal of pharmacology, 1988, Volume: 48, Issue:4

    Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Electroshock; gamma-Aminobutyric Acid; Hydantoins; Injections, Intraperitoneal; Male; Mephenytoin; Mice; Mice, Inbred Strains; Phenytoin; Radioligand Assay

1988
Effects of mephenytoin on schedule-controlled responding in the pigeon.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:1

    Topics: Animals; Columbidae; Food; Hydantoins; Mephenytoin; Reaction Time; Reinforcement Schedule

1988
Effects of mephenytoin and methsuximide on the reaction time of pigeons.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:4

    Topics: Animals; Anticonvulsants; Columbidae; Dose-Response Relationship, Drug; Hydantoins; Mephenytoin; Reaction Time; Succinimides

1988
P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats.
    Cancer research, 1988, May-01, Volume: 48, Issue:9

    Topics: Animals; Barbital; Barbiturates; Body Weight; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Hydantoins; Liver; Liver Neoplasms, Experimental; Male; Mephenytoin; Organ Size; Phenobarbital; Rats; Rats, Inbred F344; Thyroid Neoplasms

1988
Mephenytoin hydroxylation in the Cuna Amerindians of Panama.
    British journal of clinical pharmacology, 1988, Volume: 25, Issue:1

    Topics: Humans; Hydantoins; Hydroxylation; Indians, Central American; Mephenytoin; Panama; Polymorphism, Genetic; White People

1988
GC and GC-MS procedures for simultaneous phenotyping with dextromethorphan and mephenytoin.
    Clinica chimica acta; international journal of clinical chemistry, 1988, Feb-15, Volume: 171, Issue:2-3

    Topics: Adult; Chromatography, Gas; Dextromethorphan; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydantoins; Hydroxylation; Levorphanol; Male; Mephenytoin; Phenotype

1988
Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:3

    Topics: Cytochrome P-450 Enzyme System; Hexobarbital; Humans; Hydantoins; Hydroxylation; In Vitro Techniques; Liver; Male; Mephenytoin; Oxidation-Reduction; Polymorphism, Genetic

1988
The non-human primate: a possible model for human genetically determined polymorphisms in oxidative drug metabolism.
    Molecular pharmacology, 1988, Volume: 34, Issue:2

    Topics: Animals; Biotransformation; Debrisoquin; Female; Hydantoins; Isoquinolines; Macaca; Macaca fascicularis; Male; Mephenytoin; Oxidation-Reduction; Polymorphism, Genetic

1988
A comparison of the S(+) and R(-) enantiomers of 5-ethyl-5-phenylhydantoin as hypolipidemic agents in rodents.
    Biomedica biochimica acta, 1987, Volume: 46, Issue:7

    Topics: Administration, Oral; Animals; Cholesterol; Feces; Hydantoins; Hypolipidemic Agents; Injections, Intraperitoneal; Intestine, Small; Isomerism; Lipid Metabolism; Lipoproteins; Liver; Male; Mephenytoin; Mice; Rats; Rats, Inbred Strains; Reference Values; Structure-Activity Relationship; Triglycerides

1987
Effects of methsuximide and mephenytoin on the behavior of pigeons under a repeated acquisition procedure.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 28, Issue:4

    Topics: Animals; Anticonvulsants; Behavior, Animal; Columbidae; Conditioning, Operant; Female; Hydantoins; Learning; Mephenytoin; Reinforcement Schedule; Succinimides

1987
Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin.
    International clinical psychopharmacology, 1986, Volume: 1, Issue:2

    Topics: Adult; Amitriptyline; Debrisoquin; Depressive Disorder; Female; Humans; Hydantoins; Hydroxylation; Isoquinolines; Kinetics; Male; Mephenytoin; Middle Aged; Nortriptyline; Phenotype; Polymorphism, Genetic

1986
S-mephenytoin 4-hydroxylase is inherited as an autosomal-recessive trait in Japanese families.
    Clinical pharmacology and therapeutics, 1987, Volume: 42, Issue:1

    Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Female; Humans; Hydantoins; Hydroxylation; Japan; Male; Mephenytoin; Mixed Function Oxygenases; Pedigree; Phenotype

1987
Polymorphic metabolism of mephenytoin in man: pharmacokinetic interaction with a co-regulated substrate, mephobarbital.
    Clinical pharmacology and therapeutics, 1986, Volume: 39, Issue:6

    Topics: Administration, Oral; Adult; Aged; Drug Interactions; Female; Humans; Hydantoins; Kinetics; Male; Mephenytoin; Mephobarbital; Metabolic Clearance Rate; Middle Aged; Phenotype; Polymorphism, Genetic; Stereoisomerism

1986
Family studies of mephenytoin hydroxylation deficiency.
    American journal of human genetics, 1986, Volume: 38, Issue:5

    Topics: Adolescent; Adult; Female; Genes, Recessive; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Middle Aged; Pedigree; Phenotype

1986
A problem with quantitation of mephenytoin enantiomers due to chiral interference from its N-demethylated metabolite.
    Journal of chromatography, 1986, Aug-22, Volume: 381, Issue:1

    Topics: Chromatography, Gas; Dealkylation; Hydantoins; Mephenytoin; Stereoisomerism

1986
[Distribution of the mephenytoin hydroxylator phenotype in the Hungarian adult population].
    Orvosi hetilap, 1986, Nov-30, Volume: 127, Issue:48

    Topics: Female; Genetics, Population; Humans; Hungary; Hydantoins; Hydroxylation; Male; Mephenytoin; Middle Aged; Phenotype; Roma; White People

1986
Polymorphic debrisoquine and mephenytoin hydroxylation in patients with pulmonary hypertension of vascular origin after aminorex fumarate.
    European journal of clinical pharmacology, 1986, Volume: 31, Issue:4

    Topics: Adult; Aged; Aminorex; Animals; Appetite Depressants; Debrisoquin; Female; Humans; Hydantoins; Hydroxylation; Hypertension, Pulmonary; In Vitro Techniques; Isoquinolines; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Oxazoles; Phenotype; Polymorphism, Genetic; Rats; Rats, Inbred Strains

1986
Genetic polymorphism of mephenytoin p(4')-hydroxylation: difference between Orientals and Caucasians.
    British journal of clinical pharmacology, 1985, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Aged; Asian People; Canada; China; Chromatography, Gas; Female; Humans; Hydantoins; Hydroxylation; Japan; Male; Mephenytoin; Middle Aged; Polymorphism, Genetic; White People

1985
Participation of a rat liver cytochrome P-450 induced by pregnenolone 16 alpha-carbonitrile and other compounds in the 4-hydroxylation of mephenytoin.
    Molecular pharmacology, 1985, Volume: 28, Issue:2

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine-N-Demethylase; Hydantoins; Hydroxylation; Isoenzymes; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Pregnenolone Carbonitrile; Rats

1985
Phenotypic differences in mephenytoin pharmacokinetics in normal subjects.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:3

    Topics: Adult; Aged; Humans; Hydantoins; Hydroxylation; Kinetics; Male; Mephenytoin; Middle Aged; Phenotype; Stereoisomerism

1985
Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations.
    Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Debrisoquin; Female; Genotype; Humans; Hydantoins; Hydroxylation; Isoquinolines; Japan; Male; Mephenytoin; Middle Aged; Phenotype; Random Allocation; White People

1985
Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation.
    Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:4

    Topics: Administration, Oral; Chromatography, High Pressure Liquid; Humans; Hydantoins; Hydroxylation; Mephenytoin; Mephobarbital; Phenotype; Stereoisomerism

1985
Mephenytoin hydroxylation polymorphism: characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo.
    Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:5

    Topics: Adult; Aged; Cytochrome P-450 Enzyme System; Female; Humans; Hydantoins; Hydroxylation; Kinetics; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Phenotype; Polymorphism, Genetic

1985
Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography.
    Analytical biochemistry, 1985, Volume: 151, Issue:2

    Topics: Chromatography, High Pressure Liquid; Humans; Hydantoins; Hydroxylation; Kinetics; Mephenytoin; Microsomes, Liver; Stereoisomerism; Structure-Activity Relationship

1985
[Changes in reactivity to halothane after administration of mephenytoin].
    Veterinarni medicina, 1983, Volume: 28, Issue:5

    Topics: Animals; Halothane; Hydantoins; Malignant Hyperthermia; Mephenytoin; Swine; Swine Diseases

1983
Stereoselectivity of the arene epoxide pathway of mephenytoin hydroxylation in man.
    Epilepsia, 1984, Volume: 25, Issue:1

    Topics: Ethers, Cyclic; Glucuronidase; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Molecular Conformation; Multienzyme Complexes; Sulfatases; Urine

1984
Disposition of mephenytoin and its metabolite, nirvanol, in epileptic patients.
    Neurology, 1984, Volume: 34, Issue:8

    Topics: Adolescent; Adult; Epilepsies, Partial; Female; Humans; Hydantoins; Male; Mephenytoin

1984
Mephenytoin and sparteine pharmacogenetics in Canadian Caucasians.
    Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:5

    Topics: Administration, Oral; Adult; Aged; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Middle Aged; Pharmacogenetics; Sparteine; White People

1984
Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man.
    European journal of clinical pharmacology, 1984, Volume: 26, Issue:6

    Topics: Adult; Debrisoquin; Female; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Phenotype; Polymorphism, Genetic

1984
Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism.
    Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Chromatography, High Pressure Liquid; Debrisoquin; Female; Humans; Hydantoins; Hydroxylation; Male; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic; Tennessee; White People

1984
Mephenytoin hydroxylation deficiency: kinetics after repeated doses.
    Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:1

    Topics: Adult; Female; Humans; Hydantoins; Hydroxylation; Kinetics; Male; Mephenytoin; Metabolism, Inborn Errors; Middle Aged; Pedigree; Stereoisomerism; Tritium

1984
Sparteine oxidation by the human liver: absence of inhibition by mephenytoin.
    Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:3

    Topics: Binding, Competitive; Cytochrome P-450 Enzyme System; Humans; Hydantoins; In Vitro Techniques; Liver; Mephenytoin; Oxidation-Reduction; Sparteine

1984
Direct enantiomeric resolution of mephenytoin and its N-demethylated metabolite in plasma and blood using chiral capillary gas chromatography.
    Journal of chromatography, 1984, Apr-13, Volume: 307, Issue:1

    Topics: Anticonvulsants; Chromatography, Gas; Half-Life; Humans; Hydantoins; Mephenytoin; Stereoisomerism

1984
Stereoselective metabolism and pharmacogenetic control of 5-phenyl-5-ethylhydantoin (nirvanol) in humans.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Half-Life; Humans; Hydantoins; Male; Mephenytoin; Stereoisomerism; Time Factors

1984
Mesantoin and pulmonary changes.
    Annals of internal medicine, 1982, Volume: 96, Issue:2

    Topics: Adult; Female; Humans; Hydantoins; Mephenytoin; Respiratory Hypersensitivity

1982
Relation of in vivo drug metabolism to stereoselective fetal hydantoin toxicology in mouse: evaluation of mephenytoin and its metabolite, nirvanol.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 221, Issue:1

    Topics: Animals; Embryo, Mammalian; Female; Fetus; Hydantoins; Mephenytoin; Mice; Mice, Inbred ICR; Pregnancy; Stereoisomerism

1982
Stereoselective metabolism and disposition of the enantiomers of mephenytoin during chronic oral administration of the racemic drug in man.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 221, Issue:3

    Topics: Administration, Oral; Adult; Biotransformation; Blood Proteins; Humans; Hydantoins; Injections, Intravenous; Kinetics; Male; Mephenytoin; Stereoisomerism; Time Factors

1982
Analysis of hydroxylated and demethylated metabolites of mephenytoin in man and laboratory animals using gas-liquid chromatography and high-performance liquid chromatography.
    Journal of chromatography, 1982, Oct-08, Volume: 232, Issue:1

    Topics: Animals; Chromatography, Gas; Chromatography, High Pressure Liquid; Dealkylation; Dogs; Guinea Pigs; Humans; Hydantoins; Hydroxylation; Mephenytoin; Mice; Rabbits; Rats

1982
Increased systemic availability of drugs during acute ethanol intoxication: studies with mephenytoin in the dog.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 213, Issue:1

    Topics: Administration, Oral; Alcoholic Intoxication; Animals; Biological Availability; Biotransformation; Dogs; Drug Interactions; Ethanol; Female; Humans; Hydantoins; Injections, Intravenous; Mephenytoin

1980
Stereoselective metabolism of mephenytoin in man.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 218, Issue:1

    Topics: Adult; Biotransformation; Carbon Radioisotopes; Chromatography, Gas; Chromatography, High Pressure Liquid; Humans; Hydantoins; Isotope Labeling; Male; Mephenytoin; Middle Aged; Stereoisomerism; Tritium

1981
Mesantoin (methoin)
    The Medical journal of Australia, 1981, Apr-18, Volume: 1, Issue:8

    Topics: Australia; Hydantoins; Mephenytoin; Pharmacopoeias as Topic

1981
The synthesis of some 11C-labelled antiepileptic drugs with potential utility as radiopharmaceuticals: hydantoins and barbiturates.
    The International journal of applied radiation and isotopes, 1981, Volume: 32, Issue:11

    Topics: Anticonvulsants; Barbital; Barbiturates; Carbon Radioisotopes; Hydantoins; Isotope Labeling; Mephenytoin; Phenobarbital; Phenytoin

1981
Aplastic anemia following mesantoin with recovery, case report.
    Annals of western medicine and surgery, 1952, Volume: 6, Issue:9

    Topics: Anemia; Anemia, Aplastic; Biological Phenomena; Hydantoins; Mephenytoin; Physiological Phenomena

1952
The control with mesantoin on convulsive seizures due to neurosyphilis; clinical and electroencephalographic studies.
    The Journal of nervous and mental disease, 1952, Volume: 116, Issue:3

    Topics: Electroencephalography; Epilepsy; Humans; Hydantoins; Mephenytoin; Neurosyphilis; Seizures

1952
[Granulocytopenic syndromes in mesantoin therapy].
    Minerva medica, 1952, Oct-01, Volume: 43, Issue:79

    Topics: Agranulocytosis; Epilepsy; Humans; Hydantoins; Mephenytoin; Syndrome

1952
Two cases of fatal pancytopenia following mesantoin therapy.
    California medicine, 1953, Volume: 78, Issue:2

    Topics: Anemia; Anemia, Aplastic; Hydantoins; Mephenytoin; Pancytopenia; Tracheophyta

1953
[Complications in mesantoin therapy of epilepsy].
    Svenska lakartidningen, 1953, Feb-27, Volume: 50, Issue:9

    Topics: Epilepsy; Hydantoins; Mephenytoin

1953
Hemolytic anemia secondary to mesantoin.
    Annals of internal medicine, 1953, Volume: 39, Issue:3

    Topics: Anemia; Anemia, Hemolytic; Humans; Hydantoins; Mephenytoin

1953
[The treatment of epilepsy with mesantoin].
    Munchener medizinische Wochenschrift (1950), 1953, Aug-21, Volume: 95, Issue:34

    Topics: Epilepsy; Hydantoins; Mephenytoin

1953
[Treatment of epilepsy with mesantoin].
    Munchener medizinische Wochenschrift (1950), 1953, Aug-28, Volume: 95, Issue:35

    Topics: Epilepsy; Hydantoins; Mephenytoin

1953
[Fatal pancytopenia caused by mesantoin therapy].
    Duodecim; laaketieteellinen aikakauskirja, 1953, Volume: 69, Issue:7-8

    Topics: Hematologic Diseases; Humans; Hydantoins; Mephenytoin; Pancytopenia

1953
Quantitative studies of the physiological disposition of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin) and 5-ethyl-5-phenyl hydantoin (nirvanol).
    The Journal of pharmacology and experimental therapeutics, 1953, Volume: 109, Issue:3

    Topics: Anticonvulsants; Blood; Humans; Hydantoins; Imidazoles; Mephenytoin

1953
Leukopenia and scarlatiniform exanthema resulting from medication with mesantoin.
    Acta dermato-venereologica, 1953, Volume: 33, Issue:5

    Topics: Drug Eruptions; Exanthema; Humans; Hydantoins; Leukocyte Count; Leukopenia; Mephenytoin

1953
A clinical evaluation of mesantoin in epilepsy.
    The Journal of nervous and mental disease, 1953, Volume: 118, Issue:3

    Topics: Epilepsy; Humans; Hydantoins; Mephenytoin

1953
A pharmacological comparison of the optical isomers of 5-ethyl-5-phenyl hydantoin (nirvanol) and of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin).
    The Journal of pharmacology and experimental therapeutics, 1954, Volume: 110, Issue:1

    Topics: Anticonvulsants; Hydantoins; Imidazoles; Mephenytoin

1954
Mesantoin in the treatment of epilepsy; a study of its effect on the leukocyte count in seventy-nine cases.
    The New England journal of medicine, 1954, Feb-04, Volume: 250, Issue:5

    Topics: Epilepsy; Hydantoins; Leukocyte Count; Mephenytoin

1954
[Mesantoin therapy of epilepsy].
    Ugeskrift for laeger, 1953, Nov-12, Volume: 115, Issue:46

    Topics: Epilepsy; Hydantoins; Mephenytoin

1953
[Lymph node swellings after mesantoin medication and their cytological picture].
    Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete, 1953, Volume: 34, Issue:10

    Topics: Disease; Humans; Hydantoins; Lymph Nodes; Lymphatic Diseases; Mephenytoin

1953
[Mesantoin and severe bone marrow aplasias].
    Ugeskrift for laeger, 1954, Feb-18, Volume: 116, Issue:7

    Topics: Bone Marrow; Bone Marrow Diseases; Humans; Hydantoins; Mephenytoin

1954
[Experimental production of lymph node swellings by feeding of mesantoin].
    Wiener klinische Wochenschrift, 1953, Dec-11, Volume: 65, Issue:50

    Topics: Disease; Humans; Hydantoins; Lymph Nodes; Lymphatic Diseases; Mephenytoin

1953
Mesantoin (methyl-phenylethyl-hydantoin) as the anticonvulsant of choice.
    American practitioner and digest of treatment, 1954, Volume: 5, Issue:5

    Topics: Anticonvulsants; Behavior; Choice Behavior; Craniocerebral Trauma; Epilepsy; Hydantoins; Imidazoles; Intellectual Disability; Mephenytoin

1954
Accidental mesantoin poisoning in an infant.
    Canadian Medical Association journal, 1954, Volume: 71, Issue:3

    Topics: Child; Humans; Hydantoins; Infant; Mephenytoin; Poisoning

1954
[Action of 5-ethyl-3-methyl-5-phenylhydantoin on experimental reflex epilepsy].
    Archives internationales de pharmacodynamie et de therapie, 1954, Jun-01, Volume: 98, Issue:2

    Topics: Epilepsy; Epilepsy, Reflex; Hydantoins; Mephenytoin

1954
[Experiences with mesantoin].
    Deutsche medizinische Wochenschrift (1946), 1954, Aug-13, Volume: 79, Issue:33-34

    Topics: Hydantoins; Mephenytoin

1954
[Additional experience with mesantoin therapy of epilepsy].
    Der Nervenarzt, 1954, Jun-20, Volume: 25, Issue:6

    Topics: Epilepsy; Hydantoins; Mephenytoin

1954
Mesantoin in the treatment of epilepsy.
    The Psychiatric quarterly, 1955, Volume: 29, Issue:3

    Topics: Epilepsy; Humans; Hydantoins; Mephenytoin

1955
Fatal aplastic anemia due to methylphenylethyl hydantoin (mesantoin).
    New York state journal of medicine, 1955, Dec-01, Volume: 55, Issue:23

    Topics: Anemia; Anemia, Aplastic; Anticonvulsants; Humans; Hydantoins; Imidazoles; Mephenytoin

1955
The metabolic conversion of 3-methyl-5-ethyl-5-phenyl hydantoin (mesantoin) and of 5-ethyl-5-phenyl hydantoin (nirvanol) to 5 - ethyl -5- (p-hydroxyphenyl) hydantoin.
    The Journal of pharmacology and experimental therapeutics, 1956, Volume: 117, Issue:2

    Topics: Anticonvulsants; Hydantoins; Imidazoles; Mephenytoin

1956
Lupus erythematosus disseminatus after administration of mesantoin; report of two cases.
    Acta medica Scandinavica, 1957, Aug-13, Volume: 158, Issue:2

    Topics: Humans; Hydantoins; Lupus Erythematosus, Systemic; Mephenytoin

1957
[Mesantoin (sedantoinal) therapy of epilepsy].
    Revista clinica espanola, 1957, Jun-30, Volume: 65, Issue:6

    Topics: Epilepsy; Hydantoins; Mephenytoin

1957
[Metabolism of an antiepileptic drug, 5-ethyl-3-methyl-5-phenylhydantoin].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1957, Volume: 151, Issue:6

    Topics: Anticonvulsants; Hydantoins; Mephenytoin

1957
[An example of the application of radioisotopes in the pharmacological study of an anti-epileptic drug: 5-ethyl-3-methyl-5-phenylhydantoin].
    Therapie, 1958, Volume: 13, Issue:4

    Topics: Humans; Hydantoins; Mephenytoin; Radioisotopes

1958
[Regular blood counts after treatment with mesantoin & dimedione].
    Nordisk medicin, 1958, Nov-06, Volume: 60, Issue:45

    Topics: Agranulocytosis; Anticonvulsants; Humans; Hydantoins; Mephenytoin

1958
[Mesantoin injury and infectious mononucleosis].
    Deutsche medizinische Wochenschrift (1946), 1959, Apr-03, Volume: 84, Issue:14

    Topics: Humans; Hydantoins; Infectious Mononucleosis; Mephenytoin

1959
[Acute nephrotic syndrome caused by mesantoin treatment].
    Deutsche medizinische Wochenschrift (1946), 1959, Apr-24, Volume: 84, Issue:17

    Topics: Humans; Hydantoins; Mephenytoin; Nephrotic Syndrome

1959
Aplastic anaemia due to 3-methyl-5-phenyl-5-ethyl-hydantoin ("mesantoin").
    Clinical reports, 1960, Volume: 10

    Topics: Anemia; Anemia, Aplastic; Humans; Hydantoins; Mephenytoin

1960
[Mesantoin reaction simulating infection].
    Nordisk medicin, 1961, Mar-23, Volume: 65

    Topics: Hydantoins; Infections; Mephenytoin

1961
[Case of generalized lymphadenopathy with high fever, diffuse dermal eruptions, eosinophilia and plasmocytosis due to the administration of an anticonvulsant (mesantoin)].
    Turk Tip Cemiyeti mecmuasi, 1959, Volume: 25

    Topics: Anticonvulsants; Eosinophilia; Exanthema; Humans; Hydantoins; Leukocyte Disorders; Lymphatic Diseases; Mephenytoin

1959
[Experimental ophthalmopathic syndrome in guinea pigs caused by prolonged administration of 3-methyl-5-ethylphenylhydantoin].
    Rivista di anatomia patologica e di oncologia, 1961, Volume: 19

    Topics: Animals; Cataract; Eye Diseases; Guinea Pigs; Hydantoins; Keratitis; Mephenytoin

1961
Severe drug reaction with bone marrow depression due to mesantoin.
    The Journal of the Oklahoma State Medical Association, 1962, Volume: 55

    Topics: Bone Marrow; Bone Marrow Diseases; Depression; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Hydantoins; Mephenytoin

1962
[Clinical experiences with new anticonvulsants similar to mesantoin (N3, N5 and N7)].
    Schweizerische medizinische Wochenschrift, 1962, May-26, Volume: 92

    Topics: Anticonvulsants; Humans; Hydantoins; Mephenytoin

1962
MESANTOIN LYMPHADENOPATHY MORPHOLOGICALLY SIMULATING HODGKIN'S DISEASE.
    Annals of internal medicine, 1963, Volume: 59

    Topics: Drug Hypersensitivity; Epilepsy; Hodgkin Disease; Humans; Hydantoins; Hyperplasia; Hypertrophy; Lymph Nodes; Lymphatic Diseases; Mephenytoin; Toxicology

1963
[CONSIDERATIONS ON THE INTRAPARENCHYMAL CORNEAL OPACITY AND VASCULARIZATIONS INDUCED IN GUINEA PIGS WITH ADMINISTRATION OF MESANTOIN AND ALLOXAN].
    Rivista di anatomia patologica e di oncologia, 1963, Volume: 24

    Topics: Alloxan; Blood Vessels; Corneal Opacity; Guinea Pigs; Hydantoins; Mephenytoin; Neovascularization, Pathologic; Pharmacology; Research; Toxicology

1963
[DATA TO THE PROBLEM OF CHRONIC MESANTOIN POISONING].
    Medizinische Klinik, 1964, Jun-05, Volume: 59

    Topics: Adolescent; Blood Transfusion; Electroencephalography; Epilepsy; Epilepsy, Absence; Exanthema; Hydantoins; Lymphadenitis; Mephenytoin; Prednisolone; Toxicology

1964
[MESANTOIN SIDE-EFFECT AND LYMPHOID CELL REACTION WITH SPECIAL REFERENCE TO THE DIFFERENTIAL DIAGNOSIS OF TOXIC CHANGES AND INFECTIOUS MONONUCLEOSIS].
    Munchener medizinische Wochenschrift (1950), 1965, May-07, Volume: 107

    Topics: Diagnosis, Differential; Drug-Related Side Effects and Adverse Reactions; Humans; Hydantoins; Iatrogenic Disease; Infectious Mononucleosis; Lymphocytes; Lymphocytosis; Mephenytoin; Poisoning; Toxicology

1965
Fatal pancytopenia as a result of improperly supervised mesantoin therapy.
    American practitioner and digest of treatment, 1955, Volume: 6, Issue:5

    Topics: Anemia; Anemia, Aplastic; Epilepsy; Hydantoins; Mephenytoin; Pancytopenia; Research Personnel; Tracheophyta

1955
[Manifestations of mesantoin reactions].
    Zeitschrift fur Haut- und Geschlechtskrankheiten, 1954, Dec-01, Volume: 17, Issue:11

    Topics: Humans; Hydantoins; Hypersensitivity; Immune System Diseases; Mephenytoin

1954
[Phenantoin, diphydan Leo, phenytoinum NFN on the 25th anniversary of its synthesis].
    Ugeskrift for laeger, 1962, Jun-29, Volume: 124

    Topics: Anniversaries and Special Events; Hydantoins; Mephenytoin

1962
[Hydantal and mesantoin in treatment of epilepsy].
    Wiener klinische Wochenschrift, 1950, Aug-25, Volume: 62, Issue:34

    Topics: Epilepsy; Hydantoins; Mephenytoin

1950
Clinical evaluation of mesantoin in treatment of epilepsy.
    A.M.A. archives of neurology and psychiatry, 1951, Volume: 65, Issue:1

    Topics: Epilepsy; Hydantoins; Mephenytoin

1951
[Manifestations of intoxication in mesantoin therapy of epilepsy].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1950, Oct-01, Volume: 70, Issue:19

    Topics: Epilepsy; Hydantoins; Mephenytoin

1950
[Differentiation of methylphenylethylhydantoin's (mesantoin's) mode of action in epileptic and in tetanic convulsions].
    Wiener klinische Wochenschrift, 1950, Oct-20, Volume: 62, Issue:42

    Topics: Epilepsy; Humans; Hydantoins; Mephenytoin; Seizures; Tetany

1950
Pancytopenia following the use of mesantoin and thiantoin. Report of a fatal case.
    United States Armed Forces medical journal, 1951, Volume: 2, Issue:1

    Topics: Anemia; Anemia, Aplastic; Humans; Hydantoins; Mephenytoin; Pancytopenia; Tracheophyta

1951
Methoin in the treatment of epilepsy.
    British medical journal, 1951, Jan-13, Volume: 1, Issue:4697

    Topics: Epilepsy; Hydantoins; Mephenytoin

1951
Fatal aplastic anemia associated with mesantoin; report of a case with autopsy.
    The Journal of the Florida Medical Association. Florida Medical Association, 1951, Volume: 37, Issue:8

    Topics: Anemia; Anemia, Aplastic; Autopsy; Humans; Hydantoins; Mephenytoin; Tracheophyta

1951
Effect of dilantin and mesantoin on the giant axon of the squid.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1951, Volume: 76, Issue:2

    Topics: Animals; Axons; Decapodiformes; Hydantoins; Mephenytoin; Phenytoin; Shellfish

1951
[Toxic effects of mesantoin].
    Wiener klinische Wochenschrift, 1950, Dec-22, Volume: 62, Issue:51

    Topics: Epilepsy; Hydantoins; Mephenytoin

1950
[Another case of importance bone-marrow lesion by mesantoin].
    Wiener klinische Wochenschrift, 1951, Feb-16, Volume: 63, Issue:7

    Topics: Bone Marrow; Epilepsy; Hydantoins; Mephenytoin

1951
Comparative results in seizure control using phenobarbital, dilantin, and mesantoin.
    The American journal of psychiatry, 1950, Volume: 107, Issue:6

    Topics: Barbital; Epilepsy; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Seizures

1950
[Mesantoin premedication and electroshock therapy].
    Nordisk medicin, 1950, Nov-17, Volume: 44, Issue:46

    Topics: Convulsive Therapy; Electroconvulsive Therapy; Humans; Hydantoins; Mephenytoin; Premedication

1950
[New antiepileptic; 3-methyl-5,5-phenylethyl-hydantoin. (mesantoin Sandoz)].
    Rassegna internazionale di clinica e terapia, 1951, Feb-28, Volume: 31, Issue:4

    Topics: Anticonvulsants; Epilepsy; Hydantoins; Imidazoles; Mephenytoin

1951
[A case of scarlatinoform dermatitis produced by mesantoin administration].
    Boletin medico del Hospital Infantil de Mexico, 1950, Volume: 7, Issue:6

    Topics: Dermatitis; Hydantoins; Mephenytoin

1950
Mesantoin in difficult cases of epilepsy.
    The Nebraska state medical journal, 1951, Volume: 36, Issue:7

    Topics: Epilepsy; Hydantoins; Mephenytoin

1951
[Aplastic anemia caused by the hydantoin derivative mesantoin; fatal case].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1951, Jul-01, Volume: 71, Issue:13-14

    Topics: Anemia; Anemia, Aplastic; Anticonvulsants; Epilepsy; Humans; Hydantoins; Mephenytoin

1951
Treatment of epilepsy with mesantoin or hydantal.
    Virginia medical monthly, 1951, Volume: 78, Issue:8

    Topics: Epilepsy; Hydantoins; Mephenytoin

1951
[Complications of electro-convulsontherapy caused by mesantoin].
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1951, Jul-07, Volume: 25, Issue:27

    Topics: Convulsive Therapy; Hydantoins; Mephenytoin

1951
Mesantoin in the management of the hospitalized psychotic epileptic; report of toxic effects and one fatality.
    Southern medical journal, 1951, Volume: 44, Issue:9

    Topics: Disease Management; Epilepsy; Hydantoins; Mental Disorders; Mephenytoin; Psychotic Disorders

1951
[Injurious effects of mesantoin].
    Wiener medizinische Wochenschrift (1946), 1951, Jun-09, Volume: 101, Issue:23

    Topics: Communicable Diseases; Hydantoins; Infectious Mononucleosis; Mephenytoin

1951
Occurrence of skin pigmentation during mesantoin therapy.
    Journal of the American Medical Association, 1951, Oct-20, Volume: 147, Issue:8

    Topics: Epilepsy; Hydantoins; Mephenytoin; Skin; Skin Pigmentation

1951
Aplasia of the bone marrow during mesantoin therapy; report of a fatal case.
    Journal of the American Medical Association, 1951, Oct-20, Volume: 147, Issue:8

    Topics: Bone Marrow; Epilepsy; Hydantoins; Mephenytoin

1951
[Another case of aplastic anemia due to mesantoin].
    Wiener klinische Wochenschrift, 1951, Aug-17, Volume: 63, Issue:33

    Topics: Anemia; Anemia, Aplastic; Hydantoins; Mephenytoin

1951
Mesantoin in the treatment of convulsive disorders.
    Diseases of the nervous system, 1951, Volume: 12, Issue:9

    Topics: Epilepsy; Hydantoins; Mephenytoin; Seizures

1951
Fast electroencephalographic activity due to mesantoin.
    Bulletin of the Los Angeles Neurological Society, 1951, Volume: 16, Issue:4

    Topics: Electroencephalography; Fasting; Humans; Hydantoins; Mephenytoin

1951
Treatment of epilepsy with mesantoin and phenantoin.
    Acta psychiatrica et neurologica Scandinavica. Supplementum, 1951, Volume: 74

    Topics: Epilepsy; Hydantoins; Mephenytoin

1951
Metabolic demethylation of 3-methyl-5-ethyl-5-phenyl hydantoin (Mesantoin).
    The Journal of pharmacology and experimental therapeutics, 1952, Volume: 104, Issue:3

    Topics: Anticonvulsants; Hydantoins; Mephenytoin

1952
Serious idiosyncrasy to methoin.
    Lancet (London, England), 1952, Mar-22, Volume: 1, Issue:6708

    Topics: Agranulocytosis; Hydantoins; Mephenytoin

1952
[Results of mesantoin therapy of epilepsy].
    Medizinische Monatsschrift, 1951, Volume: 5, Issue:11

    Topics: Epilepsy; Hydantoins; Mephenytoin

1951
[Experiences with hydantal Sandoz and Mesantoin in the therapy of epilepsy of children].
    Osterreichische Zeitschrift fur Kinderheilkunde und Kinderfursorge, 1952, Volume: 7, Issue:1-2

    Topics: Child; Epilepsy; Hydantoins; Infant; Mephenytoin

1952
[Skin eruptions caused by new antiepileptics (mesantoin)].
    Zeitschrift fur Haut- und Geschlechtskrankheiten, 1952, Mar-01, Volume: 12, Issue:5

    Topics: Anticonvulsants; Drug Eruptions; Exanthema; Hydantoins; Mephenytoin

1952
Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors.
    Archives of biochemistry and biophysics, 2004, Sep-01, Volume: 429, Issue:1

    Topics: Aryl Hydrocarbon Hydroxylases; Barbiturates; Binding Sites; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Design; Enzyme Activation; Hydantoins; Mephenytoin; Mixed Function Oxygenases; Models, Chemical; Models, Molecular; Phenobarbital; Phenytoin; Protein Binding

2004
Mesantoin toxicity; a clinical note.
    Diseases of the nervous system, 1950, Volume: 11, Issue:2

    Topics: Hydantoins; Mephenytoin

1950
Fatal granulocytopenia following hydantoins, mesantoin and dilantin; report of a case.
    Journal of the Medical Association of the State of Alabama, 1950, Volume: 19, Issue:7

    Topics: Agranulocytosis; Hydantoins; Mephenytoin; Phenytoin

1950
Pancytopenia due to mesantoin: report of a case.
    The New England journal of medicine, 1950, Jun-01, Volume: 242, Issue:22

    Topics: Anemia; Hydantoins; Mephenytoin; Pancytopenia

1950
Dermatitis medicamentosa caused by mesantoin.
    The Illinois medical journal, 1950, Volume: 98, Issue:1

    Topics: Drug Eruptions; Hydantoins; Mephenytoin; Pharmaceutical Preparations

1950
Mesantoin in epilepsy; report of 80 cases.
    Journal of the American Medical Association, 1950, Aug-26, Volume: 143, Issue:17

    Topics: Epilepsy; Hydantoins; Mephenytoin

1950
Fatal pancytopenia following the use of mesantoin; report of a case.
    The New England journal of medicine, 1949, Jul-07, Volume: 241, Issue:1

    Topics: Aged; Anemia, Aplastic; Humans; Hydantoins; Mephenytoin; Pancytopenia

1949
Changes in the electroencephalogram following administration o mesantoin (methyl-phenyl-ethyl hydantoin).
    Electroencephalography and clinical neurophysiology, 1949, Volume: 1, Issue:3

    Topics: Anticonvulsants; Electroencephalography; Epilepsy; Hydantoins; Mephenytoin

1949
THE TREATMENT OF EPILEPSY WITH METHYLPHENYLETHYL HYDANTOIN (MESANTOIN).
    California medicine, 1948, Volume: 68, Issue:3

    Topics: Anticonvulsants; Epilepsy; Humans; Hydantoins; Imidazoles; Mephenytoin

1948
Mesantoin, a new anticonvulsant in the management of epilepsy; a preliminary report.
    Rocky Mountain medical journal, 1947, Volume: 44, Issue:8

    Topics: Anticonvulsants; Disease Management; Epilepsy; Humans; Hydantoins; Imidazoles; Mephenytoin

1947
The use of hydantoin (mesantoin) as an anticonvulsive drug.
    Texas state journal of medicine, 1947, Volume: 43, Issue:5

    Topics: Anticonvulsants; Humans; Hydantoins; Imidazoles; Mephenytoin

1947
Epilepsy; treatment with new drug; 3-methyl 5,5-phenyl-ethyl-hydantoin (phenantoin).
    The American journal of psychiatry, 1946, Volume: 103, Issue:2

    Topics: Anticonvulsants; Epilepsy; Hydantoins; Imidazoles; Mephenytoin

1946