mephenytoin has been researched along with dextromethorphan in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.56) | 18.7374 |
| 1990's | 15 (41.67) | 18.2507 |
| 2000's | 10 (27.78) | 29.6817 |
| 2010's | 4 (11.11) | 24.3611 |
| 2020's | 5 (13.89) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Dubrovskyi, O; Dye, K; Gutgesell, LM; Huang, F; Li, Y; Ratia, K; Shen, Z; Thatcher, GRJ; Tonetti, DA; Xiong, R; Zhao, H; Zhao, J | 1 |
| Chen, FE; Clercq, E; Hao, QQ; Ling, X; Pannecouque, C | 1 |
| Baettig, D; Baumann, P; Breyer-Pfaff, U; Jonzier-Perey, M; Monney, C; Nill, K; Nusser, E; Pfandl, B | 1 |
| Amey, M; Baettig, D; Baumann, P; Bryois, C; Jonzier-Perey, M; Koeb, L; Meyer, JW; Monney, C; Woggon, B | 1 |
| Bosco, O; Funck-Brentano, C; Jacqz-Aigrain, E; Jaillon, P; Keundjian, A | 1 |
| Funck-Brentano, C; Jacqz-Aigrain, E; Jaillon, P; Leenhardt, A; Poirier, JM; Roux, A | 1 |
| Britto, MR; Bruckner, GG; McKean, HE; Wedlund, PJ | 1 |
| Blouin, RA; Britto, M; Foster, TS; Guttendorf, RJ; John, W; Pittman, KA; Wedlund, PJ | 1 |
| Dulac, H; Jacqz, E; Mathieu, H | 1 |
| Baumann, P; Jonzier-Perey, M | 1 |
| Evans, DA; Krahn, P; Narayanan, N | 1 |
| Caslavska, J; Desiderio, C; Hufschmid, E; Theurillat, R; Thormann, W; Wolfisberg, H | 1 |
| Coutts, RT | 1 |
| Baumann, P; Eap, CB; Hemmeter, U; Holsboer-Trachsler, E; Seifritz, E | 1 |
| Bertilsson, L; Kiivet, RA; Sjöqvist, F; Svensson, JO | 1 |
| Baumann, P; Eap, CB; Guentert, TW; Koeb, L; Powell, K; Schãublin-Loidl, M; Stabl, M | 1 |
| Amey, M; Baettig, D; Baumann, P; Jonzier-Perey, M; Kasas, A; Lambert, S; Montaldi, S; Nil, R; Souche, A; Uehlinger, C | 1 |
| Endres, HG; Henschel, L; Hippius, M; Hoffmann, A; Merkel, U | 1 |
| Chen, P; Flockhart, DA; Ko, JW; Sukhova, N; Thacker, D | 1 |
| Desta, Z; Flockhart, DA; Ko, JW; Soukhova, NV; Tracy, T | 1 |
| Arcavi, L; Bialer, M; Britzi, M; Kapitulnik, T; Shachbari, A; Soback, S | 1 |
| Ekins, S; Lawton, MP; Mankowski, DC | 1 |
| Baumann, P; Bondolfi, G; Bryois, C; Eap, CB; Fuciec, M; Jonzier-Perey, M; Savary, L; Zullino, D | 1 |
| Chiba, K; Kobayashi, K; Shimada, N; Urashima, K | 1 |
| Feldman, AM; Frye, CS; Frye, RF; Schneider, VM | 1 |
| Bell, AR; Crewe, HK; Graham, MJ; Lennard, MS; Moorcraft, CL; Walker, L; Whittaker, EF | 1 |
| Baker, GB; Holt, A; Salsali, M | 1 |
| Ekman, S; Fransson-Steen, R; Hagbjörk, AL; Löfgren, S; Terelius, Y | 1 |
| Delaporte, E; Rodrigues, AD | 1 |
| Baumann, P; Eap, CB; Gastpar, M | 1 |
| Baumann, P; Bertschy, G; Nil, R; Ramseier, F | 1 |
| Chantratita, W; Fukunaga, K; Hiratsuka, M; Hishinuma, E; Kordou, Z; Koromina, M; Lauschke, VM; Mushiroda, T; Patrinos, GP; Siamoglou, S; Tsermpini, EE; Yamazaki, S; Zhou, Y | 1 |
2 review(s) available for mephenytoin and dextromethorphan
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Polymorphism in the metabolism of drugs, including antidepressant drugs: comments on phenotyping.
Topics: Clomipramine; Cytochromes; Dealkylation; Depressive Disorder; Desipramine; Dextromethorphan; Drug Interactions; Female; Humans; Hydroxylation; Imipramine; Isoenzymes; Male; Mephenytoin; Nortriptyline; Phenotype; Polymorphism, Genetic | 1994 |
6 trial(s) available for mephenytoin and dextromethorphan
| Article | Year |
|---|---|
Relation between chloroguanide bioactivation to cycloguanil and the genetically determined metabolism of mephenytoin in humans.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Humans; Hydroxylation; Male; Mephenytoin; Polymorphism, Genetic; Prodrugs; Proguanil; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Triazines | 1992 |
Rapid screening for polymorphisms in dextromethorphan and mephenytoin metabolism.
Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Hydantoins; Levorphanol; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Oxidation-Reduction; Phenotype; Polymorphism, Genetic | 1990 |
Screening for hydroxylation and acetylation polymorphisms in man via simultaneous analysis of urinary metabolites of mephenytoin, dextromethorphan and caffeine by capillary electrophoretic procedures.
Topics: Acetylation; Adult; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Dextromethorphan; Electrophoresis, Polyacrylamide Gel; Humans; Hydroxylation; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic | 1994 |
Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin.
Topics: Adult; Aged; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Depressive Disorder; Dextromethorphan; Double-Blind Method; Female; Humans; Male; Mephenytoin; Mesoridazine; Middle Aged; Mixed Function Oxygenases; Phenothiazines; Stereoisomerism; Thioridazine | 1996 |
A double-blind, placebo-controlled study of citalopram with and without lithium in the treatment of therapy-resistant depressive patients: a clinical, pharmacokinetic, and pharmacogenetic investigation.
Topics: Adult; Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Citalopram; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Depressive Disorder; Dextromethorphan; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Humans; Lithium Carbonate; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Selective Serotonin Reuptake Inhibitors | 1996 |
Lack of pharmacokinetic interaction between dextromethorphan, coumarin and mephenytoin in man after simultaneous administration.
Topics: Administration, Oral; Adult; Anticoagulants; Anticonvulsants; Antitussive Agents; Coumarins; Dextromethorphan; Drug Interactions; Humans; Liver Function Tests; Male; Mephenytoin; Phenotype | 1996 |
28 other study(ies) available for mephenytoin and dextromethorphan
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Fulvestrant; Humans; MCF-7 Cells; Mice; Models, Molecular; Piperazines; Protein Domains; Pyridines; Pyridones; Receptors, Estrogen; Tissue Distribution; Transcription Factors; Xenograft Model Antitumor Assays | 2020 |
Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase.
Topics: Animals; Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Mice; Molecular Docking Simulation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Structure-Activity Relationship | 2022 |
Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes.
Topics: Adult; Amitriptyline; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Humans; Isoenzymes; Male; Mephenytoin; Metabolic Clearance Rate; Middle Aged; Nortriptyline; Phenotype; Regression Analysis; Stereoisomerism | 1992 |
Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitriptyline.
Topics: Adult; Amitriptyline; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Humans; Liver; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Phenotype; Thioridazine | 1992 |
Influence of amiodarone on genetically determined drug metabolism in humans.
Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Arrhythmias, Cardiac; Arylamine N-Acetyltransferase; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Humans; Isoniazid; Liver; Male; Mephenytoin; Middle Aged; Phenotype | 1991 |
Polymorphisms in oxidative drug metabolism: relationship to food preference.
Topics: Adult; Cytochrome P-450 Enzyme System; Dextromethorphan; Food Preferences; Humans; Male; Mephenytoin; Oxidation-Reduction; Pharmaceutical Preparations; Phenotype; Polymorphism, Genetic; Surveys and Questionnaires | 1991 |
Phenotyping polymorphic drug metabolism in the French Caucasian population.
Topics: Adult; Dextromethorphan; Female; France; Humans; Hydantoins; Levorphanol; Male; Mephenytoin; Middle Aged; Phenotype; Polymorphism, Genetic; White People | 1988 |
GC and GC-MS procedures for simultaneous phenotyping with dextromethorphan and mephenytoin.
Topics: Adult; Chromatography, Gas; Dextromethorphan; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydantoins; Hydroxylation; Levorphanol; Male; Mephenytoin; Phenotype | 1988 |
The mephenytoin (cytochrome P450 2C 19) and dextromethorphan (cytochrome P450 2D6) polymorphisms in Saudi Arabians and Filipinos.
Topics: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Ethnicity; Female; Humans; Hydroxylation; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Philippines; Polymorphism, Genetic; Saudi Arabia; Sex Characteristics | 1995 |
Increased trimipramine plasma levels during fluvoxamine comedication.
Topics: Aged; Citalopram; Depressive Disorder; Dextromethorphan; Drug Interactions; Female; Fluvoxamine; Humans; Mephenytoin; Phenotype; Trimipramine | 1994 |
Polymorphism of debrisoquine and mephenytoin hydroxylation among Estonians.
Topics: Adult; Chromatography, Gas; Chromatography, High Pressure Liquid; Debrisoquin; Dextromethorphan; Estonia; Female; Humans; Hydroxylation; Male; Mephenytoin; Phenotype; Polymorphism, Genetic | 1993 |
Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Lansoprazole; Mephenytoin; Microsomes, Liver; Omeprazole; Phenacetin; Tolbutamide | 1997 |
In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.
Topics: Anticonvulsants; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Chlorzoxazone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Humans; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Muscle Relaxants, Central; Phenacetin; Platelet Aggregation Inhibitors; Recombinant Proteins; Ticlopidine; Tolbutamide | 2000 |
Genetic polymorphism of CYP2D6 and CYP2C19 metabolism determined by phenotyping Israeli ethnic groups.
Topics: Adult; Anticonvulsants; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Administration Schedule; Female; Gas Chromatography-Mass Spectrometry; Humans; Israel; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Phenotype; Polymorphism, Genetic; Reference Values; White People | 2000 |
Characterization of transgenic mouse strains using six human hepatic cytochrome P450 probe substrates.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Ethanolamines; Humans; Intestines; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Obese; Mice, Transgenic; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenacetin; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Substrate Specificity; Testosterone | 2000 |
Pharmacokinetic drug interaction potential of risperidone with cytochrome p450 isozymes as assessed by the dextromethorphan, the caffeine, and the mephenytoin test.
Topics: Adult; Antipsychotic Agents; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Phenotype; Risperidone | 2001 |
Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Baculoviridae; Cells, Cultured; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Gene Expression; Humans; Insecta; Isoenzymes; Mephenytoin; Midazolam; Nitrophenols; Pharmaceutical Preparations; Phenacetin; Rats; Substrate Specificity; Testosterone; Tumor Cells, Cultured | 2002 |
Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure.
Topics: Adult; Aged; Biomarkers; Cytochrome P-450 Enzyme System; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Genetic Markers; Genotype; Heart Failure; Humans; Interleukin-6; Male; Mephenytoin; Middle Aged; Mutation; Phenotype; Polymorphism, Genetic; Prevalence; Statistics as Topic; Tumor Necrosis Factor-alpha | 2002 |
mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates.
Topics: Algorithms; Animals; Cytochrome P-450 Enzyme System; Dextromethorphan; Dogs; Female; Humans; Isoenzymes; Kinetics; Liver; Male; Mephenytoin; Microsomes, Liver; Omeprazole; Protein Biosynthesis; RNA, Messenger; Warfarin | 2003 |
Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Energy Metabolism; Mephenytoin; Mitochondria; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Tolbutamide; Tranylcypromine | 2004 |
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison.
Topics: Amiodarone; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Female; Humans; Kinetics; Lauric Acids; Male; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrophenols; Oxidoreductases, N-Demethylating; Oxygen; Paclitaxel; Phenacetin; Rats; Sex Factors; Species Specificity; Substrate Specificity; Testosterone | 2004 |
Cytochrome p450 assays.
Topics: Animals; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Enzyme Inhibitors; Humans; Mephenytoin; Paclitaxel; Phenacetin; Testosterone | 2002 |
The effect of perazine on the CYP2D6 and CYP2C19 phenotypes as measured by the dextromethorphan and mephenytoin tests in psychiatric patients.
Topics: Adult; Antipsychotic Agents; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Drug Interactions; Female; Humans; Male; Mephenytoin; Middle Aged; Perazine; Phenotype; Schizophrenia; Young Adult | 2020 |
Plasma Concentrations and Cardiovascular Effects of Citalopram Enantiomers After Oral Versus Infusion Citalopram Therapy in Dextromethorphan-Mephenytoin-Phenotyped Patients With Major Depression.
Topics: Citalopram; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Depressive Disorder, Major; Dextromethorphan; Humans; Mephenytoin | 2021 |
Identification and functional validation of novel pharmacogenomic variants using a next-generation sequencing-based approach for clinical pharmacogenomics.
Topics: Algorithms; Cell Line; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Cytochromes b5; Dextromethorphan; High-Throughput Nucleotide Sequencing; Humans; Mephenytoin; Microsomes; Mutation, Missense; Pharmacogenomic Variants; Reproducibility of Results | 2022 |