mephenytoin has been researched along with cycloguanil in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (90.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Bosco, O; Funck-Brentano, C; Jacqz-Aigrain, E; Jaillon, P; Keundjian, A | 1 |
| Breckenridge, AM; Brøsen, K; Gram, LF; Helsby, NA; Skjelbo, E; Ward, SA | 1 |
| Funck-Brentano, C; Jacqz-Aigrain, E; Jaillon, P; Keundjian, A; Partovian, C | 1 |
| Chiba, K; Darmansjah, I; Ishizaki, T; Kusaka, M; Setiabudy, R | 1 |
| Brøsen, K; Flachs, H; Skjelbo, E | 1 |
| Chiba, K; Ishizaki, T; Kusaka, M; Setiabudy, R | 1 |
| Brøsen, K; Jeppesen, U; Rasmussen, BB | 1 |
| Bochner, F; Coller, JK; Somogyi, AA | 1 |
| Bathum, L; Brøsen, K; Hørder, M; Madsen, H; Mutabingwa, TK; Skjelbo, E | 1 |
3 trial(s) available for mephenytoin and cycloguanil
| Article | Year |
|---|---|
Relation between chloroguanide bioactivation to cycloguanil and the genetically determined metabolism of mephenytoin in humans.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Humans; Hydroxylation; Male; Mephenytoin; Polymorphism, Genetic; Prodrugs; Proguanil; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Triazines | 1992 |
Comparison of chloroguanide and mephenytoin for the in vivo assessment of genetically determined CYP2C19 activity in humans.
Topics: Adult; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; Isoenzymes; Male; Mephenytoin; Omeprazole; Proguanil; Triazines | 1995 |
Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide.
Topics: Administration, Oral; Adult; Antimetabolites; Aryl Hydrocarbon Hydroxylases; Biguanides; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Fluvoxamine; Folic Acid Antagonists; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Proguanil; Selective Serotonin Reuptake Inhibitors; Triazines | 1997 |
7 other study(ies) available for mephenytoin and cycloguanil
| Article | Year |
|---|---|
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study.
Topics: Adult; Female; Humans; Male; Mephenytoin; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Proguanil; Reference Values; Sparteine; Triazines | 1991 |
Metabolic disposition of proguanil in extensive and poor metabolisers of S-mephenytoin 4'-hydroxylation recruited from an Indonesian population.
Topics: Adult; Biguanides; Chromatography, High Pressure Liquid; Cohort Studies; Female; Half-Life; Humans; Hydroxylation; Indonesia; Male; Mephenytoin; Middle Aged; Polymorphism, Genetic; Proguanil; Regression Analysis; Triazines | 1995 |
Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark.
Topics: Administration, Oral; Adult; Biguanides; Denmark; Female; Humans; Male; Mephenytoin; Middle Aged; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Proguanil; Sparteine; Triazines; Vietnam | 1993 |
Simultaneous measurement of proguanil and its metabolites in human plasma and urine by reversed-phase high-performance liquid chromatography, and its preliminary application in relation to genetically determined S-mephenytoin 4'-hydroxylation status.
Topics: Adult; Antimalarials; Biguanides; Chromatography, High Pressure Liquid; Humans; Hydroxylation; Male; Mephenytoin; Middle Aged; Phenotype; Proguanil; Triazines | 1996 |
Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms.
Topics: Adult; Aged; Antibodies, Monoclonal; Anticonvulsants; Antimetabolites; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Folic Acid Antagonists; Genotype; Humans; In Vitro Techniques; Isoenzymes; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Oxidation-Reduction; Proguanil; Triazines | 1999 |
Phenotypes and genotypes for CYP2D6 and CYP2C19 in a black Tanzanian population.
Topics: Adult; Alleles; Aryl Hydrocarbon Hydroxylases; Black People; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Female; Genetic Variation; Genetics, Population; Genotype; Humans; Male; Mephenytoin; Mixed Function Oxygenases; Phenotype; Proguanil; Sparteine; Tanzania; Triazines | 1999 |