mephenytoin and carbamazepine

mephenytoin has been researched along with carbamazepine in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19907 (41.18)18.7374
1990's1 (5.88)18.2507
2000's2 (11.76)29.6817
2010's7 (41.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bruno-Blanch, L; Gálvez, J; García-Domenech, R1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bohlen, N; Hertl, M1
Buchthal, A1
Burk, PG; Nathanson, G; Pollack, MA1
Rosenmund, H; Wad, N1
Kullander, S1
Ojemann, LM; Troupin, AS1
Eadie, MJ1
Burke, JT; Thénot, JP1
Kalhorn, TF; Lakehal, F; Levy, RH; Wurden, CJ1
Bialer, M1

Reviews

4 review(s) available for mephenytoin and carbamazepine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Pharmacotherapy of epilepsy. II].
    Die Medizinische Welt, 1978, Jun-02, Volume: 29, Issue:22

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; Humans; Mephenytoin; Mephobarbital; Phenobarbital; Phenytoin; Primidone; Succinimides; Thiazines; Valproic Acid

1978
Formation of active metabolites of anticonvulsant drugs. A review of their pharmacokinetic and therapeutic significance.
    Clinical pharmacokinetics, 1991, Volume: 21, Issue:1

    Topics: Anticonvulsants; Benzodiazepines; Biotransformation; Carbamazepine; Humans; Mephenytoin; Mephobarbital; Oxcarbazepine; Phenytoin; Primidone; Valproic Acid

1991
Determination of antiepileptic drugs.
    Journal of chromatography, 1985, May-10, Volume: 340

    Topics: Anticonvulsants; Barbiturates; Carbamazepine; Chromatography, Gas; Chromatography, Liquid; Clonazepam; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Humans; Mephenytoin; Monitoring, Physiologic; Phenytoin; Primidone; Succinimides; Valproic Acid

1985

Other Studies

13 other study(ies) available for mephenytoin and carbamazepine

ArticleYear
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship

2003
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity

2013
[Adverse effects of anti-epileptic drugs].
    Deutsche medizinische Wochenschrift (1946), 1975, Sep-19, Volume: 100, Issue:38

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Mephenytoin; Nitrazepam; Phenytoin; Primidone; Succinimides; Thiazines; Trimethadione; Valproic Acid

1975
Mucocutaneous eruptions due to antiepileptic drug therapy in children.
    Annals of neurology, 1979, Volume: 5, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Erythema Multiforme; Female; Humans; Male; Mephenytoin; Phenobarbital; Phenytoin; Primidone; Stevens-Johnson Syndrome

1979
Rapid quantitative method for the simultaneous determination of carbamazepine, carbamazepine-10,11-epoxide, diphenylhydantion, mephenytoin, phenobarbital and primidone in serum by thin-layer chromatography.
    Journal of chromatography, 1978, Jul-01, Volume: 146, Issue:1

    Topics: Carbamazepine; Chromatography, Thin Layer; Drug Combinations; Epoxy Compounds; Humans; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Primidone

1978
Effect of 2 br-alpha-ergocryptin (CB 154) on serum prolactin and the clinical picture in a case of progressive gigantomastia in pregnancy.
    Annales chirurgiae et gynaecologiae, 1976, Volume: 65, Issue:4

    Topics: Adult; Breast Diseases; Bromocriptine; Carbamazepine; Diazepam; Epilepsy, Temporal Lobe; Ergolines; Female; Humans; Mephenytoin; Phenobarbital; Pregnancy; Pregnancy Complications; Prolactin

1976
Paradoxical intoxication--a complication of anticonvulsant administration.
    Epilepsia, 1975, Volume: 16, Issue:5

    Topics: Carbamazepine; Drug Therapy, Combination; Humans; Hydantoins; Mephenytoin; Phenytoin; Seizures

1975
Carbamazepine and oxcarbazepine decrease phenytoin metabolism through inhibition of CYP2C19.
    Epilepsy research, 2002, Volume: 52, Issue:2

    Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Chlorophyll; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; In Vitro Techniques; Liver; Mephenytoin; Microsomes; Mixed Function Oxygenases; Oxcarbazepine; Phenytoin; Recombinant Proteins

2002
How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)?
    Epilepsia, 2012, Volume: 53 Suppl 8

    Topics: Anticonvulsants; Carbamazepine; Drug Discovery; Epilepsy; Ethosuximide; History, 20th Century; Humans; Mephenytoin; Mephobarbital; Phenobarbital; Phenytoin; Primidone; Structure-Activity Relationship; Succinimides; Valproic Acid

2012
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