menaquinone-7 and futalosine

menaquinone-7 has been researched along with futalosine* in 1 studies

Other Studies

1 other study(ies) available for menaquinone-7 and futalosine

ArticleYear
Inhibition of the futalosine pathway for menaquinone biosynthesis suppresses Chlamydia trachomatis infection.
    FEBS letters, 2021, Volume: 595, Issue:24

    Chlamydia trachomatis, an obligate intracellular bacterium with limited metabolic capabilities, possesses the futalosine pathway for menaquinone biosynthesis. Futalosine pathway enzymes have promise as narrow-spectrum antibiotic targets, but the activity and essentiality of chlamydial menaquinone biosynthesis have yet to be established. In this work, menaquinone-7 (MK-7) was identified as a C. trachomatis-produced quinone through liquid chromatography-tandem mass spectrometry. An immunofluorescence-based assay revealed that treatment of C. trachomatis-infected HeLa cells with the futalosine pathway inhibitor docosahexaenoic acid (DHA) reduced inclusion number, inclusion size, and infectious progeny. Supplementation with MK-7 nanoparticles rescued the effect of DHA on inclusion number, indicating that the futalosine pathway is a target of DHA in this system. These results open the door for menaquinone biosynthesis inhibitors to be pursued in antichlamydial development.

    Topics: Anti-Bacterial Agents; Automation; Biosynthetic Pathways; Chlamydia Infections; Chlamydia trachomatis; Docosahexaenoic Acids; HeLa Cells; Humans; Inclusion Bodies; Nanoparticles; Nucleosides; Vitamin K 2

2021