menaquinone-6 and 1-2-dipalmitoyl-3-phosphatidylethanolamine

Menaquinones (MKs) are essential for electron transport in prokaryotes, and importantly, partially saturated MKs represent a novel virulence factor. However, little is known regarding how the degree of saturation in the isoprenyl side chain influences conformation or quinone redox potential. MenJ is an enzyme that selectively reduces the second isoprene unit on MK-9 and is contextually essential for the survival of Mycobacterium tuberculosis in J774A.1 macrophage-like cells, suggesting that MenJ may be a conditional drug target for pathogenic mycobacteria. Therefore, fundamental information about the properties of this system is important, and we synthesized the simplest MKs, unsaturated MK-1 and the saturated analogue, MK-1(H

Topics: 1,2-Dipalmitoylphosphatidylcholine; Bacterial Proteins; Membranes, Artificial; Micelles; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Oxidoreductases Acting on CH-CH Group Donors; Phosphatidylethanolamines; Proton Magnetic Resonance Spectroscopy; Vitamin K 2