memantine has been researched along with glutamic acid in 141 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (12.77) | 18.2507 |
| 2000's | 57 (40.43) | 29.6817 |
| 2010's | 50 (35.46) | 24.3611 |
| 2020's | 16 (11.35) | 2.80 |
| Authors | Studies |
|---|---|
| Feuerstein, TJ; Jackisch, R; Koch, R; Lücking, CH; Lupp, A | 1 |
| Deshpande, SS; Filbert, MG; Smith, CD | 1 |
| Herrera, AJ; Osborne, NN | 1 |
| Dimpfel, W | 1 |
| Finiels-Marlier, F; Marini, AM; Martin, B; Paul, SM; Weller, M | 1 |
| Lipton, SA; Pellegrini, JW | 1 |
| Finiels-Marlier, F; Paul, SM; Weller, M | 1 |
| Dreyer, EB; Hyman, BT; Lipton, SA; Sabel, BA; Vorwerk, CK; Zurakowski, D | 1 |
| Benke, TA; Bresink, I; Collett, VJ; Collingridge, GL; Henley, JM; Parsons, CG; Seal, AJ | 1 |
| Korinthenberg, R | 1 |
| Krieglstein, J; Lippert, K; Pöch, G | 1 |
| Chamuleau, RA; Daalhuisen, J; Maas, MA; Quack, G; Vogels, BA | 1 |
| Dreyer, EB; Grosskreutz, CL | 1 |
| Bach, M; Feuerstein, TJ; Knörle, R; Lagrèze, WA | 1 |
| Grigortsevich, N; Khodorov, B; Pinelis, V; Sorokina, E; Storozhevykh, T; Vergun, O; Vinskaya, N | 1 |
| Dreyer, EB; Heng, JE; Lessell, E; Levin, LA; Vorwerk, CK; Zurakowski, D | 1 |
| Brown, DR | 1 |
| Anderson, C; Bell, JE; Geiger, JD; Haughey, NJ; Jones, M; Nath, A | 1 |
| Dreyer, EB; Naskar, R; Vorwerk, CK | 1 |
| Belozertseva, IV; Bespalov, AY; Danysz, W; Dravolina, OA; Neznanova, ON | 1 |
| Danysz, W; Hauss-Wegrzyniak, B; Wenk, GL; Willard, LB | 1 |
| Kryzhanovskii, GN; Kucheryanu, VG | 1 |
| Anttila, V; Heinonen, H; Hirvonen, J; Jäntti, V; Juvonen, T; Kiviluoma, K; Ohtonen, P; Pokela, M; Rimpiläinen, J; Vainionpää, V | 1 |
| Gordienko, DV; Krivobok, GK; Pankrat'ev, DV; Talalaenko, AN; Zinkovich, II | 1 |
| Dalton, R | 1 |
| Arcuino, G; Gao, Q; Lin, JH; Nedergaard, M; Takano, T; Yang, J | 1 |
| Ehrenberger, K; Felix, D; Oestreicher, E | 1 |
| Alvarez, XA; Cacabelos, R; Miguel-Hidalgo, JJ; Quack, G | 1 |
| Goncharenko, NV; Pankrat'ev, DV; Talalaenko, AN | 1 |
| Molinuevo, JL | 1 |
| Butterfield, DA; Pocernich, CB | 1 |
| Brookes, SJ; Chen, BN; Costa, M; Zagorodnyuk, VP | 1 |
| Haen, E; Koch, HJ; Szecsey, A | 1 |
| Grundke-Iqbal, I; Haque, N; Iqbal, K; Li, L; Sengupta, A | 1 |
| Bier, JC; Sternon, J | 1 |
| Richartz, E; Schott, KJ; Wormstall, H | 1 |
| Farlow, MR | 1 |
| Chun, T; Hare, WA; Lai, RK; Ruiz, G; Ton, H; Wheeler, L; WoldeMussie, E | 1 |
| Rands, GS | 1 |
| Hermanussen, M; Tresguerres, JA | 1 |
| Aisen, PS | 1 |
| Fischer-Barnicol, D; Koch, HJ; Uyanik, G | 1 |
| Genever, PG; Gillbro, JM; Hitchcock, IS; Hoogduijn, MJ; Schallreuter, KU; Smit, NP | 1 |
| Birbaumer, N; Konrad, CJ; Schaller, HE; Schley, M; Schmelz, M; Topfner, S; Wiech, K | 1 |
| Godwin, T; Ota, KS | 1 |
| Geerts, H; Grossberg, GT | 1 |
| Bahr, BA; Baude, AS; Brown, QB; Karanian, DA; Parsons, CG | 1 |
| Danysz, W; Parsons, CG; Wenk, GL | 1 |
| Bezprozvanny, I; Tang, T; Wu, J | 1 |
| Ayuyao, N; Cook, EH; Grieve, A; Guter, S; Leventhal, BL; Owley, T; Salt, J; Walton, L | 1 |
| Tai, KK; Truong, DD | 1 |
| Chan, HH; Chen, K; Fu, H; Han, Y; Jiang, H; Kan, KK; Lam, CS; Lee, NT; Li, C; Li, M; Li, W; Li, X; Luo, J; Niu, C; Pang, Y; Tsim, KW; Xue, H; Xue, J | 1 |
| Howland, RH | 1 |
| Cao, J; Li, YP; Li, ZR; Tao, YJ | 1 |
| Baker, EJ; Chen, PE; Wrighton, DC; Wyllie, DJ | 1 |
| Devine, DP; Muehlmann, AM | 1 |
| Francis, PT | 2 |
| Ai, YX; Chang, DC; Fu, HJ; Han, YF; Lao, YZ; Li, CY; Li, WM; Li, ZW; Liu, LJ; Liu, YW; Luo, JL; Pang, YP; Peoples, RW | 1 |
| de Leon, MJ; De Santi, S; Glodzik, L; Gonen, O; King, KG; Liu, S | 1 |
| Egashira, N; Fujiwara, M; Harada, S; Iwasaki, K; Matsushita, M; Mishima, K; Nishimura, R; Oishi, R; Okuno, R | 1 |
| Buisson, A; El Gaamouch, F; Gouix, E; Lecocq, M; Léveillé, F; Lobner, D; Nicole, O | 1 |
| Cooper, NG; Fan, W | 1 |
| Baker, GB; Kar, S; Rauw, G; Song, MS | 1 |
| Green, AJ | 1 |
| Cente, M; Filipcik, P; Mandakova, S | 1 |
| Gilling, KE; Hechenberger, M; Jatzke, C; Parsons, CG | 1 |
| Hugdahl, K; Jørgensen, HA; Specht, K; van Wageningen, H | 2 |
| Hashimoto, K | 1 |
| Chang, RC; Ho, YS; So, KF; Yik, SY; Yu, MS; Yuen, WH | 1 |
| Lin, N; Liu, C; Qiu, Y; Wu, B | 1 |
| Emre, M | 1 |
| Aarsland, D; Alves, G; Ballard, C; Bostrom, F; Kossakowski, K; Leroi, I; Londos, E; Minthon, L; Pozo-Rodriguez, F; Walker, Z | 1 |
| Anwy, R; Anwyl, R; Hu, NW; Klyubin, I; Rowan, MJ | 1 |
| Barber, TA; Haggarty, MK | 1 |
| Fang, JH; Jiang, FG; Wang, XH; Xu, ZR | 1 |
| Lin, TY; Lu, CW; Wang, SJ | 1 |
| Affaticati, P; Capiod, T; Cohen-Kaminsky, S; Collingridge, GL; Degrouard, J; Gouadon, E; Jambou, F; Klingel-Schmitt, I; Liblau, R; Mignen, O; Peineau, S; Potier, MC | 1 |
| Adams, S; Brew, BJ; Chung, R; Guillemin, GJ; Lee, MC; Ting, KK | 1 |
| Firestein, BL; Kutzing, MK; Luo, V | 1 |
| Annweiler, C; Beauchet, O | 1 |
| Anand, A; Barkay, G; Ghosh, S; Gunn, AD; Karne, HS; Mathew, SJ; Nurnberger, JI | 1 |
| Burdzhanadze, MA; Dashniani, MG; Kruashvili, LB; Naneĭshvili, TL; Sephashvili, MM | 1 |
| Haas, CB; Kalinine, E; Muller, AP; Portela, LV; Souza, DO; Torrez, VR; Zimmer, ER | 1 |
| Danysz, W; Parsons, CG | 1 |
| Baker, GB; Jhamandas, J; Kar, S; Revett, TJ | 1 |
| Andrés, E; Arcega, R; Garcia-Campayo, J; López-del-Hoyo, Y; Magallon, R; Masluk, B; Olivan-Blázquez, B; Pérez-Yus, MC; Puebla, M; Roca, M | 1 |
| Deng, Y; Liu, W; Wei, Y; Xu, B; Xu, Z; Yang, T | 1 |
| Abraham, WC; Hulme, SR; Jones, OD | 1 |
| Blecic, S; De Witte, O; Lefranc, F; Rynkowski, M | 1 |
| Annweiler, C; Bartha, R; Beauchet, O; Brugg, B; Peyrin, JM | 1 |
| Bausch, SB; He, S | 1 |
| Brison, E; Desforges, M; Jacomy, H; Talbot, PJ | 1 |
| Buisson, A; Rush, T | 1 |
| During, MJ; Green, TN; Kalev-Zylinska, ML; Lasham, A; Morel-Kopp, MC; Park, YE; Sun, PP; Ward, CM | 1 |
| Klivényi, P; Szalárdy, L; Toldi, J; Vécsei, L; Veres, G; Zádori, D | 1 |
| Abraham, R; Nirogi, R; Shinde, A | 1 |
| de Haan, L; Schulte, PF; Veerman, SR | 1 |
| Andrés, E; Fayed, N; Garcia-Campayo, J; Herrera-Mercadal, P; López del Hoyo, Y; Magallon, R; Olivan-Blázquez, B; Pérez-Yus, MC; Puebla-Guedea, M; Viguera, L | 1 |
| Fern, R; Gibson, CL; Trotman, M; Vermehren, P | 1 |
| Deakin, JFW; Dutta, A; McKie, S | 1 |
| Ellisman, MH; Hoshijima, M; Ju, WK; Kim, KY; Lukas, TJ; Noh, YH; Perkins, GA; Weinreb, RN | 1 |
| Kuszczyk, M; Makarewicz, D; Słomka, M; Łazarewicz, JW | 1 |
| Barnham, KJ; Donnelly, PS; Hill, AF; Johanssen, T; Liu, XM; Petrou, S; Suphantarida, N | 1 |
| Bai, Z; Ge, RL; Jeton, F; Jin, G; Marchant, D; Pichon, AP; Richalet, JP; Voituron, N; Wuren, T | 1 |
| DeBold, JF; Holly, EN; Hwa, LS; Miczek, KA; Nathanson, AJ; Newman, EL; Shimamoto, A; Tayeh, JK; Wilens, AR | 1 |
| Cheng, Q; Feng, D; Han, J; Huang, X; Huang, Y; Li, L; Li, Y; Liu, W; Liu, Y; Luo, S; Luo, Z; Peng, X; Yue, SJ; Zhao, F | 1 |
| Bali, J; Birnbaum, JH; Nitsch, RM; Rajendran, L; Tackenberg, C | 1 |
| Cryan, JF; Glennon, J; Moloney, RD; O'Connor, RM; Vlachou, S | 1 |
| Hayn, L; Koch, M | 1 |
| Akishita, M; Ogawa, S; Ota, H; Ouchi, Y | 1 |
| Cai, X; Chen, D; Gao, H; Jin, K; Liao, J; Liu, X; Ma, L; Tang, B; Wang, Q; Wei, X; Xia, Y; Xu, Y; Zhang, Z; Zou, J | 1 |
| Banaschewski, T; Buitelaar, JK; Dijkhuizen, RM; Dittmann, RW; Franke, B; Häge, A; Lythgoe, DJ; Mechler, K; Williams, SC | 1 |
| Mahfooz, K; Marco, S; Martínez-Turrillas, R; Pérez-Otaño, I; Raja, MK; Wesseling, JF | 1 |
| Abdul, KK; Justin, A; Ramanathan, M | 1 |
| Aizenman, E; Brueckner, F; Chen, W; Chiavacci, R; Elsen, G; Falk, MJ; Hakonarson, H; Hedrich, UB; Hörtnagel, K; Hu, C; Kosobucki, GJ; Kusumoto, H; Lemke, JR; Li, D; Marsh, ED; McCormick, EM; Naase, C; Ortiz-Gonzalez, XR; Schulien, AJ; Tankovic, A; Tian, L; Traynelis, SF; von Stülpnagel-Steinbeis, C; Yuan, H | 1 |
| Aizenman, E; Bhattacharya, S; Chen, W; Cohen, AE; Fan, LZ; Hu, C; Kosobucki, GJ; Kusumoto, H; McDaniel, MJ; Ogden, KK; Pecha, J; Petrovski, S; Schulien, AJ; Su, Z; Swanger, SA; Tankovic, A; Traynelis, SF; Yuan, H | 1 |
| Banaschewski, T; Dijkhuizen, RM; Dittmann, RW; Durston, S; Glennon, JC; Häge, A; K Buitelaar, J; Mechler, K; Murphy, D; Schweinfurth, N; Tactics Consortium, T; Williams, S | 1 |
| Abraham, R; Benade, V; Bhyrapuneni, G; Jasti, V; Jayarajan, P; Kambhampati, R; Medapati, RB; Mekala, VR; Muddana, N; Nirogi, R; Shinde, A; Subramanian, R | 1 |
| Bhakoo, KK; Duytschaever, H; Garnell, JF; Grandjean, J; Sekar, S; Seramani, S; Su, H; Ver Donck, L; Willems, R | 1 |
| Fukuyama, K; Kawano, Y; Okada, M; Shiroyama, T; Ueda, Y | 1 |
| Chrienova, Z; Hepnarova, V; Holubova, K; Horak, M; Kaniakova, M; Kleteckova, L; Kobrlova, T; Korabecny, J; Kucera, T; Nepovimova, E; Skrenkova, K; Soukup, O; Vales, K | 1 |
| Kashimoto, Y; Kitano, Y; Makino, M; Murasawa, H; Pawlak, A; Takahashi-Ito, K | 1 |
| Ciric, D; Foretz, M; Isakovic, A; Jovanovic, M; Korolchuk, VI; Markovic, I; Martinovic, T; Misirkic, M; Rabanal-Ruiz, Y; Saponjic, J; Trajkovic, V; Vucicevic, L | 1 |
| Cui, G; Guo, B; Han, Y; Hu, S; Liu, Z; Luo, F; Mak, S; Sun, Y; Wang, J; Wang, Y; Wu, L; Zhang, G; Zhang, Z | 1 |
| Binvignat, O; Olloquequi, J | 1 |
| Cui, G; Guo, B; Han, Y; Hu, S; Liu, Z; Luo, F; Mak, S; Qiu, X; Sun, Y; Wang, J; Wang, Y; Xu, D; Zhang, G; Zhang, Z | 1 |
| Albayrak, G; Bagriacik, EU; Bali, EB; Korkmaz, FD | 1 |
| Chayrov, R; Jiang, H; Li, Y; Li, Z; Liu, R; Mitrev, Y; Perlovich, GL; Stankova, I; Štícha, M; Tencheva, A; Volkova, TV | 1 |
| Adeniyi, PA; Adigun, OO; Arietarhire, LO; Arogundade, T; Asogwa, NT; Bamisi, O; Gbadamosi, IT; Idowu, OK; Kareem, R; Lambe, E; Lewu, FS; Ogunrinola, KY; Olajide, OJ; Oluyomi, OO; Yawson, EO | 1 |
| Ge, RL; Ji, W; Liu, J; Luo, J; Wan, Y; Zhang, Y | 1 |
| Chuchmacz, J; Czarnecka, K; Szymański, P; Wójtowicz, P | 1 |
| Abuelezz, SA; Hendawy, N | 1 |
| Burns, MP; Caccavano, AP; Cookson, MR; Harvey, AC; Kaganovich, A; Korthas, HT; Main, BS; Partridge, JG; Sloley, SS; Vicini, S; Winston, CN; Wu, JY; Zapple, DN | 1 |
| Abulseoud, OA; Angebrandt, A; Montemitro, C; Pettorruso, M; Wang, TY | 1 |
| Chalupska, D; Hemelikova, K; Horak, M; Kadkova, A; Klima, M; Kolcheva, M; Kortus, S; Krausova, BH; Ladislav, M; Misiachna, A; Netolicky, J; Rehakova, K | 1 |
| Angius, R; Cadeddu, F; Casu, MA; Collu, M; Diana, A; Fanti, M; Liscia, A; Mocci, I; Muroni, P; Setzu, MD; Sogos, V; Talani, G | 1 |
| Behnke, JE; Chapp, AD; Chen, QH; Collins, AR; Driscoll, KM; Shan, Z; Zhang, L | 1 |
| Dąbrowska-Bouta, B; Sidoryk-Węgrzynowicz, M; Strużyńska, L; Sulkowski, G | 1 |
29 review(s) available for memantine and glutamic acid
| Article | Year |
|---|---|
Excitatory mechanisms in retinal ganglion cell death in primary open angle glaucoma (POAG).
Topics: Animals; Cell Death; Excitatory Amino Acid Antagonists; Glaucoma, Open-Angle; Glutamic Acid; Humans; Memantine; Retinal Ganglion Cells; Vitreous Body | 1997 |
Saving the nerve from glaucoma: memantine to caspaces.
Topics: Animals; Apoptosis; Caspase Inhibitors; Caspases; Excitatory Amino Acid Antagonists; Glaucoma; Glutamic Acid; Humans; Memantine; Nitric Oxide Synthase; Optic Nerve Diseases; Retinal Ganglion Cells | 1999 |
[Memantine].
Topics: Aged; Alzheimer Disease; Antiparkinson Agents; Brain; Glutamic Acid; Humans; Memantine | 2003 |
The glutamatergic system and Alzheimer's disease: therapeutic implications.
Topics: Alzheimer Disease; Cell Death; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Learning; Memantine; Memory; Receptors, N-Methyl-D-Aspartate | 2003 |
NMDA-antagonism (memantine): an alternative pharmacological therapeutic principle in Alzheimer's and vascular dementia.
Topics: Alzheimer Disease; Clinical Trials as Topic; Dementia, Vascular; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Humans; Memantine; Receptors, N-Methyl-D-Aspartate | 2004 |
[Memantine (Ebixa), glutaminergic modulator].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutamine; Humans; Indans; Memantine; Piperidines | 2004 |
[Psychotropic drug treatment in dementia disorders].
Topics: Aged; Aged, 80 and over; Aging; Antidepressive Agents; Cholinesterase Inhibitors; Dementia; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glutamic Acid; Humans; Male; Memantine; Psychotropic Drugs; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2004 |
NMDA receptor antagonists. A new therapeutic approach for Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Disease Progression; Donepezil; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Indans; Memantine; Piperidines; Receptors, N-Methyl-D-Aspartate | 2004 |
Pharmacologic treatment options in Alzheimer's disease: optimizing disease management.
Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Disease Management; Donepezil; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Galantamine; Glutamic Acid; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome | 2005 |
Memantine: a therapeutic approach in treating Alzheimer's and vascular dementia.
Topics: Alzheimer Disease; Animals; Dementia, Vascular; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Nootropic Agents; Receptors, N-Methyl-D-Aspartate | 2005 |
Pharmacology of acetylcholinesterase inhibitors and N-methyl-D-aspartate receptors for combination therapy in the treatment of Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Galantamine; Glutamic Acid; Humans; Memantine; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic | 2006 |
Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine.
Topics: Alzheimer Disease; Animals; Brain; Cell Death; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate | 2006 |
Glutamate-modulating drugs & the treatment of mental disorders.
Topics: Acamprosate; Amantadine; Cycloserine; Glutamic Acid; Humans; Ketamine; Lamotrigine; Memantine; Mental Disorders; Psychotropic Drugs; Riluzole; Taurine; Triazines | 2007 |
Glutamatergic approaches to the treatment of cognitive and behavioural symptoms of Alzheimer's disease.
Topics: Alzheimer Disease; Behavioral Symptoms; Cognition Disorders; Glutamic Acid; Humans; Memantine; Neuroprotective Agents; Serotonin Antagonists | 2008 |
Emerging role of glutamate in the pathophysiology of major depressive disorder.
Topics: Brain; Depressive Disorder, Major; Glutamic Acid; Humans; Ketamine; Memantine; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2009 |
Altered glutamate neurotransmission and behaviour in dementia: evidence from studies of memantine.
Topics: Dementia; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycogen Synthase Kinase 3; Humans; Memantine; Neurofibrillary Tangles; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; tau Proteins | 2009 |
Possibility of a new anti-alzheimer's disease pharmaceutical composition combining memantine and vitamin D.
Topics: Alzheimer Disease; Animals; Drug Combinations; Glutamic Acid; Humans; Memantine; Neuroprotective Agents; Vitamin D | 2012 |
Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine--searching for the connections.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Dopamine Agents; Glutamic Acid; Humans; Memantine; Receptors, N-Methyl-D-Aspartate | 2012 |
Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Neurofibrillary Tangles; Phosphorylation; Synaptic Membranes; tau Proteins | 2013 |
Emerging roles of metaplasticity in behaviour and disease.
Topics: Animals; Behavior; Behavior, Animal; Cognition Disorders; Conditioning, Classical; Gene Expression Regulation; Glutamic Acid; Humans; Learning; Memantine; Memory; Mice; Models, Neurological; Models, Psychological; Nerve Tissue Proteins; Neurodegenerative Diseases; Neuronal Plasticity; Nootropic Agents; Rats; Receptors, Ionotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Stroke; Time Factors; Transcranial Magnetic Stimulation; Up-Regulation | 2013 |
[Glutamate and malignant gliomas, from epilepsia to biological aggressiveness: therapeutic implications].
Topics: Benzodiazepines; Brain Neoplasms; Cell Death; Cell Movement; Cell Proliferation; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glioma; Glutamic Acid; Humans; Memantine; Neoplasm Invasiveness; Neuroglia; Neurons; Receptors, AMPA; Receptors, Glutamate; Seizures; Sulfasalazine | 2013 |
Reciprocal disruption of neuronal signaling and Aβ production mediated by extrasynaptic NMDA receptors: a downward spiral.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Calcium Signaling; Cell Survival; Dopamine Agents; Glutamic Acid; Humans; Memantine; Receptors, N-Methyl-D-Aspartate | 2014 |
Glutamatergic dysfunctioning in Alzheimer's disease and related therapeutic targets.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2014 |
The glutamate hypothesis: a pathogenic pathway from which pharmacological interventions have emerged.
Topics: Clozapine; Drug Delivery Systems; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2014 |
Ketamine and other potential glutamate antidepressants.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Humans; Ketamine; Memantine; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2015 |
Glutamatergic Agents in the Treatment of Compulsivity and Impulsivity in Child and Adolescent Psychiatry: a Systematic Review of the Literature.
Topics: Acetylcysteine; Adolescent; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Brain; Child; Corpus Striatum; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Memantine; Obsessive-Compulsive Disorder; Randomized Controlled Trials as Topic; Receptors, Glutamate; Risk Assessment; Treatment Outcome | 2018 |
Excitotoxicity as a Target Against Neurodegenerative Processes.
Topics: Alzheimer Disease; Glutamic Acid; Humans; Memantine; Neurons | 2020 |
Memantine in neurological disorders - schizophrenia and depression.
Topics: Alzheimer Disease; Antidepressive Agents; Antipsychotic Agents; Clinical Trials as Topic; Depression; Drug Repositioning; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serotonin 5-HT3 Receptor Antagonists | 2021 |
Mechanistic insights into the efficacy of memantine in treating certain drug addictions.
Topics: Animals; Brain; Cocaine; Ethanol; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Neurons; Opiate Alkaloids; Receptors, N-Methyl-D-Aspartate; Substance-Related Disorders | 2021 |
6 trial(s) available for memantine and glutamic acid
| Article | Year |
|---|---|
Continuous brachial plexus blockade in combination with the NMDA receptor antagonist memantine prevents phantom pain in acute traumatic upper limb amputees.
Topics: Adult; Amides; Amputation, Traumatic; Anesthetics, Local; Brachial Plexus; Double-Blind Method; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Male; Memantine; Middle Aged; Nerve Block; Nociceptors; Pain Measurement; Pain Threshold; Pain, Intractable; Phantom Limb; Receptors, N-Methyl-D-Aspartate; Ropivacaine; Treatment Outcome | 2007 |
Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial.
Topics: Aged; Aged, 80 and over; Brain; Cognition; Cognition Disorders; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Lewy Body Disease; Male; Memantine; Neuropsychological Tests; Outcome Assessment, Health Care; Parkinson Disease; Patient Selection; Placebo Effect; Placebos; Psychomotor Performance; Reaction Time; Treatment Outcome | 2009 |
Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double-blind, randomized, placebo-controlled trial.
Topics: Adult; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Depression; Dopamine Agents; Double-Blind Method; Drug Therapy, Combination; Female; Glutamic Acid; Humans; Lamotrigine; Male; Memantine; Middle Aged; Pilot Projects; Treatment Outcome; Triazines | 2012 |
Evaluation of the efficacy of memantine in the treatment of fibromyalgia: study protocol for a doubled-blind randomized controlled trial with six-month follow-up.
Topics: Brain; Clinical Protocols; Cognition; Double-Blind Method; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Fibromyalgia; Glutamic Acid; Health Status; Humans; Magnetic Resonance Spectroscopy; Memantine; Pain; Pain Measurement; Pain Perception; Pain Threshold; Quality of Life; Research Design; Spain; Time Factors; Treatment Outcome | 2013 |
Changes in metabolites after treatment with memantine in fibromyalgia. A double-blind randomized controlled trial with magnetic resonance spectroscopy with a 6-month follow-up.
Topics: Adult; Aspartic Acid; Brain; Creatine; Dopamine Agents; Double-Blind Method; Female; Fibromyalgia; Follow-Up Studies; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memantine; Mental Status Schedule; Middle Aged; Surveys and Questionnaires; Treatment Outcome | 2014 |
Glutamatergic medication in the treatment of obsessive compulsive disorder (OCD) and autism spectrum disorder (ASD) - study protocol for a randomised controlled trial.
Topics: Adolescent; Adolescent Behavior; Autism Spectrum Disorder; Brain; Child; Child Behavior; Clinical Protocols; Double-Blind Method; Europe; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Male; Memantine; Neuroimaging; Obsessive-Compulsive Disorder; Psychiatric Status Rating Scales; Research Design; Time Factors; Treatment Outcome | 2016 |
106 other study(ies) available for memantine and glutamic acid
| Article | Year |
|---|---|
Inhibitory effects of the antiparkinsonian drugs memantine and amantadine on N-methyl-D-aspartate-evoked acetylcholine release in the rabbit caudate nucleus in vitro.
Topics: Acetylcholine; Amantadine; Animals; Caudate Nucleus; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; Memantine; N-Methylaspartate; Rabbits; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Tritium | 1992 |
Assessment of primary neuronal culture as a model for soman-induced neurotoxicity and effectiveness of memantine as a neuroprotective drug.
Topics: Acetylcholine; Animals; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Injections, Subcutaneous; L-Lactate Dehydrogenase; Lethal Dose 50; Male; Memantine; N-Methylaspartate; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Soman | 1995 |
The effect of experimental ischaemia and excitatory amino acid agonists on the GABA and serotonin immunoreactivities in the rabbit retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cycloleucine; Dextromethorphan; Eye Proteins; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Intraocular Pressure; Ischemia; Kainic Acid; Kynurenic Acid; Memantine; N-Methylaspartate; Oxygen; Potassium Cyanide; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Vessels; Serotonin | 1994 |
Effects of memantine on synaptic transmission in the hippocampus in vitro.
Topics: Animals; Electric Stimulation; Glutamic Acid; Hippocampus; In Vitro Techniques; Interneurons; Long-Term Potentiation; Male; Memantine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Serine; Synapses; Synaptic Transmission; Theta Rhythm | 1995 |
MK-801 and memantine protect cultured neurons from glutamate toxicity induced by glutamate carboxypeptidase-mediated cleavage of methotrexate.
Topics: Animals; Astrocytes; Brain; Carboxypeptidases; Cells, Cultured; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Memantine; Methotrexate; Neurons; Rats; Rats, Sprague-Dawley | 1993 |
Delayed administration of memantine prevents N-methyl-D-aspartate receptor-mediated neurotoxicity.
Topics: Animals; Cell Survival; Cells, Cultured; Glutamates; Glutamic Acid; Memantine; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Time Factors | 1993 |
NMDA receptor-mediated glutamate toxicity of cultured cerebellar, cortical and mesencephalic neurons: neuroprotective properties of amantadine and memantine.
Topics: Amantadine; Animals; Cell Survival; Cells, Cultured; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Memantine; Mesencephalon; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine.
Topics: Animals; Antiparkinson Agents; Cell Count; Cell Survival; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Intraperitoneal; Memantine; Rats; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Vitreous Body | 1996 |
Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells.
Topics: Binding, Competitive; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ion Channels; Kidney; Kinetics; Memantine; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transfection | 1996 |
Is infantile alternating hemiplegia mediated by glutamate toxicity and can it be treated with memantine?
Topics: Amino Acid Metabolism, Inborn Errors; Child; Excitatory Amino Acid Antagonists; Glutamic Acid; Hemiplegia; Humans; Male; Memantine | 1996 |
Apparent independent action of nimodipine and glutamate antagonists to protect cultured neurons against glutamate-induced damage.
Topics: Animals; Cells, Cultured; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Memantine; Neurons; Neurotoxins; Nimodipine; Quinoxalines; Rats; Rats, Inbred F344 | 1996 |
Memantine, a noncompetitive NMDA receptor antagonist improves hyperammonemia-induced encephalopathy and acute hepatic encephalopathy in rats.
Topics: Ammonia; Animals; Body Water; Brain; Disease Models, Animal; Electroencephalography; Glutamic Acid; Hepatic Encephalopathy; Intracranial Pressure; Ischemia; Liver; Male; Memantine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia.
Topics: Animals; Cell Count; Chromatography, High Pressure Liquid; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Intraocular Pressure; Ischemia; Male; Memantine; N-Methylaspartate; Ocular Hypertension; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Retinal Vessels; Vitreous Body | 1998 |
Role of Na+/Ca2+ exchange in regulation of neuronal Ca2+ homeostasis requires re-evaluation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cell Survival; Cells, Cultured; Excitatory Amino Acid Antagonists; Glutamic Acid; Homeostasis; Hydrogen-Ion Concentration; Meglumine; Memantine; Mitochondria; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium; Sodium-Calcium Exchanger | 1998 |
Ethambutol is toxic to retinal ganglion cells via an excitotoxic pathway.
Topics: Animals; Antitubercular Agents; Calcium; Carbocyanines; Cell Survival; Dose-Response Relationship, Drug; Ethambutol; Ethylenediamines; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glutamic Acid; Memantine; Membrane Potentials; Mitochondria; N-Methylaspartate; Rats; Retinal Ganglion Cells; Tetrazolium Salts; Thiazoles | 1999 |
Neurons depend on astrocytes in a coculture system for protection from glutamate toxicity.
Topics: Animals; Astrocytes; Cell Communication; Cells, Cultured; Cerebellum; Culture Media, Conditioned; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Memantine; Mice; Neurons; Neurotoxins; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Signal Transduction; Tritium | 1999 |
Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine.
Topics: AIDS Dementia Complex; Brain; Calcium; Cell Survival; Cells, Cultured; Drug Synergism; Encephalitis; Fetus; Gene Products, tat; Glutamic Acid; HIV Envelope Protein gp120; Humans; Intracellular Fluid; Memantine; Neurons; Neuroprotective Agents; tat Gene Products, Human Immunodeficiency Virus; Time Factors | 2000 |
Antinociceptive activity of combination of morphine and NMDA receptor antagonists depends on the inter-injection interval.
Topics: Analgesics; Animals; Drug Synergism; Drug Therapy, Combination; Drug Tolerance; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Memantine; Mice; Morphine; Piperazines; Receptors, N-Methyl-D-Aspartate | 2000 |
The cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholinergic Fibers; Chronic Disease; Cyclooxygenase 2; Encephalitis; Excitatory Amino Acid Antagonists; Glutamic Acid; Image Cytometry; Isoenzymes; Male; Memantine; Nerve Tissue Proteins; Phenols; Prosencephalon; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Thiazoles | 2000 |
Effect of glutamate and antagonists of N-methyl-D-aspartate receptors on experimental parkinsonian syndrome in rats.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Male; Memantine; Parkinson Disease, Secondary; Rats; Receptors, N-Methyl-D-Aspartate | 2000 |
The N-methyl-D-aspartate antagonist memantine has no neuroprotective effect during hypothermic circulatory arrest: a study in the chronic porcine model.
Topics: Animals; Behavior, Animal; Brain; Cardiopulmonary Bypass; Electroencephalography; Female; Glucose; Glutamic Acid; Glycerol; Heart Arrest, Induced; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Lactic Acid; Memantine; Microdialysis; N-Methylaspartate; Neuroprotective Agents; Swine | 2001 |
The role of neurochemical mechanisms of ventromedial hypothalamus in various models of anxiety in rats.
Topics: Adrenergic Agents; Animals; Anxiety; Apomorphine; Avoidance Learning; Disease Models, Animal; Dopamine; Dopamine Agents; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamus, Middle; Male; Memantine; Microinjections; Neurotransmitter Agents; Phenylephrine; Picrotoxin; Rats; Serotonin; Sulpiride; Yohimbine | 2001 |
Private investigations.
Topics: Animals; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Confidentiality; Glaucoma; Glutamic Acid; Guinea Pigs; Haplorhini; Humans; Massachusetts; Memantine; Meniere Disease; National Institutes of Health (U.S.); Neurosciences; Pennsylvania; Research; Scientific Misconduct; United States; United States Food and Drug Administration; United States Office of Research Integrity | 2001 |
Glutamate release promotes growth of malignant gliomas.
Topics: Amino Acid Transport System X-AG; Animals; Brain Neoplasms; Carrier Proteins; Cell Division; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glioma; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Luminescent Measurements; Male; Memantine; Neoplasm Transplantation; Neurons; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Symporters; Tumor Cells, Cultured | 2001 |
Different action of memantine and caroverine on glutamatergic transmission in the mammalian cochlea.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cochlea; Dopamine Agents; Female; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory, Inner; Memantine; N-Methylaspartate; Neurons, Afferent; Quinoxalines | 2002 |
Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cell Death; Dentate Gyrus; Ectodysplasins; Excitatory Amino Acid Antagonists; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Immunohistochemistry; Memantine; Membrane Proteins; Microglia; Microtubule-Associated Proteins; Motor Activity; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2002 |
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Apomorphine; Avoidance Learning; Biguanides; Brain Chemistry; Chlordiazepoxide; Clonidine; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Droperidol; Drug Interactions; GABA Agents; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Male; Memantine; Mephenytoin; Microinjections; Pentylenetetrazole; Phentolamine; Picrotoxin; Piperazines; Propranolol; Pyrimidines; Rats; Serotonin; Sulpiride; Ventromedial Hypothalamic Nucleus; Yohimbine | 2003 |
Mechanotransduction by intraganglionic laminar endings of vagal tension receptors in the guinea-pig oesophagus.
Topics: Action Potentials; Adenosine Triphosphate; Amiloride; Animals; Cadmium; Calcium; Carrier Proteins; Dose-Response Relationship, Drug; Electric Stimulation; Esophagus; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gadolinium; Ganglia; Glutamic Acid; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Mechanoreceptors; Mechanotransduction, Cellular; Memantine; Membrane Transport Proteins; Nerve Endings; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Stress, Mechanical; Synaptophysin; Tetrodotoxin; Vagus Nerve; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2; Vesicular Transport Proteins | 2003 |
Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration.
Topics: 2-Amino-5-phosphonovalerate; Alzheimer Disease; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kynurenic Acid; Memantine; Microtubule-Associated Proteins; Nerve Degeneration; Neurofibrils; Neuroprotective Agents; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Wistar; tau Proteins | 2004 |
Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, I: Functional measures.
Topics: Administration, Oral; Animals; Cell Count; Chronic Disease; Disease Models, Animal; Electroretinography; Evoked Potentials, Visual; Excitatory Amino Acid Antagonists; Glaucoma; Glutamic Acid; Intraocular Pressure; Macaca fascicularis; Memantine; Ocular Hypertension; Optic Nerve Diseases; Retina; Retinal Ganglion Cells; Safety; Treatment Outcome; Vitreous Body | 2004 |
Memantine as a neuroprotective treatment in schizophrenia.
Topics: Calcium; Glutamic Acid; Humans; Memantine; Neurons; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2005 |
A new anti-obesity drug treatment: first clinical evidence that, antagonising glutamate-gated Ca2+ ion channels with memantine normalises binge-eating disorders.
Topics: Adult; Anti-Obesity Agents; Calcium Channel Blockers; Calcium Channels; Excitatory Amino Acid Antagonists; Feeding and Eating Disorders; Female; Germany; Glutamic Acid; Humans; Ion Channel Gating; Memantine | 2005 |
Glutamate receptors on human melanocytes regulate the expression of MiTF.
Topics: Apoptosis; Benzodiazepinones; Cell Shape; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gene Expression Profiling; Gene Expression Regulation; Glutamic Acid; Humans; Melanocytes; Memantine; Microphthalmia-Associated Transcription Factor; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Protein Isoforms; Receptors, Glutamate | 2006 |
[Also consider non-cognitive disorders].
Topics: Aged; Alzheimer Disease; Brain; Cognition Disorders; Depressive Disorder; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Mental Disorders; Treatment Outcome | 2005 |
Memantine: the next trend in academic performance enhancement?
Topics: Alzheimer Disease; Cognition; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Memory; Neurons; Receptors, N-Methyl-D-Aspartate | 2006 |
3-Nitropropionic acid toxicity in hippocampus: protection through N-methyl-D-aspartate receptor antagonism.
Topics: Animals; Animals, Newborn; Cytoskeleton; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Memantine; Mitochondria; Nerve Degeneration; Neural Pathways; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Organ Culture Techniques; Propionates; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2006 |
Evaluation of clinically relevant glutamate pathway inhibitors in in vitro model of Huntington's disease.
Topics: Amines; Animals; Apoptosis; Cells, Cultured; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Folic Acid; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Huntington Disease; Lamotrigine; Male; Memantine; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; Riluzole; Triazines | 2006 |
A prospective, open-label trial of memantine in the treatment of cognitive, behavioral, and memory dysfunction in pervasive developmental disorders.
Topics: Child; Child Behavior Disorders; Child Development Disorders, Pervasive; Child, Preschool; Cognition Disorders; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Intelligence; Language Development Disorders; Male; Memantine; Memory Disorders; Neuropsychological Tests; Prospective Studies; Treatment Outcome | 2006 |
NMDA receptor-mediated excitotoxicity contributes to the cerebral hypoxic injury of a rat model of posthypoxic myoclonus.
Topics: Animals; Brain Damage, Chronic; Cerebellum; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Hypoxia, Brain; Intralaminar Thalamic Nuclei; Male; Memantine; Myoclonus; Nerve Degeneration; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2007 |
Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cells, Cultured; Computer Simulation; Drug Synergism; Glutamic Acid; Isoenzymes; Memantine; Molecular Sequence Data; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tacrine; Time Factors | 2007 |
[Synthesis and neuroprotective activity in cell culture of aminoadamantane analogues].
Topics: Amantadine; Cell Death; Cell Line, Tumor; Glutamic Acid; Humans; L-Lactate Dehydrogenase; Memantine; Neuroblastoma; Neuroprotective Agents | 2007 |
Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes.
Topics: Animals; Chimera; Dopamine Agents; Dose-Response Relationship, Drug; Electrophysiology; Evoked Potentials; Female; Glutamic Acid; Magnesium; Memantine; Oocytes; Patch-Clamp Techniques; Quinolinic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 2008 |
Glutamate-mediated neuroplasticity in an animal model of self-injurious behaviour.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Memantine; Neuronal Plasticity; Neurotransmitter Uptake Inhibitors; Pemoline; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Self-Injurious Behavior | 2008 |
Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cytoprotection; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Memantine; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tacrine | 2008 |
Memantine decreases hippocampal glutamate levels: a magnetic resonance spectroscopy study.
Topics: Adult; Aged; Aging; Alzheimer Disease; Cognition Disorders; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memantine | 2008 |
Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder.
Topics: Acoustic Stimulation; Amantadine; Animals; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Memantine; Mice; Mice, Inbred ICR; Motor Activity; Obsessive-Compulsive Disorder; Quinoxalines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Riluzole | 2008 |
Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.
Topics: Animals; Calcium; Calcium Signaling; Cell Survival; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Memantine; Mice; Neurons; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses; Synaptic Transmission | 2008 |
Glutamate-induced NFkappaB activation in the retina.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Culture Techniques; Egtazic Acid; Electrophoretic Mobility Shift Assay; Fluorescent Antibody Technique, Indirect; Glutamic Acid; Memantine; NF-kappa B; NF-kappa B p50 Subunit; NF-kappa B p52 Subunit; Organ Culture Techniques; Proto-Oncogene Proteins c-rel; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Signal Transduction; Transcription Factor RelA; Transcription Factor RelB | 2009 |
Memantine protects rat cortical cultured neurons against beta-amyloid-induced toxicity by attenuating tau phosphorylation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Caspase 3; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Excitatory Amino Acid Antagonists; Extracellular Fluid; Glutamic Acid; Memantine; Neurons; Neuroprotective Agents; Peptide Fragments; Phosphorylation; Phosphotransferases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; tau Proteins; Up-Regulation | 2008 |
Understanding pseudo: the symptoms are real, the cause is unclear.
Topics: Brain; Chemotaxis, Leukocyte; Clinical Trials as Topic; Encephalitis; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Iatrogenic Disease; Inflammation Mediators; Memantine; Multiple Sclerosis, Relapsing-Remitting; Nystagmus, Pathologic; Secondary Prevention | 2009 |
Memantine prevents sensitivity to excitotoxic cell death of rat cortical neurons expressing human truncated tau protein.
Topics: Animals; Cell Culture Techniques; Cell Death; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Hippocampus; Memantine; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Transgenic; Reactive Oxygen Species; tau Proteins | 2009 |
Potency, voltage-dependency, agonist concentration-dependency, blocking kinetics and partial untrapping of the uncompetitive N-methyl-D-aspartate (NMDA) channel blocker memantine at human NMDA (GluN1/GluN2A) receptors.
Topics: Animals; Cell Line; Cerebral Cortex; Dizocilpine Maleate; Glutamic Acid; Humans; In Vitro Techniques; Ion Channel Gating; Ketamine; Kinetics; Male; Memantine; Patch-Clamp Techniques; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2009 |
Evidence for glutamatergic neurotransmission in cognitive control in an auditory attention task.
Topics: Acoustic Stimulation; Adult; Attention; Brain; Brain Mapping; Cognition; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Male; Memantine; Synaptic Transmission | 2009 |
Polysaccharides from wolfberry antagonizes glutamate excitotoxicity in rat cortical neurons.
Topics: Animals; Antioxidants; Cell Death; Cerebral Cortex; Glutamic Acid; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Lycium; Memantine; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Phosphorylation; Polysaccharides; Rats | 2009 |
Neuroprotective effect of memantine combined with topiramate in hypoxic-ischemic brain injury.
Topics: Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Brain; Brain Infarction; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Fructose; Glutamic Acid; Hypoxia-Ischemia, Brain; In Situ Nick-End Labeling; Male; Memantine; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Topiramate; Treatment Outcome | 2009 |
Memantine: a new hope for treatment of Lewy body-related dementias?
Topics: Aged; Brain; Brain Chemistry; Clinical Trials as Topic; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Lewy Body Disease; Memantine; Parkinson Disease; Placebo Effect; Synaptic Transmission; Treatment Outcome | 2009 |
A 1H-MR spectroscopy study of changes in glutamate and glutamine (Glx) concentrations in frontal spectra after administration of memantine.
Topics: Acoustic Stimulation; Administration, Oral; Adult; Analysis of Variance; Antiparkinson Agents; Brain Mapping; Dichotic Listening Tests; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memantine; Neuropsychological Tests; Oxygen; Psychoacoustics; Radionuclide Imaging; Tritium; Young Adult | 2010 |
GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Electrophysiology; Glutamic Acid; Hippocampus; Male; Memantine; Neuronal Plasticity; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Tumor Necrosis Factor-alpha | 2009 |
Memantine ameliorates scopolamine-induced amnesia in chicks trained on taste-avoidance learning.
Topics: Amnesia; Animals; Avoidance Learning; Chickens; Cholinergic Antagonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Memantine; Memory; Neuropsychological Tests; Nootropic Agents; Receptors, Cholinergic; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Scopolamine; Taste Perception | 2010 |
Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage.
Topics: Animals; Apoptosis; Cell Death; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; Inhibitory Concentration 50; Male; Memantine; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Tacrine; Time Factors | 2010 |
Memantine depresses glutamate release through inhibition of voltage-dependent Ca2+ entry and protein kinase C in rat cerebral cortex nerve terminals: an NMDA receptor-independent mechanism.
Topics: 4-Aminopyridine; Animals; Blotting, Western; Cerebral Cortex; Dose-Response Relationship, Drug; Glutamic Acid; Male; Memantine; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2010 |
Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells.
Topics: Amino Acid Transport System X-AG; Animals; Apoptosis; Calcium; Calcium Signaling; Caspase 3; Dendritic Cells; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanylate Kinases; Intracellular Signaling Peptides and Proteins; Memantine; Membrane Proteins; Mice; Receptors, N-Methyl-D-Aspartate; Thyroid Gland | 2011 |
Characterisation of the expression of NMDA receptors in human astrocytes.
Topics: Adult; Astrocytes; Brain; Calcium; Cell Membrane; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Gene Expression Profiling; Glutamic Acid; Humans; Immunohistochemistry; L-Lactate Dehydrogenase; Memantine; Microscopy, Confocal; Protein Subunits; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction | 2010 |
Protection from glutamate-induced excitotoxicity by memantine.
Topics: Animals; Brain Injuries; Electrophysiological Phenomena; Excitatory Amino Acid Antagonists; Glutamic Acid; Memantine; Neurons; Neuroprotective Agents; Rats; Receptors, N-Methyl-D-Aspartate | 2012 |
Effects of chronic memantine treatment on hippocampal extracellular glutamate and GABA levels during spatial alternation testing.
Topics: Animals; Chlorides; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Maze Learning; Memantine; Memory, Short-Term; Microdialysis; Motor Activity; Potassium; Rats | 2012 |
Pretreatment with memantine prevents Alzheimer-like alterations induced by intrahippocampal okadaic acid administration in rats.
Topics: Alzheimer Disease; Animals; Carcinogens; Chromatography, High Pressure Liquid; Cyclin-Dependent Kinase 5; Disease Models, Animal; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Exploratory Behavior; Glutamic Acid; Hippocampus; Locomotion; Male; Maze Learning; Memantine; Okadaic Acid; Rats; Rats, Wistar; Signal Transduction; Statistics as Topic; tau Proteins | 2012 |
Protective effects of memantine against methylmercury-induced glutamate dyshomeostasis and oxidative stress in rat cerebral cortex.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Female; Glutamic Acid; Homeostasis; Male; Memantine; Methylmercury Compounds; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species | 2013 |
Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-beta and glutamate.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Axons; Cells, Cultured; Drug Synergism; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Glutamic Acid; Memantine; Mice; Nerve Degeneration; Neuroprotective Agents; Vitamin D | 2014 |
Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis.
Topics: Animals; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Memantine; Neuronal Plasticity; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses; Synaptic Transmission | 2014 |
Novel treatment with neuroprotective and antiviral properties against a neuroinvasive human respiratory virus.
Topics: Animals; Antiviral Agents; Central Nervous System; Central Nervous System Viral Diseases; Coronavirus Infections; Coronavirus OC43, Human; Female; Glutamic Acid; Humans; Memantine; Mice; Mice, Inbred BALB C; Motor Activity; Spike Glycoprotein, Coronavirus; Virus Replication | 2014 |
N-methyl-D-aspartate receptors amplify activation and aggregation of human platelets.
Topics: 2-Amino-5-phosphonovalerate; Blood Platelets; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Male; Memantine; P-Selectin; Platelet Activation; Platelet Aggregation; Receptors, N-Methyl-D-Aspartate | 2014 |
Role of glutamate and advantages of combining memantine with a 5HT6 ligand in a model of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Glutamic Acid; Ligands; Male; Memantine; Motor Activity; N-Methylaspartate; Piperazines; Prefrontal Cortex; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Sulfonamides; Swimming | 2014 |
The dichotomy of memantine treatment for ischemic stroke: dose-dependent protective and detrimental effects.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Brain Ischemia; Calcium Signaling; Cell Death; Cells, Cultured; Coculture Techniques; Corpus Striatum; Dose-Response Relationship, Drug; Glutamic Acid; Memantine; Mice; Mice, Inbred BALB C; Stroke; Time Factors | 2015 |
Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes.
Topics: Aged; Aged, 80 and over; Aldehyde Dehydrogenase; Animals; Astrocytes; Cell Count; Cells, Cultured; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glaucoma; Glutamic Acid; Humans; Intraocular Pressure; Memantine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Mitochondria; Mitochondrial Dynamics; N-Methylaspartate; Optic Disk; Oxidoreductases Acting on CH-NH Group Donors; Retinal Ganglion Cells | 2015 |
NMDA receptor antagonists MK-801 and memantine induce tolerance to oxygen and glucose deprivation in primary cultures of rat cerebellar granule cells.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Count; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Hypoxia; Memantine; Neurons; Rats; Rats, Wistar; Statistics, Nonparametric; Time Factors | 2014 |
PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning.
Topics: Animals; Animals, Newborn; Calcineurin; Cerebral Cortex; Clioquinol; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycogen Synthase Kinase 3; Memantine; Metals; Mice; Mice, Inbred C57BL; Neurons; Time Factors | 2015 |
Role of glutamate and serotonin on the hypoxic ventilatory response in high-altitude-adapted plateau Pika.
Topics: Adaptation, Physiological; Altitude; Analysis of Variance; Animals; Enzyme Inhibitors; Excitatory Amino Acid Agents; Female; Glutamic Acid; Hypoxia; Lagomorpha; Male; Memantine; NG-Nitroarginine Methyl Ester; Plethysmography; Pulmonary Ventilation; Serotonin; Serotonin Agents; Tidal Volume | 2015 |
Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred mice.
Topics: Aggression; Animals; Behavior, Animal; Ethanol; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Male; Memantine; Mice; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Social Behavior; Substance Withdrawal Syndrome | 2015 |
NMDA Receptor Antagonist Attenuates Bleomycin-Induced Acute Lung Injury.
Topics: Acute Lung Injury; Amino Acids; Animals; Antibiotics, Antineoplastic; Bleomycin; Bronchoalveolar Lavage Fluid; Capillary Permeability; CD11b Antigen; Cytokines; Disease Models, Animal; Dopamine Agents; Female; Glutamic Acid; Malondialdehyde; Memantine; Mice; Neutrophil Infiltration; Neutrophils; Receptors, N-Methyl-D-Aspartate | 2015 |
Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Dendritic Spines; Dizocilpine Maleate; Egtazic Acid; Glutamic Acid; GTP-Binding Proteins; Hippocampus; Memantine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Valine | 2015 |
Enhancing glutamatergic transmission during adolescence reverses early-life stress-induced deficits in the rewarding effects of cocaine in rats.
Topics: Administration, Intravenous; Aging; Amino Acid Transport System X-AG; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Maternal Deprivation; Memantine; Rats; Receptors, N-Methyl-D-Aspartate; Reward; Riluzole; Self Administration; Stress, Psychological | 2015 |
Suppression of excitotoxicity and foreign body response by memantine in chronic cannula implantation into the rat brain.
Topics: Animals; Antigens, Nuclear; Astrocytes; Biomechanical Phenomena; Calcium-Binding Proteins; Catheters, Indwelling; Cell Survival; Cicatrix; Excitatory Amino Acid Antagonists; Forelimb; Glial Fibrillary Acidic Protein; Glutamic Acid; Macrophages; Male; Memantine; Microfilament Proteins; Microglia; Motor Activity; Motor Cortex; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Rats | 2015 |
Protective effects of NMDA receptor antagonist, memantine, against senescence of PC12 cells: A possible role of nNOS and combined effects with donepezil.
Topics: Aging; Alzheimer Disease; Animals; beta-Galactosidase; Cholinesterase Inhibitors; Cognition; Disease Models, Animal; Donepezil; Glutamic Acid; Hippocampus; Indans; Male; Maze Learning; Memantine; Memory; Mice; Neuronal Plasticity; Nitric Oxide Synthase Type I; PC12 Cells; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate | 2015 |
Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mechanism for Memantine-Induced Anti-inflammation and Anti-mitochondrial Impairment.
Topics: Animals; Cell Survival; Cytochromes c; Dopamine Plasma Membrane Transport Proteins; Gene Knockdown Techniques; Glutamic Acid; Inflammation; Interleukin-6; L-Lactate Dehydrogenase; MAP Kinase Signaling System; Memantine; Mitochondria; Nerve Degeneration; Neuroprotection; Nuclear Receptor Subfamily 4, Group A, Member 1; Nuclear Receptor Subfamily 4, Group A, Member 2; Oxidopamine; PC12 Cells; Rats; Subcellular Fractions; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2016 |
GluN3A promotes NMDA spiking by enhancing synaptic transmission in Huntington's disease models.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Glutamic Acid; Huntington Disease; Memantine; Mice; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2016 |
Low dose of L-glutamic acid attenuated the neurological dysfunctions and excitotoxicity in bilateral common carotid artery occluded mice.
Topics: Animals; Brain; Brain Ischemia; Carotid Artery, Common; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Male; Memantine; Mice; Neuroprotective Agents; Nitric Oxide; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Time Factors | 2016 |
GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers.
Topics: Amino Acid Sequence; Base Sequence; Cell Death; Child; Dendrites; DNA Mutational Analysis; Electroencephalography; Exome; Female; Genes, Dominant; Glutamic Acid; Humans; Infant; Infant, Newborn; Ketamine; Magnesium; Memantine; Models, Molecular; Mutation; Precision Medicine; Receptors, N-Methyl-D-Aspartate; Seizures; Spasms, Infantile | 2016 |
Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.
Topics: Animals; Cells, Cultured; Excitatory Amino Acid Antagonists; Glutamic Acid; HEK293 Cells; Humans; Ion Channel Gating; Memantine; Mutation, Missense; Nerve Tissue Proteins; Nervous System Diseases; Neurons; Protein Domains; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Xenopus | 2017 |
SUVN-502, a novel, potent, pure, and orally active 5-HT6 receptor antagonist: pharmacological, behavioral, and neurochemical characterization.
Topics: Acetylcholine; Animals; Behavior, Animal; Brain; Brain Waves; CHO Cells; Cricetulus; Culture Media, Serum-Free; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Electroencephalography; Glutamic Acid; Indoles; Male; Maze Learning; Memantine; Memory Disorders; Microdialysis; Nootropic Agents; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Recognition, Psychology; Scopolamine; Serotonin; Serotonin Antagonists | 2019 |
Neuro-metabolite profiles of rodent models of psychiatric dysfunctions characterised by MR spectroscopy.
Topics: Anhedonia; Animals; Choline; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutamine; Hippocampus; Inositol; Magnetic Resonance Spectroscopy; Male; Memantine; Motor Activity; Rats; Rats, Wistar; Schizophrenia; Stress, Psychological; Sucrose; Taurine | 2019 |
Memantine protects thalamocortical hyper-glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc.
Topics: Amino Acid Transport Systems, Acidic; Animals; Astrocytes; Cells, Cultured; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mediodorsal Thalamic Nucleus; Memantine; Microdialysis; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Thalamus | 2019 |
Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Capillary Permeability; Cell Survival; CHO Cells; Cholinesterase Inhibitors; Cricetulus; Glutamic Acid; HEK293 Cells; Humans; Ligands; Male; Memantine; Molecular Docking Simulation; Neuroprotective Agents; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tacrine; Tissue Culture Techniques | 2019 |
Memantine ameliorates learning and memory disturbance and the behavioral and psychological symptoms of dementia in thiamine-deficient mice.
Topics: Administration, Oral; Animals; Anxiety; Behavior, Animal; Biogenic Monoamines; Body Weight; Dementia; Depression; Disease Models, Animal; Glutamic Acid; Hippocampus; Locomotion; Male; Maze Learning; Memantine; Memory; Mice; Thiamine Deficiency | 2019 |
Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-deprived SH-SY5Y neuroblastoma cells.
Topics: AMP-Activated Protein Kinases; Autophagosomes; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Cell Line, Tumor; Energy Metabolism; Forkhead Box Protein O3; Glutamic Acid; Humans; Ibotenic Acid; Intracellular Signaling Peptides and Proteins; Mechanistic Target of Rapamycin Complex 1; Memantine; Microtubule-Associated Proteins; Necrosis; Neuroblastoma; Nutrients; Receptors, N-Methyl-D-Aspartate; Sequestosome-1 Protein; Transcription, Genetic | 2020 |
Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation
Topics: Alzheimer Disease; Animals; Brain; Dementia, Vascular; Glutamic Acid; Memantine; Neurons; Neuroprotection; Neuroprotective Agents; Nitrates; Phosphatidylinositol 3-Kinases; Rats; Spatial Memory; Vasodilation | 2020 |
Multifunctional memantine nitrate significantly protects against glutamate-induced excitotoxicity via inhibiting calcium influx and attenuating PI3K/Akt/GSK3beta pathway.
Topics: Animals; Apoptosis; Biological Transport; Calcium; Cell Count; Cerebellum; Glutamic Acid; Glycogen Synthase Kinase 3 beta; Hippocampus; Memantine; Molecular Docking Simulation; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Protein Conformation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2020 |
Antitumorigenic Effect of Memantine via Interfering Glutamate Metabolism in Mouse 4T1 Breast Tumor Model.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Glutamic Acid; Memantine; Mice; Mice, Inbred BALB C; Tumor Cells, Cultured | 2021 |
Synthetic analogues of memantine as neuroprotective and influenza viral inhibitors: in vitro and physicochemical studies.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Dogs; Glutamic Acid; Humans; Influenza, Human; Madin Darby Canine Kidney Cells; Memantine; Neuroprotective Agents; Orthomyxoviridae; Oxidative Stress | 2020 |
Hippocampal Degeneration and Behavioral Impairment During Alzheimer-Like Pathogenesis Involves Glutamate Excitotoxicity.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Dentate Gyrus; Disks Large Homolog 4 Protein; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Glutathione Peroxidase; Glutathione Transferase; Ki-67 Antigen; Male; Memantine; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2021 |
Memantine ameliorates cognitive impairment induced by exposure to chronic hypoxia environment at high altitude by inhibiting excitotoxicity.
Topics: Altitude; Altitude Sickness; Alzheimer Disease; Animals; Cell Death; Cognition; Cognitive Dysfunction; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Hypoxia; Male; Memantine; Memory; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2021 |
HMGB1/RAGE/TLR4 axis and glutamate as novel targets for PCSK9 inhibitor in high fat cholesterol diet induced cognitive impairment and amyloidosis.
Topics: Amyloidosis; Animals; Antibodies, Monoclonal, Humanized; Cholesterol; Cognitive Dysfunction; Diet, High-Fat; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; HMGB1 Protein; Male; Memantine; PCSK9 Inhibitors; Rats; Rats, Wistar; Receptor for Advanced Glycation End Products; Toll-Like Receptor 4 | 2021 |
High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice.
Topics: Amyloid beta-Peptides; Animals; Behavior Rating Scale; Brain Injuries, Traumatic; Cognition; Cognitive Dysfunction; Electrophysiology; Gene Ontology; Glutamic Acid; Memantine; Mice; Microglia; Multigene Family; Neuronal Plasticity; Neurons; Receptors, N-Methyl-D-Aspartate; Synapses; tau Proteins; Transcriptome | 2021 |
The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors.
Topics: Animals; Female; Glutamic Acid; HEK293 Cells; Humans; Male; Mammals; Memantine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2023 |
Effects of memantine on mania-like phenotypes exhibited by Drosophila Shaker mutants.
Topics: Animals; Drosophila; Drosophila melanogaster; Glutamic Acid; Humans; Mania; Memantine; Phenotype; Receptors, N-Methyl-D-Aspartate | 2023 |
Ethanol Metabolite, Acetate, Increases Excitability of the Central Nucleus of Amygdala Neurons through Activation of NMDA Receptors.
Topics: Acetates; Acetic Acid; Action Potentials; Animals; Calcium; Catalytic Domain; Cells, Cultured; Central Amygdaloid Nucleus; Ethanol; Glutamic Acid; Glycine; Memantine; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium; Sodium Acetate; Synaptic Transmission | 2023 |
Memantine Improves the Disturbed Glutamine and γ-Amino Butyric Acid Homeostasis in the Brain of Rats Subjected to Experimental Autoimmune Encephalomyelitis.
Topics: Amino Acids; Animals; Antifibrinolytic Agents; Brain; Encephalomyelitis, Autoimmune, Experimental; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Homeostasis; Memantine; Rats; Rats, Inbred Lew | 2023 |