memantine and amantadine

memantine has been researched along with amantadine in 129 studies

Research

Studies (129)

Timeframe	Studies, this research(%)	All Research%
pre-1990	43 (33.33)	18.7374
1990's	30 (23.26)	18.2507
2000's	24 (18.60)	29.6817
2010's	21 (16.28)	24.3611
2020's	11 (8.53)	2.80

Authors

Authors	Studies
Gianutsos, G; Hane, JT; Henkel, JG	1
Hecht, P; Kornhuber, J; Koutsilieri, E; Kroemer, RT; Liedl, KR; Riederer, P	1
Akhoundova, A; Arndt, P; Baumann, C; Busch, AE; Gorboulev, V; Karbach, U; Koepsell, H; Lang, F; Miska, D; Sonders, MS; Ulzheimer, JC; Volk, C; Waldegger, S	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Camins, A; Camps, P; Cortés, D; De Clercq, E; Duque, MD; Ivorra, D; Kelly, JM; López-Querol, M; Naesens, L; Pallàs, M; Prathalingam, SR; Romero, V; Sureda, FX; Vázquez, S	1
Camps, P; De Clercq, E; Duque, MD; Kelly, JM; López-Querol, M; Mallol, J; Montaner, S; Naesens, L; Prathalingam, SR; Profire, L; Sureda, FX; Vázquez, S	1
Camins, A; Camps, P; Duque, MD; Kelly, JM; López-Querol, M; Prathalingam, SR; Sureda, FX; Torres, E; Valverde, E; Vázquez, S	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Glen, RC; Lowe, R; Mitchell, JB	1
Duque, MD; Kelly, JM; López-Querol, M; Ma, C; Naesens, L; Pinto, LH; Sureda, FX; Taylor, MC; Torres, E; Vázquez, S	1
Chen, W; Hanaoka, K; Ichinose, F; Liu, J; Marutani, E; Nagano, T; Sakaguchi, M; Sasakura, K; Xian, M	1
Daniliuc, C; Ehrhardt, C; Frehland, B; Lehmkuhl, K; Schepmann, D; Torres-Gómez, H; Wünsch, B	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Barbier, J; Cintrat, JC; Davey, RA; Gillet, D; Kali, S; Noël, R; Pons, V; Popoff, MR; Shtanko, O; Tordo, N; Wu, Y	1
Egunlusi, AO; Ekpo, OE; Joubert, J; Malan, SF; Omoruyi, SI; Palchykov, VA	1
Brea, JM; Companys-Alemany, J; Griñán-Ferré, C; Johnson, JW; Kurnikova, MG; Loza, MI; Pallàs, M; Patel, DS; Pérez, B; Phillips, MB; Soto, D; Sureda, FX; Turcu, AL; Vázquez, S	1
Fischer, PA; Jacobi, P; Schneider, E; Schönberger, B	1
Clark, WG; Menon, MK	2
Schollmeyer, JD; Sturm, G; Wesemann, W	2
Cremer, H; Sontag, KH; Wand, P	1
Haacke, U; Sturm, G; Süwer, V; Wesemann, W; Wildenhahn, G	1
Grossmann, W; Jurna, I	1
Smialowska, M	2
Costall, B; Naylor, RJ	1
Przewlocki, R	1
Camanni, F; Fassio, V; Massara, F; Molinatti, GM; Müller, EE	1
Grossmann, A; Grossmann, W; Jurna, I	1
Feuerstein, TJ; Jackisch, R; Koch, R; Lücking, CH; Lupp, A	1
Kornhuber, J; Weller, M	2
Bormann, J; Hübers, M; Kornhuber, J; Riederer, P; Rusche, K	1
Hönack, D; Löscher, W	1
Koch, R; Reiser, G	1
Bormann, J	1
Bormann, J; Hübers, M; Kornhuber, J; Retz, W; Riederer, P	1
Chen, ML; Lo, SC; Tsai, GC; Tsai, MC	1
Gupta, RC; Kadel, WL	1
Dimpfel, W; Koch, R; Schatton, W; Spüler, M	1
Ljungberg, T	1
Koch, R; Schatton, W; Verspohl, EJ	1
Enomoto, K; Maeno, T; Masuo, K	1
Binmöller, FJ; Koch, R; Reiser, G	1
Ambrozi, L; Danielczyk, W	1
Buchgeher, A; Fleischhacker, WW; Schubert, H	1
Ammon, HP; Youssif, N	1
Milios, E; Mundinger, F	1
Czuczwar, SJ; Meldrum, BS; Schwarz, M; Sontag, KH; Turski, L	1
Maj, J	1
Beale, R; Golombiowska-Nikitin, K; Osborne, NN; Sontag, KH	1
Klee, MR	1
Maj, J; Sontag, KH; Wesemann, W	1
Balzereit, F; Clemens, R; Fischer, PA; Fünfgeld, EW; Haase, HJ; Schneider, E	1
Rohde, H	1
Osborne, NN; Schwarz, M; Sontag, KH; Wand, P; Wesemann, W	1
Miltner, FO	2
Grossmann, W; Schütz, W	1
Fünfgeld, EW; Sturm, G; Wesemann, W	1
Kramer, MJ; Tilley, JW	1
Danysz, W; Dill, D; Gossel, M; Quack, G; Zajaczkowski, W	1
Danysz, W; Quack, G; Rogoz, Z; Skuza, G	1
Feuerstein, TJ	1
Kornhuber, J; Riederer, P; Schoppmeyer, K; Weller, M	1
Bijak, M; Misgeld, U; Rohrbacher, J	1
Finiels-Marlier, F; Paul, SM; Weller, M	1
Danysz, W; Moryl, E; Quack, G	1
Danysz, W; Mobley, SL; Wenk, GL	1
Danysz, W; Hesselink, M; Quack, G; Spanagel, R	1
Ferger, D; Krieglstein, J	1
Krishtal, OA; Panchenko, VA; Parsons, CG; Pinchenko, VO; Tsyndrenko, AY	1
Aizenman, E; Blanpied, TA; Boeckman, FA; Johnson, JW	1
Camicioli, R; Ganzini, L; Young, BK	1
Danysz, W; Kornhuber, J; Parsons, CG; Quack, G; Schmidt, WJ	1
Koshelev, S; Sobolevsky, A	1
Albrecht-Goepfert, E; Elstner, EF; Schempp, H	1
Hartmann, S; Parsons, CG; Spielmanns, P	1
Khodorov, BI; Koshelev, SG; Sobolevsky, AI	1
Karge, E; Kerst, S; Klinger, W; Lupp, A; Quack, G	1
Balster, RL; Jones, HE; Nicholson, KL	1
Breimer, DD; Danysz, W; De Boer, BG; Hesselink, MB	1
Breimer, DD; Danysz, W; De Boer, AG; Hesselink, MB	1
Breimer, DD; Danysz, W; De Boer, AG; Hesselink, MB; Smolders, H	1
Budziszewska, B; Jaworska-Feil, L; Kajta, M; Lasoń, W	1
Archer, T; Danysz, W; Fredriksson, A; Quack, G	1
Havel, J; Pazourek, J; Polásková, P; Reichová, N	1
Fauler, G; Leis, HJ; Windischhofer, W	1
Escobar, MR; Fourie, J; Sitar, DS	1
Grützner, L	1
Balster, RL; Harvey, SA; Nicholson, KL; Wiley, JL	1
Hermans, E; Maloteaux, JM; Peeters, M	1
Block, F; Habermeyer, B	1
Fujii, Y; Higashi, Y	1
Fujii, Y; Higashi, Y; Matsumura, H; Nakamura, S	1
Caumont, AS; Hermans, E; Octave, JN	1
Blaha, CD; Call, SB; Escher, T; Mittleman, G	1
Rogóz, Z; Skuza, G	1
Howland, RH	1
Fang, F; Han, L; Ming, M; Shuangjin, C	1
Cao, J; Li, YP; Li, ZR; Tao, YJ	1
Maeng, S; Zarate, CA	1
Abdurasulova, IN; Gmiro, VE; Serdyuk, SE	1
Egashira, N; Fujiwara, M; Harada, S; Iwasaki, K; Matsushita, M; Mishima, K; Nishimura, R; Oishi, R; Okuno, R	1
Büttner, T; Csoti, I; Kassubek, J; Reichmann, H; Riederer, P; Schulz, JB; Wüllner, U	1
Chen, SH; Yang, YH; Yeh, HH	1
Greenway, LL; Kuppuswamy, PS; Lauterbach, EC	1
Bourne, PE; Dunkel, M; Koerner, S; Murgueitio, MS; Preissner, R; von Eichborn, J	1
Janka, Z; Kalman, J; Szakacs, R	1
Chen, YC; Chen, YW; Hung, CH; Leung, YM; Shieh, JP; Wang, JJ	1
Branigan, E; Dougherty, DA; Lester, HA; Limapichat, W; Yu, WY	1
Chalimoniuk, M; Dąbrowska-Bouta, B; Strużyńska, L; Sulkowski, G	1
Carta, M; Collu, M; Fidalgo, C; Gardoni, F; Morelli, M; Stancampiano, R; Tronci, E; Zianni, E	1
Ene-Stroescu, V; Nguyen, T; Waiblinger, BE	1
Sureda, FX; Valverde, E; Vázquez, S	1
Leong, NJ; Mcintosh, MP; Prankerd, RJ; Shackleford, DM	1
Chen, D; Miao, H; Wu, Y; Zhao, Y	1
Aksinenko, AY; Aliev, G; Bachurin, SO; Barreto, GE; Boltneva, NP; Bovina, EV; Echeverria, V; Fisenko, VP; Gabrelyan, AV; Grigoriev, VV; Kovaleva, NV; Lushchekina, SV; Makhaeva, GF; Neganova, ME; Redkozubova, OM; Shevtsov, PN; Shevtsova, EF; Sokolov, VB	1
Ma, HM; Zafonte, RD	1
Grieb, P; Rejdak, K	1
Brenner, SR	1
Płusa, T	1
Aksinenko, AY; Bachurin, SO; Boltneva, NP; Bovina, EV; Dubova, LG; Epishina, TA; Fisenko, VP; Gabrelyan, AV; Goreva, TV; Grigoriev, VV; Kovaleva, NV; Lushchekina, SV; Makhaeva, GF; Pushkareva, EA; Richardson, RJ; Rudakova, EV; Shevtsov, PN; Shevtsova, EF; Zamoyski, VL	1
Bukh, J; Fahnøe, U; Galli, A; Gammeltoft, KA; Gottwein, JM; Offersgaard, A; Ramirez, S; Zhou, Y	1
Fouilhé Sam-Laï, N; Jouanjus, E; Lapeyre-Mestre, M; Revol, B	1
Chaffkin, J; Josephs, IA; Katz, ER	1
Kuhn, W; Müller, T; Riederer, P	1

Reviews

15 review(s) available for memantine and amantadine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Pathophysiology and therapy of malignant neuroleptic syndrome]. Der Nervenarzt, 1992, Volume: 63, Issue:11 Topics: Amantadine; Antipsychotic Agents; Dantrolene; Dopamine; Dopamine Agents; Drug Therapy, Combination; Glutamine; Humans; Memantine; Neuroleptic Malignant Syndrome; Neurologic Examination; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate	1992
[Pharmacodynamics and pharmacokinetics of memantine]. Arzneimittel-Forschung, 1983, Volume: 33, Issue:8 Topics: Amantadine; Animals; Antidepressive Agents; Body Temperature; Catalepsy; Dopamine; Dyskinesia, Drug-Induced; Electrophysiology; gamma-Aminobutyric Acid; Guinea Pigs; Hemodynamics; Humans; Kinetics; Memantine; Mice; Motor Activity; Norepinephrine; Rabbits; Rats; Respiration; Stereotyped Behavior	1983
Aminoadamantane derivatives. Progress in medicinal chemistry, 1981, Volume: 18 Topics: Amantadine; Animals; Antiviral Agents; Humans; Memantine; Nervous System Diseases; Rimantadine	1981
Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties. Journal of neural transmission. Supplementum, 1994, Volume: 43 Topics: Adamantane; Amantadine; Animals; Behavior, Animal; Dopamine; Electrophysiology; Hallucinogens; Humans; Memantine; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Substance-Related Disorders	1994
[New therapeutic possibilities with low-affinity NMDA receptor antagonists]. Der Nervenarzt, 1996, Volume: 67, Issue:1 Topics: Aged; Alzheimer Disease; Amantadine; Antiparkinson Agents; Excitatory Amino Acid Antagonists; Glutamine; Humans; Memantine; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine	1996
Neuropsychiatric adverse effects of antiparkinsonian drugs. Characteristics, evaluation and treatment. Drugs & aging, 1997, Volume: 10, Issue:5 Topics: Aging; Akathisia, Drug-Induced; Amantadine; Antiparkinson Agents; Antipsychotic Agents; Cholinergic Antagonists; Delirium; Dementia; Depression; Dopamine Agonists; Electroconvulsive Therapy; Humans; Levodopa; Memantine; Monoamine Oxidase Inhibitors; Psychoses, Substance-Induced; Risk Factors; Serotonin Antagonists	1997
Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents--preclinical studies. Neuroscience and biobehavioral reviews, 1997, Volume: 21, Issue:4 Topics: Amantadine; Animals; Antiparkinson Agents; Excitatory Amino Acid Antagonists; Memantine; Parkinson Disease, Secondary; Receptors, N-Methyl-D-Aspartate	1997
[Glutamate antagonists for treatment of neuropathic pain]. Schmerz (Berlin, Germany), 2003, Volume: 17, Issue:4 Topics: Amantadine; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Humans; Ketamine; Memantine; Neuralgia	2003
Glutamate-modulating drugs & the treatment of mental disorders. Journal of psychosocial nursing and mental health services, 2007, Volume: 45, Issue:1 Topics: Acamprosate; Amantadine; Cycloserine; Glutamic Acid; Humans; Ketamine; Lamotrigine; Memantine; Mental Disorders; Psychotropic Drugs; Riluzole; Taurine; Triazines	2007
The role of glutamate in mood disorders: results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects. Current psychiatry reports, 2007, Volume: 9, Issue:6 Topics: Amantadine; Depressive Disorder, Major; Dopamine Agents; Excitatory Amino Acid Antagonists; Humans; Ketamine; Memantine; Mood Disorders; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate	2007
[On the role of MAO B inhibitors and NMDA antagonists in the therapy of Parkinson's disease]. Fortschritte der Neurologie-Psychiatrie, 2010, Volume: 78 Suppl 1 Topics: Amantadine; Excitatory Amino Acid Antagonists; Humans; Indans; Memantine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; N-Methylaspartate; Parkinson Disease; Piperidines; Selegiline	2010
The "blue" side of glutamatergic neurotransmission: NMDA receptor antagonists as possible novel therapeutics for major depression. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2012, Volume: 14, Issue:1 Topics: Amantadine; Antidepressive Agents; Depressive Disorder, Major; Glutamates; Hippocampus; Humans; Memantine; Receptors, N-Methyl-D-Aspartate; Severity of Illness Index; Synaptic Transmission	2012
Amantadine and memantine: a comprehensive review for acquired brain injury. Brain injury, 2020, 02-23, Volume: 34, Issue:3 Topics: Amantadine; Brain Injuries; Humans; Memantine; Neuronal Plasticity; Off-Label Use; Recovery of Function	2020
[Anti-inflammatory effects of amantadine and memantine in SARS-CoV-2 infection]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2021, 02-24, Volume: 49, Issue:289 Topics: Amantadine; Anti-Inflammatory Agents; COVID-19; Humans; Memantine; SARS-CoV-2	2021

Trials

5 trial(s) available for memantine and amantadine

Article	Year
[Effects of intravenous administration of memantine in parkinsonian patients (author's transl)]. Arzneimittel-Forschung, 1977, Volume: 27, Issue:7 Topics: Adult; Aged; Amantadine; Clinical Trials as Topic; Female; Humans; Infusions, Parenteral; Male; Memantine; Middle Aged; Parkinson Disease; Placebos; Time Factors	1977
Treatment of impaired cerebral function in psychogeriatric patients with memantine--results of a phase II double-blind study. Pharmacopsychiatry, 1988, Volume: 21, Issue:3 Topics: Aged; Amantadine; Dementia; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Memantine; Neuropsychological Tests	1988
Memantine in the treatment of senile dementia of the Alzheimer type. Progress in neuro-psychopharmacology & biological psychiatry, 1986, Volume: 10, Issue:1 Topics: Aged; Alzheimer Disease; Amantadine; Clinical Trials as Topic; Female; Humans; Male; Memantine; Random Allocation	1986
[Effects of oral memantine administration on Parkinson symptoms. Results of a placebo-controlled multicenter study]. Deutsche medizinische Wochenschrift (1946), 1984, Jun-22, Volume: 109, Issue:25 Topics: Administration, Oral; Aged; Amantadine; Clinical Trials as Topic; Female; Humans; Male; Memantine; Middle Aged; Movement Disorders; Parkinson Disease; Placebos; Substantia Nigra; Tremor	1984
[Results of clinical trials of the antispasmodic agent memantine]. Fortschritte der Medizin, 1982, Nov-18, Volume: 100, Issue:43 Topics: Aged; Amantadine; Brain Injuries; Cerebral Palsy; Child; Child, Preschool; Clinical Trials as Topic; Encephalomyelitis; Female; Humans; Male; Memantine; Middle Aged	1982

Other Studies

109 other study(ies) available for memantine and amantadine

Article	Year
Structure-anti-Parkinson activity relationships in the aminoadamantanes. Influence of bridgehead substitution. Journal of medicinal chemistry, 1982, Volume: 25, Issue:1 Topics: Amantadine; Animals; Antiparkinson Agents; Mice; Motor Activity; Receptors, Dopamine; Structure-Activity Relationship	1982
Quantitative analysis of the structural requirements for blockade of the N-methyl-D-aspartate receptor at the phencyclidine binding site. Journal of medicinal chemistry, 1998, Jan-29, Volume: 41, Issue:3 Topics: Binding Sites; Excitatory Amino Acid Antagonists; Humans; Molecular Structure; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship	1998
Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Molecular pharmacology, 1998, Volume: 54, Issue:2 Topics: Amantadine; Biological Transport; Carrier Proteins; Dopamine Agents; Hippocampus; Humans; Immunohistochemistry; Memantine; Neurons; Neurotransmitter Agents; Organic Cation Transport Proteins; Organic Cation Transporter 2; Transcription, Genetic	1998
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs. Bioorganic & medicinal chemistry, 2008, Dec-01, Volume: 16, Issue:23 Topics: Amantadine; Animals; Antiviral Agents; Cells, Cultured; Dogs; Dopamine; Influenza A virus; Inhibitory Concentration 50; Receptors, N-Methyl-D-Aspartate	2008
Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines. Bioorganic & medicinal chemistry, 2009, Apr-15, Volume: 17, Issue:8 Topics: Adamantane; Amines; Animals; Antiviral Agents; Cell Culture Techniques; Receptors, N-Methyl-D-Aspartate; Trypanocidal Agents	2009
New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities. Bioorganic & medicinal chemistry, 2010, Jan-01, Volume: 18, Issue:1 Topics: Amines; Animals; Antiparkinson Agents; Cells, Cultured; Humans; Memantine; Molecular Structure; Neurons; Parkinson Disease; Rats; Receptors, N-Methyl-D-Aspartate; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities. Bioorganic & medicinal chemistry, 2012, Jan-15, Volume: 20, Issue:2 Topics: Amines; Antiviral Agents; DNA Viruses; Humans; Receptors, N-Methyl-D-Aspartate; Trypanocidal Agents; Trypanosoma brucei brucei	2012
Cytoprotective effects of hydrogen sulfide-releasing MedChemComm, 2014, Oct-01, Volume: 5, Issue:10 Topics:	2014
Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines. Bioorganic & medicinal chemistry, 2015, Aug-01, Volume: 23, Issue:15 Topics: Amantadine; Animals; Antiviral Agents; Binding Sites; Cell Line; Chemistry Techniques, Synthetic; Crystallography, X-Ray; Dogs; Drug Evaluation, Preclinical; Humans; Influenza A virus; Madin Darby Canine Kidney Cells; Memantine; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Static Electricity; Stereoisomerism	2015
DABMA: A Derivative of ABMA with Improved Broad-Spectrum Inhibitory Activity of Toxins and Viruses. ACS medicinal chemistry letters, 2019, Aug-08, Volume: 10, Issue:8 Topics:	2019
Open and rearranged norbornane derived polycyclic cage molecules as potential neuroprotective agents through attenuation of MPP European journal of medicinal chemistry, 2020, Oct-15, Volume: 204 Topics: 1-Methyl-4-phenylpyridinium; Calcium; Cell Line, Tumor; Humans; Ion Transport; Molecular Docking Simulation; Neuroblastoma; Neuroprotective Agents; Norbornanes; Polycyclic Compounds; Receptors, N-Methyl-D-Aspartate; Spectrum Analysis; Structure-Activity Relationship	2020
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease. European journal of medicinal chemistry, 2022, Jun-05, Volume: 236 Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Disease Models, Animal; Memantine; Mice; Receptors, N-Methyl-D-Aspartate	2022
GABA-ergic drugs block the locomotor stimulant effects of 1,3-dimethyl-5-aminoadamantane (D-145). Neuropharmacology, 1979, Volume: 18, Issue:2 Topics: Amantadine; Aminooxyacetic Acid; Animals; Dextroamphetamine; gamma-Aminobutyric Acid; Memantine; Mice; Motor Activity; Time Factors	1979
[Gaschromatographic and mass spectrometric studies on metabolites of adamantane amines excreted with urine (author's transl)]. Arzneimittel-Forschung, 1977, Volume: 27, Issue:7 Topics: Amantadine; Animals; Chemical Phenomena; Chemistry; Chromatography, Gas; Male; Mass Spectrometry; Memantine; Rats; Time Factors	1977
Effects of 1,3-dimethyl-5-aminoadamantane hydrochloride (DMAA) on the stretch-induced reflex tension of flexor muscles and the excitability of the gamma-loop in decerebrate and spinal cats. Arzneimittel-Forschung, 1977, Volume: 27, Issue:7 Topics: Amantadine; Animals; Cats; Decerebrate State; Female; Male; Memantine; Motor Neurons; Muscle Tonus; Neurons, Afferent; Reflex; Spinal Cord	1977
[The action of 1-aminoadamantane. Comparative studies with isolated nerve endings and thrombocytes on the release of serotonin and dopamine]. Arzneimittel-Forschung, 1977, Volume: 27, Issue:7 Topics: Amantadine; Animals; Blood Platelets; Brain; Depression, Chemical; Dopamine; Electric Stimulation; Humans; In Vitro Techniques; Memantine; Nerve Endings; Rats; Serotonin	1977
[The effect of memantine (dimethylamino-adamantane) on membranes of sensory nerve fibres (author's transl)]. Arzneimittel-Forschung, 1977, Volume: 27, Issue:7 Topics: Action Potentials; Amantadine; Animals; In Vitro Techniques; Memantine; Membrane Potentials; Nerve Fibers; Rats; Time Factors	1977
Pharmacological evidence for the involvement of GABA-ergic system in the locomotor stimulation produced in mice by 1,3-dimethyl-5-aminoadamantane (D-145). Neuropharmacology, 1978, Volume: 17, Issue:12 Topics: Amantadine; Aminooxyacetic Acid; Animals; Dextroamphetamine; Drug Interactions; gamma-Aminobutyric Acid; Male; Memantine; Methyltyrosines; Mice; Motor Activity; Phenoxybenzamine; Reserpine	1978
Histofluorescence studies on the effect of 1,3-dimethyl-5-adamantanamine (D-145) on serotonin neurons in midbrain raphe nuclei. Polish journal of pharmacology and pharmacy, 1976, Volume: 28, Issue:3 Topics: Amantadine; Animals; Catecholamines; Dopamine; Fluorescence; Histocytochemistry; Male; Memantine; Mesencephalon; Neurons; Rats; Receptors, Drug; Serotonin; Time Factors	1976
The influence of 1,3-dimethyl-5-adamantanamine (D-145) on catecholaminergic neurons of the rat brain, Histofluorescence studies. Polish journal of pharmacology and pharmacy, 1976, Volume: 28, Issue:3 Topics: Amantadine; Animals; Behavior, Animal; Brain; Catecholamines; Depression, Chemical; Fluorescence; Histocytochemistry; Male; Memantine; Methyltyrosines; Neurons; Rats; Spiperone; Time Factors	1976
Neuropharmacological studies on D145 (1,3-dimethyl-5-aminoadamantan). Psychopharmacologia, 1975, Jul-23, Volume: 43, Issue:1 Topics: Amantadine; Animals; Apomorphine; Behavior; Corpus Striatum; Dextroamphetamine; Dopamine; Extrapyramidal Tracts; Humans; Hypothalamus; Limbic System; Male; Memantine; Methyltyrosines; Motor Activity; Parkinson Disease; Rats; Reserpine; Reticular Formation; Stereotaxic Techniques; Stereotyped Behavior; Substantia Nigra	1975
The effects of apomorphine and 1,3-dimethyl-5-aminoadamantane (DMAA) on ponto-geniculo-occipital (PGO) waves in cats. Polish journal of pharmacology and pharmacy, 1975, Volume: 27, Issue:Suppl Topics: Amantadine; Animals; Apomorphine; Benserazide; Cats; Dopamine; Electroencephalography; Geniculate Bodies; Memantine; Occipital Lobe; Serotonin	1975
Effect of five dopaminergic drugs on plasma growth hormone levels in acromegalic subjects. Neuroendocrinology, 1975, Volume: 19, Issue:3 Topics: Acromegaly; Adult; Aged; Amantadine; Bromocriptine; Ergolines; Female; Growth Hormone; Humans; Levodopa; Male; Memantine; Middle Aged; Piperazines; Piribedil	1975
The effect of dimethylaminoadamantane on neuronal membranes. European journal of pharmacology, 1976, Volume: 35, Issue:2 Topics: Amantadine; Animals; Calcium; Cell Membrane; Cell Membrane Permeability; Chlorides; Electric Stimulation; Evoked Potentials; In Vitro Techniques; Memantine; Neurons; Osmolar Concentration; Potassium; Rats; Sensory Receptor Cells; Sodium; Spinal Nerve Roots	1976
Inhibitory effects of the antiparkinsonian drugs memantine and amantadine on N-methyl-D-aspartate-evoked acetylcholine release in the rabbit caudate nucleus in vitro. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:2 Topics: Acetylcholine; Amantadine; Animals; Caudate Nucleus; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; Memantine; N-Methylaspartate; Rabbits; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Tritium	1992
Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study. European journal of pharmacology, 1991, Apr-25, Volume: 206, Issue:4 Topics: Adamantane; Amantadine; Binding Sites; Brain; Dizocilpine Maleate; Humans; Ion Channel Gating; Ion Channels; Kinetics; Memantine; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tritium	1991
High doses of memantine (1-amino-3,5-dimethyladamantane) induce seizures in kindled but not in non-kindled rats. Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 341, Issue:5 Topics: Amantadine; Amygdala; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Kindling, Neurologic; Memantine; Rats; Rats, Inbred Strains; Seizures	1990
Memantine inhibits serotonin-induced rise of cytosolic Ca2+ activity and of cyclic GMP level in a neuronal cell line. European journal of pharmacology, 1989, May-11, Volume: 172, Issue:2 Topics: Amantadine; Animals; Calcium; Cyclic GMP; Cytosol; Glioma; Memantine; Nervous System Neoplasms; Neuroblastoma; Neurons; Rats; Serotonin; Serotonin Antagonists; Tumor Cells, Cultured	1989
Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels. European journal of pharmacology, 1989, Aug-03, Volume: 166, Issue:3 Topics: Amantadine; Animals; Cells, Cultured; Embryo, Mammalian; Female; Memantine; Membranes; Mice; Neuroglia; Neurons; Pregnancy; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord	1989
Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex. European journal of pharmacology, 1989, Aug-03, Volume: 166, Issue:3 Topics: Adult; Aged; Amantadine; Binding, Competitive; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Female; Humans; In Vitro Techniques; Male; Memantine; Middle Aged	1989
Effects of memantine on the twitch tension of mouse diaphragm. European journal of pharmacology, 1989, Jan-24, Volume: 160, Issue:1 Topics: Amantadine; Animals; Diaphragm; Electric Stimulation; Evoked Potentials; In Vitro Techniques; Memantine; Mice; Mice, Inbred ICR; Muscle Contraction; Phrenic Nerve; Respiratory Muscles	1989
Prevention and antagonism of acute carbofuran intoxication by memantine and atropine. Journal of toxicology and environmental health, 1989, Volume: 28, Issue:1 Topics: Acetylcholinesterase; Amantadine; Animals; Atropine; Carbofuran; Carboxylesterase; Carboxylic Ester Hydrolases; Chemical Phenomena; Chemistry; Cholinesterase Inhibitors; Drug Antagonism; Drug Synergism; Insecticides; Male; Memantine; Rats; Rats, Inbred Strains	1989
Radioelectroencephalographic comparison of memantine with receptor-specific drugs acting on dopaminergic transmission in freely moving rats. Neuropsychobiology, 1987, Volume: 18, Issue:4 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amantadine; Animals; Benzazepines; Brain; Corpus Striatum; Electroencephalography; Ergolines; Evoked Potentials; Frontal Lobe; Haloperidol; Hippocampus; Male; Memantine; Quinpirole; Rats; Rats, Inbred F344; Receptors, Dopamine; Reticular Formation; Synaptic Transmission; Telemetry	1987
Locomotion and stereotyped behaviours induced by 1-amino-3,5-dimethyladamantane (D 145) and apomorphine in the rat: a comparison. The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:7 Topics: Amantadine; Animals; Antipsychotic Agents; Apomorphine; Dose-Response Relationship, Drug; Drug Interactions; Male; Memantine; Motor Activity; Rats; Rats, Inbred Strains; Stereotyped Behavior	1986
Interaction of memantine with cholecystokinin receptors in mouse brain. The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:2 Topics: Amantadine; Animals; Brain; Cell Membrane; In Vitro Techniques; Iodine Radioisotopes; Male; Memantine; Mice; Receptors, Cholecystokinin	1988
Effects of memantine on the frog neuromuscular junction. European journal of pharmacology, 1986, Nov-04, Volume: 130, Issue:3 Topics: Acetylcholine; Amantadine; Animals; Carbachol; In Vitro Techniques; Memantine; Neuromuscular Junction; Rana pipiens; Ranidae; Synaptic Transmission	1986
Memantine (1-amino-3,5-dimethyladamantane) blocks the serotonin-induced depolarization response in a neuronal cell line. Brain research, 1988, Mar-08, Volume: 443, Issue:1-2 Topics: Amantadine; Animals; Calcium; Cell Line; Glioma; Hybrid Cells; Memantine; Membrane Potentials; Neuroblastoma; Neurons; Serotonin; Serotonin Antagonists; Sodium; Tetrodotoxin	1988
Potentiation of the locomotor activity of memantine by aminophylline. Arzneimittel-Forschung, 1986, Volume: 36, Issue:12 Topics: Amantadine; Aminophylline; Animals; Circadian Rhythm; Drug Synergism; Female; Kinetics; Male; Memantine; Mice; Motor Activity	1986
[Experiences with memantine in the treatment of severe spastic and extrapyramidal movement disorders in combination with stereotaxic surgery]. Der Nervenarzt, 1985, Volume: 56, Issue:2 Topics: Adolescent; Adult; Aged; Amantadine; Athetosis; Basal Ganglia Diseases; Cerebral Palsy; Child; Chorea; Combined Modality Therapy; Dystonia Musculorum Deformans; Female; Humans; Male; Memantine; Middle Aged; Muscle Spasticity; Stereotaxic Techniques	1985
Anticonvulsant action of 1,3-dimethyl-5-aminoadamantane. Pharmacological studies in rodents and baboon, Papio papio. Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 332, Issue:1 Topics: Amantadine; Animals; Anticonvulsants; Electroshock; Male; Memantine; Mice; Papio; Photic Stimulation; Species Specificity	1986
[Effect of memantine on central neurotransmitter systems. Review of the results]. Arzneimittel-Forschung, 1982, Volume: 32, Issue:10 Topics: Acetylcholine; Amantadine; Animals; Blood Pressure; Catalepsy; Central Nervous System; gamma-Aminobutyric Acid; Humans; Memantine; Motor Activity; Neurotransmitter Agents; Rats; Receptors, Dopamine; Receptors, Serotonin; Rotation; Stereotyped Behavior; Temperature	1982
The effect of memantine on various neurobiological processes. Arzneimittel-Forschung, 1982, Volume: 32, Issue:10 Topics: Amantadine; Animals; Autoradiography; Binding, Competitive; Biogenic Amines; Cells, Cultured; Immunochemistry; Male; Memantine; Neurotransmitter Agents; Potassium; Rats; Rats, Inbred Strains; Retina; Serotonin; Spiperone; Substance P	1982
[Effect of memantine on membrane properties and postsynaptic potentials in neurons of Aplysia californica]. Arzneimittel-Forschung, 1982, Volume: 32, Issue:10 Topics: Action Potentials; Amantadine; Animals; Aplysia; Electric Stimulation; Memantine; Membrane Potentials; Membranes; Neurons; Synapses; Synaptic Transmission	1982
[Antispasm therapy: memantine. Symposium 29-30 October 1982 at Frankfurt am Main]. Fortschritte der Medizin, 1983, Apr-21, Volume: 101, Issue:15 Topics: Amantadine; Humans; Memantine	1983
[The Effect of memantine on spinal alpha-motoneurons and on the content of dopamine, noradrenaline and serotonin in the striatum and lumbar spinal cord]. Arzneimittel-Forschung, 1982, Volume: 32, Issue:10 Topics: Amantadine; Animals; Biogenic Amines; Cats; Corpus Striatum; Dopamine; Memantine; Motor Activity; Motor Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Drug; Serotonin; Spinal Cord	1982
Distribution of memantine in brain, liver, and blood of the rat. Arzneimittel-Forschung, 1982, Volume: 32, Issue:10 Topics: Amantadine; Animals; Brain; Chromatography, Gas; Liver; Male; Memantine; Rats; Rats, Inbred Strains; Time Factors	1982
[Valve of symptomatic therapy with memantine in cerebral coma. I. Correlation with coma stages and EEG spectral patterns]. Arzneimittel-Forschung, 1982, Volume: 32, Issue:10 Topics: Adolescent; Adult; Amantadine; Coma; Electroencephalography; Female; Humans; Male; Memantine	1982
[Valve of symptomatic therapy with memantine in cerebral coma. II. Development of stretch synergisms in coma with brain stem symptoms]. Arzneimittel-Forschung, 1982, Volume: 32, Issue:10 Topics: Amantadine; Brain Stem; Coma; Electromyography; Female; Humans; Male; Memantine; Movement; Posture	1982
[Memantine and neurogenic bladder disorders within the bounds of spastic conditions]. Arzneimittel-Forschung, 1982, Volume: 32, Issue:10 Topics: Adult; Aged; Amantadine; Electromyography; Female; Humans; Male; Memantine; Middle Aged; Muscle Spasticity; Urinary Bladder, Neurogenic; Urination	1982
Distribution of metabolism of the potential anti-parkinson drug memantine in the human. Journal of neural transmission. Supplementum, 1980, Issue:16 Topics: Aged; Amantadine; Antiparkinson Agents; Brain Chemistry; Female; Humans; Memantine; Parkinson Disease; Tissue Distribution	1980
Are NMDA antagonistic properties relevant for antiparkinsonian-like activity in rats?--case of amantadine and memantine. Journal of neural transmission. Parkinson's disease and dementia section, 1994, Volume: 7, Issue:3 Topics: Amantadine; Animals; Catalepsy; Dizocilpine Maleate; Locomotion; Male; Memantine; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra	1994
Memantine, amantadine, and L-deprenyl potentiate the action of L-dopa in monoamine-depleted rats. Journal of neural transmission. General section, 1994, Volume: 98, Issue:1 Topics: Amantadine; Animals; Bromocriptine; Dopamine; Drug Synergism; Levodopa; Male; Memantine; Motor Activity; N-Methylaspartate; Parkinson Disease; Rats; Rats, Wistar; Selegiline	1994
[Ketamine inhibits n-methyl-d-aspartate (NMDA) receptor mediated acetylcholine release from rabbit caudate nucleus slices]. Der Anaesthesist, 1994, Volume: 43 Suppl 2 Topics: Acetylcholine; Action Potentials; Amantadine; Animals; Caudate Nucleus; Choline; Dizocilpine Maleate; In Vitro Techniques; Ketamine; Memantine; Rabbits; Receptors, N-Methyl-D-Aspartate; Valine	1994
Suppression by memantine and amantadine of synaptic excitation intrastriatally evoked in rat neostriatal slices. Neuroscience letters, 1994, Nov-21, Volume: 182, Issue:1 Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amantadine; Animals; Antiparkinson Agents; In Vitro Techniques; Memantine; Neostriatum; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission	1994
NMDA receptor-mediated glutamate toxicity of cultured cerebellar, cortical and mesencephalic neurons: neuroprotective properties of amantadine and memantine. Brain research, 1993, Jun-04, Volume: 613, Issue:1 Topics: Amantadine; Animals; Cell Survival; Cells, Cultured; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Memantine; Mesencephalon; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	1993
Potential antidepressive properties of amantadine, memantine and bifemelane. Pharmacology & toxicology, 1993, Volume: 72, Issue:6 Topics: Amantadine; Analysis of Variance; Animals; Antidepressive Agents; Benzhydryl Compounds; Body Temperature; Depression; Hypothermia; Male; Memantine; Mice; Motor Activity; Rats; Rats, Wistar	1993
MK-801, memantine and amantadine show neuroprotective activity in the nucleus basalis magnocellularis. European journal of pharmacology, 1995, Oct-06, Volume: 293, Issue:3 Topics: Amantadine; Animals; Basal Ganglia; Cerebral Cortex; Choline O-Acetyltransferase; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Memantine; N-Methylaspartate; Nervous System Diseases; Neuroprotective Agents; Rats; Receptors, N-Methyl-D-Aspartate	1995
Microdialysis studies with amantadine and memantine on pharmacokinetics and effects on dopamine turnover. Journal of neural transmission. Supplementum, 1995, Volume: 46 Topics: 3,4-Dihydroxyphenylacetic Acid; Amantadine; Animals; Antiparkinson Agents; Brain; Dopamine; Dopamine Agents; Excitatory Amino Acid Antagonists; Homovanillic Acid; Male; Memantine; Microdialysis; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	1995
Determination of intracellular Ca2+ concentration can be a useful tool to predict neuronal damage and neuroprotective properties of drugs. Brain research, 1996, Sep-02, Volume: 732, Issue:1-2 Topics: Amantadine; Analysis of Variance; Animals; Biomarkers; Calcium; Cell Hypoxia; Cell Survival; Cells, Cultured; Chickens; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Kinetics; Memantine; N-Methylaspartate; Neurons; Neuroprotective Agents; Quinoxalines; Sodium Cyanide; Telencephalon; Time Factors	1996
Comparative patch-clamp studies with freshly dissociated rat hippocampal and striatal neurons on the NMDA receptor antagonistic effects of amantadine and memantine. The European journal of neuroscience, 1996, Volume: 8, Issue:3 Topics: Amantadine; Animals; Dose-Response Relationship, Drug; Hippocampus; Ketamine; Memantine; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	1996
Trapping channel block of NMDA-activated responses by amantadine and memantine. Journal of neurophysiology, 1997, Volume: 77, Issue:1 Topics: Amantadine; Animals; Antiparkinson Agents; Cells, Cultured; CHO Cells; Cricetinae; DNA; Excitatory Amino Acid Agonists; Ion Channels; Kinetics; Memantine; Membrane Potentials; Models, Neurological; N-Methylaspartate; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	1997
Two blocking sites of amino-adamantane derivatives in open N-methyl-D-aspartate channels. Biophysical journal, 1998, Volume: 74, Issue:3 Topics: Adamantane; Amantadine; Animals; Binding Sites; Cell Membrane; Cell Separation; Hippocampus; In Vitro Techniques; Kinetics; Memantine; Membrane Potentials; Models, Chemical; Models, Molecular; Patch-Clamp Techniques; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship	1998
Modulation of the production of reactive oxygen species by pre-activated neutrophils by aminoadamantane derivatives. Biochemical pharmacology, 1998, Jul-01, Volume: 56, Issue:1 Topics: alpha 1-Antitrypsin; Amantadine; Amino Acids; Amino Acids, Cyclic; Animals; Antioxidants; Ethylenes; Lipid Peroxidation; Memantine; Neutrophil Activation; Neutrophils; Oxidation-Reduction; Peroxidase; Piperazines; Reactive Oxygen Species; Swine	1998
Budipine is a low affinity, N-methyl-D-aspartate receptor antagonist: patch clamp studies in cultured striatal, hippocampal, cortical and superior colliculus neurones. Neuropharmacology, 1998, Volume: 37, Issue:6 Topics: Amantadine; Animals; Antiparkinson Agents; Brain; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Hippocampus; Memantine; Neostriatum; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Superior Colliculi	1998
Interaction of memantine and amantadine with agonist-unbound NMDA-receptor channels in acutely isolated rat hippocampal neurons. The Journal of physiology, 1998, Oct-01, Volume: 512 ( Pt 1) Topics: 2-Amino-5-phosphonovalerate; Amantadine; Animals; Aspartic Acid; Evoked Potentials; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Memantine; Membrane Potentials; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	1998
Investigation on possible antioxidative properties of the NMDA-receptor antagonists ketamine, memantine, and amantadine in comparison to nicanartine in vitro. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1998, Volume: 50, Issue:4-6 Topics: 7-Alkoxycoumarin O-Dealkylase; Amantadine; Animals; Antioxidants; Antiparkinson Agents; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Hydrogen Peroxide; Ketamine; Lipid Peroxidation; Male; Memantine; Microsomes, Liver; Pyridines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Thiobarbituric Acid Reactive Substances	1998
Evaluation of the reinforcing and discriminative stimulus properties of the low-affinity N-methyl-D-aspartate channel blocker memantine. Behavioural pharmacology, 1998, Volume: 9, Issue:3 Topics: Amantadine; Animals; Discrimination, Psychological; Dopamine Agents; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Macaca mulatta; Male; Memantine; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology; Self Administration	1998
Brain penetration and in vivo recovery of NMDA receptor antagonists amantadine and memantine: a quantitative microdialysis study. Pharmaceutical research, 1999, Volume: 16, Issue:5 Topics: Amantadine; Animals; Biological Transport; Brain Chemistry; Dopamine Agents; Excitatory Amino Acid Antagonists; Extracellular Space; Male; Memantine; Microdialysis; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	1999
Adaptations of NMDA and dopamine D2, but not of muscarinic receptors following 14 days administration of uncompetitive NMDA receptor antagonists. Journal of neural transmission (Vienna, Austria : 1996), 1999, Volume: 106, Issue:5-6 Topics: Amantadine; Animals; Brain; Caudate Nucleus; Dentate Gyrus; Dizocilpine Maleate; Entorhinal Cortex; Frontal Lobe; Hippocampus; Infusions, Parenteral; Kinetics; Male; Memantine; Nucleus Accumbens; Organ Specificity; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Salicylamides; Time Factors	1999
Modifications of the behavioral profile of non-competitive NMDA receptor antagonists, memantine, amantadine and (+)MK-801 after chronic administration. Behavioural pharmacology, 1999, Volume: 10, Issue:1 Topics: Amantadine; Animals; Ataxia; Avoidance Learning; Behavior, Animal; Catalepsy; Dizocilpine Maleate; Drug Implants; Excitatory Amino Acid Antagonists; Male; Memantine; Motor Activity; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior; Sympathectomy, Chemical; Sympathomimetics; Time Factors	1999
Antidepressant drugs inhibit glucocorticoid receptor-mediated gene transcription - a possible mechanism. British journal of pharmacology, 2000, Volume: 130, Issue:6 Topics: Amantadine; Animals; Antidepressive Agents; Cell Line, Transformed; Chloramphenicol O-Acetyltransferase; Cocaine; Corticosterone; Cyclic AMP; Cyclic GMP; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Estrenes; Gene Expression Regulation; Imipramine; Lithium Chloride; Memantine; Mifepristone; Protein Kinase Inhibitors; Pyrrolidinones; Receptors, Glucocorticoid; Receptors, Steroid; Sulfonamides; Tamoxifen; Thionucleotides; Time Factors; Transcription, Genetic; Type C Phospholipases	2000
Co-administration of memantine and amantadine with sub/suprathreshold doses of L-Dopa restores motor behaviour of MPTP-treated mice. Journal of neural transmission (Vienna, Austria : 1996), 2001, Volume: 108, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amantadine; Animals; Antiparkinson Agents; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Levodopa; Male; Memantine; Mice; Mice, Inbred C57BL; Motor Activity; Parkinsonian Disorders; Recovery of Function	2001
Electrophoretic behavior of adamantane derivatives possessing antiviral activity and their determination by capillary zone electrophoresis with indirect detection. Electrophoresis, 2002, Volume: 23, Issue:2 Topics: alpha-Cyclodextrins; Amantadine; Antiviral Agents; beta-Cyclodextrins; Cyclodextrins; Electric Conductivity; Electrophoresis, Capillary; Memantine; Rimantadine	2002
Quantitative analysis of memantine in human plasma by gas chromatography/negative ion chemical ionization/mass spectrometry. Journal of mass spectrometry : JMS, 2002, Volume: 37, Issue:5 Topics: Amantadine; Antiparkinson Agents; Biological Availability; Blood Preservation; Calibration; Cryopreservation; Gas Chromatography-Mass Spectrometry; Humans; Memantine; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Specimen Handling; Spectrometry, Mass, Secondary Ion	2002
NMDA receptor antagonists to characterize rat renal organic cation transporter function. European journal of pharmacology, 2002, Sep-27, Volume: 452, Issue:1 Topics: Amantadine; Animals; Cyclopentanes; Drug Interactions; Energy Metabolism; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kidney; Kidney Tubules; Kinetics; Male; Memantine; Organic Cation Transport Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship	2002
[Case report. Dementia with apathy]. MMW Fortschritte der Medizin, 2002, Aug-08, Volume: 144, Issue:31-32 Topics: Administration, Oral; Aged; Alzheimer Disease; Amantadine; Bronchopneumonia; Confusion; Dehydration; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Memantine; Patient Admission	2002
Affinity and specificity of N-methyl- D-aspartate channel blockers affect their ability to disrupt prepulse inhibition of acoustic startle in rats. Psychopharmacology, 2003, Volume: 165, Issue:4 Topics: Acoustic Stimulation; Adrenergic Uptake Inhibitors; Alanine; Amantadine; Animals; Binding Sites; Desipramine; Dextromethorphan; Dextrorphan; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ibogaine; Loudness Perception; Male; Memantine; Muscarinic Antagonists; Neural Inhibition; Orphenadrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Selective Serotonin Reuptake Inhibitors	2003
Distinct effects of amantadine and memantine on dopaminergic transmission in the rat striatum. Neuroscience letters, 2003, Jun-12, Volume: 343, Issue:3 Topics: Amantadine; Animals; Benzazepines; Carbachol; Dopamine; Dopamine Agents; Dopamine Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Male; Memantine; Membranes; Muscarinic Agonists; Neostriatum; Rats; Rats, Wistar; Spiperone; Synaptic Transmission; Synaptosomes	2003
Simultaneous determination of the binding of amantadine and its analogues to synthetic melanin by liquid chromatography after precolumn derivatization with dansyl chloride. Journal of chromatographic science, 2005, Volume: 43, Issue:4 Topics: Amantadine; Chromatography, Liquid; Dansyl Compounds; Melanins; Memantine; Reproducibility of Results; Rimantadine	2005
Simultaneous liquid chromatographic assay of amantadine and its four related compounds in phosphate-buffered saline using 4-fluoro-7-nitro-2,1,3-benzoxadiazole as a fluorescent derivatization reagent. Biomedical chromatography : BMC, 2006, Volume: 20, Issue:5 Topics: 4-Chloro-7-nitrobenzofurazan; Amantadine; Binding, Competitive; Calibration; Chromatography, High Pressure Liquid; Fluorescent Dyes; Humans; Memantine; Phosphates; Reproducibility of Results; Rimantadine; Sodium Chloride	2006
Amantadine and memantine induce the expression of the glial cell line-derived neurotrophic factor in C6 glioma cells. Neuroscience letters, 2006, Feb-20, Volume: 394, Issue:3 Topics: 5' Untranslated Regions; Amantadine; Animals; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dopamine Agents; Glial Cell Line-Derived Neurotrophic Factor; Glioma; Immunoassay; Memantine; Molecular Sequence Data; Promoter Regions, Genetic; Rats; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles	2006
Behavioral effects of aminoadamantane class NMDA receptor antagonists on schedule-induced alcohol and self-administration of water in mice. Psychopharmacology, 2006, Volume: 187, Issue:4 Topics: Alcohol Drinking; Amantadine; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Operant; Dose-Response Relationship, Drug; Drinking; Drinking Behavior; Ethanol; Excitatory Amino Acid Antagonists; Locomotion; Male; Memantine; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Self Administration	2006
The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2006, Volume: 57, Issue:2 Topics: Adrenergic alpha-Antagonists; Amantadine; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Ethylenediamines; Indoles; Male; Memantine; Motor Activity; Piperazines; Prazosin; Progesterone; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Spiro Compounds; Sulpiride; Swimming	2006
New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma. Journal of pharmaceutical and biomedical analysis, 2007, Sep-03, Volume: 44, Issue:5 Topics: Amantadine; Animals; Antiviral Agents; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Feasibility Studies; Male; Memantine; Molecular Structure; Rats; Rats, Sprague-Dawley; Rimantadine; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Temperature; Time Factors	2007
[Synthesis and neuroprotective activity in cell culture of aminoadamantane analogues]. Yao xue xue bao = Acta pharmaceutica Sinica, 2007, Volume: 42, Issue:4 Topics: Amantadine; Cell Death; Cell Line, Tumor; Glutamic Acid; Humans; L-Lactate Dehydrogenase; Memantine; Neuroblastoma; Neuroprotective Agents	2007
Comparative study of preventive and therapeutic effects of IEM-1966 and memantine in rats with experimental allergic encephalomyelitis. Bulletin of experimental biology and medicine, 2007, Volume: 144, Issue:2 Topics: Amantadine; Animals; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino Acid Antagonists; Female; Memantine; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate	2007
Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder. European journal of pharmacology, 2008, May-31, Volume: 586, Issue:1-3 Topics: Acoustic Stimulation; Amantadine; Animals; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Memantine; Mice; Mice, Inbred ICR; Motor Activity; Obsessive-Compulsive Disorder; Quinoxalines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Riluzole	2008
Simultaneous determination of memantine and amantadine in human plasma as fluorescein derivatives by micellar electrokinetic chromatography with laser-induced fluorescence detection and its clinical application. Electrophoresis, 2010, Volume: 31, Issue:11 Topics: Acetonitriles; Alzheimer Disease; Amantadine; Antiparkinson Agents; Chemical Fractionation; Chromatography, Micellar Electrokinetic Capillary; Fluoresceins; Humans; Hydrogen-Ion Concentration; Linear Models; Memantine; Parkinson Disease; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Succinimides	2010
Differential pharmacological responses of catatonia-like signs in frontotemporal dementia. Neurocase, 2010, Volume: 16, Issue:5 Topics: Aged; Amantadine; Antipsychotic Agents; Aripiprazole; Benzothiazoles; Catatonia; Citalopram; Clinical Trials as Topic; Dibenzothiazepines; Donepezil; Dopamine Agents; Excitatory Amino Acid Antagonists; Female; Frontotemporal Dementia; Humans; Hypnotics and Sedatives; Indans; Lorazepam; Memantine; Middle Aged; Nootropic Agents; Piperazines; Piperidines; Pramipexole; Quetiapine Fumarate; Quinolones; Selective Serotonin Reuptake Inhibitors	2010
PROMISCUOUS: a database for network-based drug-repositioning. Nucleic acids research, 2011, Volume: 39, Issue:Database i Topics: Amantadine; Antidepressive Agents, Tricyclic; Databases, Factual; Dopamine Agents; Drug Repositioning; Memantine; Mianserin; Mirtazapine; Pharmaceutical Preparations; Protein Interaction Mapping; Proteins	2011
Cutaneous analgesia after subcutaneous injection of memantine and amantadine and their systemic toxicity in rats. European journal of pharmacology, 2012, Oct-15, Volume: 693, Issue:1-3 Topics: Amantadine; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Apnea; Behavior, Animal; Blood Pressure; Heart Rate; Injections, Subcutaneous; Male; Memantine; Rats; Rats, Sprague-Dawley; Seizures; Skin	2012
Key binding interactions for memantine in the NMDA receptor. ACS chemical neuroscience, 2013, Feb-20, Volume: 4, Issue:2 Topics: Amantadine; Animals; Binding Sites; Excitatory Amino Acid Antagonists; Inhibitory Concentration 50; Memantine; Patch-Clamp Techniques; Protein Structure, Tertiary; Rats; Receptors, N-Methyl-D-Aspartate; Xenopus laevis	2013
Effects of antagonists of glutamate receptors on pro-inflammatory cytokines in the brain cortex of rats subjected to experimental autoimmune encephalomyelitis. Journal of neuroimmunology, 2013, Aug-15, Volume: 261, Issue:1-2 Topics: Amantadine; Animals; Cerebral Cortex; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino Acid Antagonists; Female; Guinea Pigs; Inflammation Mediators; Memantine; Rats; Rats, Inbred Lew; Receptors, N-Methyl-D-Aspartate; Treatment Outcome	2013
Effect of memantine on L-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson's disease. Neuroscience, 2014, Apr-18, Volume: 265 Topics: Amantadine; Animals; Antiparkinson Agents; Disease Models, Animal; Dyskinesias; Excitatory Amino Acid Antagonists; Levodopa; Male; Memantine; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley	2014
Successful treatment of catatonia in a young man with schizophrenia and progressive diffuse cerebral atrophy. The Journal of neuropsychiatry and clinical neurosciences, 2014,Winter, Volume: 26, Issue:1 Topics: Adolescent; Amantadine; Anticonvulsants; Antiparkinson Agents; Antipsychotic Agents; Atrophy; Catatonia; Cerebral Cortex; Clozapine; Drug Therapy, Combination; Humans; Magnetic Resonance Imaging; Male; Memantine; Schizophrenia; Valproic Acid	2014
Novel benzopolycyclic amines with NMDA receptor antagonist activity. Bioorganic & medicinal chemistry, 2014, May-01, Volume: 22, Issue:9 Topics: Amantadine; Amines; Memantine; Neuroprotective Agents; Protein Binding; Receptors, N-Methyl-D-Aspartate	2014
The effect of intravenous sulfobutylether7 -β-cyclodextrin on the pharmacokinetics of a series of adamantane-containing compounds. Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:4 Topics: Amantadine; Animals; beta-Cyclodextrins; Drug Interactions; Erythrocytes; Injections, Intravenous; Male; Memantine; Models, Biological; Protein Binding; Rats, Sprague-Dawley; Rimantadine	2015
Dispersive micro solid phase extraction of amantadine, rimantadine and memantine in chicken muscle with magnetic cation exchange polymer. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017, Apr-15, Volume: 1051 Topics: Adsorption; Amantadine; Animals; Antiviral Agents; Cations; Chickens; Chromatography, High Pressure Liquid; Dopamine Agents; Food Contamination; Limit of Detection; Magnets; Mass Spectrometry; Memantine; Muscles; Polymers; Poultry; Rimantadine; Solid Phase Extraction	2017
Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment. Scientific reports, 2017, 03-30, Volume: 7 Topics: Alzheimer Disease; Amantadine; Carbazoles; Carboxylesterase; Cholinesterase Inhibitors; Drug Design; Erythrocytes; Humans; Memantine; Microtubules; Molecular Docking Simulation; Protein Binding; Receptors, N-Methyl-D-Aspartate	2017
Adamantanes might be protective from COVID-19 in patients with neurological diseases: multiple sclerosis, parkinsonism and cognitive impairment. Multiple sclerosis and related disorders, 2020, Volume: 42 Topics: Adamantane; Adult; Aged; Aged, 80 and over; Amantadine; Asymptomatic Infections; Betacoronavirus; Cognitive Dysfunction; Coronavirus Infections; COVID-19; Dopamine Agents; Female; Humans; Male; Memantine; Middle Aged; Multiple Sclerosis; Pandemics; Parkinson Disease; Pneumonia, Viral; Protective Factors; SARS-CoV-2; Severity of Illness Index	2020
The potential of memantine and related adamantanes such as amantadine, to reduce the neurotoxic effects of COVID-19, including ARDS and to reduce viral replication through lysosomal effects. Journal of medical virology, 2020, Volume: 92, Issue:11 Topics: Adamantane; Amantadine; COVID-19; Humans; Lysosomes; Memantine; Respiratory Distress Syndrome; Respiratory Insufficiency; SARS-CoV-2; Virus Replication	2020
Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands. Molecules (Basel, Switzerland), 2021, Sep-11, Volume: 26, Issue:18 Topics: Acetylcholinesterase; Amantadine; Animals; Butyrylcholinesterase; Carbolines; Carboxylesterase; Catalytic Domain; Cell Line; Cholinesterase Inhibitors; Horses; Humans; Kinetics; Ligands; Memantine; Mitochondrial Transmembrane Permeability-Driven Necrosis; Molecular Docking Simulation; Propidium; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Swine; Tubulin; Tubulin Modulators	2021
Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro. Viruses, 2021, 10-15, Volume: 13, Issue:10 Topics: A549 Cells; Adenosine Monophosphate; Alanine; Amantadine; Animals; Antiviral Agents; Cell Line, Tumor; Chlorocebus aethiops; COVID-19 Drug Treatment; Denmark; Drug Repositioning; Humans; Ion Channels; Memantine; Rimantadine; SARS-CoV-2; Vero Cells	2021
Association between NMDAR antagonists, drug abuse and dependence: A disproportionality analysis from the WHO pharmacovigilance database. British journal of clinical pharmacology, 2022, Volume: 88, Issue:11 Topics: Amantadine; Analgesics; Bayes Theorem; Dextromethorphan; Humans; Ketamine; Memantine; Pharmacovigilance; Receptors, N-Methyl-D-Aspartate; Substance-Related Disorders; World Health Organization	2022
Safe Use of Memantine in a Pediatric Patient With Catatonia. Journal of the American Academy of Child and Adolescent Psychiatry, 2022, Volume: 61, Issue:12 Topics: Adolescent; Amantadine; Benzodiazepines; Catatonia; Electroconvulsive Therapy; Humans; Memantine	2022
Aminoadamantanes: from treatment of Parkinson's and Alzheimer's disease to symptom amelioration of long COVID-19 syndrome? Expert review of clinical pharmacology, 2023, Volume: 16, Issue:2 Topics: Alzheimer Disease; Amantadine; COVID-19; Humans; Memantine; Parkinson Disease; Post-Acute COVID-19 Syndrome	2023