melphalan and potassium-carbonate

melphalan has been researched along with potassium-carbonate* in 1 studies

Other Studies

1 other study(ies) available for melphalan and potassium-carbonate

ArticleYear
Synthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives.
    Journal of enzyme inhibition and medicinal chemistry, 2014, Volume: 29, Issue:6

    The synthesis of some new pyrazino[1,2-a]benzimidazole derivatives and investigation of their anticancer activities were aimed in this work. Thus, 2-acetylbenzimidazole was reacted with appropriate α-bromoacetophenones and potassium carbonate in acetone to give 2-(2-acetyl-1H-benzimidazol-1-yl)-1-phenylethanone derivatives (3a-d). These diketone compounds were reacted with varied benzylamines in acetic acid to obtain 2-benzyl-1-methylidene-3-aryl-1,2-dihydropyrazino[1,2-a]benzimidazole derivatives (4a-t). The structures of the obtained compounds were elucidated by using IR, (1)H-NMR, (13)C-NMR, MS spectral data and elemental analyses results. Anticancer activities of the selected compounds were investigated in National Cancer Institute, Bethesda, MD. 3c and 4n showed remarkable anticancer activity comparing with standard drugs, melphalan and cisplatin.

    Topics: Acetophenones; Antineoplastic Agents; Benzimidazoles; Benzylamines; Carbonates; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Drug Design; Humans; Melphalan; Molecular Structure; Potassium; Pyrazines; Structure-Activity Relationship

2014