melphalan and deoxyfuconojirimycin

melphalan has been researched along with deoxyfuconojirimycin* in 1 studies

Other Studies

1 other study(ies) available for melphalan and deoxyfuconojirimycin

Article	Year
N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines. Bioorganic chemistry, 2019, Volume: 84 1,5-Dideoxy-1,5-imino-l-fucitol (1-deoxyfuconojirimycin, DFJ) is an iminosugar that inhibits fucosidases. Herein, N-alkyl DFJs have been synthesised and tested against the α-fucosidases of T. maritima (bacterial origin) and B. taurus (bovine origin). The N-alkyl derivatives were inactive against the bacterial fucosidase, while inhibiting the bovine enzyme. Docking of inhibitors to homology models, generated for the bovine and human fucosidases, was carried out. N-Decyl-DFJ was toxic to cancer cell lines and was more potent than the other N-alkyl DFJs studied. Topics: 1-Deoxynojirimycin; alpha-L-Fucosidase; Bacteria; Bacterial Proteins; Binding Sites; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Humans; Immunoglobulin G; Inhibitory Concentration 50; Melphalan; Molecular Docking Simulation; Structure-Activity Relationship; Sugar Alcohols	2019

Article

Year

N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines.

Bioorganic chemistry, 2019, Volume: 84

1,5-Dideoxy-1,5-imino-l-fucitol (1-deoxyfuconojirimycin, DFJ) is an iminosugar that inhibits fucosidases. Herein, N-alkyl DFJs have been synthesised and tested against the α-fucosidases of T. maritima (bacterial origin) and B. taurus (bovine origin). The N-alkyl derivatives were inactive against the bacterial fucosidase, while inhibiting the bovine enzyme. Docking of inhibitors to homology models, generated for the bovine and human fucosidases, was carried out. N-Decyl-DFJ was toxic to cancer cell lines and was more potent than the other N-alkyl DFJs studied.

Topics: 1-Deoxynojirimycin; alpha-L-Fucosidase; Bacteria; Bacterial Proteins; Binding Sites; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Humans; Immunoglobulin G; Inhibitory Concentration 50; Melphalan; Molecular Docking Simulation; Structure-Activity Relationship; Sugar Alcohols

2019