melphalan and chlornaphazin

Seventeen cancer chemotherapeutic agents were tested for their ability to mutate Salmonella typhimurium tester strains in the Salmonella/microsome mutagenicity test. There was a high correlation between the mutagenicity and carcinogenicity of a given agent. Carcinogens positive in the test were Adriamycin, daunomycin, 1-propanol-3,3'-iminodimethanesulfonate, cyclophosphamide, isophosphamide, hycanthone, chlornaphazin, nitrogen mustard, uracil mustard, melphalan, and thio-tepa. Two carcinogesn, actinomycin D and bleomycin, were not detected as mutagens. The presumptive noncarcinogen, methotrexate, was negative in the test. Tilorone and 6-mercaptopurine, tentatively classified as noncarcinogens, were mutagenic. The carcinogenicity of cis-dichlorodiammineplatinum(II), which was positive in the test, has not been determined.

Topics: 2-Naphthylamine; Animals; Antineoplastic Agents; Carcinogens; Cisplatin; Cyclophosphamide; Daunorubicin; Doxorubicin; Drug Evaluation, Preclinical; Hycanthone; Ifosfamide; In Vitro Techniques; Male; Mechlorethamine; Melphalan; Mercaptopurine; Mesylates; Microsomes, Liver; Mutagens; Nitrogen Mustard Compounds; Propylamines; Rats; Salmonella typhimurium; Thiotepa; Tilorone; Uracil Mustard