melphalan has been researched along with bismuth-nitrate* in 2 studies
2 other study(ies) available for melphalan and bismuth-nitrate
| Article | Year |
|---|---|
Effect of preinduction of metallothionein synthesis on clastogenicity of anticancer drugs in mice.
The effect of pretreatment with metallothionein (MT) inducers (bismuth nitrate or zinc chloride) on clastogenicity of anticancer drugs was investigated. Bismuth nitrate (50 mumol/kg) or zinc chloride (400 mumol/kg) was administered s.c. to mice once a day for two days prior to treatment with 3.3 mumol/kg of cis-diamminedichloroplatinum(II) (cis-DDP), 3.4 mumol/kg of adriamycin (ADR), 72 mumol/kg of cyclophosphamide (CPA) or 0.41 mumol/kg of L-phenylalanine mustard (L-PAM). The frequency of occurrence of erythrocytes with micronuclei in bone marrow was increased by each anticancer drug at 24 h after treatment. Micronucleus formation was significantly prevented by pretreatment with either bismuth nitrate or zinc chloride. MT concentration in bone marrow cells of mice at the time of treatment with anticancer drugs increased to 2- and 3.5-fold by pretreatment with bismuth nitrate and zinc chloride, respectively. These results indicate that MT induction in bone marrow cells effectively prevents micronucleus induction of anticancer drugs. Topics: Animals; Antineoplastic Agents; Bismuth; Bone Marrow; Chlorides; Cisplatin; Cyclophosphamide; Doxorubicin; Male; Melphalan; Metallothionein; Mice; Mice, Inbred ICR; Micronucleus Tests; Mutagens; Nitrates; Zinc Compounds | 1995 |
Prevention of carcinogenicity of anticancer drugs by metallothionein induction.
We examined the efficacy of metallothionein induction in the prevention of the carcinogenic action of cis-platinum and melphalan administered repeatedly to mice over a relatively long period. The increased pulmonary metallothionein induced by bismuth or zinc compounds during the period of chemotherapy with cis-platinum or melphalan protected the mice from carcinogenesis of these drugs in the lung. These results suggested the efficacy of metallothionein inducers in suppression of carcinogenicity considered as a secondary effect of anticancer agents in cancer chemotherapy. Topics: Animals; Anticarcinogenic Agents; Bismuth; Carcinogens; Chlorides; Cisplatin; Female; Lung; Lung Neoplasms; Melphalan; Metallothionein; Mice; Mice, Inbred A; Nitrates; Zinc Compounds | 1993 |