melatonin has been researched along with valproic acid in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 11 (34.38) | 29.6817 |
| 2010's | 14 (43.75) | 24.3611 |
| 2020's | 6 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Asaba, H; Deguchi, T; Hosoya, K; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E | 1 |
| Borriello, R; Cassandro, P; Maj, M; Monteleone, P; Natale, M; Tortorella, A | 1 |
| Alexander, G; Chatterjie, N; Wang, H | 1 |
| Aneja, S; Gupta, M; Kohli, K | 2 |
| Agarwal, S; Aneja, S; Gupta, M; Gupta, YK; Kohli, K | 1 |
| Hallam, KT; Norman, TR; Olver, JS | 1 |
| Brown, GM; Jawed, S; Kim, B; Niles, LP; Ottenhof, T; Werstiuk, ES | 1 |
| Balashova, OA; Savina, TA; Shchipakina, TG | 1 |
| Chatterjie, N; Grundke-Iqbal, I; Iqbal, K; Wang, JZ; Wang, XC; Zhang, YC | 1 |
| Grosberg, BM; Robbins, MS; Solomon, S; Tarshish, S | 1 |
| Moses, A; Potter, M; Wozniak, J | 1 |
| Coburn, KL; Doonan, SM; Lauterbach, EC; Mendez, MF; Shillcutt, SD; Victoroff, J | 1 |
| Avakian, GG; Avakian, GN; Bogomazova, MA; Kareva, EN; Lagutin, IuV; Oleĭnikova, OM | 1 |
| Chen, D; Wang, B | 1 |
| Ahmed, MM; Fukunaga, K; Han, F; Hong, LJ; Huang, JY; Liao, MH; Long, S; Lu, YM; Mao, PJ; Moriguchi, S; Tian, Y; Wang, R; Yabuki, Y; Zhang, RT; Zhou, TY | 1 |
| Cao, JJ; Fukunaga, K; Han, F; Hong, LJ; Huang, JY; Jiang, Q; Liao, MH; Long, S; Lu, YM; Tao, RR; Tian, Y; Wang, CK; Wang, H; Zhang, LD; Zhou, NM | 1 |
| Anderson, G; Rodriguez, M | 1 |
| Chen, L; Jia, Y; Li, L; Pan, H; Wang, H; Wang, Q; Wu, Q | 1 |
| Abdolrazaghnejad, A; Ebrahimi-Monfared, M; Faraji, F; Mohammadbeigi, A; Sharafkhah, M | 1 |
| Blandino, G; Lo Sardo, F; Muti, P; Strano, S | 1 |
| Chaudhary, S; Parvez, S | 1 |
| Aranarochana, A; Chaisawang, P; Pannangrong, W; Sirichoat, A; Welbat, JU; Wigmore, P | 1 |
| Buyuk, B; Coskun, O; Ovali, MA; Oztopuz, O; Sehitoglu, MH; Turkon, H; Uzun, M | 1 |
| Hartung, EE; Mukhtar, SZ; Niles, LP; Shah, SM | 1 |
| Chaudhary, S; Parvez, S; Sahu, U | 1 |
| Aranarochana, A; Pannangrong, W; Sirichoat, A; Welbat, JU; Wigmore, P | 1 |
| Cui, Y; Li, XG; Liu, W; Liu, X; Qiu, B; Wang, X; Xiang, G; Yu, M; Zhang, D; Zhang, Y | 1 |
| Jena, M; Maiti, R; Mishra, A; Mishra, BR; Puliappadamb, HM | 1 |
5 review(s) available for melatonin and valproic acid
| Article | Year |
|---|---|
Alternative treatments in pediatric bipolar disorder.
Topics: Acupuncture; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Child; Humans; Hypericum; Inositol; Lecithins; Lithium Carbonate; Melatonin; S-Adenosylmethionine; Valproic Acid | 2009 |
Psychopharmacological neuroprotection in neurodegenerative disease: assessing the preclinical data.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipsychotic Agents; Benzodiazepines; Benzothiazoles; Brain; Clonazepam; Desipramine; Dibenzothiazepines; Dopamine Agonists; Humans; Lithium Carbonate; Maprotiline; Melatonin; Neurodegenerative Diseases; Neuroprotective Agents; Olanzapine; Parkinson Disease; Pramipexole; Quetiapine Fumarate; Selective Serotonin Reuptake Inhibitors; Valproic Acid | 2010 |
Evidence for seasonal mania: a review.
Topics: Antimanic Agents; Bipolar Disorder; Circadian Rhythm; Humans; Light; Lithium Compounds; Melatonin; Seasons; Secondary Prevention; Valproic Acid | 2013 |
Multiple sclerosis: the role of melatonin and N-acetylserotonin.
Topics: Fingolimod Hydrochloride; Glatiramer Acetate; Humans; Immunologic Factors; Immunosuppressive Agents; Interferon-beta; Lithium Compounds; Melatonin; Multiple Sclerosis; Nootropic Agents; Serotonin; Valproic Acid | 2015 |
Efficacy and Safety of Melatonin as Prophylaxis for Migraine in Adults: A Meta-analysis.
Topics: Adult; Amitriptyline; Analgesics; Humans; Melatonin; Migraine Disorders; Valproic Acid | 2022 |
7 trial(s) available for melatonin and valproic acid
| Article | Year |
|---|---|
Suppression of nocturnal plasma melatonin levels by evening administration of sodium valproate in healthy humans.
Topics: Adult; Anticonvulsants; Depression, Chemical; Double-Blind Method; Enzyme Multiplied Immunoassay Technique; Female; gamma-Aminobutyric Acid; Humans; Male; Melatonin; Valproic Acid | 1997 |
Add-on melatonin improves quality of life in epileptic children on valproate monotherapy: a randomized, double-blind, placebo-controlled trial.
Topics: Anticonvulsants; Antioxidants; Child; Child, Preschool; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Epilepsy; Female; Humans; Male; Melatonin; Quality of Life; Reproducibility of Results; Surveys and Questionnaires; Treatment Outcome; Valproic Acid | 2004 |
A randomized, double-blind, placebo controlled trial of melatonin add-on therapy in epileptic children on valproate monotherapy: effect on glutathione peroxidase and glutathione reductase enzymes.
Topics: Anticonvulsants; Antioxidants; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combination; Epilepsy; Female; Glutathione Peroxidase; Glutathione Reductase; Humans; Male; Melatonin; Valproic Acid | 2004 |
Add-on melatonin improves sleep behavior in children with epilepsy: randomized, double-blind, placebo-controlled trial.
Topics: Anticonvulsants; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy, Generalized; Female; Follow-Up Studies; Humans; Male; Melatonin; Sleep Wake Disorders; Surveys and Questionnaires; Valproic Acid | 2005 |
Effect of sodium valproate on nocturnal melatonin sensitivity to light in healthy volunteers.
Topics: Adolescent; Adult; Area Under Curve; Circadian Rhythm; Female; GABA Agents; Humans; Light; Male; Melatonin; Photic Stimulation; Radioimmunoassay; Valproic Acid | 2005 |
[Concentrations of urine 6-sulfatoxymelatonin during the treatment of patients with epilepsy: a pilot clinical trial].
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Female; Humans; Male; Melatonin; Middle Aged; Pilot Projects; Valproic Acid | 2012 |
Use of melatonin versus valproic acid in prophylaxis of migraine patients: A double-blind randomized clinical trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Central Nervous System Agents; Disability Evaluation; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Melatonin; Middle Aged; Migraine Disorders; Severity of Illness Index; Treatment Outcome; Valproic Acid; Young Adult | 2017 |
20 other study(ies) available for melatonin and valproic acid
| Article | Year |
|---|---|
Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain.
Topics: Animals; Antimetabolites; Biological Transport; Blood-Brain Barrier; Brain; Capillaries; Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endothelium, Vascular; GABA Agonists; Homovanillic Acid; Indican; Male; Microinjections; Neurotransmitter Agents; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Uremia; Xenopus laevis | 2002 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship | 2017 |
Synthesis of valproic acid amides of a melatonin derivative, a piracetam and amantadine for biological tests.
Topics: Amantadine; Animals; Melatonin; Pentylenetetrazole; Piracetam; Rodentia; Seizures; Valproic Acid | 2001 |
Human melatonin MT1 receptor induction by valproic acid and its effects in combination with melatonin on MCF-7 breast cancer cell proliferation.
Topics: Animals; Anticonvulsants; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Therapy, Combination; Gene Expression; Humans; Melatonin; Rats; Receptor, Melatonin, MT1; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation; Valproic Acid | 2007 |
Effect of chronic consumption of sodium valproate and melatonin on seizure activity in Krushinskii-Molodkina rats.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Drug Combinations; Epilepsies, Myoclonic; Epilepsy, Reflex; Melatonin; Rats; Valproic Acid | 2006 |
Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Melatonin; Mice; Neuroblastoma; Neurofilament Proteins; Valproic Acid | 2008 |
Cluster attacks responsive to recreational cannabis and dronabinol.
Topics: Analgesics, Non-Narcotic; Cannabis; Cluster Headache; Dihydroergotamine; Diphenhydramine; Dronabinol; Drug Resistance; Drug Therapy, Combination; Fructose; Humans; Male; Melatonin; Metoclopramide; Topiramate; Treatment Outcome; Valproic Acid; Young Adult | 2009 |
Melatonin reverses the decreases in hippocampal protein serine/threonine kinases observed in an animal model of autism.
Topics: Analysis of Variance; Animals; Antioxidants; Autistic Disorder; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Female; Hippocampus; Immunohistochemistry; Male; Melatonin; Phosphorylation; Rats; Rats, Sprague-Dawley; Valproic Acid | 2014 |
Valproic Acid Influences MTNR1A Intracellular Trafficking and Signaling in a β-Arrestin 2-Dependent Manner.
Topics: Animals; beta-Arrestins; Cyclic AMP-Dependent Protein Kinases; Endocytosis; Extracellular Signal-Regulated MAP Kinases; Fluorescence Resonance Energy Transfer; HEK293 Cells; Humans; Intracellular Space; Melatonin; Mice; Phosphorylation; Protein Binding; Protein Transport; rab GTP-Binding Proteins; Receptor, Melatonin, MT1; Signal Transduction; Valproic Acid | 2016 |
VPA and MEL induce apoptosis by inhibiting the Nrf2-ARE signaling pathway in TMZ-resistant U251 cells.
Topics: Antioxidant Response Elements; Apoptosis; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Melatonin; NF-E2-Related Factor 2; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Receptor, IGF Type 1; Signal Transduction; TOR Serine-Threonine Kinases; Valproic Acid | 2017 |
Melatonin and Hippo Pathway: Is There Existing Cross-Talk?
Topics: Animals; Antioxidants; Circadian Rhythm; Epilepsy; Humans; Melatonin; Protein Serine-Threonine Kinases; Rats; Signal Transduction; Valproic Acid | 2017 |
Valproic Acid Induced Neurotoxicological Manifestations and its Mitigation by Melatonin in Rat Brain Synaptosomes.
Topics: Animals; Antioxidants; Brain; Glutathione; Lipid Peroxidation; Male; Melatonin; Membrane Potential, Mitochondrial; Neurotoxicity Syndromes; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Synaptosomes; Valproic Acid | 2018 |
Protective effects of melatonin against valproic acid-induced memory impairments and reductions in adult rat hippocampal neurogenesis.
Topics: Animals; Cell Proliferation; Dentate Gyrus; Hippocampus; Male; Melatonin; Memory Disorders; Neural Stem Cells; Neurogenesis; Neuroprotective Agents; Rats, Sprague-Dawley; Valproic Acid | 2019 |
Melatonin ameliorates sodium valproate-induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Hepatocytes; Isoenzymes; Lipid Peroxidation; Liver; Male; Malondialdehyde; Melatonin; NF-kappa B; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Superoxide Dismutase; Valproic Acid | 2020 |
5-Azacytidine upregulates melatonin MT
Topics: Animals; Azacitidine; Cell Line; Cell Line, Tumor; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation, Neoplastic; Glioma; Histone Deacetylase Inhibitors; Hydroxamic Acids; Melatonin; Rats; Receptor, Melatonin, MT1; Receptors, Melatonin; RNA, Messenger; Transcriptional Activation; Valproic Acid | 2020 |
Melatonin attenuates branch chain fatty acid induced apoptosis mediated neurodegeneration.
Topics: Animals; Antioxidants; Apoptosis; Behavior, Animal; Cell Line, Tumor; Cell Survival; Cerebellum; Cerebral Cortex; Disease Models, Animal; Fatty Acids; Humans; Melatonin; Neurons; Neurotoxicity Syndromes; Oxidative Stress; Rats; Rats, Wistar; Valproic Acid | 2021 |
Melatonin Ameliorates Valproic Acid-Induced Neurogenesis Impairment: The Role of Oxidative Stress in Adult Rats.
Topics: Animals; Anticonvulsants; Antioxidants; Hippocampus; Male; Melatonin; Memory Disorders; Neurogenesis; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Valproic Acid | 2021 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Models, Animal; Dysbiosis; Female; Gastrointestinal Microbiome; Melatonin; Mice; Pregnancy; Valproic Acid | 2022 |