melatonin has been researched along with tacrine in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 15 (75.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bartolomé, B; Fernández-Bachiller, MI; Hernández-Ledesma, B; Pérez, C; Rodríguez-Franco, MI | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| de Los Ríos, C; Egea, J; Gálvez, E; García, AG; Iriepa, I; León, R; López, MG; Marco-Contelles, J; Moraleda, I; Romero, A; Samadi, A; Villarroya, M | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M | 1 |
| Carmo Carreiras, M; Chioua, M; Jimeno, ML; López, MG; Marco-Contelles, J; Mendes, E; Ríos, Cde L; Romero, A; Samadi, A; Silva, D; Villarroya, M | 1 |
| Fernández-Bachiller, MI; Monjas, L; Pérez, C; Rademann, J; Rodríguez-Franco, MI | 1 |
| Chabchoub, F; Chioua, M; de los Ríos, C; Esquivias-Pérez, M; González, MP; Iriepa, I; Maalej, E; Marco-Contelles, J; Monjas, L; Moraleda, I; Oset-Gasque, MJ; Pérez, C; Rodríguez-Franco, MI; Romero, A; Samadi, A | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Alonso-Gil, S; Conde, S; López, MG; López-Iglesias, B; Morales-García, JA; Pérez, C; Pérez-Castillo, A; Rodríguez-Franco, MI; Romero, A; Villarroya, M | 1 |
| Kong, LY; Li, F; Li, XM; Wang, J; Wang, XB; Wang, ZM; Wu, JJ | 1 |
| Cai, P; Kong, LY; Liu, QH; Wang, XB; Wang, ZM; Wu, JJ; Xu, DQ; Yang, XL | 1 |
| Bautista-Aguilera, OM; Benchekroun, M; Buendía, I; Egea, J; Ismaili, L; Janockova, J; Jimeno, ML; Jun, D; León, R; Marco-Contelles, J; Michalska, P; Ouari, O; Refouvelet, B; Romero, A; Sepsova, V; Soukup, O | 1 |
| Kumar, S; Mishra, S; Modi, G; Rai, H; Singh, G; Singh, GK; Singh, YP; Srikrishna, S | 1 |
| Sternon, J | 1 |
| Calabrese, EJ | 1 |
| Campillo, NE; Fernández-Bachiller, MI; García, AG; García-Palomero, E; González-Muñoz, GC; López, MG; Martínez, A; Páez, JA; Pérez, C; Rodríguez-Franco, MI; Usán, P; Villarroya, M | 1 |
| Antequera, D; Carro, E; Isabel Fernandez-Bachiller, M; Isabel Rodríguez-Franco, M; Spuch, C | 1 |
| Czarnocki, Z; Lozińska, I; Molęda, Z; Panasiewicz, M; Zawadzka, A | 1 |
| Czarnocki, Z; Dudkowska, M; Kucharewicz, K; Ogrodnik, M; Sikora, E; Szczepankiewicz, AA; Zawadzka, A | 1 |
2 review(s) available for melatonin and tacrine
| Article | Year |
|---|---|
A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Line, Tumor; Coumaric Acids; Humans; Neuroprotective Agents; Oxidative Stress; Protein Multimerization | 2021 |
Apoptosis: biphasic dose responses.
Topics: Animals; Antioxidants; Apoptosis; Cycloheximide; Dementia; Dimethylformamide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Homeostasis; Humans; Melatonin; Necrosis; Nootropic Agents; Protein Synthesis Inhibitors; Radiation Injuries; Staurosporine; Tacrine; Tumor Necrosis Factor-alpha | 2001 |
18 other study(ies) available for melatonin and tacrine
| Article | Year |
|---|---|
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Blood-Brain Barrier; Cholinesterase Inhibitors; Humans; In Vitro Techniques; Melatonin; Permeability; Structure-Activity Relationship; Swine; Tacrine; Tissue Extracts | 2006 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Calcium; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytotoxins; Electron Transport Chain Complex Proteins; Electrophorus; Glucose; Hippocampus; Humans; Isomerism; Models, Molecular; Naphthyridines; Neuroprotective Agents; Okadaic Acid; Oligomycins; Oxygen; Peptide Fragments; Protein Binding; Protein Phosphatase 2; Rats; Rotenone; Structure-Activity Relationship | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2011 |
Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives.
Topics: Animals; Cholinesterase Inhibitors; Horses; Inhibitory Concentration 50; Pyrazoles | 2011 |
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Antioxidants; Aspartic Acid Endopeptidases; Benzopyrans; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Cattle; Cholinesterase Inhibitors; Chromones; Free Radical Scavengers; Humans; Membranes, Artificial; Permeability; Structure-Activity Relationship; Tacrine | 2012 |
Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Electron Transport Complex I; Electron Transport Complex IV; Hep G2 Cells; Humans; Kinetics; Models, Molecular; Neuroprotective Agents; Permeability; Quinolines; Rats; Reactive Oxygen Species; Stereoisomerism | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.
Topics: Alzheimer Disease; Antioxidants; Blood-Brain Barrier; Cell Line; Cholinesterase Inhibitors; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Melatonin; Neuroprotective Agents; Spectrometry, Mass, Electrospray Ionization | 2014 |
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Cell Line, Tumor; Chelating Agents; Cholinesterase Inhibitors; Donepezil; Electrophorus; Horses; Humans; Indans; Indoles; Iron; Kinetics; Melatonin; Molecular Docking Simulation; Peptide Fragments; Piperidines; Protein Multimerization; Rats; Zinc | 2016 |
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Copper; Donepezil; Drug Design; Humans; Indans; Kinetics; Liver; Mice; Models, Molecular; Peptide Fragments; Piperidines; Protein Aggregates; Protein Conformation | 2016 |
The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.
Topics: Alzheimer Disease; Antioxidants; Cell Death; Cell Survival; Cholinesterase Inhibitors; Cholinesterases; Coumaric Acids; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Melatonin; Molecular Structure; NF-E2-Related Factor 2; Structure-Activity Relationship | 2016 |
[Melatonin, methadone, tacrine, vitamin K antagonists and low-molecular-weight heparin].
Topics: Aged; Anticoagulants; Cholinesterase Inhibitors; Circadian Rhythm; Cognition Disorders; Heroin Dependence; Humans; Melatonin; Methadone; Narcotics; Tacrine; Vitamin K | 1996 |
Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties.
Topics: Acetylcholinesterase; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Catalytic Domain; Cell Line; Cholinergic Agents; Cholinesterase Inhibitors; Humans; Melatonin; Models, Chemical; Molecular Sequence Data; Neuroprotective Agents; Sequence Alignment; Tacrine | 2009 |
A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Behavioral Symptoms; Brain; Caspases; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; Drug Combinations; Humans; Maze Learning; Melatonin; Mice; Mice, Transgenic; Mutation; Neurons; Neuroprotective Agents; Organ Culture Techniques; Presenilin-1; Rats; Tacrine; Time Factors | 2010 |
Highly selective inhibition of butyrylcholinesterase by a novel melatonin-tacrine heterodimers.
Topics: Butyrylcholinesterase; Cholinesterase Inhibitors; Melatonin; Tacrine | 2013 |
Simultaneous induction and blockade of autophagy by a single agent.
Topics: Antineoplastic Agents; Autophagy; Cell Death; Cell Proliferation; Cell Survival; Cellular Senescence; Cholinesterase Inhibitors; Fibroblasts; G1 Phase; HCT116 Cells; Humans; MCF-7 Cells; Melatonin; Tacrine | 2018 |