melatonin and ramelteon

melatonin has been researched along with ramelteon in 86 studies

Research

Studies (86)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	24 (27.91)	29.6817
2010's	41 (47.67)	24.3611
2020's	21 (24.42)	2.80

Authors

Authors	Studies
Fukatsu, K; Hinuma, S; Hirai, K; Imai, Y; Kato, K; Kawada, M; Matsumoto, K; Miyamoto, M; Nishikawa, H; Ohkawa, S; Tokunoh, R; Uchikawa, O	1
Chandrasena, G; Doller, D; Jiang, Y; Keim, H; Li, G; Poda, SB; Ren, Y; Topiol, SW; Zhou, H	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Cecon, E; Jockers, R; Rivara, S; Witt-Enderby, PA; Zlotos, DP	1
Kimura, H; Miyamoto, M; Nishikawa, H; Ohkawa, S; Yoshikubo, S; Yukuhiro, N	1
Gillette, MU; Turek, FW	1
Doken, Y; Hirai, K; Miyamoto, M; Nishikawa, H; Ohkawa, S; Uchikawa, O	1
Cardinali, DP; Pandi-Perumal, SR; Srinivasan, V; Zisapel, N	1
Erman, M; Sainati, S; Seiden, D; Zammit, G; Zhang, J	1
Wurtman, R	1
Bellon, A	1
Steinhilber, D	1
Davidson, K; Eleutheriades, A; Sugden, D; Tsotinis, A	1
Pulisetty, S; Tariq, SH	1
Miyamoto, M	1
Davidson, K; Fisher, SP; Kulla, A; Sugden, D	1
Cardinali, DP; Hardeland, R; Pandi-Perumal, SR; Poeggeler, B; Srinivasan, V; Trakht, I	1
Cardinali, DP; Hardeland, R; Pandi-Perumal, SR; Poeggeler, B; Spence, DW; Srinivasan, V; Trakht, I	1
Arendt, J; Rajaratnam, SM	1
Peng, X; Richardson, GS; Rodriguez, L; Wang-Weigand, S; Zee, PC	1
Cardinali, DP; Golombek, DA	1
Richardson, GS; Wang-Weigand, S; Zammit, G; Zhang, J	1
Cardinali, DP; Hardeland, R; Pandi-Perumal, SR; Poeggeler, B; Spence, DW; Srinivasan, V; Trahkt, I	1
Cespuglio, R; Delagrange, P; Descamps, A; Millan, M; Millan, MJ; Rousset, C; Spedding, M	1
Hirai, K; Nishiyama, K; Shintani, Y; Yoshikubo, S	1
Brown, GM; Cardinali, DP; Hardeland, R; Moscovitch, A; Pandi-Perumal, SR; Spence, DW; Srinivasan, V	1
Prendergast, BJ	1
Dawson, D; Ferguson, SA; Rajaratnam, SM	1
Peng, X; Roth, T; Wang-Weigand, S; Wright, KP; Zee, PC	1
Fonteles, MM; Macedo, D; Rios, ER; Rocha, NF; Sousa, FC; Vasconcelos, S; Venâncio, ET; Woods, DJ	1
Brown, GM; Cardinali, DP; Pandi-Perumal, SR; Singh, J; Spence, DW; Srinivasan, V	1
Dubocovich, ML; Hudson, RL; Rawashdeh, O; Stepien, I	1
Brown, GM; Brzezinski, A; Cardinali, DP; Pandi-Perumal, SR; Spence, DW; Srinivasan, V	1
Carazo, A; Casado, J; de la Cueva, P; León, J; Maté, A; Muñoz de Rueda, P; Quiles, R; Ruíz, S; Ruíz-Extremera, A; Salmerón, J; Sanjuán, L	1
Brown, GM; Brzezinski, A; Cardinali, DP; Srinivasan, V	1
Bellantuono, C; Catena-Dell'Osso, M; Marazziti, D; Rotella, F	1
Brown, GM; Brzezinski, A; Othaman, Z; Prasad, A; Srinivasan, V; Zakaria, R	1
Ito, T	1
Hardeland, R; Poeggeler, B	1
Baño Otalora, B; Bonet-Costa, V; Camello, PJ; Gambini, J; Madrid, JA; Popovic, M; Popovic, N; Reiter, RJ; Rol, MÁ; Viña, J	1
Aritake, S; Enomoto, M; Hida, A; Higuchi, S; Kamei, Y; Katayose, Y; Kitamura, S; Mishima, K; Moriguchi, Y; Nozaki, K; Watanabe, M	1
Furuya, M; Horiguchi, J; Miyaoka, T; Otsuka, S; Tanaka, I; Wake, R; Yamashita, S; Yasuda, H	1
Inagaki, K; Iwasaki, Y; Makino, H; Nakamura, E; Ogura-Ochi, K; Otsuka, F; Terasaka, T; Toma, K; Tsukamoto, N	1
Fink, T; Glas, M; Kiefer, D; Kleber, A; Mathes, AM; Rensing, H; Reus, E; Volk, T; Wolf, A; Wolf, B; Wolff, M	1
Araki, A; Cho, K; Fukuda, I; Miyamoto, A; Oka, R; Tanaka, H	1
Cohen, DA; McCleery, J; Sharpley, AL	2
Chakraborti, D; Tampi, DJ; Tampi, RR	1
Cai, C; Gao, C; Guan, JH; Guo, J; Huang, YL; Liang, XB; Qian, LQ; Zhao, GP	1
Frydman-Marom, A; Laudon, M	1
Fukumizu, M; Hayashi, M; Ishizaki, A; Kohyama, J; Miyajima, T; Tanaka, H	1
Bellivier, F; Etain, B; Franchi, JA; Geoffroy, PA; Ritter, P	1
Abdallah, GT; Mo, Y; Scheer, CE	1
Abend, M; Fink, T; Glas, M; Kleber, A; Mathes, AM; Ruf, CG; Volk, T; Wolf, A; Wolf, B	1
Chen, S; Desislava, D; Liang, F; Shi, L; Wu, Q; Xu, L; Zhang, J	1
Abrahamsson, KE; Cooper, JM; Gamble, KL; Hablitz, LM; Molzof, HE; Prosser, RA	1
Bahk, WM; Wang, HR; Woo, YS	1
Alagiakrishnan, K	1
Gales, MA; Walker, CK	1
He, ZY; Liang, JP; Song, ZC; Zhang, X; Zhou, W; Zhu, CL	1
Fazzari, M; James, SA; Lam, S; Pinkhasov, A; Singh, D	1
Batyuk, A; Cherezov, V; Gati, C; Grandner, JM; Han, GW; Hao, S; Huang, XP; Johansson, LC; Katritch, V; Li, C; Liu, W; McCorvy, JD; Olsen, RHJ; Patel, N; Roth, BL; Slocum, ST; Stauch, B; Stevens, RC; Tribo, AR; Weierstall, U; Yous, S; Zaare, S; Zatsepin, NA; Zhu, L	1
Batyuk, A; Brehm, W; Cherezov, V; Gati, C; Grandner, JM; Grant, TD; Han, GW; Huang, XP; Ishchenko, A; Johansson, LC; Katritch, V; Liu, W; Madsen, C; McCorvy, JD; Michaelian, N; Olsen, RHJ; Patel, N; Roth, BL; Shiriaeva, A; Slocum, ST; Stauch, B; Stevens, RC; Tribo, AR; Weierstall, U; White, TA; Yous, S; Zhu, L	1
Gao, F; Li, Z; Sun, W; Zhang, Q; Zhang, S	1
Khor, AJ; Ng, KT; Teoh, WY	1
Pei-Chen Chang, J; Satyanarayanan, SK; Su, H; Su, KP; Tseng, PT; Yang, CP	1
Jena, M; Maiti, R; Mishra, A; Mishra, BR; Nath, S; Sahu, P	1
Cubała, WJ; Lewandowska, K; Małkiewicz, MA; Mędrzycka-Dąbrowska, WA; Siemiński, M; Winklewski, PJ	1
Chen, Z; Fu, W; Han, Y; Li, J; Li, X; Qin, Z; Sha, T; Sun, M; Wang, W; Wu, J; Zeng, Z; Zhao, B	1
Aydın, A; Gürbüz, MA; Halıcı, Z; Karaman, A; Köse, A; Köse, D; Toktay, E; Ugan, RA	1
McCleery, J; Sharpley, AL	1
DeGrado, JR; Dube, KM; Lupi, KE; Romero, N	1
Bomsel, M; Cecon, E; Dam, J; Ghigna, MR; Izabelle, C; Jockers, R; Klonjkowski, B; Poder, SL; Real, F; Tu, L; Zhu, A	1
Hashimoto, T; Kataoka, Y; Matsumoto, M; Suzuki, T; Tsunemitsu, T	1
Jiang, YJ; Liu, J; Wang, YH; Wang, YQ; Zhao, HQ; Zou, MS	1
Du, Y; Gong, Q; Guo, Q; Li, X; Liu, Z; Lu, Q; Tao, Y; Teng, M; Wang, Q	1
Kawilapat, S; Kongsaengdao, S; Likhitsathian, S; Maneeton, B; Maneeton, N; Srisurapanont, M; Woottiluk, P	1
Inoue, T; Kanno, T; Shimura, A	1
Carvalho, AF; Chang, CH; Hsu, CW; Hsu, TW; Liang, CS; Thompson, T; Tsai, TC; Tseng, PT; Tu, YK; Yang, FC; Yang, SN; Yu, CL	1
Beaucage-Charron, J; Coveney, R; Rinfret, J; Williamson, D	1
Chiba, A; Iwashita, H; Kawaguchi, M; Sano, M; Suzuki, C	1
Jin, Y; Li, S; Zhang, H	1
Bourgin, P; Chambe, J; Geoffroy, PA; Maruani, J; Palagini, L; Reynaud, E	1
Aksakalli-Magden, ZB; Alper, F; Aydin, P; Civelek, MS; Halici, Z; Karabulut-Uzuncakmak, S; Mokhtare, B; Ozkaraca, M	1
Balpınar, Ö; Hacımüftüoğlu, A; Nadaroğlu, H	1

Reviews

40 review(s) available for melatonin and ramelteon

Article	Year
Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists. Sleep medicine, 2004, Volume: 5, Issue:6 Topics: Acetamides; Antioxidants; Humans; Hypothalamus; Indenes; Indoles; Melatonin; Receptors, Melatonin; Sleep Disorders, Circadian Rhythm	2004
Melatonin and sleep in aging population. Experimental gerontology, 2005, Volume: 40, Issue:12 Topics: Aged; Aging; Alzheimer Disease; Body Temperature Regulation; Female; Humans; Indenes; Indoles; Male; Melatonin; Pineal Gland; Receptors, Melatonin; Sleep; Sleep Wake Disorders; Suprachiasmatic Nucleus	2005
Ramelteon: a novel treatment for the treatment of insomnia. Expert review of neurotherapeutics, 2006, Volume: 6, Issue:7 Topics: Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Indenes; Melatonin; Practice Patterns, Physicians'; Receptors, Melatonin; Sleep Initiation and Maintenance Disorders; Treatment Outcome	2006
Searching for new options for treating insomnia: are melatonin and ramelteon beneficial? Journal of psychiatric practice, 2006, Volume: 12, Issue:4 Topics: Administration, Intranasal; Adult; Aged; Circadian Rhythm; Female; Humans; Indenes; Injections, Intravenous; Male; Melatonin; Middle Aged; Randomized Controlled Trials as Topic; Sleep; Sleep Initiation and Maintenance Disorders	2006
[Melatonin, melatonin receptor agonists and tryptophan as sleep aids]. Pharmazie in unserer Zeit, 2007, Volume: 36, Issue:3 Topics: Acetamides; Animals; Antioxidants; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Receptors, Melatonin; Sleep Wake Disorders; Tryptophan	2007
Pharmacotherapy for insomnia. Clinics in geriatric medicine, 2008, Volume: 24, Issue:1 Topics: Antidepressive Agents; Azabicyclo Compounds; Central Nervous System Depressants; Eszopiclone; GABA Agonists; GABA-A Receptor Antagonists; Humans; Indenes; Melatonin; Phytotherapy; Piperazines; Pyridines; Sleep Initiation and Maintenance Disorders; Valerian; Zolpidem	2008
[Drugs for insomnia and improving quality of life (QOL): research and development of ramelteon, an MT1/MT2-receptor agonist]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2008, Volume: 131, Issue:1 Topics: Animals; Humans; Indenes; Melatonin; Quality of Life; Receptors, Melatonin; Sleep Initiation and Maintenance Disorders	2008
Melatonergic drugs in clinical practice. Arzneimittel-Forschung, 2008, Volume: 58, Issue:1 Topics: Acetamides; Animals; Antidepressive Agents; Biological Clocks; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Receptors, Melatonin; Sleep Initiation and Maintenance Disorders	2008
The effect of melatonergic and non-melatonergic antidepressants on sleep: weighing the alternatives. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2009, Volume: 10, Issue:4 Pt 2 Topics: Acetamides; Affect; Antidepressive Agents; Brain; Depressive Disorder, Major; Humans; Indenes; Melatonin; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Sleep; Sleep Initiation and Maintenance Disorders	2009
Melatonin and melatonergic drugs on sleep: possible mechanisms of action. The International journal of neuroscience, 2009, Volume: 119, Issue:6 Topics: Acetamides; Aging; Animals; Antidepressive Agents; Circadian Rhythm; Depressive Disorder; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Receptors, Melatonin; Signal Transduction; Sleep; Sleep Initiation and Maintenance Disorders; Suprachiasmatic Nucleus	2009
Ramelteon: a review of its therapeutic potential in sleep disorders. Advances in therapy, 2009, Volume: 26, Issue:6 Topics: Animals; Humans; Indenes; Melatonin; Sleep; Sleep Initiation and Maintenance Disorders	2009
Melatonin agonists and insomnia. Expert review of neurotherapeutics, 2010, Volume: 10, Issue:2 Topics: Acetamides; Animals; Benzofurans; Circadian Rhythm; Cyclopropanes; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Sleep Initiation and Maintenance Disorders	2010
Melatonin: pharmacological aspects and clinical trends. The International journal of neuroscience, 2010, Volume: 120, Issue:9 Topics: Animals; Antidepressive Agents; Antioxidants; Depression; Free Radical Scavengers; Humans; Indenes; Jet Lag Syndrome; Melatonin; Receptors, Melatonin; Sleep; Sleep Disorders, Circadian Rhythm	2010
Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. Advances in therapy, 2010, Volume: 27, Issue:11 Topics: Acetamides; Benzofurans; Central Nervous System Depressants; Cyclopropanes; Depressive Disorder; Humans; Indenes; Jet Lag Syndrome; Melatonin; Sleep Disorders, Circadian Rhythm	2010
Melatonin agonists in primary insomnia and depression-associated insomnia: are they superior to sedative-hypnotics? Progress in neuro-psychopharmacology & biological psychiatry, 2011, Jun-01, Volume: 35, Issue:4 Topics: Acetamides; Animals; Benzodiazepines; Benzofurans; Clinical Trials as Topic; Cyclopropanes; Depressive Disorder; Humans; Hypnotics and Sedatives; Indenes; Indoles; Melatonin; Sleep Initiation and Maintenance Disorders	2011
Melatonin and its analogs in insomnia and depression. Journal of pineal research, 2012, Volume: 52, Issue:4 Topics: Acetamides; Animals; Depression; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Mice; Sleep Initiation and Maintenance Disorders	2012
Emerging targets for the pharmacological treatment of depression: focus on melatonergic system. Current medicinal chemistry, 2012, Volume: 19, Issue:3 Topics: Acetamides; Antidepressive Agents; Circadian Clocks; Depression; Humans; Indenes; Melatonin; Receptors, Melatonin	2012
Melatonergic drugs for therapeutic use in insomnia and sleep disturbances of mood disorders. CNS & neurological disorders drug targets, 2012, Volume: 11, Issue:2 Topics: Animals; Central Nervous System Depressants; Humans; Indenes; Melatonin; Mood Disorders; Sleep Initiation and Maintenance Disorders	2012
Melatonin and synthetic melatonergic agonists: actions and metabolism in the central nervous system. Central nervous system agents in medicinal chemistry, 2012, Volume: 12, Issue:3 Topics: Acetamides; Animals; Antidepressive Agents; Central Nervous System; Humans; Indenes; Melatonin; Receptors, Melatonin; Sleep	2012
Pharmacotherapies for sleep disturbances in Alzheimer's disease. The Cochrane database of systematic reviews, 2014, Mar-21, Issue:3 Topics: Alzheimer Disease; Humans; Indenes; Melatonin; Randomized Controlled Trials as Topic; Sleep; Sleep Wake Disorders; Trazodone	2014
Melatonin and melatonin agonist for delirium in the elderly patients. American journal of Alzheimer's disease and other dementias, 2015, Volume: 30, Issue:2 Topics: Aged; Delirium; Humans; Indenes; Melatonin; Randomized Controlled Trials as Topic	2015
Therapeutic effects of melatonin receptor agonists on sleep and comorbid disorders. International journal of molecular sciences, 2014, Sep-09, Volume: 15, Issue:9 Topics: Acetamides; Animals; Benzofurans; Clinical Trials as Topic; Cyclopropanes; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Neurodegenerative Diseases; Receptors, Melatonin; Sleep Wake Disorders	2014
Melatonin and Melatonin Agonists as Adjunctive Treatments in Bipolar Disorders. Current pharmaceutical design, 2015, Volume: 21, Issue:23 Topics: Antipsychotic Agents; Benzofurans; Bipolar Disorder; Circadian Rhythm; Cyclopropanes; Humans; Inappropriate Prescribing; Indenes; Melatonin; Off-Label Use; Patient Safety; Practice Patterns, Physicians'; Receptors, Melatonin; Risk Assessment; Risk Factors; Sleep; Treatment Outcome	2015
Emerging Role of Melatonin and Melatonin Receptor Agonists in Sleep and Delirium in Intensive Care Unit Patients. Journal of intensive care medicine, 2016, Volume: 31, Issue:7 Topics: Central Nervous System Depressants; Critical Care; Critical Illness; Delirium; Humans; Indenes; Intensive Care Units; Melatonin; Receptors, Melatonin; Sleep; Sleep Deprivation	2016
Exogenous Melatonin for Delirium Prevention: a Meta-analysis of Randomized Controlled Trials. Molecular neurobiology, 2016, Volume: 53, Issue:6 Topics: Aged; Aged, 80 and over; Delirium; Female; Humans; Indenes; Male; Melatonin; Outcome Assessment, Health Care; Publication Bias; Randomized Controlled Trials as Topic; Risk Factors	2016
The role of melatonin and melatonin agonists in counteracting antipsychotic-induced metabolic side effects: a systematic review. International clinical psychopharmacology, 2016, Volume: 31, Issue:6 Topics: Antioxidants; Antipsychotic Agents; Humans; Indenes; Melatonin; Metabolic Syndrome; Randomized Controlled Trials as Topic; Weight Gain	2016
Melatonin based therapies for delirium and dementia. Discovery medicine, 2016, Volume: 21, Issue:117 Topics: Aged; Animals; Antipsychotic Agents; Benzodiazepines; Chronobiology Phenomena; Clinical Trials as Topic; Delirium; Dementia; Drug Therapy, Combination; Galantamine; Humans; Indenes; Melatonin; Memantine; Neuroprotection; Practice Guidelines as Topic	2016
Melatonin Receptor Agonists for Delirium Prevention. The Annals of pharmacotherapy, 2017, Volume: 51, Issue:1 Topics: Clinical Trials as Topic; Delirium; Female; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Prospective Studies; Receptors, Melatonin; Treatment Outcome; Tryptophan	2017
Pharmacotherapies for sleep disturbances in dementia. The Cochrane database of systematic reviews, 2016, 11-16, Volume: 11 Topics: Alzheimer Disease; Humans; Indenes; Melatonin; Randomized Controlled Trials as Topic; Sleep; Sleep Wake Disorders; Time Factors; Trazodone	2016
Prophylactic use of exogenous melatonin and melatonin receptor agonists to improve sleep and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials. Sleep & breathing = Schlaf & Atmung, 2019, Volume: 23, Issue:4 Topics: Adult; Benzofurans; Case-Control Studies; Correlation of Data; Cross-Sectional Studies; Cyclopropanes; Delirium; Hospital Mortality; Humans; Indenes; Intensive Care Units; Length of Stay; Melatonin; Randomized Controlled Trials as Topic; Receptors, Melatonin; Respiration, Artificial; Risk Factors; Sleep; Sleep Wake Disorders; Treatment Outcome; Wakefulness	2019
The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis. Journal of clinical anesthesia, 2020, Volume: 59 Topics: Delirium; Dizziness; Headache; Hospital Mortality; Humans; Hypnotics and Sedatives; Incidence; Indenes; Intensive Care Units; Length of Stay; Melatonin; Nausea; Paresthesia; Randomized Controlled Trials as Topic; Respiration, Artificial; Restraint, Physical; Treatment Outcome	2020
Melatonergic agents in the prevention of delirium: A network meta-analysis of randomized controlled trials. Sleep medicine reviews, 2020, Volume: 50 Topics: Aged; Delirium; Humans; Indenes; Melatonin; Network Meta-Analysis; Randomized Controlled Trials as Topic; Risk Factors	2020
The role of melatonin and melatonin receptor agonist in the prevention of sleep disturbances and delirium in intensive care unit - a clinical review. Sleep medicine, 2020, Volume: 69 Topics: Chronobiology Disorders; Delirium; Humans; Indenes; Intensive Care Units; Melatonin; Receptors, Melatonin; Sleep; Sleep Deprivation	2020
Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis. Journal of pineal research, 2020, Volume: 68, Issue:4 Topics: Emergence Delirium; Humans; Indenes; Melatonin	2020
Pharmacotherapies for sleep disturbances in dementia. The Cochrane database of systematic reviews, 2020, 11-15, Volume: 11 Topics: Alzheimer Disease; Azepines; Caregiver Burden; Cognition; Humans; Indenes; Melatonin; Pyridines; Pyrimidines; Randomized Controlled Trials as Topic; Sleep; Sleep Wake Disorders; Time Factors; Trazodone; Triazoles	2020
Antidepressant actions of melatonin and melatonin receptor agonist: Focus on pathophysiology and treatment. Behavioural brain research, 2022, 02-26, Volume: 420 Topics: Animals; Antidepressive Agents; Antioxidants; Benzofurans; Chronobiology Disorders; Cyclopropanes; Depression; Humans; Hypothalamo-Hypophyseal System; Indenes; Melatonin; Pituitary-Adrenal System; Receptors, Melatonin; Sleep Wake Disorders	2022
Melatonin Receptor Agonists for the Prevention of Delirium: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. Current neuropharmacology, 2022, Volume: 20, Issue:10 Topics: Aged; Delirium; Humans; Indenes; Melatonin; Randomized Controlled Trials as Topic; Receptors, Melatonin	2022
Ramelteon for delirium prevention in hospitalized patients: An updated meta-analysis and trial sequential analysis of randomized controlled trials. Journal of pineal research, 2023, Volume: 74, Issue:3 Topics: Delirium; Humans; Melatonin; Middle Aged; Randomized Controlled Trials as Topic; Reproducibility of Results	2023
Melatonin and Ramelteon for the treatment of delirium: A systematic review and meta-analysis. Journal of psychosomatic research, 2023, Volume: 170 Topics: Aged; Antipsychotic Agents; Delirium; Humans; Indenes; Melatonin	2023
Efficacy of melatonin and ramelteon for the acute and long-term management of insomnia disorder in adults: A systematic review and meta-analysis. Journal of sleep research, 2023, Volume: 32, Issue:6 Topics: Adult; Humans; Indenes; Melatonin; Sleep; Sleep Initiation and Maintenance Disorders	2023

Trials

8 trial(s) available for melatonin and ramelteon

Article	Year
An efficacy, safety, and dose-response study of Ramelteon in patients with chronic primary insomnia. Sleep medicine, 2006, Volume: 7, Issue:1 Topics: Adolescent; Adult; Chronic Disease; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Indenes; Male; Melatonin; Middle Aged; Polysomnography; Sleep Initiation and Maintenance Disorders; Surveys and Questionnaires; Treatment Outcome	2006
Circadian phase-shifting effects of repeated ramelteon administration in healthy adults. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2008, Oct-15, Volume: 4, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Circadian Rhythm; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indenes; Male; Melatonin; Polysomnography; Sleep; Young Adult	2008
Safety and subjective sleep effects of ramelteon administration in adults and older adults with chronic primary insomnia: a 1-year, open-label study. The Journal of clinical psychiatry, 2009, Volume: 70, Issue:4 Topics: Adolescent; Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Indenes; Male; Melatonin; Middle Aged; Severity of Illness Index; Single-Blind Method; Sleep Initiation and Maintenance Disorders; Surveys and Questionnaires; Testosterone; Thyroxine; Young Adult	2009
Effects of ramelteon on insomnia symptoms induced by rapid, eastward travel. Sleep medicine, 2010, Volume: 11, Issue:6 Topics: Actigraphy; Adult; Case-Control Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indenes; Jet Lag Syndrome; Male; Melatonin; Neuropsychological Tests; Pain Measurement; Young Adult	2010
Intrinsic circadian period of sighted patients with circadian rhythm sleep disorder, free-running type. Biological psychiatry, 2013, Jan-01, Volume: 73, Issue:1 Topics: Adolescent; Adult; Case-Control Studies; Chronotherapy; Circadian Rhythm; Female; Humans; Indenes; Male; Melatonin; Middle Aged; Photoperiod; Phototherapy; Polysomnography; Receptors, Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Wakefulness	2013
[Treatment with ramelteon for sleep disturbance in severely disabled children and young adults]. No to hattatsu = Brain and development, 2013, Volume: 45, Issue:6 Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Indenes; Male; Melatonin; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Stages; Treatment Outcome; Young Adult	2013
Effect of add-on ramelteon therapy on sleep and circadian rhythm disruption in patients with schizophrenia: A randomized controlled trial. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2020, Volume: 31 Topics: Adult; Antipsychotic Agents; Circadian Rhythm; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Indenes; Male; Melatonin; Middle Aged; Schizophrenia; Single-Blind Method; Sleep; Treatment Outcome; Young Adult	2020
Effect of enterally administered sleep-promoting medication on the intravenous sedative dose and its safety and cost profile in mechanically ventilated patients: A retrospective cohort study. PloS one, 2021, Volume: 16, Issue:12 Topics: Administration, Intravenous; Aged; Central Nervous System Depressants; Enteral Nutrition; Female; Humans; Hypnotics and Sedatives; Indenes; Intensive Care Units; Length of Stay; Male; Melatonin; Middle Aged; Propofol; Respiration, Artificial; Retrospective Studies; Sleep	2021

Other Studies

38 other study(ies) available for melatonin and ramelteon

Article	Year
Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists. Journal of medicinal chemistry, 2002, Sep-12, Volume: 45, Issue:19 Topics: Animals; Binding Sites; Cats; CHO Cells; Cricetinae; Cyclic AMP; Female; Humans; In Vitro Techniques; Indans; Male; Melatonin; Mesocricetus; Models, Molecular; Organ Specificity; Pituitary Gland; Radioligand Assay; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Sleep; Stereoisomerism; Structure-Activity Relationship; Wakefulness	2002
Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands. Bioorganic & medicinal chemistry letters, 2011, Feb-15, Volume: 21, Issue:4 Topics: Amides; Animals; Cyclopropanes; Drug Design; Humans; Ligands; Microsomes; Piperidines; Rats; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Structure-Activity Relationship	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential. Journal of medicinal chemistry, 2014, Apr-24, Volume: 57, Issue:8 Topics: Animals; Binding Sites; Depressive Disorder; Humans; Ligands; Melatonin; Models, Molecular; Protein Multimerization; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Sleep Initiation and Maintenance Disorders; Structure-Activity Relationship	2014
Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeys. Brain research, 2004, Nov-19, Volume: 1027, Issue:1-2 Topics: Amides; Animals; Dose-Response Relationship, Drug; Electroencephalography; Female; Hypnotics and Sedatives; Indenes; Macaca fascicularis; Melatonin; Polysomnography; Pyridines; Reaction Time; Receptors, Melatonin; Sleep; Time Factors; Wakefulness; Zolpidem	2004
The sleep-promoting action of ramelteon (TAK-375) in freely moving cats. Sleep, 2004, Nov-01, Volume: 27, Issue:7 Topics: Animals; Arousal; Cats; Circadian Rhythm; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Indenes; Male; Melatonin; Polysomnography; Sleep; Sleep, REM; Suprachiasmatic Nucleus; Wakefulness	2004
Ramelteon (Rozerem) for insomnia. The Medical letter on drugs and therapeutics, 2005, Nov-07, Volume: 47, Issue:1221 Topics: Humans; Indenes; Melatonin; Receptor, Melatonin, MT1; Sleep Initiation and Maintenance Disorders	2005
Design and synthesis of new N1 and C3-substituted 4-fluoroindolic melatoninergics. Current drug discovery technologies, 2007, Volume: 4, Issue:3 Topics: Animals; Chromatography; Drug Design; Humans; Indenes; Indoles; Iodine Radioisotopes; Mass Spectrometry; Melanophores; Melatonin; Mice; Molecular Structure; NIH 3T3 Cells; Protein Binding; Radioligand Assay; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Transition Temperature; Tryptamines; Xenopus laevis	2007
Acute sleep-promoting action of the melatonin agonist, ramelteon, in the rat. Journal of pineal research, 2008, Volume: 45, Issue:2 Topics: Animals; Electroencephalography; Humans; Indenes; Melatonin; Mice; Molecular Structure; NIH 3T3 Cells; Rats; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Sleep	2008
Melatonin and its agonists: an update. The British journal of psychiatry : the journal of mental science, 2008, Volume: 193, Issue:4 Topics: Acetamides; Benzofurans; Cyclopropanes; Drug Administration Schedule; Humans; Indenes; Melatonin; Receptors, Melatonin	2008
Let there be sleep--on time. Lancet (London, England), 2009, Feb-07, Volume: 373, Issue:9662 Topics: Circadian Rhythm; Humans; Indenes; Melatonin; Randomized Controlled Trials as Topic; Receptors, Melatonin; Sleep; Sleep Initiation and Maintenance Disorders	2009
Influence of the novel antidepressant and melatonin agonist/serotonin2C receptor antagonist, agomelatine, on the rat sleep-wake cycle architecture. Psychopharmacology, 2009, Volume: 205, Issue:1 Topics: Acetamides; Analysis of Variance; Animals; Behavior, Animal; Central Nervous System Depressants; Circadian Rhythm; Hypnotics and Sedatives; Indenes; Indoles; Melatonin; Pyridines; Rats; Rats, Wistar; Serotonin Antagonists; Sleep; Wakefulness	2009
Molecular cloning and pharmacological characterization of monkey MT1 and MT2 melatonin receptors showing high affinity for the agonist ramelteon. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 330, Issue:3 Topics: Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; DNA; Female; Indenes; Macaca fascicularis; Male; Melatonin; Molecular Sequence Data; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sleep	2009
MT1 melatonin receptors mediate somatic, behavioral, and reproductive neuroendocrine responses to photoperiod and melatonin in Siberian hamsters (Phodopus sungorus). Endocrinology, 2010, Volume: 151, Issue:2 Topics: 5-Methoxytryptamine; Animals; Circadian Rhythm; Cricetinae; Indenes; Male; Melatonin; Motor Activity; Phodopus; Photoperiod; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Seasons; Signal Transduction	2010
Circadian periods of sensitivity for ramelteon on the onset of running-wheel activity and the peak of suprachiasmatic nucleus neuronal firing rhythms in C3H/HeN mice. Chronobiology international, 2011, Volume: 28, Issue:1 Topics: Animals; Circadian Rhythm; Indenes; Male; Melatonin; Mice; Mice, Inbred C3H; Motor Activity; Receptors, Melatonin; Running; Sleep Initiation and Maintenance Disorders; Suprachiasmatic Nucleus	2011
Gender-related invasion differences associated with mRNA expression levels of melatonin membrane receptors in colorectal cancer. Molecular carcinogenesis, 2012, Volume: 51, Issue:8 Topics: Aged; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Dose-Response Relationship, Drug; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Immunoblotting; Indenes; Male; Melatonin; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sex Factors	2012
[Delirium, insomnia in hospitalization and ramelteon]. Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70, Issue:5 Topics: Delirium; Hospitalization; Humans; Indenes; Melatonin; Sleep Initiation and Maintenance Disorders	2012
Circadian system functionality, hippocampal oxidative stress, and spatial memory in the APPswe/PS1dE9 transgenic model of Alzheimer disease: effects of melatonin or ramelteon. Chronobiology international, 2012, Volume: 29, Issue:7 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Body Temperature; Circadian Rhythm; Disease Models, Animal; Hippocampus; Indenes; Male; Melatonin; Memory; Mice; Mice, Transgenic; Motor Activity; Mutant Proteins; Oxidative Stress; Presenilin-1; Receptors, Melatonin	2012
Marked improvement in delirium with ramelteon: five case reports. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2012, Volume: 12, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Circadian Rhythm; Delirium; Female; Humans; Indenes; Male; Melatonin; Treatment Outcome	2012
Melatonin receptor activation suppresses adrenocorticotropin production via BMP-4 action by pituitary AtT20 cells. Molecular and cellular endocrinology, 2013, Aug-15, Volume: 375, Issue:1-2 Topics: Adrenocorticotropic Hormone; Animals; Bone Morphogenetic Protein 4; Cell Line; Corticotrophs; Culture Media, Serum-Free; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression; Humans; Indenes; MAP Kinase Signaling System; Melatonin; Mice; Pituitary Gland; Pro-Opiomelanocortin; Rats; Rats, Wistar; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Smad Proteins	2013
Melatonin receptors mediate improvements of survival in a model of polymicrobial sepsis. Critical care medicine, 2014, Volume: 42, Issue:1 Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Indenes; Interleukin-10; Interleukin-6; Male; Melatonin; Mice; Mice, Inbred C3H; Mice, Knockout; Rats; Rats, Sprague-Dawley; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, Melatonin; Sepsis; Tryptamines; Tumor Necrosis Factor-alpha	2014
Effects of Kaixin Powder on melatonin receptor expression and (125)I-Mel binding affinity in a rat model of depression. Chinese journal of integrative medicine, 2015, Volume: 21, Issue:7 Topics: Animals; Brain; Depression; Disease Models, Animal; Drinking Behavior; Drugs, Chinese Herbal; Gene Expression Regulation; Indenes; Iodine Radioisotopes; Male; Melatonin; Rats, Wistar; Receptors, Melatonin; Weight Gain	2015
[A nationwide survey on the uses of melatonin and ramelteon in Japanese children]. No to hattatsu = Brain and development, 2015, Volume: 47, Issue:1 Topics: Adolescent; Adult; Child; Child, Preschool; Circadian Rhythm; Data Collection; Female; Humans; Indenes; Infant; Japan; Male; Melatonin; Sleep; Sleep Initiation and Maintenance Disorders; Young Adult	2015
Melatonin or ramelteon therapy differentially affects hepatic gene expression profiles after haemorrhagic shock in rat--A microarray analysis. Experimental and molecular pathology, 2015, Volume: 99, Issue:2 Topics: Animals; Antioxidants; Biomarkers, Tumor; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Indenes; Liver; Male; Melatonin; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Shock, Hemorrhagic; Tumor Cells, Cultured	2015
GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Nov-11, Volume: 35, Issue:45 Topics: Animals; Bee Venoms; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Indenes; Male; Melatonin; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Culture Techniques; Potassium Channel Blockers; Suprachiasmatic Nucleus	2015
Melatonin Receptor Agonists as the "Perioceutics" Agents for Periodontal Disease through Modulation of Porphyromonas gingivalis Virulence and Inflammatory Response. PloS one, 2016, Volume: 11, Issue:11 Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Biofilms; Cells, Cultured; Fibroblasts; Gene Expression Regulation, Bacterial; Hemolysis; Humans; Indenes; Interleukin-6; Interleukin-8; Melatonin; Periodontal Diseases; Porphyromonas gingivalis; Receptors, Melatonin; Sheep	2016
Role of Ramelteon in Reduction of As-Needed Antipsychotics in Elderly Patients with Delirium in a General Hospital Setting. Clinical drug investigation, 2017, Volume: 37, Issue:12 Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Delirium; Female; Hospitals, General; Humans; Incidence; Indenes; Male; Melatonin; Retrospective Studies	2017
XFEL structures of the human MT Nature, 2019, Volume: 569, Issue:7755 Topics: Crystallization; Diabetes Mellitus, Type 2; Electrons; Humans; Indenes; Lasers; Ligands; Melatonin; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Structure-Activity Relationship; Substrate Specificity	2019
Structural basis of ligand recognition at the human MT Nature, 2019, Volume: 569, Issue:7755 Topics: Acetamides; Amino Acid Sequence; Antidepressive Agents; Crystallization; Electrons; Humans; Indenes; Lasers; Ligands; Melatonin; Models, Molecular; Molecular Docking Simulation; Mutation; Receptor, Melatonin, MT1; Receptor, Serotonin, 5-HT2C; Structure-Activity Relationship; Substrate Specificity	2019
Do peripheral melatonin agonists improve bone fracture healing? The effects of agomelatine and ramelteon on experimental bone fracture. European journal of pharmacology, 2020, Nov-15, Volume: 887 Topics: Acetamides; Animals; Femoral Fractures; Fracture Healing; Fractures, Bone; Indenes; Male; Melatonin; Osteogenesis; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; X-Rays	2020
Evaluation of Delirium in Critically Ill Patients Prescribed Melatonin or Ramelteon. The Annals of pharmacotherapy, 2021, Volume: 55, Issue:11 Topics: Critical Illness; Delirium; Humans; Hypnotics and Sedatives; Indenes; Intensive Care Units; Melatonin; Respiration, Artificial; Retrospective Studies	2021
Therapeutic potential of melatonin and melatonergic drugs on K18-hACE2 mice infected with SARS-CoV-2. Journal of pineal research, 2022, Volume: 72, Issue:1 Topics: Acetamides; Animals; COVID-19; COVID-19 Drug Treatment; Indenes; Lung; Melatonin; Mice; Mice, Inbred C57BL; Mice, Transgenic; SARS-CoV-2; Viral Load	2022
Structural basis of the ligand binding and signaling mechanism of melatonin receptors. Nature communications, 2022, 01-24, Volume: 13, Issue:1 Topics: Amino Acid Motifs; Cryoelectron Microscopy; Humans; Indenes; Ligands; Melatonin; Protein Binding; Protein Conformation; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2	2022
Ultra-low-dose early night ramelteon administration for the treatment of delayed sleep-wake phase disorder: case reports with a pharmacological review. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2022, 12-01, Volume: 18, Issue:12 Topics: Circadian Rhythm; Humans; Indenes; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Sleep Wake Disorders	2022
Effects of melatonin on phosphorylation of memory-related proteins in the hippocampus and the perirhinal cortex in male mice. Neuroreport, 2023, 06-07, Volume: 34, Issue:9 Topics: Animals; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Male; Melatonin; Mice; Perirhinal Cortex; Phosphorylation	2023
Remote ischemic preconditioning-induced late cardioprotection: possible role of melatonin-mitoKATP-H2S signaling pathway. Acta cirurgica brasileira, 2023, Volume: 38 Topics: Animals; Ischemia; Ischemic Preconditioning; Ischemic Preconditioning, Myocardial; KATP Channels; Melatonin; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Signal Transduction; Tumor Necrosis Factor-alpha	2023
The melatonin agonist ramelteon attenuates bleomycin-induced lung fibrosis by suppressing the NLRP3/TGF-Β1/HMGB1 signaling pathway. Advances in medical sciences, 2023, Volume: 68, Issue:2 Topics: Animals; Bleomycin; HMGB1 Protein; Lung; Melatonin; NLR Family, Pyrin Domain-Containing 3 Protein; Pulmonary Fibrosis; Rats; Signal Transduction; Transforming Growth Factor beta1	2023
Green synthesis, characterization of melatonin-like drug bioconjugated CoS quantum dots and its antiproliferative effect on different cancer cells. Molecular biology reports, 2023, Volume: 50, Issue:11 Topics: Cell Line, Tumor; Humans; Male; Melatonin; Neuroblastoma; Prostatic Neoplasms; Quantum Dots	2023