melatonin has been researched along with morphine in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (17.95) | 18.7374 |
| 1990's | 6 (15.38) | 18.2507 |
| 2000's | 12 (30.77) | 29.6817 |
| 2010's | 8 (20.51) | 24.3611 |
| 2020's | 6 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, ZQ; Ying, SW | 1 |
| Brown, GM; Grota, LJ; Psarakis, S | 1 |
| Gosnell, BA; Levine, AS; Morley, JE; Waggoner, DW | 1 |
| Esposti, D; Esposti, G; Fraschini, F; Lissoni, P; Parravicini, L | 1 |
| Larin, F; Shein, HM; Wurtman, RJ | 1 |
| Hirst, M; Kavaliers, M; Podesta, RB; Young, B | 1 |
| Hirst, M; Kavaliers, M; Teskey, GC | 1 |
| Lakin, ML; Miller, CH; Stott, ML; Winters, WD | 1 |
| Ikemoto, S; Nelson, E; Panksepp, J | 1 |
| Chetsawang, B; Ebadi, M; Govitrapong, P; Jitaijamjang, W; Phansuwan-Pujito, P | 1 |
| Kulkarni, SK; Raghavendra, V | 2 |
| Gold, SJ; Lerner, MR; Nestler, EJ; Potenza, MN; Roby-Shemkowitz, A | 1 |
| Brivio, F; Lissoni, P; Mandalà, M | 1 |
| Kang, L; Qiu, X; Qiu, Y | 1 |
| Pang, CS; Tsang, SF; Yang, JC | 1 |
| Li, JC; Zhang, RD; Zou, D | 1 |
| Chetsawang, B; Govitrapong, P | 1 |
| Cadet, P | 1 |
| Dehpour, AR; Ghahremani, MH; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N | 2 |
| Dehpour, AR; Ghahremani, MH; Riazi, K; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N | 1 |
| Han, J; Shen, J; Wei, YM; Xu, Y; Yu, CX | 1 |
| Caumo, W; Hidalgo, MP; Levandovski, R | 1 |
| Han, J; Wei, YM; Xu, Y; Yu, CX | 1 |
| Jiang, WG; Kosten, TR; Le Foll, B; Li, SX; Liu, LJ; Lu, L; Sun, LL; Zhang, XY; Zhou, SJ | 1 |
| Feng, YM; Jia, YF; Lv, L; Su, LY; Wang, D; Xu, L; Yao, YG | 1 |
| Song, L; Wu, C; Zuo, Y | 1 |
| Bakhtazad, A; Garmabi, B; Vosough, M; Vousooghi, N; Yoonessi, A; Zarrindast, MR | 1 |
| Huang, YN; Kao, JH; Lin, SH; Tien, LT; Tsai, RY; Wong, CS | 1 |
| Caumo, W; Deitos, A; Laste, G; Macedo, IC; Oliveira, C; Rozisky, JR; Scarabelot, VL; Torres, IL | 1 |
| Fan, Y; Liang, X; Song, L; Wang, R | 1 |
| Chen, IJ; Cheng, YC; Mao, YY; Sung, YT; Tsai, RY; Tu, TY; Wong, CS | 1 |
| Jiao, L; Liu, Q; Luo, R; Miao, Y; Su, LY; Sun, C; Xiong, W; Xu, M; Xue, T; Yao, YG; Zheng, P; Zhou, R; Zuo, X | 1 |
| Dehdashtian, E; Fatemi, I; Hemati, K; Hosseinzadeh, A; Mehrzadi, S; Pourhanifeh, MH; Reiter, RJ | 1 |
| Jiao, L; Liu, Q; Su, LY; Yao, YG | 1 |
| Alghamdi, BS; Alshehri, AA; Alshehri, FS; Althobaiti, YS; Hakami, AY | 1 |
| De, A; Grasing, KW | 1 |
| Eulenburg, V; Gao, F; Jia, X; Ju, J; Li, Z; Peng, X; Wang, J; Zhang, A | 1 |
2 review(s) available for melatonin and morphine
| Article | Year |
|---|---|
Melatonin and morphine: potential beneficial effects of co-use.
Topics: Analgesics; Arachidonate 5-Lipoxygenase; Calcium; Drug Tolerance; Humans; Hyperalgesia; Melatonin; Morphine | 2021 |
Molecular Mechanism of Neuroprotective Effect of Melatonin on Morphine Addiction and Analgesic Tolerance: an Update.
Topics: Autophagy; Drug Tolerance; Humans; Melatonin; Mitochondria; Morphine; Morphine Dependence; Neuroprotective Agents; Pain Measurement | 2021 |
2 trial(s) available for melatonin and morphine
| Article | Year |
|---|---|
Abrogation of the negative influence of opioids on IL-2 immunotherapy of renal cell cancer by melatonin.
Topics: Adjuvants, Immunologic; Adult; Analgesics, Opioid; Carcinoma, Renal Cell; Female; Follow-Up Studies; Humans; Immunotherapy; Interleukin-2; Kidney Neoplasms; Male; Melatonin; Middle Aged; Morphine | 2000 |
Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study.
Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anxiety; Central Nervous System Depressants; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hysterectomy; Melatonin; Middle Aged; Morphine; Pain Measurement; Pain Threshold; Pain, Postoperative; Placebos; Preoperative Care; Treatment Outcome; Young Adult | 2009 |
35 other study(ies) available for melatonin and morphine
| Article | Year |
|---|---|
[Effects of the pineal body and melatonin on sensitivity to pain in mice].
Topics: Animals; Circadian Rhythm; Female; Melatonin; Meperidine; Mice; Morphine; Pain; Pineal Gland; Sensory Thresholds | 1990 |
Analgesia induced by N-acetylserotonin in the central nervous system.
Topics: Analgesia; Animals; Cerebral Ventricles; Immune Sera; Injections, Intraperitoneal; Injections, Intraventricular; Male; Melatonin; Morphine; Naloxone; Pain Measurement; Palliative Care; Rats; Rats, Inbred Strains; Serotonin | 1988 |
The pineal gland and opiate-induced feeding.
Topics: Animals; Butorphanol; Cyclazocine; Endorphins; Ethylketocyclazocine; Feeding Behavior; Male; Melatonin; Morphine; Naloxone; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Action of morphine on melatonin release in the rat.
Topics: Animals; Male; Melatonin; Morphine; Naloxone; Pineal Gland; Rats; Rats, Inbred Strains | 1988 |
Lack of a direct effect of morphine on the synthesis of pineal 14-C-indoles in organ culture.
Topics: Animals; Carbon Isotopes; Culture Techniques; Female; Melatonin; Morphine; Norepinephrine; Organ Culture Techniques; Pineal Gland; Protein Biosynthesis; Rats; Serotonin; Tryptophan | 1970 |
Evidence for the activation of the endogenous opiate system in hamsters infected with human blood flukes, Schistosoma mansoni.
Topics: Analgesia; Animals; Body Temperature; Cricetinae; Kinetics; Male; Melatonin; Mesocricetus; Morphine; Naloxone; Pineal Gland; Receptors, Opioid; Schistosoma mansoni; Schistosomiasis; Time Factors | 1984 |
Ageing, opioid analgesia and the pineal gland.
Topics: Aging; Analgesia; Animals; Benserazide; Circadian Rhythm; Endorphins; Latency Period, Psychological; Male; Melatonin; Mice; Morphine; Naloxone; Photic Stimulation; Pineal Gland | 1983 |
Involvement of the pineal gland and melatonin in murine analgesia.
Topics: Analgesia; Animals; Circadian Rhythm; Dose-Response Relationship, Drug; Male; Melatonin; Mice; Morphine; Naloxone; Pineal Gland; Reaction Time; Time Factors | 1981 |
The effects of melatonin on isolation distress in chickens.
Topics: Animals; Chickens; Dextroamphetamine; Melatonin; Morphine; Naloxone; Pineal Gland; Social Isolation; Vocalization, Animal | 1994 |
Existence and function of opioid receptors on mammalian pinealocytes.
Topics: Animals; Arylamine N-Acetyltransferase; Binding Sites; Cattle; Cells, Cultured; Diprenorphine; Male; Melatonin; Morphine; Narcotic Antagonists; Pineal Gland; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1998 |
Reversal of morphine tolerance and dependence by melatonin: possible role of central and peripheral benzodiazepine receptors.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Female; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Melatonin; Mice; Mice, Inbred BALB C; Morphine; Morphine Dependence; Narcotics; Receptors, GABA-A | 1999 |
Effects of regulators of G protein-signaling proteins on the functional response of the mu-opioid receptor in a melanophore-based assay.
Topics: Animals; Cells, Cultured; Fibroblasts; Melanophores; Melatonin; Morphine; Pigments, Biological; Plasmids; Protein Sorting Signals; Receptors, Opioid, mu; RGS Proteins; Time Factors; Transfection; Xenopus | 1999 |
[The inhibitory effect of melatonin on morphine withdrawal syndromes and serum monoamines in morphine dependent mice].
Topics: Animals; Dopamine; Male; Melatonin; Mice; Morphine; Morphine Dependence; Norepinephrine; Substance Withdrawal Syndrome | 1998 |
Possible mechanisms of action in melatonin reversal of morphine tolerance and dependence in mice.
Topics: Animals; Anticonvulsants; Arginine; Drug Tolerance; Enzyme Inhibitors; Male; Melatonin; Metallothionein 3; Mice; Mice, Inbred BALB C; Morphine; Morphine Dependence; Narcotics; NG-Nitroarginine Methyl Ester; Pain Measurement | 2000 |
Effects of melatonin, morphine and diazepam on formalin-induced nociception in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Diazepam; Drug Synergism; Drug Therapy, Combination; Hypnotics and Sedatives; Male; Melatonin; Mice; Mice, Inbred ICR; Morphine; Nociceptors; Pain Measurement | 2001 |
[Effect of atropine on the inhibition of melatonin to the unit discharges evoked in the posterior group of thalamic nuclei in cats].
Topics: Analgesics; Animals; Atropine; Cats; Electric Stimulation; Evoked Potentials; Female; Injections, Intraventricular; Male; Melatonin; Morphine; Muscarinic Antagonists; Neurons; Splanchnic Nerves; Thalamic Nuclei | 2003 |
Stimulatory effect of morphine on rat pineal melatonin synthesis via a cyclic AMP-dependent transcription pathway.
Topics: Animals; Cyclic AMP; Melatonin; Morphine; Pineal Gland; Rats; Receptors, Opioid; RNA, Messenger; Transcription, Genetic | 2005 |
Morphine and neuro-endocrine function.
Topics: Animals; Humans; Melatonin; Morphine; Neurosecretory Systems | 2005 |
Effect of light/dark cycle alteration on morphine-induced conditioned place preference.
Topics: Animals; Antioxidants; Circadian Rhythm; Conditioning, Operant; Darkness; Light; Male; Melatonin; Mice; Morphine; Narcotics; Photoperiod; Reward | 2005 |
Melatonin enhances the rewarding properties of morphine: involvement of the nitric oxidergic pathway.
Topics: Animals; Conditioning, Psychological; Drug Synergism; Enzyme Inhibitors; Male; Melatonin; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Reward | 2007 |
Melatonin enhances the anticonvulsant and proconvulsant effects of morphine in mice: role for nitric oxide signaling pathway.
Topics: Animals; Anticonvulsants; Antioxidants; Convulsants; Dose-Response Relationship, Drug; Electric Stimulation; Male; Melatonin; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Seizures; Signal Transduction | 2007 |
Melatonin reverses the expression of morphine-induced conditioned place preference through its receptors within central nervous system in mice.
Topics: Animals; Central Nervous System; Conditioning, Operant; Dose-Response Relationship, Drug; Indoles; Injections, Intraperitoneal; Injections, Intraventricular; Male; Melatonin; Mice; Morphine; Morphine Dependence; Narcotic Antagonists; Narcotics; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Tryptamines | 2008 |
Melatonin enhances the expression of β-endorphin in hypothalamic arcuate nucleus of morphine-dependent mice.
Topics: Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Male; Melatonin; Mice; Morphine; Morphine Dependence; Naloxone; Pro-Opiomelanocortin; RNA, Messenger; Substance Withdrawal Syndrome | 2009 |
Circadian alteration in neurobiology during protracted opiate withdrawal in rats.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; beta-Endorphin; Brain; Circadian Rhythm; Disease Models, Animal; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Male; Maze Learning; Melatonin; Morphine; Neurobiology; Neuropeptides; Orexins; Period Circadian Proteins; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Time Factors | 2010 |
Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin.
Topics: Analgesics; Animals; Autophagy; Behavior, Animal; Cells, Cultured; Dendrites; DNA, Mitochondrial; Gene Dosage; Heroin; Hippocampus; Humans; Male; Melatonin; Mice; Mitochondria; Models, Biological; Morphine; Neurons; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2013 |
Melatonin prevents morphine-induced hyperalgesia and tolerance in rats: role of protein kinase C and N-methyl-D-aspartate receptors.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Hyperalgesia; Male; Melatonin; Morphine; Pain Measurement; Protein Kinase C; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2015 |
Effect of circadian rhythm disturbance on morphine preference and addiction in male rats: Involvement of period genes and dopamine D1 receptor.
Topics: Animals; Circadian Rhythm; Corpus Striatum; Disease Models, Animal; Male; Melatonin; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Period Circadian Proteins; Photic Stimulation; Prefrontal Cortex; Rats, Wistar; Receptors, Dopamine D1; RNA, Messenger; Substance Withdrawal Syndrome | 2016 |
Melatonin reverses morphine tolerance by inhibiting microglia activation and HSP27 expression.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Gene Expression Regulation; HSP27 Heat-Shock Proteins; Injections, Spinal; Macrophage Activation; Male; Melatonin; Microglia; Morphine; Pain Measurement; Rats; Rats, Wistar; Up-Regulation | 2016 |
Melatonin as a potential counter-effect of hyperalgesia induced by neonatal morphine exposure.
Topics: Analgesics, Non-Narcotic; Animals; Animals, Newborn; Hyperalgesia; Male; Melatonin; Morphine; Narcotics; Rats, Wistar | 2016 |
Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Drug Tolerance; Hyperalgesia; Male; Melatonin; Morphine; Pain; Pain Management; Pain Measurement; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Melatonin; Receptors, Opioid, mu; Spinal Cord; Spinal Cord Dorsal Horn | 2017 |
Melatonin regulation of transcription in the reversal of morphine tolerance: Microarray analysis of differential gene expression.
Topics: Analgesics, Opioid; Animals; Central Nervous System Depressants; Down-Regulation; Drug Interactions; Drug Tolerance; Injections, Spinal; Male; Melatonin; Microarray Analysis; Molecular Targeted Therapy; Morphine; Rats; Rats, Wistar; Transcription, Genetic; Up-Regulation | 2019 |
Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation.
Topics: Analgesics; Animals; Humans; Inflammasomes; Melatonin; Mice; Morphine; NLR Family, Pyrin Domain-Containing 3 Protein | 2020 |
Melatonin attenuates morphine-induced conditioned place preference in Wistar rats.
Topics: Analgesics, Opioid; Animals; Conditioning, Classical; Male; Melatonin; Morphine; Rats; Rats, Wistar | 2021 |
The antidepressant agomelatine attenuates morphine-induced reinstatement but not self-administration or precipitated withdrawal.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Male; Melatonin; Morphine; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2023 |
Toll-like Receptor 2-Melatonin Feedback Loop Regulates the Activation of Spinal NLRP3 Inflammasome in Morphine-Tolerant Rats.
Topics: Analgesics; Animals; Feedback; Inflammasomes; Melatonin; Microglia; Morphine; Neuroinflammatory Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; NLR Proteins; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 2 | 2023 |