melatonin and morphine

melatonin has been researched along with morphine in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19907 (17.95)18.7374
1990's6 (15.38)18.2507
2000's12 (30.77)29.6817
2010's8 (20.51)24.3611
2020's6 (15.38)2.80

Authors

AuthorsStudies
Huang, ZQ; Ying, SW1
Brown, GM; Grota, LJ; Psarakis, S1
Gosnell, BA; Levine, AS; Morley, JE; Waggoner, DW1
Esposti, D; Esposti, G; Fraschini, F; Lissoni, P; Parravicini, L1
Larin, F; Shein, HM; Wurtman, RJ1
Hirst, M; Kavaliers, M; Podesta, RB; Young, B1
Hirst, M; Kavaliers, M; Teskey, GC1
Lakin, ML; Miller, CH; Stott, ML; Winters, WD1
Ikemoto, S; Nelson, E; Panksepp, J1
Chetsawang, B; Ebadi, M; Govitrapong, P; Jitaijamjang, W; Phansuwan-Pujito, P1
Kulkarni, SK; Raghavendra, V2
Gold, SJ; Lerner, MR; Nestler, EJ; Potenza, MN; Roby-Shemkowitz, A1
Brivio, F; Lissoni, P; Mandalà, M1
Kang, L; Qiu, X; Qiu, Y1
Pang, CS; Tsang, SF; Yang, JC1
Li, JC; Zhang, RD; Zou, D1
Chetsawang, B; Govitrapong, P1
Cadet, P1
Dehpour, AR; Ghahremani, MH; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N2
Dehpour, AR; Ghahremani, MH; Riazi, K; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N1
Han, J; Shen, J; Wei, YM; Xu, Y; Yu, CX1
Caumo, W; Hidalgo, MP; Levandovski, R1
Han, J; Wei, YM; Xu, Y; Yu, CX1
Jiang, WG; Kosten, TR; Le Foll, B; Li, SX; Liu, LJ; Lu, L; Sun, LL; Zhang, XY; Zhou, SJ1
Feng, YM; Jia, YF; Lv, L; Su, LY; Wang, D; Xu, L; Yao, YG1
Song, L; Wu, C; Zuo, Y1
Bakhtazad, A; Garmabi, B; Vosough, M; Vousooghi, N; Yoonessi, A; Zarrindast, MR1
Huang, YN; Kao, JH; Lin, SH; Tien, LT; Tsai, RY; Wong, CS1
Caumo, W; Deitos, A; Laste, G; Macedo, IC; Oliveira, C; Rozisky, JR; Scarabelot, VL; Torres, IL1
Fan, Y; Liang, X; Song, L; Wang, R1
Chen, IJ; Cheng, YC; Mao, YY; Sung, YT; Tsai, RY; Tu, TY; Wong, CS1
Jiao, L; Liu, Q; Luo, R; Miao, Y; Su, LY; Sun, C; Xiong, W; Xu, M; Xue, T; Yao, YG; Zheng, P; Zhou, R; Zuo, X1
Dehdashtian, E; Fatemi, I; Hemati, K; Hosseinzadeh, A; Mehrzadi, S; Pourhanifeh, MH; Reiter, RJ1
Jiao, L; Liu, Q; Su, LY; Yao, YG1
Alghamdi, BS; Alshehri, AA; Alshehri, FS; Althobaiti, YS; Hakami, AY1
De, A; Grasing, KW1
Eulenburg, V; Gao, F; Jia, X; Ju, J; Li, Z; Peng, X; Wang, J; Zhang, A1

Reviews

2 review(s) available for melatonin and morphine

ArticleYear
Melatonin and morphine: potential beneficial effects of co-use.
    Fundamental & clinical pharmacology, 2021, Volume: 35, Issue:1

    Topics: Analgesics; Arachidonate 5-Lipoxygenase; Calcium; Drug Tolerance; Humans; Hyperalgesia; Melatonin; Morphine

2021
Molecular Mechanism of Neuroprotective Effect of Melatonin on Morphine Addiction and Analgesic Tolerance: an Update.
    Molecular neurobiology, 2021, Volume: 58, Issue:9

    Topics: Autophagy; Drug Tolerance; Humans; Melatonin; Mitochondria; Morphine; Morphine Dependence; Neuroprotective Agents; Pain Measurement

2021

Trials

2 trial(s) available for melatonin and morphine

ArticleYear
Abrogation of the negative influence of opioids on IL-2 immunotherapy of renal cell cancer by melatonin.
    European urology, 2000, Volume: 38, Issue:1

    Topics: Adjuvants, Immunologic; Adult; Analgesics, Opioid; Carcinoma, Renal Cell; Female; Follow-Up Studies; Humans; Immunotherapy; Interleukin-2; Kidney Neoplasms; Male; Melatonin; Middle Aged; Morphine

2000
Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study.
    The journal of pain, 2009, Volume: 10, Issue:1

    Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Analysis of Variance; Anxiety; Central Nervous System Depressants; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hysterectomy; Melatonin; Middle Aged; Morphine; Pain Measurement; Pain Threshold; Pain, Postoperative; Placebos; Preoperative Care; Treatment Outcome; Young Adult

2009

Other Studies

35 other study(ies) available for melatonin and morphine

ArticleYear
[Effects of the pineal body and melatonin on sensitivity to pain in mice].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:5

    Topics: Animals; Circadian Rhythm; Female; Melatonin; Meperidine; Mice; Morphine; Pain; Pineal Gland; Sensory Thresholds

1990
Analgesia induced by N-acetylserotonin in the central nervous system.
    Life sciences, 1988, Volume: 42, Issue:10

    Topics: Analgesia; Animals; Cerebral Ventricles; Immune Sera; Injections, Intraperitoneal; Injections, Intraventricular; Male; Melatonin; Morphine; Naloxone; Pain Measurement; Palliative Care; Rats; Rats, Inbred Strains; Serotonin

1988
The pineal gland and opiate-induced feeding.
    Physiology & behavior, 1985, Volume: 34, Issue:1

    Topics: Animals; Butorphanol; Cyclazocine; Endorphins; Ethylketocyclazocine; Feeding Behavior; Male; Melatonin; Morphine; Naloxone; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa

1985
Action of morphine on melatonin release in the rat.
    Journal of pineal research, 1988, Volume: 5, Issue:1

    Topics: Animals; Male; Melatonin; Morphine; Naloxone; Pineal Gland; Rats; Rats, Inbred Strains

1988
Lack of a direct effect of morphine on the synthesis of pineal 14-C-indoles in organ culture.
    Life sciences, 1970, Jan-01, Volume: 9, Issue:1

    Topics: Animals; Carbon Isotopes; Culture Techniques; Female; Melatonin; Morphine; Norepinephrine; Organ Culture Techniques; Pineal Gland; Protein Biosynthesis; Rats; Serotonin; Tryptophan

1970
Evidence for the activation of the endogenous opiate system in hamsters infected with human blood flukes, Schistosoma mansoni.
    Life sciences, 1984, Dec-03, Volume: 35, Issue:23

    Topics: Analgesia; Animals; Body Temperature; Cricetinae; Kinetics; Male; Melatonin; Mesocricetus; Morphine; Naloxone; Pineal Gland; Receptors, Opioid; Schistosoma mansoni; Schistosomiasis; Time Factors

1984
Ageing, opioid analgesia and the pineal gland.
    Life sciences, 1983, May-09, Volume: 32, Issue:19

    Topics: Aging; Analgesia; Animals; Benserazide; Circadian Rhythm; Endorphins; Latency Period, Psychological; Male; Melatonin; Mice; Morphine; Naloxone; Photic Stimulation; Pineal Gland

1983
Involvement of the pineal gland and melatonin in murine analgesia.
    Life sciences, 1981, Dec-14, Volume: 29, Issue:24

    Topics: Analgesia; Animals; Circadian Rhythm; Dose-Response Relationship, Drug; Male; Melatonin; Mice; Morphine; Naloxone; Pineal Gland; Reaction Time; Time Factors

1981
The effects of melatonin on isolation distress in chickens.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:2

    Topics: Animals; Chickens; Dextroamphetamine; Melatonin; Morphine; Naloxone; Pineal Gland; Social Isolation; Vocalization, Animal

1994
Existence and function of opioid receptors on mammalian pinealocytes.
    Journal of pineal research, 1998, Volume: 24, Issue:4

    Topics: Animals; Arylamine N-Acetyltransferase; Binding Sites; Cattle; Cells, Cultured; Diprenorphine; Male; Melatonin; Morphine; Narcotic Antagonists; Pineal Gland; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid

1998
Reversal of morphine tolerance and dependence by melatonin: possible role of central and peripheral benzodiazepine receptors.
    Brain research, 1999, Jul-10, Volume: 834, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Female; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Isoquinolines; Melatonin; Mice; Mice, Inbred BALB C; Morphine; Morphine Dependence; Narcotics; Receptors, GABA-A

1999
Effects of regulators of G protein-signaling proteins on the functional response of the mu-opioid receptor in a melanophore-based assay.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2

    Topics: Animals; Cells, Cultured; Fibroblasts; Melanophores; Melatonin; Morphine; Pigments, Biological; Plasmids; Protein Sorting Signals; Receptors, Opioid, mu; RGS Proteins; Time Factors; Transfection; Xenopus

1999
[The inhibitory effect of melatonin on morphine withdrawal syndromes and serum monoamines in morphine dependent mice].
    Zhonghua yi xue za zhi, 1998, Volume: 78, Issue:9

    Topics: Animals; Dopamine; Male; Melatonin; Mice; Morphine; Morphine Dependence; Norepinephrine; Substance Withdrawal Syndrome

1998
Possible mechanisms of action in melatonin reversal of morphine tolerance and dependence in mice.
    European journal of pharmacology, 2000, Dec-15, Volume: 409, Issue:3

    Topics: Animals; Anticonvulsants; Arginine; Drug Tolerance; Enzyme Inhibitors; Male; Melatonin; Metallothionein 3; Mice; Mice, Inbred BALB C; Morphine; Morphine Dependence; Narcotics; NG-Nitroarginine Methyl Ester; Pain Measurement

2000
Effects of melatonin, morphine and diazepam on formalin-induced nociception in mice.
    Life sciences, 2001, Jan-12, Volume: 68, Issue:8

    Topics: Analgesics; Analgesics, Opioid; Animals; Diazepam; Drug Synergism; Drug Therapy, Combination; Hypnotics and Sedatives; Male; Melatonin; Mice; Mice, Inbred ICR; Morphine; Nociceptors; Pain Measurement

2001
[Effect of atropine on the inhibition of melatonin to the unit discharges evoked in the posterior group of thalamic nuclei in cats].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2003, Volume: 38, Issue:3

    Topics: Analgesics; Animals; Atropine; Cats; Electric Stimulation; Evoked Potentials; Female; Injections, Intraventricular; Male; Melatonin; Morphine; Muscarinic Antagonists; Neurons; Splanchnic Nerves; Thalamic Nuclei

2003
Stimulatory effect of morphine on rat pineal melatonin synthesis via a cyclic AMP-dependent transcription pathway.
    Neuroscience letters, 2005, Nov-25, Volume: 389, Issue:1

    Topics: Animals; Cyclic AMP; Melatonin; Morphine; Pineal Gland; Rats; Receptors, Opioid; RNA, Messenger; Transcription, Genetic

2005
Morphine and neuro-endocrine function.
    Medical science monitor : international medical journal of experimental and clinical research, 2005, Volume: 11, Issue:9

    Topics: Animals; Humans; Melatonin; Morphine; Neurosecretory Systems

2005
Effect of light/dark cycle alteration on morphine-induced conditioned place preference.
    Neuroreport, 2005, Dec-19, Volume: 16, Issue:18

    Topics: Animals; Antioxidants; Circadian Rhythm; Conditioning, Operant; Darkness; Light; Male; Melatonin; Mice; Morphine; Narcotics; Photoperiod; Reward

2005
Melatonin enhances the rewarding properties of morphine: involvement of the nitric oxidergic pathway.
    Journal of pineal research, 2007, Volume: 42, Issue:4

    Topics: Animals; Conditioning, Psychological; Drug Synergism; Enzyme Inhibitors; Male; Melatonin; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Reward

2007
Melatonin enhances the anticonvulsant and proconvulsant effects of morphine in mice: role for nitric oxide signaling pathway.
    Epilepsy research, 2007, Volume: 75, Issue:2-3

    Topics: Animals; Anticonvulsants; Antioxidants; Convulsants; Dose-Response Relationship, Drug; Electric Stimulation; Male; Melatonin; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Seizures; Signal Transduction

2007
Melatonin reverses the expression of morphine-induced conditioned place preference through its receptors within central nervous system in mice.
    European journal of pharmacology, 2008, Oct-10, Volume: 594, Issue:1-3

    Topics: Animals; Central Nervous System; Conditioning, Operant; Dose-Response Relationship, Drug; Indoles; Injections, Intraperitoneal; Injections, Intraventricular; Male; Melatonin; Mice; Morphine; Morphine Dependence; Narcotic Antagonists; Narcotics; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Tryptamines

2008
Melatonin enhances the expression of β-endorphin in hypothalamic arcuate nucleus of morphine-dependent mice.
    Sheng li xue bao : [Acta physiologica Sinica], 2009, Jun-25, Volume: 61, Issue:3

    Topics: Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Male; Melatonin; Mice; Morphine; Morphine Dependence; Naloxone; Pro-Opiomelanocortin; RNA, Messenger; Substance Withdrawal Syndrome

2009
Circadian alteration in neurobiology during protracted opiate withdrawal in rats.
    Journal of neurochemistry, 2010, Volume: 115, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; beta-Endorphin; Brain; Circadian Rhythm; Disease Models, Animal; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Male; Maze Learning; Melatonin; Morphine; Neurobiology; Neuropeptides; Orexins; Period Circadian Proteins; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Time Factors

2010
Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin.
    Autophagy, 2013, Volume: 9, Issue:9

    Topics: Analgesics; Animals; Autophagy; Behavior, Animal; Cells, Cultured; Dendrites; DNA, Mitochondrial; Gene Dosage; Heroin; Hippocampus; Humans; Male; Melatonin; Mice; Mitochondria; Models, Biological; Morphine; Neurons; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome

2013
Melatonin prevents morphine-induced hyperalgesia and tolerance in rats: role of protein kinase C and N-methyl-D-aspartate receptors.
    BMC anesthesiology, 2015, Volume: 15

    Topics: Analgesics, Opioid; Animals; Drug Tolerance; Hyperalgesia; Male; Melatonin; Morphine; Pain Measurement; Protein Kinase C; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord

2015
Effect of circadian rhythm disturbance on morphine preference and addiction in male rats: Involvement of period genes and dopamine D1 receptor.
    Neuroscience, 2016, May-13, Volume: 322

    Topics: Animals; Circadian Rhythm; Corpus Striatum; Disease Models, Animal; Male; Melatonin; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Period Circadian Proteins; Photic Stimulation; Prefrontal Cortex; Rats, Wistar; Receptors, Dopamine D1; RNA, Messenger; Substance Withdrawal Syndrome

2016
Melatonin reverses morphine tolerance by inhibiting microglia activation and HSP27 expression.
    Life sciences, 2016, May-01, Volume: 152

    Topics: Analgesics, Opioid; Animals; Drug Tolerance; Gene Expression Regulation; HSP27 Heat-Shock Proteins; Injections, Spinal; Macrophage Activation; Male; Melatonin; Microglia; Morphine; Pain Measurement; Rats; Rats, Wistar; Up-Regulation

2016
Melatonin as a potential counter-effect of hyperalgesia induced by neonatal morphine exposure.
    Neuroscience letters, 2016, 10-28, Volume: 633

    Topics: Analgesics, Non-Narcotic; Animals; Animals, Newborn; Hyperalgesia; Male; Melatonin; Morphine; Narcotics; Rats, Wistar

2016
Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats.
    Brain research bulletin, 2017, Volume: 135

    Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Drug Tolerance; Hyperalgesia; Male; Melatonin; Morphine; Pain; Pain Management; Pain Measurement; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Melatonin; Receptors, Opioid, mu; Spinal Cord; Spinal Cord Dorsal Horn

2017
Melatonin regulation of transcription in the reversal of morphine tolerance: Microarray analysis of differential gene expression.
    International journal of molecular medicine, 2019, Volume: 43, Issue:2

    Topics: Analgesics, Opioid; Animals; Central Nervous System Depressants; Down-Regulation; Drug Interactions; Drug Tolerance; Injections, Spinal; Male; Melatonin; Microarray Analysis; Molecular Targeted Therapy; Morphine; Rats; Rats, Wistar; Transcription, Genetic; Up-Regulation

2019
Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation.
    Redox biology, 2020, Volume: 34

    Topics: Analgesics; Animals; Humans; Inflammasomes; Melatonin; Mice; Morphine; NLR Family, Pyrin Domain-Containing 3 Protein

2020
Melatonin attenuates morphine-induced conditioned place preference in Wistar rats.
    Brain and behavior, 2021, Volume: 11, Issue:12

    Topics: Analgesics, Opioid; Animals; Conditioning, Classical; Male; Melatonin; Morphine; Rats; Rats, Wistar

2021
The antidepressant agomelatine attenuates morphine-induced reinstatement but not self-administration or precipitated withdrawal.
    Pharmacology, biochemistry, and behavior, 2023, Volume: 223

    Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Male; Melatonin; Morphine; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Substance Withdrawal Syndrome

2023
Toll-like Receptor 2-Melatonin Feedback Loop Regulates the Activation of Spinal NLRP3 Inflammasome in Morphine-Tolerant Rats.
    Neurochemical research, 2023, Volume: 48, Issue:12

    Topics: Analgesics; Animals; Feedback; Inflammasomes; Melatonin; Microglia; Morphine; Neuroinflammatory Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; NLR Proteins; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 2

2023