melatonin has been researched along with methotrexate in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.33) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 11 (45.83) | 24.3611 |
| 2020's | 4 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Cha, SH; Endou, H; Kanai, Y; Kojima, R; Kusuhara, H; Sekine, T; Sugiyama, Y; Tsuda, M; Utsunomiya-Tate, N | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Barni, S; Crispino, S; Esposti, D; Esposti, G; Ferri, L; Fumagalli, G; Lissoni, P; Paolorossi, F; Rovelli, F; Tancini, G | 1 |
| Aherne, W; Arendt, J; English, J; Marks, V | 1 |
| Kajdaniuk, D; Marek, B | 1 |
| Kajdaniuk, D; Kos-Kudla, B; Marek, B | 1 |
| Cevik, H; Jahovic, N; Sehirli, AO; Sener, G; Yeğen, BC | 1 |
| Karasek, M; Kunert-Radek, J; Lawnicka, H; Pawlikowski, M; Winczyk, K | 1 |
| Badgwell, C; Rosen, T | 1 |
| Abraham, P; Kolli, VK; Rabi, S | 1 |
| Abraham, P; Isaac, B; Kasthuri, N; Kolli, VK | 1 |
| Abraham, P; Faith, M; Isaac, B; Kanakasabapathy, I; Kolli, VK; Natarajan, K; Ramamoorthy, H | 1 |
| Wang, YP; Yang, ZP | 1 |
| Aksoy, N; Kocarslan, S; Oguz, E; Sezen, H; Tabur, S; Yilmaz, Z | 1 |
| Wang, H; Wang, Y; Zhao, HY; Zhao, TT | 1 |
| Aranarochana, A; Chaisawang, P; Krutsri, S; Pannangrong, W; Sirichoat, A; Suwannakot, K; Welbat, JU; Wigmore, P | 1 |
| Chen, YC; Hsiao, CC; Hsu, MH; Huang, LT; Sheen, JM; Wang, SC | 1 |
| Accardi, G; Aiello, A | 1 |
| Abdel-Raheem, IT; Ghoneim, AI; Khatab, LA | 1 |
| Aranarochana, A; Naewla, S; Pannangrong, W; Sirichoat, A; Sritawan, N; Suwannakot, K; Welbat, JU; Wigmore, P | 1 |
| Chen, YC; Hsiao, CC; Hsieh, HY; Huang, LT; Huang, YC; Lo, WS; Sheen, JM; Wang, SC | 1 |
2 review(s) available for melatonin and methotrexate
| Article | Year |
|---|---|
Chronopharmacology.
Topics: Adrenal Cortex Hormones; Animals; Circadian Rhythm; Humans; Kinetics; Melatonin; Methotrexate; Methylprednisolone; Pharmaceutical Preparations; Prednisolone; Toxicology | 1985 |
Cutaneous sarcoidosis therapy updated.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Allopurinol; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antigen Presentation; Antimalarials; Chlorambucil; Contraindications; Cyclosporine; Cytokines; Dermatologic Agents; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Infliximab; Isoxazoles; Laser Therapy; Leflunomide; Male; Melatonin; Methotrexate; Models, Immunological; Pentoxifylline; Pregnancy; Pregnancy Complications; Sarcoidosis; Skin Diseases; Tetracyclines; Th1 Cells; Thalidomide | 2007 |
22 other study(ies) available for melatonin and methotrexate
| Article | Year |
|---|---|
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain.
Topics: Amino Acid Sequence; Animals; Brain; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Estrone; Molecular Sequence Data; Ochratoxins; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis | 1999 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Acute effects of various chemotherapeutic combinations on hypophyseal and pineal hormone secretions in cancer patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; beta-Endorphin; Cisplatin; Cyclophosphamide; Doxorubicin; Endorphins; Epirubicin; Female; Fluorouracil; Humans; Hydrocortisone; Male; Melatonin; Methotrexate; Neoplasms; Pineal Gland; Pituitary Gland, Anterior; Pituitary Hormones, Anterior; Secretory Rate; Vincristine | 1987 |
Influence of adjuvant chemotherapy with cyclophosphamide, methotrexate and 5-fluorouracil on plasma insulin-like growth factor-I and chosen hormones in breast cancer pre-menopausal patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Estradiol; Female; Fluorouracil; Humans; Hydrocortisone; Insulin-Like Growth Factor I; Melatonin; Methotrexate; Middle Aged; Premenopause; Progesterone; Prolactin | 2000 |
Influence of adjuvant chemotherapy with cyclophosphamide, methotrexate and 5-fluorouracil on plasma melatonin and chosen hormones in breast cancer premenopausal patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Fluorouracil; Humans; Melatonin; Methotrexate; Middle Aged; Premenopause | 2001 |
Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats.
Topics: Animals; Antioxidants; Female; Glutathione; Kidney; Liver; Male; Malondialdehyde; Melatonin; Methotrexate; Oxidative Stress; Peroxidase; Rats; Rats, Wistar | 2003 |
Growth-inhibitory action of melatonin and thiazolidinedione derivative CGP 52608 on murine 16/C breast cancer cells.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Melatonin; Methotrexate; Mice; Nuclear Receptor Subfamily 1, Group F, Member 2; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Statistics, Nonparametric; Thiazoles; Thiosemicarbazones | 2006 |
Melatonin attenuates methotrexate-induced oxidative stress and renal damage in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Creatinine; Injections, Intraperitoneal; Kidney; Male; Malondialdehyde; Melatonin; Methotrexate; Oxidative Stress; Peroxidase; Rats; Rats, Wistar | 2010 |
Preclinical efficacy of melatonin to reduce methotrexate-induced oxidative stress and small intestinal damage in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Intestine, Small; Male; Melatonin; Methotrexate; Mucositis; Oxidative Stress; Rats; Rats, Wistar | 2013 |
A preclinical study on the protective effect of melatonin against methotrexate-induced small intestinal damage: effect mediated by attenuation of nitrosative stress, protein tyrosine nitration, and PARP activation.
Topics: Animals; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Enterocolitis; Intestinal Mucosa; Intestine, Small; Male; Melatonin; Methotrexate; Nitrates; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Tyrosine | 2013 |
Effects of melatonin combined with Cis-platinum or methotrexate on the proliferation of osteosarcoma cell line SaOS-2.
Topics: Apoptosis; Bone Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cisplatin; Flow Cytometry; Humans; Melatonin; Methotrexate; Osteosarcoma | 2015 |
Effects of Lycopene Alone or Combined with Melatonin on Methotrexate-Induced Nephrotoxicity in Rats.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antioxidants; Carotenoids; Drug Therapy, Combination; Glutathione; Interleukin-1beta; Kidney Diseases; Lycopene; Male; Melatonin; Methotrexate; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2015 |
Melatonin protects methotrexate-induced testicular injury in rats.
Topics: Animals; Antioxidants; Male; Melatonin; Methotrexate; NF-E2-Related Factor 2; NF-kappa B; Protective Agents; Rats; Rats, Sprague-Dawley; Testis | 2018 |
Melatonin protects against methotrexate-induced memory deficit and hippocampal neurogenesis impairment in a rat model.
Topics: Animals; Behavior, Animal; Cell Proliferation; Hippocampus; Male; Melatonin; Memory Disorders; Methotrexate; Neurogenesis; Neurons; Rats; Rats, Sprague-Dawley | 2019 |
Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats.
Topics: Animals; Animals, Newborn; Antimetabolites, Antineoplastic; Arginine; Disease Models, Animal; Hippocampus; Hyperhomocysteinemia; Male; Maze Learning; Melatonin; Methotrexate; Rats; Rats, Sprague-Dawley; Spatial Behavior | 2020 |
Aging Successfully: The Role of Genetics and Environment in the Era of the Aging-Boom. Potential Therapeutic Implications.
Topics: Aging; Epigenesis, Genetic; Eye Diseases; Humans; Immune System; Longevity; Melatonin; Methotrexate; MicroRNAs; Toll-Like Receptors; Vaccination | 2019 |
Protective effects of melatonin and L-carnitine against methotrexate-induced toxicity in isolated rat hepatocytes.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Carnitine; Chemical and Drug Induced Liver Injury; Hepatocytes; Male; Melatonin; Methotrexate; Rats; Rats, Sprague-Dawley | 2022 |
Melatonin Attenuates Methotrexate-Induced Reduction of Antioxidant Activity Related to Decreases of Neurogenesis in Adult Rat Hippocampus and Prefrontal Cortex.
Topics: Animals; Antineoplastic Agents; Antioxidants; Hippocampus; Male; Melatonin; Methotrexate; Neurogenesis; Oxidative Stress; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2022 |
Melatonin protects against methotrexate hepatotoxicity in young rats: Impact of PI3K/Akt/mTOR signaling.
Topics: Animals; Chemical and Drug Induced Liver Injury; Melatonin; Methotrexate; Phosphatidylinositol 3-Kinases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Rats; TOR Serine-Threonine Kinases | 2023 |