melatonin has been researched along with fluorouracil in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.90) | 18.7374 |
| 1990's | 3 (10.34) | 18.2507 |
| 2000's | 4 (13.79) | 29.6817 |
| 2010's | 11 (37.93) | 24.3611 |
| 2020's | 9 (31.03) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Fan, X; Hu, X; Liang, Z; Liu, D; Luo, T; Ma, S; Shi, T; Tan, W; Wang, Z; Zhu, L | 1 |
| Archili, C; Barni, S; Crispino, S; Lissoni, P; Paolorossi, F; Tancini, G | 1 |
| Iwano, I; Kato, K; Kikuchi, Y; Kita, T; Miyauchi, M | 1 |
| Barni, S; Crispino, S; Esposti, D; Esposti, G; Ferri, L; Fumagalli, G; Lissoni, P; Paolorossi, F; Rovelli, F; Tancini, G | 1 |
| Furuya, Y; Kohno, N; Ku, Y; Saitoh, Y; Yamamoto, K | 1 |
| Furuya, Y; Kohno, N; Saitoh, Y; Yamamoto, K; Yamamoto, M | 1 |
| Kajdaniuk, D; Marek, B | 1 |
| Kajdaniuk, D; Kos-Kudla, B; Marek, B | 1 |
| Iwaki, M; Ogiso, T; Okajima, K; Shiraki, T; Tanino, T; Wada, T | 1 |
| Arjona, A; Montilla, P; Muntané, J; Padillo, J; Perea, D; Ruiz-Rabelo, J; Túnez, I; Vázquez, R | 1 |
| Bejarano, I; Cig, B; Espino, J; Naziroglu, M; Pariente, JA; Rodríguez, AB; Uguz, AC | 1 |
| Bai, L; Chen, DL; Chen, LZ; Ju, HQ; Lu, YX; Mo, HY; Sheng, H; Wang, DS; Wang, F; Wu, QN; Xie, D; Xu, RH; Yu, HE; Yun, JP; Zeng, ZL | 1 |
| Chen, M; Deng, W; Feng, X; Gao, Y; Guo, W; Hao, J; Huang, W; Li, Z; Wu, X; Xiao, B; Xiao, X; Xiong, S; Yu, W; Zhang, C; Zhang, K; Zhang, Z | 1 |
| Bejarano, I; Espino, J; Pariente, JA; Pariente, R; Rodríguez, AB | 1 |
| Akyuz, C; Duman, M; Peker, KD; Sehirli, AO; Sunamak, O; Uzun, O; Yasar, NF; Yol, S | 1 |
| Baek, MJ; Han, YS; Jeong, D; Kim, H; Kim, S; Kwon, HY; Lee, JH; Lee, SH; Yun, CW | 1 |
| Goel, A; Sakatani, A; Sonohara, F | 1 |
| Daduang, J; Damrongrungruang, T; Mahakunakorn, P; Panpitakkul, P; Panyatip, P; Priprem, A; Puthongking, P; Sangchart, P; Somudorn, J; Uthaiwat, P | 1 |
| Aranarochana, A; Chaisawang, P; Pannangrong, W; Sirichoat, A; Suwannakot, K; Welbat, JU; Wigmore, P | 1 |
| Boonsiri, P; Chio-Srichan, S; Daduang, J; Lee, YC; Mahakunakorn, P; Priprem, A; Settasatian, C; Uthaiwat, P | 1 |
| Anisimov, VN; Artemyeva, AS; Baldueva, IA; Belyaev, AM; Golubev, AG; Kireeva, GS; Kruglov, SS; Maydin, MA; Panchenko, AV; Tyndyk, ML | 1 |
| Li, R; Zhang, M; Zhang, R; Zhang, Y | 1 |
| Boonsiri, P; Chio-Srichan, S; Daduang, J; Lee, YC; Leelayuwat, C; Mahakunakorn, P; Priprem, A; Puthongking, P; Settasatian, C; Tippayawat, P; Uthaiwat, P | 1 |
| Aarabi, MH; Asemi, Z; Hedayati, N; Hogan, SD; Mafi, A; Reiter, RJ; Rezaee, M | 1 |
| Amer, ME; El-Missiry, MA; Elbanan, ME; Othman, AI; Shabana, SM | 1 |
1 review(s) available for melatonin and fluorouracil
| Article | Year |
|---|---|
Melatonin and 5-fluorouracil combination chemotherapy: opportunities and efficacy in cancer therapy.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Fluorouracil; Humans; Melatonin | 2023 |
28 other study(ies) available for melatonin and fluorouracil
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Melatonin derivatives combat with inflammation-related cancer by targeting the Main Culprit STAT3.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Inflammation; Melatonin; Molecular Docking Simulation; Molecular Structure; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Structure-Activity Relationship; Tumor Cells, Cultured | 2021 |
A study of the pineal hormone melatonin as a second line therapy in metastatic colorectal cancer resistant to fluorouracil plus folates.
Topics: Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Drug Resistance; Female; Fluorouracil; Folic Acid; Humans; Male; Melatonin; Middle Aged; Neoplasm Metastasis | 1990 |
Inhibition of human ovarian cancer cell proliferation in vitro by neuroendocrine hormones.
Topics: beta-Endorphin; Cell Division; Cystadenocarcinoma; DNA, Neoplasm; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Female; Fluorouracil; Humans; In Vitro Techniques; Melatonin; Naloxone; Ovarian Neoplasms; Prostaglandins D; Protein Precursors; RNA, Neoplasm; Tumor Cells, Cultured | 1989 |
Acute effects of various chemotherapeutic combinations on hypophyseal and pineal hormone secretions in cancer patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; beta-Endorphin; Cisplatin; Cyclophosphamide; Doxorubicin; Endorphins; Epirubicin; Female; Fluorouracil; Humans; Hydrocortisone; Male; Melatonin; Methotrexate; Neoplasms; Pineal Gland; Pituitary Gland, Anterior; Pituitary Hormones, Anterior; Secretory Rate; Vincristine | 1987 |
5-Fluorouracil attenuates an oncostatic effect of melatonin on estrogen-sensitive human breast cancer cells (MCF7).
Topics: Breast Neoplasms; Cell Division; Drug Interactions; Estrogens; Female; Fluorouracil; Humans; Melatonin; Tumor Cells, Cultured | 1994 |
Nocturnal 5-fluorouracil infusion to patients with breast cancer prior to surgery: appearance of 5-fluorouracil-induced AgNORs aggregation (FAA).
Topics: Aged; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Fluorouracil; Humans; Lymphatic Metastasis; Melatonin; Middle Aged; Nucleolus Organizer Region; Receptors, Estrogen | 1997 |
Influence of adjuvant chemotherapy with cyclophosphamide, methotrexate and 5-fluorouracil on plasma insulin-like growth factor-I and chosen hormones in breast cancer pre-menopausal patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Estradiol; Female; Fluorouracil; Humans; Hydrocortisone; Insulin-Like Growth Factor I; Melatonin; Methotrexate; Middle Aged; Premenopause; Progesterone; Prolactin | 2000 |
Influence of adjuvant chemotherapy with cyclophosphamide, methotrexate and 5-fluorouracil on plasma melatonin and chosen hormones in breast cancer premenopausal patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Fluorouracil; Humans; Melatonin; Methotrexate; Middle Aged; Premenopause | 2001 |
Transfollicular drug delivery: penetration of drugs through human scalp skin and comparison of penetration between scalp and abdominal skins in vitro.
Topics: Abdomen; Acyclovir; Administration, Cutaneous; Adult; Drug Delivery Systems; Female; Fluorouracil; Hair Follicle; Humans; In Vitro Techniques; Ketoprofen; Male; Melatonin; Middle Aged; Scalp; Skin Absorption | 2002 |
Improvement of capecitabine antitumoral activity by melatonin in pancreatic cancer.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antioxidants; Capecitabine; Cricetinae; Deoxycytidine; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Lipid Peroxides; Male; Melatonin; Mesocricetus; Nitrosamines; Pancreatic Neoplasms; Prodrugs | 2011 |
Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Cell Line, Tumor; Cisplatin; Doxorubicin; Fluorouracil; Melatonin; Pancreatic Neoplasms; Rats; Time Factors | 2012 |
Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway.
Topics: Carcinoma, Squamous Cell; Cell Death; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Synergism; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Extracellular Signal-Regulated MAP Kinases; Fluorouracil; Glycogen Synthase Kinase 3 beta; Humans; Melatonin; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Neoplasm Invasiveness; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Tumor Stem Cell Assay | 2016 |
Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-κB/iNOS signaling pathways.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromatin Immunoprecipitation; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Immunohistochemistry; Melatonin; Mice; Mice, Nude; Microscopy, Confocal; NF-kappa B; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Xenograft Model Antitumor Assays | 2017 |
Melatonin increases the effect of 5-fluorouracil-based chemotherapy in human colorectal adenocarcinoma cells in vitro.
Topics: Adenocarcinoma; Cell Line, Tumor; Colorectal Neoplasms; Fluorouracil; Humans; Melatonin | 2018 |
Effects of melatonin on colonic anastomosis healing following chemotherapy in rats.
Topics: Anastomosis, Surgical; Animals; Antineoplastic Agents; Colon; Colonic Diseases; Disease Models, Animal; Fluorouracil; Interleukin-1beta; Male; Melatonin; Postoperative Period; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Wound Healing | 2018 |
Melatonin and 5-fluorouracil co-suppress colon cancer stem cells by regulating cellular prion protein-Oct4 axis.
Topics: Aged; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Autophagy; Colon; Colonic Neoplasms; Female; Flow Cytometry; Fluorouracil; Humans; Immunohistochemistry; Male; Melatonin; Middle Aged; Neoplastic Stem Cells; Octamer Transcription Factor-3; Prion Proteins; Prions; Retinal Dehydrogenase; RNA, Small Interfering; SOXB1 Transcription Factors | 2018 |
Melatonin-mediated downregulation of thymidylate synthase as a novel mechanism for overcoming 5-fluorouracil associated chemoresistance in colorectal cancer cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Down-Regulation; Drug Resistance, Neoplasm; Fluorouracil; Humans; Melatonin; MicroRNAs; Thymidylate Synthase | 2019 |
Glutaryl Melatonin Niosome Gel for Topical Oral Mucositis: Anti- Inflammatory and Anticandidiasis.
Topics: Administration, Topical; Anhydrides; Animals; Anti-Inflammatory Agents; Antifungal Agents; Candida albicans; Candidiasis; Drug Liberation; Edema; Fluorouracil; Gels; Glutarates; Liposomes; Male; Melatonin; Mice; Mice, Inbred ICR; RAW 264.7 Cells; Stomatitis | 2020 |
Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats.
Topics: Animals; Antimetabolites; Biomarkers; Cell Proliferation; Cognitive Dysfunction; Dentate Gyrus; Doublecortin Domain Proteins; Doublecortin Protein; Drug Administration Schedule; Fluorouracil; Hippocampus; Injections, Intravenous; Ki-67 Antigen; Male; Melatonin; Memory Disorders; Microtubule-Associated Proteins; Neurogenesis; Neurons; Neuropeptides; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Spatial Memory | 2020 |
Topical Melatonin Niosome Gel for the Treatment of 5-FU-Induced Oral Mucositis in Mice.
Topics: Animals; Fluorouracil; Liposomes; Melatonin; Mice; Mice, Inbred ICR; Quality of Life; Stomatitis | 2021 |
Melatonin Administered before or after a Cytotoxic Drug Increases Mammary Cancer Stabilization Rates in HER2/Neu Mice.
Topics: Anemia; Animals; Antineoplastic Agents; Blood Cell Count; Breast Neoplasms; Cyclophosphamide; Disease Models, Animal; Docetaxel; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Leukopenia; Melatonin; Mice; Mice, Transgenic; Receptor, ErbB-2 | 2020 |
Melatonin sensitizes esophageal cancer cells to 5‑fluorouracil via promotion of apoptosis by regulating EZH2 expression.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Esophageal Neoplasms; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Melatonin | 2021 |
Oral Administration of Melatonin or Succinyl Melatonin Niosome Gel Benefits 5-FU-Induced Small Intestinal Mucositis Treatment in Mice.
Topics: Administration, Oral; Animals; Fluorouracil; Interleukin-1beta; Intestinal Mucosa; Intestine, Small; Lipid Peroxidation; Liposomes; Male; Melatonin; Mice; Mice, Inbred ICR; Mucositis; Particle Size; Tumor Necrosis Factor-alpha | 2021 |
Melatonin protected against kidney impairment induced by 5-fluorouracil in mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Fluorouracil; Kidney; Male; Melatonin; Mice | 2023 |