melatonin has been researched along with donepezil in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 21 (87.50) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| de Los Ríos, C; Egea, J; Gálvez, E; García, AG; Iriepa, I; León, R; López, MG; Marco-Contelles, J; Moraleda, I; Romero, A; Samadi, A; Villarroya, M | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Hu, Y; Li, Y; Peng, P; Sheng, R; Tang, L | 1 |
| Huang, ZG; Liu, Y; Luo, XT; Wang, CM | 1 |
| Brogi, S; Butini, S; Campiani, G; Esteban, G; Inokuchi, T; Marco-Contelles, J; Shionoya, M; Unzeta, M; Wang, L; Wu, MY | 1 |
| Kong, LY; Li, F; Li, XM; Wang, J; Wang, XB; Wang, ZM; Wu, JJ | 1 |
| Cai, P; Kong, LY; Liu, QH; Wang, XB; Wang, ZM; Wu, JJ; Xu, DQ; Yang, XL | 1 |
| Arce, MP; Conde, S; Egea, J; Gil, C; León, R; López, MG; Monjas, L; Pérez, C; Rodríguez-Franco, MI; Villarroya, M | 1 |
| Cai, P; Kong, LY; Li, F; Wang, J; Wang, XB; Wu, JJ; Yang, XL | 1 |
| Chan, ASC; Feng, X; Hu, J; Huang, L; Li, X; Wang, Z; Yang, X | 1 |
| de Andrés, L; Estrada Valencia, M; Herrera-Arozamena, C; Laurini, E; Morales-García, JA; Pérez, C; Pérez-Castillo, A; Pricl, S; Ramos, E; Rodríguez-Franco, MI; Romero, A; Viña, D; Yáñez, M | 1 |
| Arribas, RL; Chabchoub, F; de Los Ríos, C; Demougeot, C; Diez-Iriepa, D; Egea, J; Godyń, J; Głuch-Lutwin, M; Iriepa, I; Ismaili, L; Kiec-Kononowicz, K; Kobrlova, T; Malawska, B; Malek, R; Marco-Contelles, J; Moraleda, I; Mordyl, B; Palomino-Antolin, A; Panek, D; Siwek, A; Soukup, O; Totoson, P | 1 |
| Kumar, S; Mishra, S; Modi, G; Rai, H; Singh, G; Singh, GK; Singh, YP; Srikrishna, S | 1 |
| Agrawal, R; Nath, C; Shukla, R; Tyagi, E | 2 |
| Au, J; Berry-Kravis, E; Hagerman, R; Lauterborn, J | 1 |
| Goel, R; Hanif, K; Najmi, AK; Nath, C; Pachauri, SD; Rajasekar, N; Tota, S | 1 |
| Huang, LQ; Li, P; Li, YP; Liu, Y; Pan, X; Yang, Y; Yin, Y; Zhao, ZQ; Zhao, ZX; Zhuang, J | 1 |
| Czarnocki, Z; Hartman, AM; Hirsch, AKH; Molęda, Z; Świerczyńska, A; Łozińska, I | 1 |
| Andrýs, R; Diez-Iriepa, D; Iriepa, I; Ismaili, L; Luzet, V; Marco-Contelles, J; Martin, H; Moraleda, I; Musilek, K; Oset-Gasque, MJ; Pachón-Angona, I; Refouvelet, B | 1 |
| Majidazar, R; Naseri, A; Rezazadeh-Gavgani, E; Sadigh-Eteghad, S | 1 |
3 review(s) available for melatonin and donepezil
| Article | Year |
|---|---|
A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Line, Tumor; Coumaric Acids; Humans; Neuroprotective Agents; Oxidative Stress; Protein Multimerization | 2021 |
Fragile X syndrome and targeted treatment trials.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Baclofen; Brain-Derived Neurotrophic Factor; Central Nervous System Stimulants; Clinical Trials as Topic; Dendritic Spines; Donepezil; Dopamine; Enzyme Inhibitors; Fragile X Mental Retardation Protein; Fragile X Syndrome; Humans; Indans; Lithium Compounds; Melatonin; Mice; Mice, Knockout; Minocycline; Nootropic Agents; Piperidines; Receptor, Metabotropic Glutamate 5; Receptors, GABA; Receptors, Metabotropic Glutamate; Signal Transduction; Vitamin E | 2012 |
Pharmacotherapy of Alzheimer's disease: an overview of systematic reviews.
Topics: Alzheimer Disease; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Cholinesterase Inhibitors; Donepezil; Galantamine; Glycogen Synthase Kinase 3; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Indans; Lithium; Melatonin; Memantine; Neurodegenerative Diseases; Rivastigmine; Systematic Reviews as Topic | 2022 |
1 trial(s) available for melatonin and donepezil
| Article | Year |
|---|---|
Low-Dose Atypical Antipsychotic Risperidone Improves the 5-Year Outcome in Alzheimer's Disease Patients with Sleep Disturbances.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Caregivers; Donepezil; Female; Humans; Hypnotics and Sedatives; Indans; Male; Melatonin; Neuropsychological Tests; Nootropic Agents; Nursing Homes; Piperidines; Polysomnography; Pyridines; Risperidone; Sleep Wake Disorders; Treatment Outcome; Zolpidem | 2015 |
20 other study(ies) available for melatonin and donepezil
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Calcium; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytotoxins; Electron Transport Chain Complex Proteins; Electrophorus; Glucose; Hippocampus; Humans; Isomerism; Models, Molecular; Naphthyridines; Neuroprotective Agents; Okadaic Acid; Oligomycins; Oxygen; Peptide Fragments; Protein Binding; Protein Phosphatase 2; Rats; Rotenone; Structure-Activity Relationship | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Curcumin; Dose-Response Relationship, Drug; Drug Design; Ligands; Molecular Docking Simulation; Molecular Structure; Phenylcarbamates; Rivastigmine; Structure-Activity Relationship | 2014 |
New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease.
Topics: Alzheimer Disease; Antioxidants; Cell Line, Tumor; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Drug Design; Humans; Indoles; Melatonin; Models, Molecular; Molecular Structure; Neuroblastoma; Neuroprotective Agents; Pyridinium Compounds; Structure-Activity Relationship | 2015 |
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.
Topics: Acetylcholinesterase; Antioxidants; Chelating Agents; Chemistry Techniques, Synthetic; Donepezil; Drug Design; Humans; Indans; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperidines; Protein Conformation; Structure-Activity Relationship | 2016 |
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Cell Line, Tumor; Chelating Agents; Cholinesterase Inhibitors; Donepezil; Electrophorus; Horses; Humans; Indans; Indoles; Iron; Kinetics; Melatonin; Molecular Docking Simulation; Peptide Fragments; Piperidines; Protein Multimerization; Rats; Zinc | 2016 |
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Copper; Donepezil; Drug Design; Humans; Indans; Kinetics; Liver; Mice; Models, Molecular; Peptide Fragments; Piperidines; Protein Aggregates; Protein Conformation | 2016 |
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.
Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Donepezil; Glutamates; Hippocampus; Humans; Indans; Neuroprotective Agents; Piperidines; Rats; Solid-Phase Synthesis Techniques | 2017 |
Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzylamines; Blood-Retinal Barrier; Butyrylcholinesterase; Cell Death; Cholinergic Agents; Cholinesterase Inhibitors; Cinnamates; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Structure-Activity Relationship | 2017 |
Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline-Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Proliferation; Drug Design; Hippocampus; Humans; Indoles; Ligands; Memory Disorders; Mice; Quinolines | 2018 |
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Donepezil; Enzyme Inhibitors; Flavonoids; Humans; Indans; Lipoxygenase Inhibitors; Male; Mice, Inbred BALB C; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurogenesis; Neuroprotective Agents; Piperidines; Receptors, sigma; Sigma-1 Receptor | 2018 |
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H
Topics: Alzheimer Disease; Animals; Calcium Channel Blockers; Cholinesterase Inhibitors; Humans; Memory Disorders; Mice; Neuroblastoma; Neuroprotective Agents; Receptors, Histamine H3; Small Molecule Libraries; Tumor Cells, Cultured; Vasodilator Agents | 2019 |
Effect of insulin and melatonin on acetylcholinesterase activity in the brain of amnesic mice.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Avoidance Learning; Brain; Cholinergic Fibers; Donepezil; Hypoglycemic Agents; Indans; Insulin; Male; Melatonin; Mice; Motor Activity; Nootropic Agents; Piperidines; Reaction Time; Scopolamine; Transfer, Psychology | 2008 |
Insulin receptor signaling in rat hippocampus: a study in STZ (ICV) induced memory deficit model.
Topics: Animals; Blood Glucose; Chromones; Disease Models, Animal; Donepezil; Gene Expression; Hippocampus; Indans; Infusions, Intraventricular; Male; Maze Learning; Melatonin; Memory; Memory Disorders; Morpholines; Nootropic Agents; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Streptozocin | 2011 |
Effect of angiotensin II on spatial memory, cerebral blood flow, cholinergic neurotransmission, and brain derived neurotrophic factor in rats.
Topics: Acetylcholine; Acetylcholinesterase; Adenosine Triphosphate; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Hippocampus; Imidazoles; Indans; Male; Melatonin; Memory; Oxidative Stress; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetrazoles | 2013 |
Donepezil-melatonin hybrids as butyrylcholinesterase inhibitors: Improving binding affinity through varying mode of linking fragments.
Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Erythrocytes; Humans; Melatonin; Molecular Structure; Structure-Activity Relationship | 2018 |
Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Chromones; Donepezil; Dose-Response Relationship, Drug; Humans; Melatonin; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2019 |