melatonin and donepezil

melatonin has been researched along with donepezil in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (4.17)29.6817
2010's21 (87.50)24.3611
2020's2 (8.33)2.80

Authors

AuthorsStudies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
de Los Ríos, C; Egea, J; Gálvez, E; García, AG; Iriepa, I; León, R; López, MG; Marco-Contelles, J; Moraleda, I; Romero, A; Samadi, A; Villarroya, M1
Ekins, S; Williams, AJ; Xu, JJ1
Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Hu, Y; Li, Y; Peng, P; Sheng, R; Tang, L1
Huang, ZG; Liu, Y; Luo, XT; Wang, CM1
Brogi, S; Butini, S; Campiani, G; Esteban, G; Inokuchi, T; Marco-Contelles, J; Shionoya, M; Unzeta, M; Wang, L; Wu, MY1
Kong, LY; Li, F; Li, XM; Wang, J; Wang, XB; Wang, ZM; Wu, JJ1
Cai, P; Kong, LY; Liu, QH; Wang, XB; Wang, ZM; Wu, JJ; Xu, DQ; Yang, XL1
Arce, MP; Conde, S; Egea, J; Gil, C; León, R; López, MG; Monjas, L; Pérez, C; Rodríguez-Franco, MI; Villarroya, M1
Cai, P; Kong, LY; Li, F; Wang, J; Wang, XB; Wu, JJ; Yang, XL1
Chan, ASC; Feng, X; Hu, J; Huang, L; Li, X; Wang, Z; Yang, X1
de Andrés, L; Estrada Valencia, M; Herrera-Arozamena, C; Laurini, E; Morales-García, JA; Pérez, C; Pérez-Castillo, A; Pricl, S; Ramos, E; Rodríguez-Franco, MI; Romero, A; Viña, D; Yáñez, M1
Arribas, RL; Chabchoub, F; de Los Ríos, C; Demougeot, C; Diez-Iriepa, D; Egea, J; Godyń, J; Głuch-Lutwin, M; Iriepa, I; Ismaili, L; Kiec-Kononowicz, K; Kobrlova, T; Malawska, B; Malek, R; Marco-Contelles, J; Moraleda, I; Mordyl, B; Palomino-Antolin, A; Panek, D; Siwek, A; Soukup, O; Totoson, P1
Kumar, S; Mishra, S; Modi, G; Rai, H; Singh, G; Singh, GK; Singh, YP; Srikrishna, S1
Agrawal, R; Nath, C; Shukla, R; Tyagi, E2
Au, J; Berry-Kravis, E; Hagerman, R; Lauterborn, J1
Goel, R; Hanif, K; Najmi, AK; Nath, C; Pachauri, SD; Rajasekar, N; Tota, S1
Huang, LQ; Li, P; Li, YP; Liu, Y; Pan, X; Yang, Y; Yin, Y; Zhao, ZQ; Zhao, ZX; Zhuang, J1
Czarnocki, Z; Hartman, AM; Hirsch, AKH; Molęda, Z; Świerczyńska, A; Łozińska, I1
Andrýs, R; Diez-Iriepa, D; Iriepa, I; Ismaili, L; Luzet, V; Marco-Contelles, J; Martin, H; Moraleda, I; Musilek, K; Oset-Gasque, MJ; Pachón-Angona, I; Refouvelet, B1
Majidazar, R; Naseri, A; Rezazadeh-Gavgani, E; Sadigh-Eteghad, S1

Reviews

3 review(s) available for melatonin and donepezil

ArticleYear
A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease.
    European journal of medicinal chemistry, 2021, Apr-05, Volume: 215

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Line, Tumor; Coumaric Acids; Humans; Neuroprotective Agents; Oxidative Stress; Protein Multimerization

2021
Fragile X syndrome and targeted treatment trials.
    Results and problems in cell differentiation, 2012, Volume: 54

    Topics: Animals; Anti-Bacterial Agents; Antioxidants; Baclofen; Brain-Derived Neurotrophic Factor; Central Nervous System Stimulants; Clinical Trials as Topic; Dendritic Spines; Donepezil; Dopamine; Enzyme Inhibitors; Fragile X Mental Retardation Protein; Fragile X Syndrome; Humans; Indans; Lithium Compounds; Melatonin; Mice; Mice, Knockout; Minocycline; Nootropic Agents; Piperidines; Receptor, Metabotropic Glutamate 5; Receptors, GABA; Receptors, Metabotropic Glutamate; Signal Transduction; Vitamin E

2012
Pharmacotherapy of Alzheimer's disease: an overview of systematic reviews.
    European journal of clinical pharmacology, 2022, Volume: 78, Issue:10

    Topics: Alzheimer Disease; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Cholinesterase Inhibitors; Donepezil; Galantamine; Glycogen Synthase Kinase 3; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Indans; Lithium; Melatonin; Memantine; Neurodegenerative Diseases; Rivastigmine; Systematic Reviews as Topic

2022

Trials

1 trial(s) available for melatonin and donepezil

ArticleYear
Low-Dose Atypical Antipsychotic Risperidone Improves the 5-Year Outcome in Alzheimer's Disease Patients with Sleep Disturbances.
    Pharmacology, 2015, Volume: 96, Issue:3-4

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Caregivers; Donepezil; Female; Humans; Hypnotics and Sedatives; Indans; Male; Melatonin; Neuropsychological Tests; Nootropic Agents; Nursing Homes; Piperidines; Polysomnography; Pyridines; Risperidone; Sleep Wake Disorders; Treatment Outcome; Zolpidem

2015

Other Studies

20 other study(ies) available for melatonin and donepezil

ArticleYear
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
    Journal of medicinal chemistry, 2010, Jul-22, Volume: 53, Issue:14

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Calcium; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytotoxins; Electron Transport Chain Complex Proteins; Electrophorus; Glucose; Hippocampus; Humans; Isomerism; Models, Molecular; Naphthyridines; Neuroprotective Agents; Okadaic Acid; Oligomycins; Oxygen; Peptide Fragments; Protein Binding; Protein Phosphatase 2; Rats; Rotenone; Structure-Activity Relationship

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
    Bioorganic & medicinal chemistry, 2013, May-15, Volume: 21, Issue:10

    Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy.
    Bioorganic & medicinal chemistry, 2014, Sep-01, Volume: 22, Issue:17

    Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Curcumin; Dose-Response Relationship, Drug; Drug Design; Ligands; Molecular Docking Simulation; Molecular Structure; Phenylcarbamates; Rivastigmine; Structure-Activity Relationship

2014
New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease.
    European journal of medicinal chemistry, 2015, Oct-20, Volume: 103

    Topics: Alzheimer Disease; Antioxidants; Cell Line, Tumor; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Drug Design; Humans; Indoles; Melatonin; Models, Molecular; Molecular Structure; Neuroblastoma; Neuroprotective Agents; Pyridinium Compounds; Structure-Activity Relationship

2015
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.
    European journal of medicinal chemistry, 2016, Oct-04, Volume: 121

    Topics: Acetylcholinesterase; Antioxidants; Chelating Agents; Chemistry Techniques, Synthetic; Donepezil; Drug Design; Humans; Indans; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperidines; Protein Conformation; Structure-Activity Relationship

2016
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.
    Bioorganic & medicinal chemistry, 2016, 09-15, Volume: 24, Issue:18

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Cell Line, Tumor; Chelating Agents; Cholinesterase Inhibitors; Donepezil; Electrophorus; Horses; Humans; Indans; Indoles; Iron; Kinetics; Melatonin; Molecular Docking Simulation; Peptide Fragments; Piperidines; Protein Multimerization; Rats; Zinc

2016
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2016, Nov-10, Volume: 123

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Copper; Donepezil; Drug Design; Humans; Indans; Kinetics; Liver; Mice; Models, Molecular; Peptide Fragments; Piperidines; Protein Aggregates; Protein Conformation

2016
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.
    European journal of medicinal chemistry, 2017, Apr-21, Volume: 130

    Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Donepezil; Glutamates; Hippocampus; Humans; Indans; Neuroprotective Agents; Piperidines; Rats; Solid-Phase Synthesis Techniques

2017
Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.
    European journal of medicinal chemistry, 2017, Oct-20, Volume: 139

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzylamines; Blood-Retinal Barrier; Butyrylcholinesterase; Cell Death; Cholinergic Agents; Cholinesterase Inhibitors; Cinnamates; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Structure-Activity Relationship

2017
Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline-Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer's Disease.
    Journal of medicinal chemistry, 2018, 03-08, Volume: 61, Issue:5

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Proliferation; Drug Design; Hippocampus; Humans; Indoles; Ligands; Memory Disorders; Mice; Quinolines

2018
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.
    European journal of medicinal chemistry, 2018, Aug-05, Volume: 156

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Donepezil; Enzyme Inhibitors; Flavonoids; Humans; Indans; Lipoxygenase Inhibitors; Male; Mice, Inbred BALB C; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurogenesis; Neuroprotective Agents; Piperidines; Receptors, sigma; Sigma-1 Receptor

2018
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H
    Journal of medicinal chemistry, 2019, 12-26, Volume: 62, Issue:24

    Topics: Alzheimer Disease; Animals; Calcium Channel Blockers; Cholinesterase Inhibitors; Humans; Memory Disorders; Mice; Neuroblastoma; Neuroprotective Agents; Receptors, Histamine H3; Small Molecule Libraries; Tumor Cells, Cultured; Vasodilator Agents

2019
Effect of insulin and melatonin on acetylcholinesterase activity in the brain of amnesic mice.
    Behavioural brain research, 2008, Jun-03, Volume: 189, Issue:2

    Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Avoidance Learning; Brain; Cholinergic Fibers; Donepezil; Hypoglycemic Agents; Indans; Insulin; Male; Melatonin; Mice; Motor Activity; Nootropic Agents; Piperidines; Reaction Time; Scopolamine; Transfer, Psychology

2008
Insulin receptor signaling in rat hippocampus: a study in STZ (ICV) induced memory deficit model.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2011, Volume: 21, Issue:3

    Topics: Animals; Blood Glucose; Chromones; Disease Models, Animal; Donepezil; Gene Expression; Hippocampus; Indans; Infusions, Intraventricular; Male; Maze Learning; Melatonin; Memory; Memory Disorders; Morpholines; Nootropic Agents; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Streptozocin

2011
Effect of angiotensin II on spatial memory, cerebral blood flow, cholinergic neurotransmission, and brain derived neurotrophic factor in rats.
    Psychopharmacology, 2013, Volume: 226, Issue:2

    Topics: Acetylcholine; Acetylcholinesterase; Adenosine Triphosphate; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Hippocampus; Imidazoles; Indans; Male; Melatonin; Memory; Oxidative Stress; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetrazoles

2013
Donepezil-melatonin hybrids as butyrylcholinesterase inhibitors: Improving binding affinity through varying mode of linking fragments.
    Archiv der Pharmazie, 2018, Volume: 351, Issue:11

    Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Erythrocytes; Humans; Melatonin; Molecular Structure; Structure-Activity Relationship

2018
Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.
    Journal of enzyme inhibition and medicinal chemistry, 2019, Volume: 34, Issue:1

    Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Chromones; Donepezil; Dose-Response Relationship, Drug; Humans; Melatonin; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship

2019