melatonin and caffeine

melatonin has been researched along with caffeine in 71 studies

Research

Studies (71)

TimeframeStudies, this research(%)All Research%
pre-19903 (4.23)18.7374
1990's7 (9.86)18.2507
2000's23 (32.39)29.6817
2010's24 (33.80)24.3611
2020's14 (19.72)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Arce, MP; Conde, S; Egea, J; Gil, C; León, R; López, MG; Monjas, L; Pérez, C; Rodríguez-Franco, MI; Villarroya, M1
Atkinson, BN; Bayle, ED; Fish, PV; Steadman, D; Svensson, F; Vincent, JP; Whiting, P; Willis, NJ; Woodward, HL1
Buhrley, LE; Ellis, LC; Sorenson, DK1
Bagnara, JT; Hadley, ME1
Heath, JR; Zatz, M1
Babey, AM; Palmour, RM; Young, SN1
Fauteck, JD; Fischer, B; Madeja, M; Musshoff, U; Speckmann, EJ; Wittkowski, W1
Badia, P; Hakel, M; Myers, BL; Plenzler, SC; Wright, KP1
Lagarde, D1
Doireau, P; Lagarde, D1
Badia, P; Drake, CL; Myers, BL; Plenzler, SC; Wright, KP1
Billaud, PF; Chappuis, B; Chauffard, F; French, J; Lagarde, D; Ramont, L1
Bertilsson, L; Christensen, M; Härtter, S; Morita, S; Röjdmark, S; Tybring, G; Ursing, C; von Bahr, C1
Beaumont, M; Chauffard, F; Coste, O; Enslen, M; Fontan, A; French, J; Lagarde, D; Piérard, C; Reiter, RJ; Tan, DX1
Sparaco, P1
Babkoff, H; French, J; Sutherlin, R; Whitmore, J1
Bertilsson, L; Härtter, S; Röjdmark, S; Tybring, G; Ursing, C; von Bahr, C1
Lieberman, HR1
Brismar, K; Röjdmark, S; Ursing, C; Wikner, J1
Batéjat, D; Beaumont, M; Chauffard, F; Coste, O; Denis, JB; Doireau, P; French, J; Lagarde, D; Piérard, C; Van Beers, P1
MALAWISTA, SE1
Heath, J; Straume, M; Yadav, G; Zatz, M1
Bertilsson, L; Härtter, S; Laine, K; Nordmark, A; Rose, DM; Tybring, G1
Cajochen, C; Czeisler, CA; Dijk, DJ; Ritz-De Cecco, A; Wyatt, JK1
Edwards, B; Reilly, T; Waterhouse, J1
Cajochen, Ch1
Härtter, S; Korhonen, T; Laine, K; Lundgren, S; Rane, A; Tolonen, A; Turpeinen, M1
Roth, T; Schwartz, JR1
Baron, JA; Comi, R; Keisari, R; Kim, J; Larson, R; MacKenzie, T; Manwar, S; Sluss, P1
Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ1
Coste, O; Lagarde, D1
Herxheimer, A1
Myslobodsky, M1
Holle, D; Obermann, M1
Auger, RR; Kolla, BP1
Igaz, P; Tulassay, Z1
Amali, OO; Obochi, GO; Ochalefu, DO1
Samuels, CH1
Ong, JC; Park, M1
Arendash, GW; Bradshaw, PC; Cao, C; Copes, N; Delic, V; Dragicevic, N; Lin, X; Mamcarz, M; Wang, L1
Aitken, RJ; Jones, KT; Lord, T; Nixon, B1
Boakye, CH; Etukala, JR; Marepally, S; Shah, PP; Singh, M; Vemuri, A1
Famenini, S; Goh, C1
Costa, G; Driscoll, TR; Isotalo, LK; Liira, J; Ruotsalainen, JH; Sallinen, M; Verbeek, JH1
Cao, C; Du, YH; He, ZX; Wang, ZH; Zhang, LF; Zhou, SF; Zhou, ZW1
Lockley, SW; St Hilaire, MA1
Bessman, SC; Burke, TM; Chinoy, ED; Jung, CM; Markwald, RR; McHill, AW; O'Neill, JS; Snider, JA; Wright, KP1
Banks, S; Dorrian, J; Hilditch, CJ1
Byun, S; Han, JW; Kim, KW; Kim, T; Lee, JR; Park, J; Suh, SW; Yoon, IY1
Burke, LM; Halson, SL; Pearce, J1
Chuproski, AP; D Dos Santos, P; D Noseda, AC; D S Targa, A; Fagotti, J; L Ilkiwa, J; M S Lima, M; Rodrigues, LS; W C Dorieux, F1
Drevet, JR; Evenson, DP; Hallak, J; Monteiro, RAC; Pariz, JR; Ranéa, C1
Borgwardt, S; Cajochen, C; Garbazza, C; Kistler, J; Kolodyazhniy, V; Landolt, HP; Lin, YS; Rehm, S; Reichert, CF; Rentsch, K; Weibel, J1
Haber, JJ; Wallace, PJ1
Benetti, C; Bose, A; Chong, PW; Colombo, P; Razali, S; Wong, TW1
Ahammed, GJ; Deng, WW; Fu, JY; Han, WY; Li, MH; Li, X; Wei, JP; Yan, P; Zhang, LP1
Akyüz, E; Arıkan, ES; Ertekin, T; Göçmen, AY; Güler, H; Nisari, M; Sabitaliyevich, UY; Tokpınar, A; Unur, E; Yalçın, B; Yay, AH; Yılmaz, H; Yılmaz, S1
Deka, A; Fogg, LF; Gottlieb, M; Kravitz, HM; Sholtes, D; Westrick, J1
Bühler, M; Deuring, G; Garbazza, C; Gruber, G; Lin, YS; Meyer, M; Rehm, SS; Reichert, CF; Rentsch, K; Slawik, H; Veitz, S; Weibel, J1
Daali, Y; Desmeules, J; Magliocco, G; Samer, CF; Thomas, A1
Benetti, C; Bose, A; Chong, PW; Colombo, G; Colombo, P; Miller, M; Razali, S; Wong, TW1
Fatarova, M; Guy, PA; Hoeng, J; Ivanov, NV; Kuczaj, A; Laszlo, C; Majeed, S; Mazurov, A; Pak, C; Peitsch, MC; Steiner, S; Vidal-de-Miguel, G; Zivkovic Semren, T1
Antonijevic, MD; Derrar, Y; Douroumis, D; Grau, C; Katsamenis, OL; Mithu, MS; Morales, A; Tabriz, AG; Vilain, L1
Bernis, ME; Imam, FB; Maes, E; Maltepe, E; Pang, R; Pasca, AM; Robertson, NJ; Sabir, H; Schleehuber, Y; Silverman, J; White, Y; Zweyer, M1
Azevedo, LM; Bicalho, EM; Carvalho, GR; de Andrade, FHA; de Oliveira Santos, M; de Resende, MLV; Ferreira, AMO; Silva, VA1

Reviews

17 review(s) available for melatonin and caffeine

ArticleYear
[Role of the pharmacopoeia in the prevention of jet-lag].
    Bulletin de la Societe de pathologie exotique (1990), 1997, Volume: 90, Issue:4

    Topics: Caffeine; Central Nervous System Stimulants; Chronotherapy; Circadian Rhythm; Humans; Hypnotics and Sedatives; Melatonin; Sleep Wake Disorders; Travel

1997
[Jet lag].
    Medecine tropicale : revue du Corps de sante colonial, 1997, Volume: 57, Issue:4 Bis

    Topics: Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Humans; Hypnotics and Sedatives; Melatonin; Psychomotor Performance; Risk Factors; Sunlight; Travel

1997
Nutrition, brain function and cognitive performance.
    Appetite, 2003, Volume: 40, Issue:3

    Topics: Adult; Brain; Caffeine; Cognition; Dietary Carbohydrates; Dietary Proteins; Humans; Melatonin; Nutritional Physiological Phenomena; Tryptophan; Tyrosine

2003
Jet lag and air travel: implications for performance.
    Clinics in sports medicine, 2005, Volume: 24, Issue:2

    Topics: Aircraft; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Female; Humans; Hypnotics and Sedatives; Jet Lag Syndrome; Male; Melatonin; Phototherapy; Psychomotor Performance; Sports; Sports Medicine; Travel

2005
[Sleep disruption in shift work and jet lag: the role of the circadian timing system].
    Praxis, 2005, Sep-21, Volume: 94, Issue:38

    Topics: Adult; Antioxidants; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Humans; Hypnotics and Sedatives; Jet Lag Syndrome; Melatonin; Sleep; Sleep Disorders, Circadian Rhythm; Time Factors; Work Schedule Tolerance

2005
Shift work sleep disorder: burden of illness and approaches to management.
    Drugs, 2006, Volume: 66, Issue:18

    Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Cost of Illness; Exercise Therapy; Humans; Hypnotics and Sedatives; Melatonin; Modafinil; Phototherapy; Quality of Life; Sleep; Sleep Disorders, Circadian Rhythm; Wakefulness

2006
Clinical management of jet lag: what can be proposed when performance is critical?
    Travel medicine and infectious disease, 2009, Volume: 7, Issue:2

    Topics: Aircraft; Caffeine; Central Nervous System Stimulants; Chronobiology Phenomena; Circadian Rhythm; Humans; Hypnotics and Sedatives; Jet Lag Syndrome; Melatonin; Travel

2009
Jet lag.
    BMJ clinical evidence, 2008, Dec-04, Volume: 2008

    Topics: Air Travel; Azabicyclo Compounds; Caffeine; Humans; Hypnotics and Sedatives; Jet Lag Syndrome; Melatonin; Saliva

2008
The paradox of caffeine-zolpidem interaction: a network analysis.
    Current drug targets, 2009, Volume: 10, Issue:10

    Topics: Animals; Antioxidants; Caffeine; Central Nervous System Stimulants; Drug Synergism; Humans; Hypnotics and Sedatives; Melatonin; Pyridines; Reactive Oxygen Species; Software; Zolpidem

2009
Hypnic headache.
    Expert review of neurotherapeutics, 2010, Volume: 10, Issue:9

    Topics: Antidepressive Agents; Caffeine; Central Nervous System Stimulants; Cyclooxygenase Inhibitors; Headache Disorders, Primary; Humans; Indomethacin; Melatonin

2010
Jet lag and shift work sleep disorders: how to help reset the internal clock.
    Cleveland Clinic journal of medicine, 2011, Volume: 78, Issue:10

    Topics: Actigraphy; Age Factors; Benzodiazepines; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Humans; Hypnotics and Sedatives; Jet Lag Syndrome; Light; Lighting; Melatonin; Monitoring, Physiologic; Sleep; Sleep Disorders, Circadian Rhythm; Travel

2011
Chronic headaches and insomnia: working toward a biobehavioral model.
    Cephalalgia : an international journal of headache, 2012, Volume: 32, Issue:14

    Topics: Actigraphy; Adaptation, Psychological; Caffeine; Chronobiology Phenomena; Comorbidity; Headache Disorders; Humans; Hypnotics and Sedatives; Melatonin; Migraine Disorders; Models, Neurological; Models, Psychological; Polysomnography; Self Report; Sleep Initiation and Maintenance Disorders; Sleep Stages; Tension-Type Headache; Wakefulness

2012
Pharmacological interventions for sleepiness and sleep disturbances caused by shift work.
    The Cochrane database of systematic reviews, 2014, Aug-12, Issue:8

    Topics: Azabicyclo Compounds; Benzhydryl Compounds; Caffeine; Humans; Hypnotics and Sedatives; Melatonin; Modafinil; Piperazines; Randomized Controlled Trials as Topic; Sleep; Sleep Disorders, Circadian Rhythm; Wakefulness; Wakefulness-Promoting Agents

2014
Time to wake up: reactive countermeasures to sleep inertia.
    Industrial health, 2016, Dec-07, Volume: 54, Issue:6

    Topics: Caffeine; Humans; Light; Melatonin; Sleep; Sound; Temperature; Time Factors; Wakefulness

2016
Nutrition for Travel: From Jet lag To Catering.
    International journal of sport nutrition and exercise metabolism, 2019, Mar-01, Volume: 29, Issue:2

    Topics: Athletes; Caffeine; Humans; Jet Lag Syndrome; Light; Meals; Melatonin; Sports Nutritional Physiological Phenomena; Time Factors; Travel

2019
Potential new therapies against a toxic relationship: neuroinflammation and Parkinson's disease.
    Behavioural pharmacology, 2019, Volume: 30, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Caffeine; Cannabinoids; Dietary Supplements; Humans; Melatonin; Neuroimmunomodulation; Parkinson Disease

2019
Optimising sleep and performance during night float: A systematic review of evidence and implications for graduate medical education trainees.
    Journal of sleep research, 2021, Volume: 30, Issue:4

    Topics: Adaptation, Physiological; Attention; Caffeine; Education, Medical, Graduate; Energy Drinks; Fatigue; Humans; Melatonin; Modafinil; Reaction Time; Sleep; Sleep Deprivation; Sleep Disorders, Circadian Rhythm; Work Schedule Tolerance

2021

Trials

14 trial(s) available for melatonin and caffeine

ArticleYear
Caffeine and light effects on nighttime melatonin and temperature levels in sleep-deprived humans.
    Brain research, 1997, Jan-30, Volume: 747, Issue:1

    Topics: Adolescent; Adult; Body Temperature; Caffeine; Central Nervous System Stimulants; Depression, Chemical; Humans; Light; Male; Melatonin; Sleep Deprivation

1997
Acute effects of bright light and caffeine on nighttime melatonin and temperature levels in women taking and not taking oral contraceptives.
    Brain research, 2000, Aug-11, Volume: 873, Issue:2

    Topics: Adolescent; Adult; Body Temperature; Caffeine; Circadian Rhythm; Contraceptives, Oral; Drug Interactions; Female; Humans; Melatonin; Photic Stimulation; Time Factors

2000
Evaluation of pharmacological aids on physical performance after a transmeridian flight.
    Medicine and science in sports and exercise, 2001, Volume: 33, Issue:4

    Topics: Adult; Analysis of Variance; Antioxidants; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Delayed-Action Preparations; Double-Blind Method; Exercise Test; Female; Hand Strength; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged

2001
Resynchronization of hormonal rhythms after an eastbound flight in humans: effects of slow-release caffeine and melatonin.
    European journal of applied physiology, 2001, Volume: 85, Issue:1-2

    Topics: Adjuvants, Immunologic; Adult; Caffeine; Central Nervous System Stimulants; Delayed-Action Preparations; Female; Humans; Hydrocortisone; Jet Lag Syndrome; Male; Melatonin; Middle Aged; Saliva

2001
Single-dose bright light and/or caffeine effect on nocturnal performance.
    Aviation, space, and environmental medicine, 2002, Volume: 73, Issue:4

    Topics: Adult; Arousal; Body Temperature; Caffeine; Female; Humans; Lighting; Male; Melatonin; Reaction Time; Saliva; Space Perception; Task Performance and Analysis; Visual Perception

2002
Caffeine raises the serum melatonin level in healthy subjects: an indication of melatonin metabolism by cytochrome P450(CYP)1A2.
    Journal of endocrinological investigation, 2003, Volume: 26, Issue:5

    Topics: Caffeine; Capsules; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Female; Humans; Male; Melatonin; Reference Values

2003
Caffeine or melatonin effects on sleep and sleepiness after rapid eastward transmeridian travel.
    Journal of applied physiology (Bethesda, Md. : 1985), 2004, Volume: 96, Issue:1

    Topics: Adult; Anticonvulsants; Body Temperature; Caffeine; Central Nervous System Stimulants; Female; Humans; Jet Lag Syndrome; Male; Melatonin; Middle Aged; Sleep; Sleep Stages

2004
Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity.
    British journal of clinical pharmacology, 2003, Volume: 56, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Drug Combinations; Female; Heterozygote; Homozygote; Humans; Male; Melatonin

2003
Low-dose repeated caffeine administration for circadian-phase-dependent performance degradation during extended wakefulness.
    Sleep, 2004, May-01, Volume: 27, Issue:3

    Topics: Adolescent; Adult; Body Temperature; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Female; Homeostasis; Humans; Male; Melatonin; Periodicity; Polysomnography; Severity of Illness Index; Sleep; Sleep Disorders, Circadian Rhythm; Wakefulness

2004
Metabolic and hormonal effects of caffeine: randomized, double-blind, placebo-controlled crossover trial.
    Metabolism: clinical and experimental, 2007, Volume: 56, Issue:12

    Topics: Adult; Androstenedione; Blood Glucose; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Dehydroepiandrosterone; Double-Blind Method; Female; Humans; Hydrocortisone; Insulin; Male; Melatonin; Salivary Glands

2007
Caffeine does not entrain the circadian clock but improves daytime alertness in blind patients with non-24-hour rhythms.
    Sleep medicine, 2015, Volume: 16, Issue:6

    Topics: Affect; Aged; Arousal; Blindness; Caffeine; Circadian Clocks; Humans; Male; Melatonin; Middle Aged; Polysomnography; Sleep Disorders, Circadian Rhythm

2015
Effects of caffeine on the human circadian clock in vivo and in vitro.
    Science translational medicine, 2015, Sep-16, Volume: 7, Issue:305

    Topics: Adult; Analysis of Variance; Biosensing Techniques; Caffeine; Cell Line, Tumor; Circadian Clocks; Circadian Rhythm; Cyclic AMP; Dose-Response Relationship, Drug; Double-Blind Method; Female; Healthy Volunteers; Humans; Luminescence; Male; Melatonin; RNA, Small Interfering; Young Adult

2015
Melatonin and Caffeine Supplementation Used, Respectively, as Protective and Stimulating Agents in the Cryopreservation of Human Sperm Improves Survival, Viability, and Motility after Thawing compared to Traditional TEST-Yolk Buffer.
    Oxidative medicine and cellular longevity, 2019, Volume: 2019

    Topics: Adult; Buffers; Caffeine; Cell Survival; Cryopreservation; Humans; Male; Melatonin; Middle Aged; Reactive Oxygen Species; Sperm Motility; Spermatozoa

2019
Wide awake at bedtime? Effects of caffeine on sleep and circadian timing in male adolescents - A randomized crossover trial.
    Biochemical pharmacology, 2021, Volume: 191

    Topics: Adolescent; Brain; Caffeine; Central Nervous System Stimulants; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Humans; Male; Melatonin; Saliva; Sleep; Wakefulness

2021

Other Studies

40 other study(ies) available for melatonin and caffeine

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:6

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.
    European journal of medicinal chemistry, 2017, Apr-21, Volume: 130

    Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Donepezil; Glutamates; Hippocampus; Humans; Indans; Neuroprotective Agents; Piperidines; Rats; Solid-Phase Synthesis Techniques

2017
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.
    Journal of medicinal chemistry, 2021, 04-22, Volume: 64, Issue:8

    Topics: Binding Sites; Catalytic Domain; Cell Nucleus; Cytoplasm; Enzyme Inhibitors; Esterases; Humans; Molecular Dynamics Simulation; Small Molecule Libraries; Wnt Signaling Pathway

2021
Mechanisms and interactions in testicular steroidogenesis and prostaglandin synthesis.
    Journal of steroid biochemistry, 1975, Volume: 6, Issue:6

    Topics: Adrenal Glands; Adrenal Medulla; Adrenalectomy; Animals; Bucladesine; Caffeine; Cyclic AMP; Hydrocortisone; Hypophysectomy; Lipid Metabolism; Male; Melatonin; Muscle Contraction; Peroxidases; Pituitary Gland; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Serotonin; Steroids; Testis

1975
Integrated nature of chromatophore responses in the in vitro frog skin bioassay.
    Endocrinology, 1969, Volume: 84, Issue:1

    Topics: Acetylcholine; Animals; Anura; Biological Assay; Caffeine; Chromatophores; Female; In Vitro Techniques; Male; Melanins; Melanocyte-Stimulating Hormones; Melatonin; Norepinephrine; Photometry; Pigmentation; Skin; Stimulation, Chemical

1969
Calcium and photoentrainment in chick pineal cells revisited: effects of caffeine, thapsigargin, EGTA, and light on the melatonin rhythm.
    Journal of neurochemistry, 1995, Volume: 65, Issue:3

    Topics: Animals; Caffeine; Calcium; Cells, Cultured; Chickens; Circadian Rhythm; Egtazic Acid; Light; Melatonin; Pineal Gland; Terpenes; Thapsigargin

1995
Caffeine and propranolol block the increase in rat pineal melatonin production produced by stimulation of adenosine receptors.
    Neuroscience letters, 1994, Jul-18, Volume: 176, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Animals; Binding, Competitive; Caffeine; Caudate Nucleus; Circadian Rhythm; Male; Melatonin; Pineal Gland; Propranolol; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Vasodilator Agents

1994
Expression and functional characterization of a melatonin-sensitive receptor in Xenopus oocytes.
    FEBS letters, 1996, Feb-26, Volume: 381, Issue:1-2

    Topics: Animals; Anthracenes; Autoradiography; Binding Sites; Brain; Caffeine; Colforsin; Cyclic AMP; Female; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Melatonin; Membrane Potentials; Microinjections; Oocytes; Patch-Clamp Techniques; Pertussis Toxin; Rats; Receptors, Cell Surface; Receptors, Melatonin; RNA, Messenger; Virulence Factors, Bordetella

1996
Orally given melatonin may serve as a probe drug for cytochrome P450 1A2 activity in vivo: a pilot study.
    Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:1

    Topics: Administration, Oral; Adult; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Male; Melatonin; Phenotype; Pilot Projects; Reference Values; Time Factors

2001
Combating fatigue to enhance safety.
    Aviation week & space technology, 1996, Nov-04, Volume: 145, Issue:19

    Topics: Accidents, Aviation; Aerospace Medicine; Caffeine; Circadian Rhythm; Ergonomics; Fatigue; Humans; Melatonin; Occupational Health; Personnel Staffing and Scheduling; Sleep Deprivation; Task Performance and Analysis; Work Schedule Tolerance; Workload

1996
Does hepatic metabolism of melatonin affect the endogenous serum melatonin level in man?
    Journal of endocrinological investigation, 2002, Volume: 25, Issue:5

    Topics: Adult; Aged; Area Under Curve; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Liver; Male; Melatonin; Middle Aged

2002
ON THE ACTION OF COLCHICINE, THE MELANOCYTE MODEL.
    The Journal of experimental medicine, 1965, Aug-01, Volume: 122

    Topics: Acetates; Animals; Anura; Caffeine; Cell Division; Chromatophores; Colchicine; Cytoplasm; Gout; Hydrocortisone; Melanocyte-Stimulating Hormones; Melanocytes; Melatonin; Models, Theoretical; Norepinephrine; Pharmacology; Research; Skin

1965
Are changes in MAPK/ERK necessary or sufficient for entrainment in chick pineal cells?
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Nov-05, Volume: 23, Issue:31

    Topics: Acetylserotonin O-Methyltransferase; Animals; Blood Proteins; Caffeine; Cells, Cultured; Central Nervous System Stimulants; Chickens; Circadian Rhythm; Darkness; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; Light; Melatonin; Mitogen-Activated Protein Kinases; Osmolar Concentration; Pineal Gland; Pyridines

2003
[Strategies against jet lag].
    Praxis, 2004, Apr-21, Volume: 93, Issue:17

    Topics: Anti-Anxiety Agents; Caffeine; Central Nervous System Stimulants; Complementary Therapies; Homeopathy; Humans; Jet Lag Syndrome; Melatonin; Time Factors; Triazolam

2004
Effect of caffeine intake 12 or 24 hours prior to melatonin intake and CYP1A2*1F polymorphism on CYP1A2 phenotyping by melatonin.
    Basic & clinical pharmacology & toxicology, 2006, Volume: 99, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Female; Humans; Male; Melatonin; Polymorphism, Genetic

2006
Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis.
    Journal of pineal research, 2008, Volume: 44, Issue:3

    Topics: Acalculous Cholecystitis; Animals; Caffeine; Calcium; Cholecystitis, Acute; Common Bile Duct; Disease Models, Animal; Gallbladder; Guinea Pigs; Homeostasis; Ligation; Lipid Peroxidation; Male; Melatonin; Muscle Contraction; Nitrendipine; Pinacidil; Thapsigargin

2008
[Clinical picture and treatment of jet lag].
    Orvosi hetilap, 2011, Dec-11, Volume: 152, Issue:50

    Topics: Benzhydryl Compounds; Biological Clocks; Caffeine; Central Nervous System Depressants; Central Nervous System Stimulants; Circadian Rhythm; Humans; Jet Lag Syndrome; Melatonin; Modafinil; Sleep

2011
Effect of melatonin and caffeine interaction on caffeine induced oxidative stress and sleep disorders.
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2010, Nov-24, Volume: 25, Issue:1

    Topics: Animals; Caffeine; Drug Combinations; Drug Interactions; Melatonin; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Sleep Wake Disorders; Treatment Outcome

2010
Jet lag and travel fatigue: a comprehensive management plan for sport medicine physicians and high-performance support teams.
    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine, 2012, Volume: 22, Issue:3

    Topics: Athletes; Athletic Performance; Caffeine; Circadian Rhythm; Fatigue; Humans; Hypnotics and Sedatives; Jet Lag Syndrome; Melatonin; Physicians; Sports Medicine; Workforce

2012
Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells.
    Neuropharmacology, 2012, Volume: 63, Issue:8

    Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antioxidants; Caffeine; Cells, Cultured; Central Nervous System Stimulants; Cyclic AMP; Cyclic GMP; Enzyme-Linked Immunosorbent Assay; In Vitro Techniques; Melatonin; Membrane Potential, Mitochondrial; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Diseases; Neurons; Oxygen Consumption; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Reactive Oxygen Species; Signal Transduction; Transfection

2012
Melatonin prevents postovulatory oocyte aging in the mouse and extends the window for optimal fertilization in vitro.
    Biology of reproduction, 2013, Volume: 88, Issue:3

    Topics: Animals; Antioxidants; Apoptosis; Caffeine; Cellular Senescence; Drug Evaluation, Preclinical; Female; Fertilization in Vitro; Melatonin; Mice; Mice, Inbred C57BL; Oocytes; Oxidative Stress; Phosphodiesterase Inhibitors

2013
Design, synthesis of novel lipids as chemical permeation enhancers and development of nanoparticle system for transdermal drug delivery.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: alpha-MSH; Animals; Caffeine; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Delivery Systems; Estradiol; Ethanol; Humans; Lipids; Melatonin; Nanoparticles; Permeability; Rats; Skin; Substance P

2013
Evidence for supplemental treatments in androgenetic alopecia.
    Journal of drugs in dermatology : JDD, 2014, Volume: 13, Issue:7

    Topics: Alopecia; Biological Products; Biotin; Caffeine; Female; Humans; Male; Melatonin; Zinc

2014
Coffee and caffeine potentiate the antiamyloidogenic activity of melatonin via inhibition of Aβ oligomerization and modulation of the Tau-mediated pathway in N2a/APP cells.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Amyloid beta-Peptides; Animals; Caffeine; Cell Survival; Coffee; Dose-Response Relationship, Drug; Melatonin; Mice; Molecular Docking Simulation; Protein Aggregation, Pathological; Protein Multimerization; Structure-Activity Relationship; tau Proteins; Tumor Cells, Cultured

2015
Lifetime coffee consumption, pineal gland volume, and sleep quality in late life.
    Sleep, 2018, 10-01, Volume: 41, Issue:10

    Topics: Aged; Aged, 80 and over; Caffeine; Coffee; Cognition; Dementia; Female; Humans; Imaging, Three-Dimensional; Linear Models; Longitudinal Studies; Male; Melatonin; Middle Aged; Pineal Gland; Sleep

2018
Caffeine-dependent changes of sleep-wake regulation: Evidence for adaptation after repeated intake.
    Progress in neuro-psychopharmacology & biological psychiatry, 2020, 04-20, Volume: 99

    Topics: Adaptation, Physiological; Adolescent; Adult; Caffeine; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Humans; Hydrocortisone; Male; Melatonin; Saliva; Sleep; Wakefulness; Young Adult

2020
Top 10 evidence-based countermeasures for night shift workers.
    Emergency medicine journal : EMJ, 2020, Volume: 37, Issue:9

    Topics: Caffeine; Circadian Rhythm; Eating; Efficiency; Emergency Service, Hospital; Fatigue; Female; Humans; Lighting; Male; Melatonin; Personnel Staffing and Scheduling; Quality of Life; Sleep Deprivation; Temperature; Work Schedule Tolerance

2020
Design of multi-particulate "Dome matrix" with sustained-release melatonin and delayed-release caffeine for jet lag treatment.
    International journal of pharmaceutics, 2020, Sep-25, Volume: 587

    Topics: Animals; Caffeine; Delayed-Action Preparations; Jet Lag Syndrome; Melatonin; Polymers; Rats; Solubility

2020
Exogenous melatonin improves tea quality under moderate high temperatures by increasing epigallocatechin-3-gallate and theanine biosynthesis in Camellia sinensis L.
    Journal of plant physiology, 2020, Volume: 253

    Topics: Caffeine; Camellia sinensis; Catechin; Climate; Glutamates; Melatonin; Photosynthesis; Plant Leaves; Tea; Temperature

2020
The protective role of melatonin against the effects of different doses of caffeine on the fetus.
    Cellular and molecular biology (Noisy-le-Grand, France), 2020, Jul-31, Volume: 66, Issue:5

    Topics: Animals; Antioxidants; Biomarkers; Bone and Bones; Caffeine; Female; Fetus; Inflammation; Liver; Male; Melatonin; Placenta; Pregnancy; Protective Agents; Rats; Rats, Wistar; Receptor, Angiotensin, Type 2; Up-Regulation

2020
Evaluation of CYP1A2 activity: Relationship between the endogenous urinary 6-hydroxymelatonin to melatonin ratio and paraxanthine to caffeine ratio in dried blood spots.
    Clinical and translational science, 2022, Volume: 15, Issue:6

    Topics: Caffeine; Cytochrome P-450 CYP1A2; Dried Blood Spot Testing; Humans; Melatonin; Theophylline

2022
Advanced Dome cellulose/alginate/chitosan composite matrix design with gastric and intestinal co-targeting capacities.
    International journal of pharmaceutics, 2022, Nov-25, Volume: 628

    Topics: Alginates; Caffeine; Cellulose; Chitosan; Hexuronic Acids; Melatonin; Stomach

2022
Application of Secondary Electrospray Ionization Coupled with High-Resolution Mass Spectrometry in Chemical Characterization of Thermally Generated Aerosols.
    Journal of the American Society for Mass Spectrometry, 2022, Nov-02, Volume: 33, Issue:11

    Topics: Aerosols; Azithromycin; Caffeine; Cannabidiol; Hydroxychloroquine; Melatonin; Spectrometry, Mass, Electrospray Ionization; Vitamin B 12

2022
3D printing of LEGO® like designs with tailored release profiles for treatment of sleep disorder.
    International journal of pharmaceutics, 2023, Feb-05, Volume: 632

    Topics: Caffeine; Drug Liberation; Humans; Melatonin; Printing, Three-Dimensional; Sleep Wake Disorders; Tablets; Technology, Pharmaceutical

2023
Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia-ischemia in newborn rats: a multi-drug randomized controlled screening trial.
    Scientific reports, 2023, 06-10, Volume: 13, Issue:1

    Topics: Allopurinol; Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Brain Injuries; Caffeine; Clemastine; Disease Models, Animal; Hedgehog Proteins; Humans; Hydroxybutyrates; Hypothermia, Induced; Hypoxia; Hypoxia-Ischemia, Brain; Infant, Newborn; Ischemia; Melatonin; Neuroprotective Agents; Rats

2023
IBA and melatonin increase trigonelline and caffeine during the induction and initiation of adventitious roots in Coffea arabica L. cuttings.
    Scientific reports, 2023, 09-13, Volume: 13, Issue:1

    Topics: Antioxidants; Caffeine; Coffea; Hydrogen Peroxide; Melatonin; Phenols

2023