melatonin and 6-hydroxymelatonin

melatonin has been researched along with 6-hydroxymelatonin in 129 studies

Research

Studies (129)

Timeframe	Studies, this research(%)	All Research%
pre-1990	53 (41.09)	18.7374
1990's	31 (24.03)	18.2507
2000's	26 (20.16)	29.6817
2010's	15 (11.63)	24.3611
2020's	4 (3.10)	2.80

Authors

Authors	Studies
Dubocovich, ML	1
Dubocovich, ML; Iacob, S; Masana, MI; Sauri, DM	1
Balsamini, C; Bordi, F; Diamantini, G; Fraschini, F; Lucini, V; Mor, M; Nonno, R; Plazzi, PV; Rivara, S; Silva, C; Spadoni, G; Stankov, BM; Tarzia, G	1
Beresford, I; Browning, C; Fraser, N; Giles, H	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Laborda, P; Shi, XC; Wang, SY	1
Colburn, RW; Kopin, IJ; Markey, SP; Sisak, ME; Zavadil, AP	1
Little, JC; Reiter, RJ; Rudeen, PK; Sackman, JW; Waring, PJ	1
Reiter, RJ; Vaughan, GM; Vaughan, MK	1
Birmaher, B; Dahl, RE; Perel, JM; Puig-Antich, J; Ryan, ND; Thomas, CR; Waterman, GS; Williamson, DE	1
Ji, L; Kanamori, M; Mikami, H; Takatori, T; Terazawa, K; Tomaru, Y	1
Anderson, LE; Brown, DP; Buschbom, RL; Miller, DL; Morris, JE; Sommers-Flannigan, R; Wilson, BW; Wright, CW	1
Kuchel, GA; Sherman, RL; Zigmond, RE	1
Flügge, G; Laitinen, JT; Saavedra, JM	1
Castro, B; de Reviers, MM; Pelletier, J; Roblot, G; Wylde, R	1
Demitrack, MA; Lewy, AJ; Reus, VI	1
Higa, S; Markey, SP	1
Arendt, J; Bearn, J; Checkley, SA; Franey, C	1
Arendt, J; Ioannides, C; Neville, S	1
Brown, GM; Garfinkel, PE; Kennedy, SH	1
Hill, BT; Shellard, SA; Whelan, RD	1
Golden, RN; Potter, WZ	1
Arendt, J; Broadway, J	1
Leone, RM; Silman, RE; Young, IM	1
Lewy, AJ; Sack, RL	1
Higa, S; Kishimoto, S; Markey, SP; Nakajima, A; Sakoda, S; Suzuki, T; Takaba, Y	1
Cowdry, RW; Golden, RN; Markey, SP; Potter, WZ; Risby, ED; Rudorfer, MV	1
Francis, PL; Leone, AM; McKenzie-Gray, B	1
Gallant, SA; Hamilton, JA; Pinkel, S	1
Arendt, J; Jacobsen, FM; James, SP; Parry, BL; Rosenthal, NE; Sack, DA; Wehr, TA	1
Francis, PL; Leone, AM; Silman, RE; Stovell, P; Young, IM	2
Krause, G; Lewy, AJ; Samples, JR	1
McMillen, IC; Nowak, R; Redman, J; Short, RV	1
Korenman, EM; Silman, RE; Watson, BW	1
Arendt, J; Bojkowski, CJ; Markey, SP; Shih, MC	1
Francis, PL; Leone, AM; Silman, RE	1
Carbone, F; Earl, CR; Kennaway, DJ; Royles, P; Shaw, PF; Webb, H	1
Adler, N; Klein, DC; Markey, SP; Witcher, J; Yanovski, J	1
Arendt, J; Bojkowski, CJ; English, J; Poulton, AL; Symons, AM	1
Law, SP	1
Aldhous, M; Arendt, J; Burton, S; Checkley, S; Franey, C	1
Grinevich, YA; Labunetz, IF	1
Erb, DL; Lewy, AJ; Sack, RL; Singer, CM; Vollmer, WM	1
Kennaway, DJ; Royles, P	1
Aubert, ML; Lang, U; Rivest, RW; Sizonenko, PC; Vinas-Bradtke, JC	1
Arendt, J; Bojkowski, C; English, J; Folkard, S; Griffiths, PA	1
Francis, P; Leone, RM; Silman, RE; Stovell, P; Young, IM	1
Boyce, PM	1
Arendt, J; Bojkowski, C; Franey, C; Marks, V; Wright, J	1
Danforth, DN; Higa, S; Markey, SP; Shih, M; Tamarkin, L	1
Dunnette, J; Mwaluko, G; Reiter, C; Van Loon, J; Weinshilboum, R	1
Miura, R; Uemura, T; Yamamoto, A; Yamano, T	1
Creed, GJ; Higa, S; Jacobowitz, DM; Klein, DC; Markey, SP; Smoot, R; Weller, JL	1
Burns, RS; Ebert, MH; Higa, S; Markey, SP; Martin, PR; Tamarkin, L	1
Leone, RM; Silman, RE	1
Fellenberg, AJ; Phillipou, G; Seamark, RF	2
Kirk, KL; Klein, DC; Martin, JE	1
Markey, SP; Mishkin, M; Perlow, MJ; Tetsuo, M	1
Markey, SP; Poth, M; Tetsuo, M	1
Buell, PE; Markey, SP	1
Kopin, IJ; Markey, SP; Tetsuo, M	1
Colburn, RW; Kopin, IJ; Markey, SP; Tetsuo, M	1
Kopin, IJ; Markey, SP; Polinsky, RJ; Tetsuo, M	1
Surh, Y	1
Baker, E; Chen, YM; Putcha, L; Whitson, PA	1
Bartsch, C; Bartsch, H; Lippert, TH; Mecke, D; Praast, G	1
Hagedorn, JE; Singer, SS; Smith, DM; Williams, JL	1
Laakso, ML; Leinonen, LM; Lindroos, OF; Veilahti, J	1
Heninger, GR; McDougle, CJ; Olcese, J; Price, LH; Schumacher, M; Zimmermann, RC	1
Courboin, G; Henriet, I; Laborit, H; Pierrefiche, G; Topall, G	1
Cavallo, A; Ritschel, WA	1
Bartsch, C; Bartsch, H	1
Klee, G; Krahn, L; Lin, SC; Lu, PY; Ory, SJ; Zimmermann, RC	1
Barrett, P; Canning, SJ; Conway, S; Delagrange, P; Drew, JE; Guardiola-Lemaitre, B; Jockers, R; Morgan, PJ; Strosberg, AD	1
Lippert, TH; Mueck, AO; Seegar, H	1
Garratt, PJ; Pickering, H; Sugden, D; Teh, MT	1
Chan, HC; Lui, KM; Poon, AM; Wong, WS	1
Hu, DN; McCormick, SA; Roberts, JE	1
Burch, JB; Keefe, TJ; Pitrat, CA; Reif, JS; Yost, MG	2
Klee, GG; Krahn, LE; Lin, SC; Lu, PY; Ory, SJ; Zimmermann, RC	1
Kissinger, PT; Wong, PS; Xie, F; Yoshioka, K	1
Calvo, JR; García-Pergañeda, A; Guerrero, JM; Paz Romero, M; Pozo, D; Rafii-El-Idrissi, M	1
Burch, JB; Reif, JS; Yost, MG	1
Burch, JB; Noonan, CW; Reif, JS; Yost, MG	1
Garcia, JJ; Manchester, LC; Qi, W; Reiter, RJ; Siu, AW; Tan, DX	1
Honma, W; Kamiyama, Y; Nagata, K; Sasano, H; Shimada, M; Yamazoe, Y; Yoshinari, K	1
Arand, M; Friedberg, T; Härtter, S; Hiemke, C; Oesch, F; Wang, X; Weigmann, H	1
Akama, Y; Hara, M; Hasegawa, T; Hirata, K; Iigo, M; Nishijima, H; Ohtani-Kaneko, R; Shimada, A; Yokosuka, M; Yoshida, M	1
Facciolá, G; Hidestrand, M; Tybring, G; von Bahr, C	1
Bertilsson, L; Bodin, K; Härtter, S; Morita, S; Tybring, G; Ursing, C	1
Bertilsson, L; Christensen, M; Härtter, S; Morita, S; Röjdmark, S; Tybring, G; Ursing, C; von Bahr, C	1
Samel, A; Vejvoda, M; Wegmann, HM	1
Blaszkewicz, M; Bröde, P; Griefahn, B; Remer, T	1
Bortkiewicz, A; Gadzicka, E; Pilacik, B; Szymczak, W	1
Bonnefont-Rousselot, D; Caudeville, B; Clavey, V; Duriez, P; Fievet, C; Foricher, R; Fruchart, JC; Furman, C; Gardes-Albert, M; Lemdani, M; Lesieur, D; Lestavel, S; Rolando, C; Tailleux, A; Teissier, E; Torpier, G	1
Chen, Z; Chua, BH; Chua, CC; Hamdy, R; Liu, X; Ma, YS; Youngberg, GA	1
Daya, S; Limson, JL; Maharaj, DS	1
Daya, S; Glass, BD; Maharaj, DS; Walker, RB	1
Lee, CG; Lee, EJ; Ying, GW	1
Frisch, H; Müllner-Eidenböck, A; Neupane, P; Schweitzer, K; Waldhauser, F; Waldhör, T	1
Hiraku, Y; Kawanishi, S; Oikawa, S; Sakano, K	1
Antunes, EM; Daya, S; Glass, BD; Maharaj, DS; Maharaj, H; Maree, DM; Nyokong, T	1
Allen, E; Burch, JB; Johnson, W; Yost, MG	1
Heikkinen, P; Juutilainen, J; Kumlin, T; Laitinen, JT	1
Daya, S; Glass, BD; Maharaj, DS; Maharaj, H	1
Daya, S; Glass, BD; Maharaj, DS	1
Antonova, M; Korik, E; Semak, I; Slominski, A; Wortsman, J	1
Balliuzek, MF; Grinenko, TN; Kvetnaia, TV	1
Bolzenius, K; Buyken, AE; Diethelm, K; Griefahn, B; Libuda, L; Remer, T	1
Agilli, M; Akgul, EO; Arslan, Y; Aydin, I; Cakir, E; Cayci, T; Deniz, O; Erbil, MK; Gumus, S; Ilhan, N; Kurt, YG; Ozkan, E; Oztosun, M; Yaman, H	1
Antoniuk-Shcheglova, IA; Bondarenko, EV; Shatilo, VB	1
Fischer, TW; Janjetovic, Z; Kim, TK; Kleszczynski, K; Li, W; Lin, Z; Reiter, RJ; Slominski, AT; Sweatman, T	1
Ioannides, C; Papagiannidou, E; Skene, DJ	1
Hanna, S; Janjetovic, Z; Jarrett, SG; Kim, TK; Nahmias, ZP; Reiter, RJ; Slominski, AT	1
Kim, TK; Li, W; Lin, Z; Slominski, AT; Tidwell, WJ	1
Álvarez-Diduk, R; Galano, A; Reiter, RJ; Tan, DX	1
Ahn, YH; Choi, HD; Kim, HS; Kim, N; Lee, YH; Lee, YS; Pack, JK; Paik, MJ	1
Back, K; Byeon, Y; Reiter, RJ; Tan, DX	1
Liu, S; Lu, X; Man, S; Wang, Y; Xu, H; Yuan, B; Zhao, H	1
Fischer, TW; Hardeland, R; Kim, TK; Kleszczyński, K; Reiter, RJ; Semak, I; Slominski, AT	1
Dhamankar, V; Donovan, MD	1
Álvarez-Idaboy, JR; Castañeda-Arriaga, R; Galano, A; Pérez-González, A; Reiter, RJ	1
Daali, Y; Desmeules, J; Le Bloc'h, F; Magliocco, G; Thomas, A	1
Daali, Y; Desmeules, J; Magliocco, G; Samer, CF; Thomas, A	1
Furihata, T; Kunimatsu, M; Ogawa, S; Ohki, S; Shibasaki, H; Takano, H; Yokokawa, A	1

Reviews

2 review(s) available for melatonin and 6-hydroxymelatonin

Article	Year
Indole-based melatonin analogues: Synthetic approaches and biological activity. European journal of medicinal chemistry, 2020, Jan-01, Volume: 185 Topics: Animals; Dose-Response Relationship, Drug; Humans; Indoles; Ligands; Melatonin; Molecular Structure; Receptors, Melatonin; Structure-Activity Relationship	2020
Melatonin: new places in therapy. Bioscience reports, 2007, Volume: 27, Issue:6 Topics: Animals; Antioxidants; Circadian Rhythm; Humans; Kynuramine; Melatonin; Neuroprotective Agents; Pineal Gland; Reactive Oxygen Species	2007

Trials

11 trial(s) available for melatonin and 6-hydroxymelatonin

Article	Year
Antidepressants reduce whole-body norepinephrine turnover while enhancing 6-hydroxymelatonin output. Archives of general psychiatry, 1988, Volume: 45, Issue:2 Topics: Adult; Animals; Antidepressive Agents; Bupropion; Depressive Disorder; Desipramine; Female; Humans; Male; Melatonin; Mice; Middle Aged; Norepinephrine; Propiophenones; Tranylcypromine	1988
Atenolol in seasonal affective disorder: a test of the melatonin hypothesis. The American journal of psychiatry, 1988, Volume: 145, Issue:1 Topics: Adult; Atenolol; Blood Pressure; Clinical Trials as Topic; Depressive Disorder; Female; Humans; Male; Melatonin; Phototherapy; Placebos; Pulse; Seasons; Secretory Rate	1988
Effect of melatonin on intraocular pressure. Current eye research, 1988, Volume: 7, Issue:7 Topics: Administration, Oral; Circadian Rhythm; Humans; Intraocular Pressure; Light; Melatonin	1988
Acute treatment with desipramine stimulates melatonin and 6-sulphatoxy melatonin production in man. British journal of clinical pharmacology, 1986, Volume: 22, Issue:1 Topics: Adult; Desipramine; Female; Humans; Male; Melatonin; Radioimmunoassay; Time Factors	1986
Urinary 6-hydroxymelatonin sulfate as a measure of melatonin secretion during acute tryptophan depletion. Psychoneuroendocrinology, 1993, Volume: 18, Issue:8 Topics: Adult; Circadian Rhythm; Double-Blind Method; Female; Humans; Male; Melatonin; Pineal Gland; Reference Values; Serotonin; Tryptophan	1993
The impact of gender on alpha-methyl-para-tyrosine mediated changes in prolactin secretion and 6-hydroxymelatonin sulfate excretion. Psychoneuroendocrinology, 1996, Volume: 21, Issue:5 Topics: Adult; Affect; alpha-Methyltyrosine; Arousal; Cross-Over Studies; Dopamine; Double-Blind Method; Female; Humans; Male; Melatonin; Methyltyrosines; Norepinephrine; Prolactin; Promethazine; Reference Values; Sex Factors	1996
Nocturnal excretion of a urinary melatonin metabolite among electric utility workers. Scandinavian journal of work, environment & health, 1998, Volume: 24, Issue:3 Topics: Adult; Analysis of Variance; Biomarkers; Circadian Rhythm; Electricity; Electromagnetic Fields; Environmental Monitoring; Humans; Male; Melatonin; Middle Aged; Occupational Exposure; Reference Values; Workplace	1998
The effect of presynaptic catecholamine depletion on 6-hydroxymelatonin sulfate: a double blind study of alpha-methyl-para-tyrosine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1999, Volume: 9, Issue:1-2 Topics: Adult; alpha-Methyltyrosine; Area Under Curve; Catecholamines; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Male; Melatonin; Norepinephrine; Receptors, Presynaptic; Tyrosine 3-Monooxygenase	1999
Geomagnetic disturbances are associated with reduced nocturnal excretion of a melatonin metabolite in humans. Neuroscience letters, 1999, May-14, Volume: 266, Issue:3 Topics: Circadian Rhythm; Electromagnetic Fields; Humans; Male; Melatonin; Occupational Exposure; Photic Stimulation	1999
Melatonin metabolite levels in workers exposed to 60-Hz magnetic fields: work in substations and with 3-phase conductors. Journal of occupational and environmental medicine, 2000, Volume: 42, Issue:2 Topics: Adult; Chromatography, High Pressure Liquid; Circadian Rhythm; Electricity; Electromagnetic Fields; Environmental Monitoring; Humans; Male; Melatonin; Middle Aged; Occupational Exposure; Power Plants; Radiation Dosage; Risk Assessment; Workplace	2000
[Metabolic disorders in elderly patients with hypertension and their correction with melatonin]. Advances in gerontology = Uspekhi gerontologii, 2012, Volume: 25, Issue:1 Topics: Aged; Antihypertensive Agents; Blood Glucose; Body Mass Index; Carbohydrate Metabolism; Drug Therapy, Combination; Humans; Hypertension; Insulin; Lipid Metabolism; Lipids; Melatonin; Metabolic Syndrome; Middle Aged; Pineal Gland; Waist Circumference	2012

Other Studies

116 other study(ies) available for melatonin and 6-hydroxymelatonin

Article	Year
Characterization of a retinal melatonin receptor. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:2 Topics: Animals; Calcium; Chickens; Corpus Striatum; Dopamine; In Vitro Techniques; Indoles; Melatonin; Olfactory Bulb; Rabbits; Receptors, Cell Surface; Receptors, Melatonin; Retina; Structure-Activity Relationship; Tryptamines	1985
Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:3 Topics: Animals; Cell Line; Humans; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Melatonin; Rabbits; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Receptors, Presynaptic; Recombinant Proteins; Retina	1997
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. Journal of medicinal chemistry, 1998, Sep-24, Volume: 41, Issue:20 Topics: Animals; Ligands; Melatonin; Models, Molecular; Molecular Conformation; Quail; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Structure-Activity Relationship; Superior Colliculi	1998
Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. British journal of pharmacology, 2000, Volume: 129, Issue:5 Topics: Animals; Binding, Competitive; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Humans; Isotope Labeling; Kinetics; Melatonin; Pertussis Toxin; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Proteins; Virulence Factors, Bordetella	2000
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Identification of 6-hydroxymelatonin in normal human urine by gas chromatography-mass spectrometry. Life sciences, 1979, Aug-27, Volume: 25, Issue:9 Topics: Chromatography, Gas; Humans; Mass Spectrometry; Melatonin	1979
The effects of pineal indoles given late in the light period on reproductive organs and pituitary prolactin levels in male golden hamsters. Hormone research, 1977, Volume: 8, Issue:2 Topics: Animals; Body Weight; Cricetinae; Genitalia, Male; Indoles; Light; Male; Melatonin; Mesocricetus; Organ Size; Periodicity; Pineal Gland; Pituitary Gland; Prolactin; Serotonin; Testis	1977
Inhibition of human chorionic gonadotrophin-induced hypertrophy of the ovaries and uterus in immature mice by some pineal indoles, 6-hydroxymelatonin and arginine vasotocin. The Journal of endocrinology, 1976, Volume: 68, Issue:3 Topics: Animals; Chorionic Gonadotropin; Depression, Chemical; Female; Indoles; Melatonin; Mice; Organ Size; Ovary; Serotonin; Uterus; Vasotocin	1976
Nocturnal urinary excretion of 6-hydroxymelatonin sulfate in prepubertal major depressive disorder. Biological psychiatry, 1992, Mar-15, Volume: 31, Issue:6 Topics: Adolescent; Child; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Personality Assessment; Pineal Gland; Puberty	1992
Radioimmunoassays for melatonin using an antiserum raised against a novel antigen. Nihon hoigaku zasshi = The Japanese journal of legal medicine, 1992, Volume: 46, Issue:2 Topics: Animals; Antigens; Immune Sera; Melatonin; Rabbits; Radioimmunoassay; Sensitivity and Specificity	1992
Evidence for an effect of ELF electromagnetic fields on human pineal gland function. Journal of pineal research, 1990, Volume: 9, Issue:4 Topics: Adult; Bedding and Linens; Electricity; Electromagnetic Fields; Female; Humans; Magnetics; Male; Melatonin; Pineal Gland	1990
Recovery of function following unilateral denervation, but not unilateral decentralization, of the pineal gland as indicated by measurements of pineal melatonin content and urinary melatonin metabolites. Neuroscience, 1990, Volume: 37, Issue:2 Topics: Animals; Arylamine N-Acetyltransferase; Central Nervous System; Circadian Rhythm; Denervation; Electrophysiology; Male; Melatonin; Nerve Endings; Pineal Gland; Rats; Rats, Inbred Strains; Serotonin; Sympathectomy, Chemical	1990
Characterization of melatonin receptors in the rat area postrema: modulation of affinity with cations and guanine nucleotides. Neuroendocrinology, 1990, Volume: 51, Issue:6 Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Calcium Chloride; Cations, Divalent; Cerebral Ventricles; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Magnesium Chloride; Male; Melatonin; Rats; Rats, Inbred Strains; Receptors, Melatonin; Receptors, Neurotransmitter; Serotonin; Thionucleotides	1990
Characterization of melatonin receptors in the ram pars tuberalis: influence of light. Acta endocrinologica, 1990, Volume: 123, Issue:5 Topics: Animals; Autoradiography; Light; Male; Median Eminence; Melatonin; Pituitary Gland; Receptors, Melatonin; Receptors, Neurotransmitter; Sheep; Temperature	1990
Pineal-adrenal interactions: the effect of acute pharmacological blockade of nocturnal melatonin secretion. Psychiatry research, 1990, Volume: 32, Issue:2 Topics: Adult; Atenolol; Circadian Rhythm; Female; Humans; Hypothalamo-Hypophyseal System; Male; Melatonin; Pineal Gland; Pituitary-Adrenal System; Propranolol	1990
Identification and quantification of 5-methoxyindole-3-acetic acid in human urine. Analytical biochemistry, 1985, Volume: 144, Issue:1 Topics: Adolescent; Adult; Child; Feces; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyindoleacetic Acid; Male; Melatonin; Menstrual Cycle; Pineal Gland	1985
A study of the effects of desipramine treatment alone and in combination with L-triiodothyronine on 6-sulphatoxymelatonin excretion in depressed patients. The British journal of psychiatry : the journal of mental science, 1989, Volume: 155 Topics: Adult; Aged; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Humans; Male; Melatonin; Middle Aged; Time Factors; Triiodothyronine	1989
A study of the mutagenicity of melatonin and 6-hydroxymelatonin. Journal of pineal research, 1989, Volume: 6, Issue:1 Topics: Animals; Cricetinae; Melatonin; Mutagenicity Tests; Mutation; Salmonella typhimurium	1989
Melatonin and sulphatoxymelatonin in eating disorder patients. The British journal of psychiatry : the journal of mental science, 1989, Volume: 154 Topics: Feeding and Eating Disorders; Female; Humans; Melatonin	1989
Growth inhibitory and cytotoxic effects of melatonin and its metabolites on human tumour cell lines in vitro. British journal of cancer, 1989, Volume: 60, Issue:3 Topics: 5-Methoxytryptamine; 5,6-Dihydroxytryptamine; Cell Line; Drug Screening Assays, Antitumor; Humans; Melatonin; Serotonin; Tryptamines; Tumor Cells, Cultured	1989
Neurochemical and neuroendocrine dysregulation in affective disorders. The Psychiatric clinics of North America, 1986, Volume: 9, Issue:2 Topics: Acetylcholine; Anxiety Disorders; Arousal; Brain; Depressive Disorder; Hormones; Humans; Melatonin; Mood Disorders; Neurocognitive Disorders; Neurotransmitter Agents; Norepinephrine; Stress, Psychological; Synaptic Transmission	1986
Delayed recovery of sleep and melatonin rhythms after nightshift work in Antarctic winter. Lancet (London, England), 1986, Oct-04, Volume: 2, Issue:8510 Topics: Antarctic Regions; Circadian Rhythm; Humans; Male; Melatonin; Seasons; Sleep Wake Disorders; Time Factors; Work Schedule Tolerance	1986
The mass spectrometric analysis of the urinary metabolites of melatonin and its deuterated analogues, confirming their identity as N-acetylserotonin and 6-hydroxymelatonin. Biomedical mass spectrometry, 1985, Volume: 12, Issue:7 Topics: Animals; Deuterium; Female; Gas Chromatography-Mass Spectrometry; Hydrolysis; Mass Spectrometry; Melatonin; Rats; Rats, Inbred Strains; Serotonin	1985
Desmethylimipramine treatment increases melatonin production in humans. Biological psychiatry, 1986, Volume: 21, Issue:4 Topics: Adult; Animals; Depressive Disorder; Desipramine; Female; Humans; Male; Melatonin; Middle Aged; Pineal Gland; Rats; Receptors, Adrenergic, beta	1986
Disturbed function of the pineal gland in familial amyloid polyneuropathy. Journal of neural transmission, 1987, Volume: 69, Issue:1-2 Topics: Adrenal Medulla; Adult; Amyloidosis; Female; Humans; Male; Melatonin; Metanephrine; Middle Aged; Normetanephrine; Peripheral Nervous System Diseases; Pineal Gland; Sympathetic Nervous System	1987
Rapid and simple synthesis for the sulphate esters of 6-hydroxy-melatonin and N-acetyl-serotonin. Journal of pineal research, 1988, Volume: 5, Issue:4 Topics: Melatonin; Serotonin; Sulfates	1988
Urinary 6-hydroxymelatonin in menstruating women. Biological psychiatry, 1988, Volume: 24, Issue:7 Topics: Adult; Estradiol; Female; Humans; Melatonin; Menstrual Cycle; Premenstrual Syndrome; Progesterone	1988
Constant pineal output and increasing body mass account for declining melatonin levels during human growth and sexual maturation. Journal of pineal research, 1988, Volume: 5, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Body Constitution; Child; Child, Preschool; Female; Humans; Male; Melatonin; Middle Aged; Pineal Gland; Sexual Maturation	1988
The correlation between serum and salivary melatonin concentrations and urinary 6-hydroxymelatonin sulphate excretion rates: two non-invasive techniques for monitoring human circadian rhythmicity. Clinical endocrinology, 1987, Volume: 27, Issue:4 Topics: Adult; Circadian Rhythm; Female; Humans; Male; Melatonin; Monitoring, Physiologic; Radioimmunoassay; Saliva; Specimen Handling	1987
The pattern of motor activity, light, and melatonin production in Syrian hamsters. Journal of pineal research, 1987, Volume: 4, Issue:1 Topics: Animals; Circadian Rhythm; Cricetinae; Light; Male; Melatonin; Motor Activity; Pineal Gland	1987
Melatonin secretion in humans assessed by measuring its metabolite, 6-sulfatoxymelatonin. Clinical chemistry, 1987, Volume: 33, Issue:8 Topics: Adolescent; Adult; Aged; Chromatography, Gas; Female; Humans; Male; Melatonin; Middle Aged; Radioimmunoassay; Specimen Handling; Statistics as Topic	1987
The isolation, purification, and characterisation of the principal urinary metabolites of melatonin. Journal of pineal research, 1987, Volume: 4, Issue:3 Topics: Adult; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Gas Chromatography-Mass Spectrometry; Glucuronates; Humans; Melatonin; Serotonin; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Sulfates	1987
Phase delay of the rhythm of 6-sulphatoxy melatonin excretion by artificial light. Journal of pineal research, 1987, Volume: 4, Issue:3 Topics: Adult; Circadian Rhythm; Humans; Hydrocortisone; Light; Male; Melatonin; Pineal Gland	1987
Stimulation of the paraventricular nucleus area of the hypothalamus elevates urinary 6-hydroxymelatonin during daytime. Brain research bulletin, 1987, Volume: 19, Issue:1 Topics: Animals; Circadian Rhythm; Electric Stimulation; Electrodes, Implanted; Female; Melatonin; Paraventricular Hypothalamic Nucleus; Rats; Rats, Inbred Strains	1987
Metabolism and pharmacokinetics of melatonin in the ewe. Journal of pineal research, 1987, Volume: 4, Issue:4 Topics: Administration, Oral; Animals; Female; Injections, Intravenous; Injections, Subcutaneous; Melatonin; Sheep	1987
The regulation of menstrual cycle and its relationship to the moon. Acta obstetricia et gynecologica Scandinavica, 1986, Volume: 65, Issue:1 Topics: Adolescent; Adult; Amenorrhea; Astronomical Phenomena; Astronomy; Chromatography, Thin Layer; Female; Humans; Melatonin; Menstrual Cycle; Periodicity	1986
Melatonin, thymic serum factor, and cortisol levels in healthy subjects of different age and patients with skin melanoma. Journal of pineal research, 1986, Volume: 3, Issue:3 Topics: Adrenal Cortex; Adult; Age Factors; Female; Humans; Hydrocortisone; Male; Melanoma; Melatonin; Menstrual Cycle; Middle Aged; Pineal Gland; Reference Values; Skin Neoplasms; Thymic Factor, Circulating; Thymus Hormones	1986
Human melatonin production decreases with age. Journal of pineal research, 1986, Volume: 3, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Aging; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Middle Aged; Sex Characteristics	1986
Circadian rhythms of 6-sulphatoxy melatonin, cortisol and electrolyte excretion at the summer and winter solstices in normal men and women. Acta endocrinologica, 1986, Volume: 113, Issue:3 Topics: Adult; Circadian Rhythm; Creatinine; Female; Humans; Hydrocortisone; Male; Melatonin; Potassium; Seasons; Sodium	1986
Gas chromatographic-mass spectrometric assay for 6-hydroxymelatonin sulfate and 6-hydroxymelatonin glucuronide in urine. Clinical chemistry, 1987, Volume: 33, Issue:4 Topics: Arylsulfatases; Deuterium; Gas Chromatography-Mass Spectrometry; Glucuronidase; Humans; Isotope Labeling; Melatonin	1987
Inhibitory action of exogenous melatonin, 5-methoxytryptamine, and 6-hydroxymelatonin on sexual maturation of male rats: activity of 5-methoxytryptamine might be due to its conversion to melatonin. Biology of reproduction, 1985, Volume: 33, Issue:3 Topics: 5-Methoxytryptamine; Acetylation; Animals; Biotransformation; Body Weight; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Luteinizing Hormone; Male; Melatonin; Organ Size; Pituitary Gland; Rats; Rats, Inbred Strains; Sexual Maturation; Spermatogenesis; Testosterone; Tryptamines	1985
Persistent 24-h variations of urinary 6-hydroxy melatonin sulphate and cortisol in Antarctica. Experientia, 1986, Apr-15, Volume: 42, Issue:4 Topics: Antarctic Regions; Circadian Rhythm; Darkness; Humans; Hydrocortisone; Light; Melatonin; Seasons	1986
Melatonin is metabolized to N-acetyl serotonin and 6-hydroxymelatonin in man. The Journal of clinical endocrinology and metabolism, 1985, Volume: 60, Issue:1 Topics: Adult; Biotransformation; Deuterium; Gas Chromatography-Mass Spectrometry; Glucuronates; Humans; Male; Melatonin; Serotonin; Sulfates	1985
6-Sulphatoxy melatonin in melancholia. The American journal of psychiatry, 1985, Volume: 142, Issue:1 Topics: Adult; Depressive Disorder; Dexamethasone; Female; Humans; Hydrocortisone; Male; Melatonin; Middle Aged; Psychiatric Status Rating Scales	1985
Immunoassay of 6-hydroxymelatonin sulfate in human plasma and urine: abolition of the urinary 24-hour rhythm with atenolol. The Journal of clinical endocrinology and metabolism, 1985, Volume: 60, Issue:6 Topics: Animals; Antibodies; Atenolol; Chromatography, Paper; Circadian Rhythm; Cross Reactions; Female; Humans; Immunoassay; Liver; Melatonin; Rats; Rats, Inbred Strains	1985
The correlation between human plasma melatonin levels and urinary 6-hydroxymelatonin excretion. Clinica chimica acta; international journal of clinical chemistry, 1985, Aug-30, Volume: 150, Issue:3 Topics: Adolescent; Adult; Aged; Circadian Rhythm; Female; Humans; Melatonin; Middle Aged; Radioimmunoassay	1985
Thermolabile and thermostable human platelet phenol sulfotransferase. Substrate specificity and physical separation. Naunyn-Schmiedeberg's archives of pharmacology, 1983, Volume: 324, Issue:2 Topics: Arylsulfotransferase; Blood Platelets; Chromatography, Ion Exchange; Hot Temperature; Humans; Kinetics; Melatonin; Neurotransmitter Agents; Nitrophenols; Substrate Specificity; Sulfurtransferases	1983
Microsomal methoxymelanin formation from 6-hydroxymelatonin. FEBS letters, 1980, Dec-29, Volume: 122, Issue:2 Topics: 5-Hydroxytryptophan; Animals; Electron Spin Resonance Spectroscopy; Male; Melanins; Melatonin; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Oxygen Consumption; Rats; Superoxides	1980
Lesions of the paraventricular nucleus area of the hypothalamus disrupt the suprachiasmatic leads to spinal cord circuit in the melatonin rhythm generating system. Brain research bulletin, 1983, Volume: 10, Issue:5 Topics: Acetylserotonin O-Methyltransferase; Animals; Arylamine N-Acetyltransferase; Circadian Rhythm; Ganglia, Sympathetic; Male; Melatonin; Neural Pathways; Paraventricular Hypothalamic Nucleus; Pineal Gland; Rats; Rats, Inbred Strains; Spinal Cord; Suprachiasmatic Nucleus; Synaptic Transmission	1983
Decreased 6-hydroxymelatonin excretion in Korsakoff's psychosis. Neurology, 1984, Volume: 34, Issue:7 Topics: Aged; Alcohol Amnestic Disorder; Female; Humans; Male; Melatonin; Middle Aged	1984
Melatonin can be differentially metabolized in the rat to produce N-acetylserotonin in addition to 6-hydroxy-melatonin. Endocrinology, 1984, Volume: 114, Issue:5 Topics: Animals; Chromatography, Thin Layer; Deuterium; Female; Gas Chromatography-Mass Spectrometry; Melatonin; Rats; Rats, Inbred Strains; Serotonin	1984
Urinary 6-sulphatoxy melatonin excretion during the human menstural cycle. Clinical endocrinology, 1982, Jul-01, Volume: 17, Issue:1 Topics: Adult; Circadian Rhythm; Female; Humans; Melatonin; Menstruation; Ovulation	1982
Effects of 6-hydroxy-, 6-fluoro-, and 4,6-difluoromelatonin on the in vitro pituitary response to luteinizing hormone-releasing hormone. Endocrinology, 1980, Volume: 106, Issue:1 Topics: Animals; Dose-Response Relationship, Drug; Gonadotropin-Releasing Hormone; Kinetics; Luteinizing Hormone; Male; Melatonin; Organ Culture Techniques; Pituitary Gland, Anterior; Rats; Structure-Activity Relationship	1980
Light exposure reduces and pinealectomy virtually stops urinary excretion of 6-hydroxymelatonin by rhesus monkeys. Endocrinology, 1982, Volume: 110, Issue:3 Topics: Animals; Circadian Rhythm; Darkness; Light; Macaca mulatta; Male; Melatonin; Pineal Gland	1982
Melatonin metabolite excretion during childhood and puberty. The Journal of clinical endocrinology and metabolism, 1982, Volume: 55, Issue:2 Topics: Adolescent; Age Factors; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Male; Melatonin; Puberty; Sex Factors	1982
Pinealectomy abolishes 6-hydroxymelatonin excretion by male rats. Endocrinology, 1982, Volume: 111, Issue:2 Topics: Animals; Male; Mass Spectrometry; Melatonin; Pineal Gland; Rats; Rats, Inbred Strains	1982
Measurement of 6-hydroxymelatonin in human urine and its diurnal variations. Life sciences, 1980, Jul-14, Volume: 27, Issue:2 Topics: Adult; Circadian Rhythm; Gas Chromatography-Mass Spectrometry; Humans; Male; Melatonin; Middle Aged	1980
Quantitative analysis of 6-hydroxymelatonin in human urine by gas chromatography--negative chemical ionization mass spectrometry. Analytical biochemistry, 1981, Jan-01, Volume: 110, Issue:1 Topics: Drug Stability; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Melatonin	1981
Urinary 6-hydroxymelatonin excretion in patients with orthostatic hypotension. The Journal of clinical endocrinology and metabolism, 1981, Volume: 53, Issue:3 Topics: Adolescent; Adult; Circadian Rhythm; Female; Humans; Hypotension, Orthostatic; Male; Melatonin; Nervous System Diseases; Reference Values	1981
Specific quantitation of urinary 6-hydroxymelatonin sulphate by gas chromatography mass spectrometry. Biomedical mass spectrometry, 1980, Volume: 7, Issue:2 Topics: Deuterium; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Melatonin	1980
Hepatic hydroxylation of melatonin in the rat is induced by phenobarbital and 7,12-dimethylbenz[a]anthracene--implications for cancer etiology. Experientia, 1995, Sep-29, Volume: 51, Issue:9-10 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Liver; Melatonin; Phenobarbital; Phosphoadenosine Phosphosulfate; Rats; Sulfones	1995
Melatonin and cortisol assessment of circadian shifts in astronauts before flight. Journal of pineal research, 1995, Volume: 18, Issue:3 Topics: Astronauts; Circadian Rhythm; Female; Humans; Hydrocortisone; Light; Male; Melatonin; Pineal Gland; Radioimmunoassay; Saliva; Sleep; Space Flight	1995
Hepatic hydroxylation of melatonin in the rat is induced by phenobarbital and 7,12-dimethylbenz[a]anthracene--implications for cancer etiology. Experientia, 1995, Apr-15, Volume: 51, Issue:4 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Hydroxylation; Liver; Melatonin; Neoplasms; Phenobarbital; Rats; Rats, Inbred F344	1995
The enzymatic basis for the rat liver 6-hydroxymelatonin sulfotransferase activity. Journal of pineal research, 1995, Volume: 18, Issue:1 Topics: Animals; Arylsulfotransferase; Chromatography, Gel; Chromatography, Ion Exchange; Cytosol; Enzyme Inhibitors; Enzyme Stability; Female; Hydrogen-Ion Concentration; Liver; Male; Melatonin; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sulfotransferases	1995
Characterization of melatonin binding to the anteroventral and anterodorsal thalamic nuclei of the rat. European journal of pharmacology, 1993, Nov-30, Volume: 250, Issue:1 Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; In Vitro Techniques; Iodine Radioisotopes; Male; Melatonin; Pineal Gland; Rats; Rats, Wistar; Thalamic Nuclei	1993
Antioxidant activity of melatonin in mice. Research communications in chemical pathology and pharmacology, 1993, Volume: 80, Issue:2 Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Injections, Intraperitoneal; Lipid Peroxidation; Male; Melatonin; Mice; Thiobarbituric Acid Reactive Substances	1993
Pharmacokinetics of melatonin in human sexual maturation. The Journal of clinical endocrinology and metabolism, 1996, Volume: 81, Issue:5 Topics: Adolescent; Adult; Aging; Body Weight; Child; Circadian Rhythm; Female; Humans; Male; Melatonin; Pilot Projects; Saliva; Sexual Maturation	1996
"The enzymatic basis for the rat liver 6-hydroxymelatonin sulfotransferase activity". Journal of pineal research, 1996, Volume: 20, Issue:3 Topics: Breast Neoplasms; Humans; Male; Melatonin; Prostatic Neoplasms; Sulfotransferases	1996
Identification of Mel1a melatonin receptors in the human embryonic kidney cell line HEK293: evidence of G protein-coupled melatonin receptors which do not mediate the inhibition of stimulated cyclic AMP levels. FEBS letters, 1997, Apr-21, Volume: 407, Issue:1 Topics: Binding, Competitive; Cell Line; Colforsin; Cyclic AMP; Genomic Library; GTP-Binding Proteins; Humans; Kidney; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger; Sequence Analysis, DNA; Serotonin; Signal Transduction; Tryptamines	1997
Effect of melatonin and metabolites on copper-mediated oxidation of flow density lipoprotein. British journal of clinical pharmacology, 1997, Volume: 44, Issue:3 Topics: Adult; Copper; Female; Humans; Lipoproteins, LDL; Melatonin; Oxidation-Reduction; Vitamin E	1997
Melatonin receptor pharmacology: toward subtype specificity. Biology of the cell, 1997, Volume: 89, Issue:8 Topics: 3T3 Cells; 5-Methoxytryptamine; Acetylation; Animals; Binding Sites; Binding, Competitive; Clone Cells; Cloning, Molecular; GTP-Binding Proteins; Humans; Ligands; Melanocytes; Melanophores; Melatonin; Methylation; Mice; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Fusion Proteins; Serotonin; Species Specificity; Structure-Activity Relationship; Transfection; Tryptamines; Xenopus laevis	1997
Effect of melatonin on chloride secretion by human colonic T84 cells. Life sciences, 1998, Volume: 62, Issue:23 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Calcium Channel Blockers; Cell Line; Chloride Channels; Chlorides; Colon; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Imines; Melatonin; ortho-Aminobenzoates; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Virulence Factors, Bordetella	1998
Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells. Melanoma research, 1998, Volume: 8, Issue:3 Topics: Cell Division; Dose-Response Relationship, Drug; Humans; Kynurenine; Melanoma; Melatonin; Serotonin; Tryptophan; Tumor Cells, Cultured; Uveal Neoplasms	1998
In vivo microdialysis/liquid chromatography/tandem mass spectrometry for the on-line monitoring of melatonin in rat. Rapid communications in mass spectrometry : RCM, 1999, Volume: 13, Issue:5 Topics: Animals; Biotransformation; Calibration; Chromatography, Liquid; Injections, Intraperitoneal; Male; Mass Spectrometry; Melatonin; Microdialysis; Rats; Rats, Sprague-Dawley	1999
Characterization of membrane melatonin receptor in mouse peritoneal macrophages: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein. Journal of neuroimmunology, 1999, Mar-01, Volume: 95, Issue:1-2 Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Blotting, Western; Colforsin; Cyclic AMP; GTP-Binding Protein alpha Subunits, Gi-Go; Iodine Radioisotopes; Kinetics; Macrophages, Peritoneal; Melatonin; Mice; Neuroimmunomodulation; Pertussis Toxin; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Serotonin; Signal Transduction; Tryptamines; Virulence Factors, Bordetella	1999
Reduced excretion of a melatonin metabolite in workers exposed to 60 Hz magnetic fields. American journal of epidemiology, 1999, Jul-01, Volume: 150, Issue:1 Topics: Adult; Circadian Rhythm; Colorado; Electromagnetic Fields; Environmental Monitoring; Humans; Least-Squares Analysis; Lighting; Male; Melatonin; Middle Aged; Occupational Exposure; Radioimmunoassay; Surveys and Questionnaires	1999
Increased levels of oxidatively damaged DNA induced by chromium(III) and H2O2: protection by melatonin and related molecules. Journal of pineal research, 2000, Volume: 29, Issue:1 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carbolines; Carcinogens; Cattle; Chromium; Deoxyguanosine; DNA; DNA Damage; Free Radical Scavengers; Hydrogen Peroxide; In Vitro Techniques; Indoles; Melatonin; Serotonin	2000
Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:3 Topics: Amino Acid Sequence; Animals; Arylsulfotransferase; Catecholamines; Chromans; Cytosol; Humans; Immunoblotting; Isoenzymes; Mefenamic Acid; Melatonin; Mice; Mice, Inbred Strains; Molecular Sequence Data; Phenols; Phylogeny; Rabbits; Rats; Rats, Inbred Strains; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Serotonin; Species Specificity; Substrate Specificity; Thiazoles; Thiazolidinediones; Troglitazone	2001
Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin. Journal of clinical psychopharmacology, 2001, Volume: 21, Issue:2 Topics: Antidepressive Agents, Second-Generation; Cytochrome P-450 CYP1A2; Enzyme Inhibitors; Fluvoxamine; Humans; Melatonin; Microsomes, Liver; Serotonin; Theophylline	2001
Melatonin, a pineal secretory product with antioxidant properties, protects against cisplatin-induced nephrotoxicity in rats. Journal of pineal research, 2001, Volume: 30, Issue:3 Topics: Animals; Antineoplastic Agents; Antioxidants; Blood Urea Nitrogen; Cisplatin; Creatinine; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Injections, Intraperitoneal; Kidney Diseases; Kidney Tubules, Proximal; Lipid Peroxidation; Male; Melatonin; Oxidative Stress; Pineal Gland; Rats; Rats, Sprague-Dawley	2001
Cytochrome P450 isoforms involved in melatonin metabolism in human liver microsomes. European journal of clinical pharmacology, 2001, Volume: 56, Issue:12 Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Fluvoxamine; Humans; Hydroxylation; Isoenzymes; Melatonin; Microsomes, Liver; Selective Serotonin Reuptake Inhibitors; Substrate Specificity	2001
Determination of exogenous melatonin and its 6-hydroxy metabolite in human plasma by liquid chromatography-mass spectrometry. Therapeutic drug monitoring, 2001, Volume: 23, Issue:3 Topics: Chromatography, Liquid; Humans; Mass Spectrometry; Melatonin	2001
Orally given melatonin may serve as a probe drug for cytochrome P450 1A2 activity in vivo: a pilot study. Clinical pharmacology and therapeutics, 2001, Volume: 70, Issue:1 Topics: Administration, Oral; Adult; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Male; Melatonin; Phenotype; Pilot Projects; Reference Values; Time Factors	2001
Pre-adaptation to shiftwork in space. Acta astronautica, 1993, Volume: 29, Issue:8 Topics: Adaptation, Physiological; Adult; Aerospace Medicine; Astronauts; Bed Rest; Body Temperature; Calcium; Circadian Rhythm; Electrocardiography; Head-Down Tilt; Heart Rate; Humans; Male; Melatonin; Personnel Staffing and Scheduling; Potassium; Sodium; Weightlessness Simulation; Work Schedule Tolerance	1993
Long-Term stability of 6-hydroxymelatonin sulfate in 24-h urine samples stored at -20 degrees C. Endocrine, 2001, Volume: 15, Issue:2 Topics: Child; Drug Stability; Enzyme-Linked Immunosorbent Assay; Female; Freezing; Humans; Male; Melatonin; Specimen Handling; Time Factors	2001
The excretion of 6-hydroxymelatonin sulfate in healthy young men exposed to electromagnetic fields emitted by cellular phone -- an experimental study. Neuro endocrinology letters, 2002, Volume: 23 Suppl 1 Topics: Adult; Blood Pressure; Circadian Rhythm; Clinical Trials as Topic; Electromagnetic Fields; Heart Rate; Humans; Male; Melatonin; Telephone	2002
Daily melatonin supplementation in mice increases atherosclerosis in proximal aorta. Biochemical and biophysical research communications, 2002, May-10, Volume: 293, Issue:3 Topics: Administration, Oral; Animals; Antioxidants; Aorta; Apolipoproteins B; Arteriosclerosis; Cell Line; Cholesterol; Diet, Atherogenic; Female; Kinetics; Lipoproteins; Melatonin; Mice; Mice, Transgenic; Oxidation-Reduction	2002
Melatonin as an effective protector against doxorubicin-induced cardiotoxicity. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:1 Topics: Animals; Antineoplastic Agents; Apoptosis; Body Weight; Cardiotonic Agents; Creatine Kinase; Cytoprotection; Dose-Response Relationship, Drug; Doxorubicin; Heart; Heart Diseases; In Vitro Techniques; Lethal Dose 50; Male; Melatonin; Mice; Mice, Inbred ICR; Myocardium; Organ Size; Perfusion; Survival Rate; Tumor Cells, Cultured; Ventricular Function, Left	2002
6-Hydroxymelatonin converts Fe (III) to Fe (II) and reduces iron-induced lipid peroxidation. Life sciences, 2003, Feb-07, Volume: 72, Issue:12 Topics: Animals; Electrochemistry; Electrodes; Ferric Compounds; Ferrous Compounds; Iron; Lipid Peroxidation; Liver; Male; Melatonin; Oxidation-Reduction; Rats; Rats, Wistar; Solutions	2003
6-Hydroxymelatonin protects against cyanide induced oxidative stress in rat brain homogenates. Journal of chemical neuroanatomy, 2003, Volume: 26, Issue:2 Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Cyanides; Free Radicals; In Vitro Techniques; Indicators and Reagents; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Melatonin; Nitroblue Tetrazolium; Oxidative Stress; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet	2003
A naturally occurring -263G/C variant of the human AA-NAT gene and overnight melatonin production. Molecular genetics and metabolism, 2004, Volume: 81, Issue:1 Topics: Arylamine N-Acetyltransferase; Chromatography, High Pressure Liquid; Gene Frequency; Genotype; Humans; Melatonin; Polymorphism, Single Nucleotide; Promoter Regions, Genetic	2004
Increase in 6-hydroxymelatonin excretion in humans during ascent to high altitudes. The Journal of clinical endocrinology and metabolism, 2004, Volume: 89, Issue:9 Topics: Adult; Age Factors; Aged; Altitude; Circadian Rhythm; Exercise; Female; Humans; Male; Melatonin; Middle Aged	2004
Oxidative DNA damage induced by a melatonin metabolite, 6-hydroxymelatonin, via a unique non-o-quinone type of redox cycle. Biochemical pharmacology, 2004, Nov-01, Volume: 68, Issue:9 Topics: 8-Hydroxy-2'-Deoxyguanosine; Chelating Agents; Deoxyguanosine; DNA; DNA Damage; Drug Interactions; Enzyme Activation; Free Radical Scavengers; HL-60 Cells; Humans; Hydrogen Peroxide; Melatonin; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxygen Consumption	2004
6-Hydroxymelatonin protects against quinolinic-acid-induced oxidative neurotoxicity in the rat hippocampus. The Journal of pharmacy and pharmacology, 2005, Volume: 57, Issue:7 Topics: Animals; Cardiotonic Agents; Free Radical Scavengers; Hippocampus; Male; Melatonin; Neuroprotective Agents; Oxidative Stress; Quinolinic Acid; Rats; Rats, Wistar	2005
Melatonin, sleep, and shift work adaptation. Journal of occupational and environmental medicine, 2005, Volume: 47, Issue:9 Topics: Accidents, Occupational; Adaptation, Physiological; Adult; Circadian Rhythm; Fatigue; Female; Humans; Male; Melatonin; Personnel Staffing and Scheduling; Risk Factors; Sleep Wake Disorders; Wounds and Injuries	2005
Exposure to a 50-hz magnetic field induces a circadian rhythm in 6-hydroxymelatonin sulfate excretion in mice. Journal of radiation research, 2005, Volume: 46, Issue:3 Topics: Animals; Biological Clocks; Circadian Rhythm; Dose-Response Relationship, Radiation; Electricity; Electromagnetic Fields; Environmental Exposure; Female; Melatonin; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Radiation Dosage	2005
Melatonin and 6-hydroxymelatonin protect against iron-induced neurotoxicity. Journal of neurochemistry, 2006, Volume: 96, Issue:1 Topics: Animals; Antioxidants; Hippocampus; Iron; Lipid Peroxidation; Male; Melatonin; Necrosis; Neurotoxicity Syndromes; Rats; Rats, Wistar	2006
Metabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes. Journal of pineal research, 2008, Volume: 45, Issue:4 Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Kinetics; Kynuramine; Liver; Male; Melatonin; Microsomes, Liver; Mitochondria, Liver; Rats; Rats, Wistar; Serotonin; Spectrometry, Mass, Electrospray Ionization	2008
[The role of melatonin in the development of metabolic syndrome]. Klinicheskaia meditsina, 2009, Volume: 87, Issue:6 Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Disease Progression; Female; Humans; Male; Melatonin; Metabolic Syndrome; Middle Aged; Prognosis; Radioimmunoassay	2009
Longitudinal associations between endogenous melatonin production and reported sleep duration from childhood to early adulthood. Hormone research in paediatrics, 2010, Volume: 74, Issue:6 Topics: Adolescent; Anthropometry; Child; Child, Preschool; Cross-Sectional Studies; Female; Humans; Life Style; Longitudinal Studies; Male; Melatonin; Pineal Gland; Prospective Studies; Regression Analysis; Sleep; Young Adult	2010
Plasma melatonin and urinary 6-hydroxymelatonin levels in patients with pulmonary tuberculosis. Inflammation, 2012, Volume: 35, Issue:4 Topics: Humans; Leukocyte Count; Male; Melatonin; Tuberculosis, Pulmonary; Young Adult	2012
Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013, Volume: 27, Issue:7 Topics: 5-Methoxytryptamine; Animals; Cell Differentiation; Cell Line; Cell Line, Tumor; Cells, Cultured; Chromatography, High Pressure Liquid; Epidermal Cells; Epidermis; Female; Fibroblasts; Humans; Keratin-10; Keratin-14; Keratinocytes; Kinetics; Kynuramine; Melanocytes; Melanoma; Melatonin; Metabolic Networks and Pathways; Serotonin; Skin; Spectrometry, Mass, Electrospray Ionization; Swine	2013
Potential drug interactions with melatonin. Physiology & behavior, 2014, May-28, Volume: 131 Topics: 5-Methoxypsoralen; Acetaminophen; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Second-Generation; Antineoplastic Agents, Hormonal; Central Nervous System Depressants; Diazepam; Drug Interactions; Estrogens; Fluvoxamine; Humans; Hypnotics and Sedatives; Male; Melatonin; Methoxsalen; Microsomes, Liver; Middle Aged; Rats, Wistar; Tamoxifen	2014
Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes. Journal of pineal research, 2014, Volume: 57, Issue:1 Topics: Cell Line; DNA Damage; Humans; Keratinocytes; Kynuramine; Melatonin; Serotonin; Ultraviolet Rays	2014
Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro. Molecular and cellular endocrinology, 2015, Mar-15, Volume: 404 Topics: 5-Methoxytryptamine; Adult; Age Factors; Aged; Aged, 80 and over; Black or African American; Cell Proliferation; Cells, Cultured; Epidermis; Female; Humans; In Vitro Techniques; Kynuramine; Male; Melanocytes; Melanoma; Melatonin; Middle Aged; Protein-Tyrosine Kinases; Sex Factors; Skin Neoplasms; White People	2015
N-Acetylserotonin and 6-Hydroxymelatonin against Oxidative Stress: Implications for the Overall Protection Exerted by Melatonin. The journal of physical chemistry. B, 2015, Jul-09, Volume: 119, Issue:27 Topics: Copper; Free Radical Scavengers; Hydroxyl Radical; Melatonin; Oxidative Stress; Peroxides; Serotonin; Solvents; Water	2015
Eight hours of nocturnal 915 MHz radiofrequency identification (RFID) exposure reduces urinary levels of melatonin and its metabolite via pineal arylalkylamine N-acetyltransferase activity in male rats. International journal of radiation biology, 2015, Volume: 91, Issue:11 Topics: Animals; Arylalkylamine N-Acetyltransferase; Enzyme Activation; Male; Melatonin; Pineal Gland; Radiation Dosage; Radiation Exposure; Radio Frequency Identification Device; Rats; Rats, Sprague-Dawley; Whole-Body Irradiation	2015
Predominance of 2-hydroxymelatonin over melatonin in plants. Journal of pineal research, 2015, Volume: 59, Issue:4 Topics: Acetylserotonin O-Methyltransferase; Arylalkylamine N-Acetyltransferase; Kinetics; Melatonin; Mixed Function Oxygenases; Oryza; Plant Proteins	2015
A novel LC-MS/MS assay for the simultaneous determination of melatonin and its two major metabolites, 6-hydroxymelatonin and 6-sulfatoxymelatonin in dog plasma: Application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis, 2016, Jan-05, Volume: 117 Topics: Animals; Chromatography, Liquid; Dogs; Female; Male; Melatonin; Tandem Mass Spectrometry	2016
[ACUTE CORONARY SYNDROME WITHOUT ST SEGMENT ELEVATION: POSSIBILITIES FOR PREDICTING THE CLINICAL COURSE AT THE POST-HOSPITAL (6 AND 12 MONTHS) STAGE]. Klinicheskaia meditsina, 2016, Volume: 94, Issue:3 Topics: Acute Coronary Syndrome; Aged; Calcium; Creatinine; Electrocardiography; Female; Follow-Up Studies; Humans; Interleukin-10; Interleukin-6; Male; Melatonin; Middle Aged; Myocardial Infarction; Potassium; Predictive Value of Tests; Prognosis; Risk Assessment; Russia; Sodium	2016
Metabolism of melatonin in the skin: Why is it important? Experimental dermatology, 2017, Volume: 26, Issue:7 Topics: Animals; Catalysis; Cricetinae; Cytochrome P-450 Enzyme System; Epidermis; Female; Homeostasis; Humans; Indoles; Keratinocytes; Male; Melatonin; Methylation; Mutation; Oxidative Stress; Phenotype; Phylogeny; Skin; Ultraviolet Rays	2017
Modulating nasal mucosal permeation using metabolic saturation and enzyme inhibition techniques. The Journal of pharmacy and pharmacology, 2017, Volume: 69, Issue:9 Topics: Administration, Intranasal; Animals; Biological Availability; Biological Transport; Cattle; Cytochrome P-450 Enzyme System; Melatonin; Microsomes; Nasal Mucosa; Permeability	2017
Melatonin and its metabolites as chemical agents capable of directly repairing oxidized DNA. Journal of pineal research, 2019, Volume: 66, Issue:2 Topics: DNA Adducts; DNA Damage; DNA Repair; Free Radical Scavengers; Melatonin; Models, Chemical; Oxidation-Reduction; Oxidative Stress	2019
Simultaneous determination of melatonin and 6-hydroxymelatonin in human overnight urine by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2021, Sep-01, Volume: 1181 Topics: Chromatography, Liquid; Humans; Limit of Detection; Linear Models; Melatonin; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry	2021
Evaluation of CYP1A2 activity: Relationship between the endogenous urinary 6-hydroxymelatonin to melatonin ratio and paraxanthine to caffeine ratio in dried blood spots. Clinical and translational science, 2022, Volume: 15, Issue:6 Topics: Caffeine; Cytochrome P-450 CYP1A2; Dried Blood Spot Testing; Humans; Melatonin; Theophylline	2022
Development and Validation of an LC-MS/MS-Based Method for Quantifying Urinary Endogenous 6-Hydroxymelatonin. Chemical & pharmaceutical bulletin, 2022, Volume: 70, Issue:5 Topics: Chromatography, Liquid; Humans; Melatonin; Sulfates; Tandem Mass Spectrometry	2022