melatonin has been researched along with 4-phenyl-2-propionamidotetraline in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (7.02) | 18.2507 |
| 2000's | 29 (50.88) | 29.6817 |
| 2010's | 21 (36.84) | 24.3611 |
| 2020's | 3 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Dubocovich, ML; Iacob, S; Masana, MI; Sauri, DM | 1 |
| Bedini, A; Fraschini, F; Lucini, V; Mor, M; Pannacci, M; Plazzi, PV; Rivara, S; Silva, C; Spadoni, G; Tarzia, G; Vacondio, F; Zuliani, V | 1 |
| Amossé, C; Audinot, V; Bonnaud, A; Boutin, JA; Delagrange, P; Dromaint, S; Galizzi, JP; Guillaumet, G; Lahaye-Brasseur, C; Le Gall, A; Lefoulon, F; Lesieur, D; Mailliet, F; Malpaux, B; Nagel, N; Renard, P; Rodriguez, M | 1 |
| Bedini, A; Lorenzi, S; Mor, M; Plazzi, PV; Rivara, S; Spadoni, G; Tarzia, G | 1 |
| Attia, MI; Julius, J; Sethi, S; Witt-Enderby, PA; Zlotos, DP | 1 |
| Audinot, V; Bennejean, C; Berthelot, P; Bochu, C; Boutin, JA; Caignard, DH; Chanu, A; Coumailleau, S; Delagrange, P; Durieux, S; Lesieur, D; Renard, P; Yous, S | 1 |
| Cecon, E; Jockers, R; Rivara, S; Witt-Enderby, PA; Zlotos, DP | 1 |
| Al-Ghoul, WM; Benloucif, S; Dubocovich, ML; Masana, MI; Yun, K | 1 |
| Doolen, S; Duckles, SP; Krause, DN | 1 |
| Li, L; Pang, CS; Pang, SF; Shiu, SY; Wong, JT; Xu, JN | 1 |
| Al-Ghoul, WM; Dubocovich, ML; Gillette, MU; Hunt, AE | 1 |
| Flemström, G; Jedstedt, G; Sjöblom, M | 1 |
| Dubocovich, ML; Farsky, SH; Lopes, C; Lotufo, CM; Markus, RP | 1 |
| Bac, P; Evrard, P; Gressens, P; Husson, I; Mesplès, B; Vamecq, J | 1 |
| Dubocovich, ML; Erşahin, C; Masana, MI | 1 |
| MacKenzie, RS; Melan, MA; Passey, DK; Witt-Enderby, PA | 1 |
| Berger, E; Fauteck, JD; Musshoff, U; Riewenherm, D; Speckmann, EJ | 1 |
| Becq, F; Falcón, J; Gaildrat, P | 1 |
| Kravtsov, GM; Pang, SF; Poon, AM | 1 |
| Dubocovich, ML; Gerdin, MJ; Masana, MI; Miller, RJ; Ren, D | 1 |
| Chen, Y; Fung, ML; Ip, SF; Liong, EC; Tipoe, GL; Tjong, YW | 1 |
| Alonso-Bedate, M; Alonso-Gómez, AL; Delgado, MJ; Guijarro, A; Isorna, E | 1 |
| Sun, RQ; Tu, Y; Willis, WD | 1 |
| Anhê, GF; Caperuto, LC; Carvalho, CR; Cipolla-Neto, J; Hirata, AE; Pereira-Da-Silva, M; Souza, LC; Velloso, LA | 1 |
| Markowska, M; Mrozkowiak, A; Pawlak, J; Skwarło-Sońta, K | 1 |
| Chen, Y; Fung, ML; Ip, SF; Tipoe, GL; Tjong, YW | 1 |
| Prada, C; Udin, SB; Wiechmann, AF; Zhdanova, IV | 1 |
| Audinot, V; Boutin, JA; Delagrange, P; Ferry, G | 1 |
| Prada, C; Udin, SB | 1 |
| Doi, M; Furusawa, K; Kameyama, K; Okamoto, H; Tanaka, D | 1 |
| Mühlbauer, E; Peschke, E; Stumpf, I | 1 |
| Chan, KW; Liu, VW; Pang, B; Shiu, SY; Tam, CW; Yao, KM | 1 |
| Fujinoki, M | 1 |
| Fuss-Chmielewska, J; Karasek, M; Lawnicka, H; Pawlikowski, M; Winczyk, K | 1 |
| Cabrera, J; Estévez, F; Loro, J; Negrín, G; Quintana, J; Reiter, RJ | 1 |
| Miao, Y; Wang, Z; Yang, XL; Zhang, M; Zhao, WJ | 1 |
| Cheng, JC; Hung, WY; Lee, SK; Man, GC; Ng, BK; Ng, TB; Qiu, Y; Wang, WW; Wong, JH; Yeung, BH | 1 |
| Pang, B; Shiu, SY; Tam, CW; Yao, KM | 1 |
| Bambico, FR; Domínguez-López, S; Gobbi, G; Labonté, B; Leyton, M; Mahar, I; Ochoa-Sánchez, R | 1 |
| Ahmad, R; Gupta, S; Haldar, C | 1 |
| Albrecht, E; Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E; Wolgast, S | 1 |
| Bedini, A; Comai, S; Fraschini, F; Gobbi, G; Mor, M; Ochoa-Sanchez, R; Rainer, Q; Rivara, S; Spadoni, G; Tarzia, G | 1 |
| Bedrosian, TA; Fonken, LK; Herring, KL; Nelson, RJ; Walton, JC; Weil, ZM | 1 |
| Markus, RP; Pires-Lapa, MA; Salustiano, EM; Tamura, EK | 1 |
| Fu, Y; Gao, C; He, C; Ji, P; Li, N; Li, Y; Liu, G; Tian, X; Wang, F; Zhang, L | 1 |
| Liu, D; Lu, Y; Man, HY; Wang, JZ; Wei, N; Zhu, LQ | 1 |
| Casao, A; Cebrián-Pérez, JA; Gonzalez-Arto, M; Luna, C; Muiño-Blanco, T; Pérez-Pé, R | 1 |
| Juszczak, M; Kowalczyk, E; Roszczyk, M; Stempniak, B | 1 |
| Fonseca, B; Martínez-Águila, A; Pérez de Lara, MJ; Pintor, J | 1 |
| Cao, J; Chen, F; Chen, Y; Dong, Y; Reheman, A; Wang, Z; Zhang, Y | 1 |
| Barberino, RS; Jiang, X; Matos, MHT; Menezes, VG; Palheta, RC; Ribeiro, AEAS; Smitz, JEJ | 1 |
| Deng, SL; Lian, ZX; Liu, YX; Sun, TC; Wang, XX; Wang, ZP; Yu, K; Zhang, BL; Zhang, Y | 1 |
| Tang, K; Wang, Y; Yang, W; Zan, L; Zhang, Y | 1 |
| Ikeuchi, T; Sakai, K; Yamamoto, Y | 1 |
| Cheng, JC; Fang, L; Li, Y; Sun, YP; Wang, S; Yan, Y; Yu, Y; Zhang, R | 1 |
| Chang, CF; Chen, SH; Huang, CT; Lin, SC; Lue, JH; Tsai, YJ | 1 |
| Forneck, A; Jantsch, J; Kirschneck, C; Paddenberg, E; Proff, P; Schröder, A; Smeda, M; Widbiller, M | 1 |
1 review(s) available for melatonin and 4-phenyl-2-propionamidotetraline
| Article | Year |
|---|---|
Molecular tools to study melatonin pathways and actions.
Topics: Animals; Antioxidants; Humans; Melatonin; Molecular Structure; Receptors, Melatonin; Signal Transduction; Tetrahydronaphthalenes; Tryptamines | 2005 |
1 trial(s) available for melatonin and 4-phenyl-2-propionamidotetraline
| Article | Year |
|---|---|
Melatonin synthesis in human colostrum mononuclear cells enhances dectin-1-mediated phagocytosis by mononuclear cells.
Topics: Adolescent; Adult; Animals; Cell Line; Colostrum; DNA-Binding Proteins; Female; Humans; Infant, Newborn; Lectins, C-Type; Leukocytes, Mononuclear; Melatonin; Mice; Nuclear Proteins; Phagocytosis; Proto-Oncogene Proteins c-rel; Tetrahydronaphthalenes; Transcription Factor RelA; Tryptamines | 2013 |
55 other study(ies) available for melatonin and 4-phenyl-2-propionamidotetraline
| Article | Year |
|---|---|
Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor.
Topics: Animals; Cell Line; Humans; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Melatonin; Rabbits; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Receptors, Presynaptic; Recombinant Proteins; Retina | 1997 |
Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.
Topics: Ligands; Melatonin; Models, Molecular; Models, Statistical; Pyrroles; Quantitative Structure-Activity Relationship; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin | 2003 |
New selective ligands of human cloned melatonin MT1 and MT2 receptors.
Topics: Animals; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Humans; Ligands; Melatonin; Protein Binding; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2 | 2003 |
Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cattle; Humans; Indoles; Mice; Models, Molecular; Molecular Sequence Data; NIH 3T3 Cells; Quantitative Structure-Activity Relationship; Radioligand Assay; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Sequence Homology, Amino Acid | 2005 |
2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Indoles; Melatonin; Receptors, Melatonin | 2009 |
Design and synthesis of 3-phenyltetrahydronaphthalenic derivatives as new selective MT2 melatoninergic ligands. Part II.
Topics: Animals; Cell Culture Techniques; Cell Line; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Design; Ligands; Melatonin; Receptor, Melatonin, MT2; Structure-Activity Relationship; Substrate Specificity; Tetrahydronaphthalenes; Transfection | 2009 |
MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.
Topics: Animals; Binding Sites; Depressive Disorder; Humans; Ligands; Melatonin; Models, Molecular; Protein Multimerization; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Sleep Initiation and Maintenance Disorders; Structure-Activity Relationship | 2014 |
Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms.
Topics: Animals; Base Sequence; CHO Cells; Circadian Rhythm; Cricetinae; Darkness; Humans; Male; Melatonin; Mice; Mice, Inbred C3H; Motor Activity; Oligonucleotides, Antisense; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tetrahydronaphthalenes; Transfection; Tryptamines | 1998 |
Estradiol modulates vascular response to melatonin in rat caudal artery.
Topics: Adrenergic Fibers; Animals; Arteries; Electric Stimulation; Estradiol; Estrus; Female; In Vitro Techniques; Melatonin; Ovariectomy; Rats; Rats, Inbred F344; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tail; Tetrahydronaphthalenes; Time Factors | 1999 |
Melatonin-induced inhibition of proliferation and G1/S cell cycle transition delay of human choriocarcinoma JAr cells: possible involvement of MT2 (MEL1B) receptor.
Topics: Cell Division; Choriocarcinoma; Epididymis; Epithelial Cells; G1 Phase; Humans; In Situ Hybridization; Male; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; S Phase; Tetrahydronaphthalenes; Tumor Cells, Cultured | 1999 |
Activation of MT(2) melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock.
Topics: Action Potentials; Animals; Biological Clocks; Circadian Rhythm; Iodine Radioisotopes; Male; Melatonin; Neurons; Oligoribonucleotides, Antisense; Protein Kinase C; Radioligand Assay; Rats; Rats, Long-Evans; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Suprachiasmatic Nucleus; Tetrahydronaphthalenes; Tryptamines | 2001 |
Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
Topics: Adrenocorticotropic Hormone; Animals; Bicarbonates; Blood Pressure; Circadian Rhythm; Corticotropin-Releasing Hormone; Duodenum; Enterochromaffin Cells; gamma-MSH; Hypophysectomy; Injections, Intra-Arterial; Injections, Intraventricular; Intestinal Mucosa; Melatonin; Neurosecretion; Phenylephrine; Pineal Gland; Prazosin; Protein Isoforms; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tetrahydronaphthalenes; Thiopental; Tryptamines; Vagotomy | 2001 |
Melatonin and N-acetylserotonin inhibit leukocyte rolling and adhesion to rat microcirculation.
Topics: Animals; Arterioles; Blood Flow Velocity; Cell Adhesion; Dose-Response Relationship, Drug; Leukocytes; Male; Melatonin; Microcirculation; Rats; Rats, Wistar; Serotonin; Tetrahydronaphthalenes; Tryptamines | 2001 |
Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge.
Topics: Animals; Animals, Newborn; Antioxidants; Cell Death; Cerebral Palsy; Cystine; Denervation; Disease Models, Animal; Excitatory Amino Acid Agonists; Free Radical Scavengers; Humans; Hypothermia, Induced; Ibotenic Acid; Infant, Newborn; Leukomalacia, Periventricular; Melatonin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neocortex; Neuroprotective Agents; Neurotoxins; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger; Tetrahydronaphthalenes; Tryptamines | 2002 |
Constitutively active melatonin MT(1) receptors in male rat caudal arteries.
Topics: Animals; Arteries; Autoradiography; Binding, Competitive; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Male; Melatonin; Rats; Rats, Inbred F344; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Sulfur Radioisotopes; Tetrahydronaphthalenes | 2002 |
Dual coupling of MT(1) and MT(2) melatonin receptors to cyclic AMP and phosphoinositide signal transduction cascades and their regulation following melatonin exposure.
Topics: Analysis of Variance; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Drug Interactions; Humans; Hydrolysis; Melatonin; Phosphatidylinositols; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Signal Transduction; Tetrahydronaphthalenes; Transfection | 2002 |
Melatonin receptors in rat hippocampus: molecular and functional investigations.
Topics: Animals; Circadian Rhythm; Electrophysiology; Hippocampus; Male; Melatonin; Membrane Potentials; Oocytes; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrahydronaphthalenes; Tryptamines; Xenopus | 2002 |
First cloning and functional characterization of a melatonin receptor in fish brain: a novel one?
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Blotting, Northern; Brain; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cystic Fibrosis Transmembrane Conductance Regulator; Melatonin; Molecular Sequence Data; Phylogeny; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Superior Colliculi; Tetrahydronaphthalenes | 2002 |
Receptor-mediated modulation of avian caecal muscle contraction by melatonin: role of tyrosine protein kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apamin; Binding, Competitive; Cecum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Indoles; Melatonin; Muscle Contraction; Muscle, Smooth; Naphthalenes; Potassium Channels; Protein-Tyrosine Kinases; Quail; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tetrahydronaphthalenes; Tryptamines | 2002 |
Short-term exposure to melatonin differentially affects the functional sensitivity and trafficking of the hMT1 and hMT2 melatonin receptors.
Topics: Animals; Arrestin; CHO Cells; Cricetinae; Humans; Iodine Radioisotopes; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tetrahydronaphthalenes; Transfection; Tryptamines | 2003 |
Melatonin attenuates rat carotid chemoreceptor response to hypercapnic acidosis.
Topics: Acidosis, Respiratory; Animals; Calcium; Carotid Body; Chemoreceptor Cells; Electrophysiology; Fura-2; Hypercapnia; Melatonin; Rats; Rats, Sprague-Dawley; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, Melatonin; Tetrahydronaphthalenes; Tryptamines | 2004 |
Characterization of melatonin binding sites in the brain and retina of the frog Rana perezi.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Diencephalon; Guanosine 5'-O-(3-Thiotriphosphate); Intracellular Membranes; Kinetics; Magnesium; Melatonin; Pertussis Toxin; Radioligand Assay; Ranidae; Receptors, Melatonin; Retina; Sodium; Subcellular Fractions; Superior Colliculi; Telencephalon; Tetrahydronaphthalenes; Tryptamines | 2004 |
Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats.
Topics: Administration, Topical; Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Drug Interactions; Hyperalgesia; Injections, Intramuscular; Injections, Spinal; Male; Melatonin; Neural Inhibition; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Skin; Spinal Cord; Spinal Cord Injuries; Tetrahydronaphthalenes; Tryptamines | 2004 |
In vivo activation of insulin receptor tyrosine kinase by melatonin in the rat hypothalamus.
Topics: Animals; Dose-Response Relationship, Drug; Hypothalamus; Injections, Intraventricular; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Male; Melatonin; Mitogen-Activated Protein Kinase 1; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptors, Melatonin; Tetrahydronaphthalenes; Tryptamines | 2004 |
Intracellular second messengers involved in melatonin signal transduction in chicken splenocytes in vitro.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Inositol 1,4,5-Trisphosphate; Male; Melatonin; Receptor, Melatonin, MT2; Receptors, Melatonin; Second Messenger Systems; Signal Transduction; Spleen; Tetrahydronaphthalenes; Tryptamines | 2004 |
Melatonin enhances the hypoxic response of rat carotid body chemoreceptor.
Topics: Animals; Calcium; Carotid Body; Chemoreceptor Cells; Circadian Rhythm; Hypoxia; In Vitro Techniques; Melatonin; Rats; Rats, Sprague-Dawley; Receptors, Melatonin; Respiration; Tetrahydronaphthalenes; Tryptamines | 2005 |
Stimulation of melatonin receptors decreases calcium levels in xenopus tectal cells by activating GABA(C) receptors.
Topics: Aniline Compounds; Animals; Bicuculline; Blotting, Northern; Blotting, Western; Brain Chemistry; Calcium; Circadian Rhythm; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Antagonists; In Vitro Techniques; Melatonin; Models, Neurological; Neurons; Pertussis Toxin; Potassium Chloride; Radioimmunoassay; Receptors, GABA-A; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tectum Mesencephali; Tetrahydronaphthalenes; Xanthenes; Xenopus laevis | 2005 |
Melatonin decreases calcium levels in retinotectal axons of Xenopus laevis by indirect activation of group III metabotropic glutamate receptors.
Topics: Aniline Compounds; Animals; Antioxidants; Axons; Calcium; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Melatonin; Models, Neurological; Phosphinic Acids; Picrotoxin; Potassium Chloride; Pyridines; Receptors, Metabotropic Glutamate; Retinal Ganglion Cells; Superior Colliculi; Tetrahydronaphthalenes; Xanthenes; Xenopus laevis | 2005 |
Melatonin signaling regulates locomotion behavior and homeostatic states through distinct receptor pathways in Caenorhabditis elegans.
Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chromatography; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Gene Expression; Homeostasis; Locomotion; Melatonin; Receptors, Melatonin; Signal Transduction; Tetrahydronaphthalenes; Time Factors | 2007 |
Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line, Tumor; Colforsin; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide-Gated Cation Channels; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Guanylate Cyclase; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Melatonin; Pineal Gland; Rats; Rats, Wistar; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Tryptamines | 2008 |
Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance.
Topics: Analysis of Variance; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Epithelial Cells; Gene Expression Regulation; Growth Substances; Humans; Immunoblotting; Immunohistochemistry; Male; Melatonin; Prostate; Prostatic Neoplasms; Protein Kinases; Receptors, Androgen; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Tetrahydronaphthalenes; Tryptamines | 2008 |
Melatonin-enhanced hyperactivation of hamster sperm.
Topics: Animals; Calcium; Cells, Cultured; Cricetinae; Culture Media; Dose-Response Relationship, Drug; Male; Melatonin; Mesocricetus; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Serum Albumin; Sperm Motility; Spermatozoa; Stimulation, Chemical; Tetrahydronaphthalenes; Time; Tryptamines | 2008 |
Luzindole but not 4-phenyl-2- propionamidotetralin (4P-PDOT) diminishes the inhibitory effect of melatonin on murine Colon 38 cancer growth in vitro.
Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Humans; Melatonin; Mice; Receptors, Melatonin; Tetrahydronaphthalenes; Tryptamines | 2009 |
Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells.
Topics: Cell Line, Tumor; Cell Proliferation; Diterpenes; Humans; Melanoma; Melatonin; p38 Mitogen-Activated Protein Kinases; Receptors, Melatonin; Signal Transduction; Tetrahydronaphthalenes | 2010 |
Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bridged-Ring Compounds; Calcium; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Egtazic Acid; Estrenes; Glycine; Guanosine Diphosphate; Indoles; Isoquinolines; Male; Maleimides; Melatonin; Norbornanes; Pertussis Toxin; Protein Kinase C; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor, Melatonin, MT2; Retinal Ganglion Cells; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Tetrahydronaphthalenes; Thiocarbamates; Thiones; Type C Phospholipases | 2010 |
Abnormal proliferation and differentiation of osteoblasts from girls with adolescent idiopathic scoliosis to melatonin.
Topics: Adolescent; Adult; Alkaline Phosphatase; Analysis of Variance; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Humans; Male; Melatonin; Osteoblasts; Photomicrography; Receptor, Melatonin, MT2; Scoliosis; Tetrahydronaphthalenes; Tryptamines | 2010 |
Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gα(s) and Gα(q) proteins.
Topics: Antioxidants; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein alpha Subunits, Gs; Human papillomavirus 18; Humans; Melatonin; Radioimmunoassay; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Tetrahydronaphthalenes; Tryptamines | 2010 |
Short-term effects of melatonin and pinealectomy on serotonergic neuronal activity across the light-dark cycle.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Idazoxan; Male; Melatonin; Mood Disorders; Neurons; Photoperiod; Pineal Gland; Piperazines; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Synaptic Transmission; Tetrahydronaphthalenes; Tryptamines | 2012 |
Melatonin membrane receptor type MT1 modulates cell-mediated immunity in the seasonally breeding tropical rodent Funambulus pennanti.
Topics: Analysis of Variance; Animals; Breeding; Cell Proliferation; Cells, Cultured; Concanavalin A; Dose-Response Relationship, Drug; Gene Expression Regulation; Immunity; In Vitro Techniques; Interleukin-2; Lymphocytes; Male; Melatonin; Mitogens; Random Allocation; Receptor, Melatonin, MT1; Sciuridae; Seasons; Spleen; Tetrahydronaphthalenes; Tryptamines | 2012 |
Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Colforsin; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Humans; Insulin-Secreting Cells; Insulinoma; Melatonin; Microscopy, Confocal; Pancreatic Neoplasms; Phosphorylation; Rats; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Time Factors; Transfection; Tryptamines | 2012 |
Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam.
Topics: Acetamides; Aniline Compounds; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Partial Agonism; Feeding Behavior; Male; Maze Learning; Melatonin; Motor Activity; Rats; Rats, Sprague-Dawley; Receptor, Melatonin, MT2; Tetrahydronaphthalenes; Tryptamines | 2012 |
Evidence for feedback control of pineal melatonin secretion.
Topics: Animals; Darkness; Feedback, Physiological; Female; Melatonin; Peromyscus; Pineal Gland; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Tetrahydronaphthalenes; Tryptamines | 2013 |
Beneficial effects of melatonin on in vitro bovine embryonic development are mediated by melatonin receptor 1.
Topics: Animals; Blastocyst; Cattle; Embryonic Development; Glutathione Peroxidase; Melatonin; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Superoxide Dismutase; Superoxide Dismutase-1; Tetrahydronaphthalenes; Tryptamines | 2014 |
The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling.
Topics: Animals; Axons; Cells, Cultured; Fluorescence Recovery After Photobleaching; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HEK293 Cells; Humans; In Vitro Techniques; Melatonin; Mice; Mice, Knockout; Neurons; Proto-Oncogene Proteins c-akt; Rats; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; RNA, Small Interfering; Signal Transduction; Synaptic Transmission; Tetrahydronaphthalenes | 2015 |
New evidence of melatonin receptor contribution to ram sperm functionality.
Topics: Animals; Male; Melatonin; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Sheep; Sperm Capacitation; Spermatozoa; Tetrahydronaphthalenes | 2016 |
The influence od melatonin receptors antagonists, luzindole and 4-phenyl-2-propionamidotetralin (4-P-PDOT), on melatonin-dependent vasopressin and adrenocorticotropic hormone (ACTH) release from the rat hypothalamo-hypophysial system. In vitro and in vivo
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Hypothalamo-Hypophyseal System; Male; Melatonin; Rats, Wistar; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Tetrahydronaphthalenes; Tryptamines; Vasopressins | 2014 |
Effect of Melatonin and 5-Methoxycarbonylamino-N-Acetyltryptamine on the Intraocular Pressure of Normal and Glaucomatous Mice.
Topics: Animals; Dose-Response Relationship, Drug; Glaucoma; Intraocular Pressure; Melatonin; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Receptor, Melatonin, MT2; Tetrahydronaphthalenes; Tryptamines | 2016 |
Effect of melatonin on monochromatic light-induced T-lymphocyte proliferation in the thymus of chickens.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chickens; Concanavalin A; Gene Expression; Immunohistochemistry; Light; Male; Melatonin; Prazosin; Proliferating Cell Nuclear Antigen; Receptors, Melatonin; RNA, Messenger; T-Lymphocytes; Tetrahydronaphthalenes; Thymus Gland; Tryptamines | 2016 |
Melatonin protects against cisplatin-induced ovarian damage in mice via the MT1 receptor and antioxidant activity.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Cell Proliferation; Cisplatin; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Melatonin; Mice; Ovary; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Tetrahydronaphthalenes; Tryptamines | 2017 |
Melatonin reduces oxidative damage and upregulates heat shock protein 90 expression in cryopreserved human semen.
Topics: Adenosine Triphosphate; Antioxidants; Benzoquinones; Cell Survival; Cryopreservation; Cryoprotective Agents; Gene Expression Regulation; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Lipid Peroxidation; Male; Melatonin; NF-E2-Related Factor 2; Oxidative Stress; Protein Biosynthesis; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Receptor, Melatonin, MT1; Semen; Semen Analysis; Sperm Motility; Tetrahydronaphthalenes; Tryptamines | 2017 |
Melatonin promotes triacylglycerol accumulation via MT2 receptor during differentiation in bovine intramuscular preadipocytes.
Topics: Adipocytes; Adipogenesis; Animals; Cattle; Cell Differentiation; Cells, Cultured; Gene Expression Regulation; Lipase; Lipolysis; Male; Melatonin; Perilipin-1; Receptor, Melatonin, MT2; Tetrahydronaphthalenes; Triglycerides | 2017 |
Vertebrates originally possess four functional subtypes of G protein-coupled melatonin receptor.
Topics: Animals; Brain; Down-Regulation; Eye; Melatonin; Oryzias; Phylogeny; Pituitary Gland; Receptors, Melatonin; Synteny; Tetrahydronaphthalenes; Tryptamines; Vertebrates | 2019 |
Melatonin stimulates VEGF expression in human granulosa-lutein cells: A potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Female; Humans; Luteal Cells; Melatonin; Ovarian Hyperstimulation Syndrome; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Up-Regulation; Vascular Endothelial Growth Factor A | 2020 |
Melatonin reduces neuropathic pain behavior and glial activation through MT
Topics: Animals; Demyelinating Diseases; Lysophosphatidylcholines; Male; Melatonin; Microinjections; Neuralgia; Neuroglia; Rats; Rats, Sprague-Dawley; Receptor, Melatonin, MT2; Tetrahydronaphthalenes | 2020 |
Impact of Melatonin on RAW264.7 Macrophages during Mechanical Strain.
Topics: Anti-Inflammatory Agents; Humans; Macrophages; Melatonin; Receptor, Melatonin, MT2 | 2022 |