Page last updated: 2024-08-21

melarsoprol and pentamidine

melarsoprol has been researched along with pentamidine in 93 studies

Research

Studies (93)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (9.68)	18.7374
1990's	11 (11.83)	18.2507
2000's	28 (30.11)	29.6817
2010's	42 (45.16)	24.3611
2020's	3 (3.23)	2.80

Authors

Authors	Studies
Ayafor, JF; Bacchi, C; Iwu, MM; Kamnaing, P; Rattendi, D; Schuster, B; Sterner, O; Tane, P; Tanifum, EA; Tchuendem, MH; Tsopmo, A	1
Baliani, A; Barrett, MP; Brun, R; Bueno, GJ; Gilbert, IH; Stewart, ML; Yardley, V	1
Brun, R; de Koning, HP; Gould, M; Kaiser, M; Koomen, GJ; Rodenko, B; van der Burg, AM; Wanner, MJ	1
Bakunov, SA; Bakunova, SM; Barszcz, T; Brun, R; Hall, JE; Tidwell, RR; Wenzler, T; Werbovetz, KA	1
Brun, R; Dardonville, C; García, RN; Kaiser, M; Nguyen, B; Rodríguez, F; Rozas, I; Wilson, WD	1
Bakunov, SA; Bakunova, SM; Barszcz, T; Brun, R; Tidwell, RR; Wenzler, T; Werbovetz, KA	2
Bakunov, SA; Bakunova, SM; Barzcz, T; Brun, R; Chen, H; Jones, SK; Kumar, EV; Patrick, DA; Tidwell, RR; Wenzler, T; Werbovetz, KA	1
Boykin, DW; Brun, R; Hall, JE; Ismail, MA; Tidwell, RR; Wenzler, T	1
Büchold, C; Gelhaus, C; Gut, J; Kisker, C; Leippe, M; Leyh, M; Machon, U; Rosenthal, PJ; Schirmeister, T; Schmuck, C; Stempka, M	1
Bakunov, SA; Bakunova, SM; Brun, R; Ghebru, M; Tidwell, RR; Wenzler, T; Werbovetz, KA	1
Breuning, A; Büchold, C; Degel, B; Gelhaus, C; Gut, J; Heppner, S; Kisker, C; Leippe, M; Leyh, M; Machon, U; Rath, J; Rosenthal, PJ; Schirmeister, T; Schmuck, C; Schulz, F; Stempka, M; Stich, A	1
Ang, KH; Compton, JE; Crews, P; McKerrow, J; Ratnam, J; Tenney, K; Watts, KR	1
Baumann, K; Bischof, SK; Bringmann, G; Brun, R; Dreher, J; Gulder, T; Kaiser, M; Moll, H; Müller, S; Stich, A; Winter, C	1
Brun, R; Fotie, J; Gershkovich, P; He, S; Liu, Q; Patrick, DA; Premalatha, K; Reid, CS; Tidwell, RR; Wang, MZ; Wasan, KM; Wenzler, T; Werbovetz, KA	1
Barrett, MP; Clark, RL; Clements, CJ; Coles, SJ; Harvey, AL; Mackay, SP; Male, L; Rathnam, RP; Spencer, J; Wong, PE	1
Capes, A; Collie, IT; Fairlamb, AH; Frearson, JA; Gilbert, IH; Hallyburton, I; McCarroll, AJ; Patterson, S; Stevens, MF; Wyatt, PG; Wyllie, S	1
Alkhaldi, AA; Chana, A; Dardonville, C; de Koning, HP; Eze, AA; Flores Pérez, EJ; Healy, A; Herrero García, V; Kaiser, M; Ríos Martínez, C; Taladriz, A	1
Rideau, E; Smith, TK; Stewart, G; Westwood, NJ; Zhou, L	1
Kaiser, M; McKeever, C; Rozas, I	1
Clayton, C; De Muylder, G; Gerwick, L; Helbig, C; Knudsen, GM; Linington, RG; Mackey, ZB; Mascuch, SM; McKerrow, JH; Sanchez, LM	1
Brun, R; Connelly, MC; Guy, RK; Holbrook, G; Hwang, JY; Kaiser, M; Smithson, D; Zhu, F	1
Behera, R; Edwards, P; Guyett, PJ; Karver, CE; Mensa-Wilmot, K; Patel, G; Pollastri, MP; Roncal, NE; Sullenberger, C	1
Arafa, RK; Boykin, DW; Brun, R; Ismail, MA; Jones, SK; Pandharkar, T; Patrick, DA; Tidwell, RR; Wenzler, T; Werbovetz, KA; Zhu, X	1
Bakunov, SA; Bakunova, SM; Barszcz, T; Boykin, DW; Brun, R; Jones, SK; Kumar, A; Patrick, DA; Tidwell, RR; Wenzler, T; Werbovetz, KA	1
Brun, R; Harel, D; Prinz, H; Schepmann, D; Schmidt, TJ; Wünsch, B	1
Bakunov, SA; Bakunova, SM; Brun, R; Patrick, DA; Tidwell, RR; Wenzler, T	1
Boykin, DW; Brun, R; Liu, ZY; Wenzler, T; Zhu, X	1
Avery, VM; Baell, JB; Bergström, CA; Charman, SA; Ferrins, L; Gazdik, M; Jones, AJ; Kaiser, M; Rahmani, R; Ryan, E; Sykes, ML; Varghese, S; White, KL	1
Brun, R; Patrick, DA; Tidwell, RR; Wang, MZ; Weiser, PT; Wenzler, T; Yang, S	1
Arroo, RRJ; Beresford, KJM; Bhambra, AS; Burrell-Saward, H; Ruparelia, KC; Tan, HL; Tasdemir, D; Yardley, V	1
Brun, R; Diederich, F; Giroud, M; Haap, W; Kaiser, M; Kuhn, B; Kuratli, C; Martin, RE; Saint-Auret, S; Schirmeister, T; Schuler, F	1
Abdel-Megeed, AM; Avery, VM; Baell, JB; Brown, RW; Hyland, CJT; Jones, AJ; Kaiser, M; Keller, PA; Sykes, ML	1
Basson, W; Myburgh, DP; Page, ML	1
Mateo, MJ; Mir, M; Roche, J; Sima, FO; Simarro, PP	1
Thomson, KD	1
Baeriswyl, S; Brun, R; Kunz, C	1
Lefrock, JL; Smith, BR	1
Gutteridge, WE	1
Balber, AE; Frommel, TO	1
Dukes, P	1
Barrett-Connor, E	1
Boa Yapo, F; Doua, F	1
Bronner, U; Doua, F; Ericsson, O; Gustafsson, LL; Miézan, T; Rais, M; Rombo, L	1
Doua, F; Yapo, FB	1
Milord, F; Pépin, J	1
Bruneel, H; De Groof, D; Mungoma, K; Ruppol, JF	1
Alafiatayo, RA; Barclay, GR; Crawley, B; Doua, F; Oppenheim, BA; Pentreath, VW	1
Scott, AG; Tait, A; Turner, CM	1
Cattand, P; Jannin, J	1
Bamba, M; Coulibaly, S; Doua, F; Miezan, TB; Youan, BB	1
Bouteille, B; Dumas, M	2
Barrett, MP; Barrett, SV	1
Legros, D; Ollivier, G	1
Etchegorry, MG; Helenport, JP; Jannin, J; Legros, D; Pecoul, B	1
Josenando, T; Ruiz, JA; Simarro, PP	1
Kager, PA	1
Nok, AJ	1
Docampo, R; Moreno, SN	1
Barrett, MP; Brun, R; Burchmore, RJ; de Koning, HP; Enyaru, JC; Geiser, F; Kaminsky, R; Mäser, P; Matovu, E; Seebeck, T; Stewart, ML; Wallace, LJ	1
Büscher, P; Etchegorry, MG; Legros, D; Lejon, V; Mbulamberi, D; Savignoni, A	1
Abel, PM; Behrend, M; Fleischmann, H; Kiala, G; Krishna, S; Lôa, V; Musolf, J; Stich, A; Théophile, J	1
Franco, JR; Jannin, J; Louis, FJ; Ndongo, P; Nguema, E; Simarro, PP	1
Berbari, EF; Jacobson, KM; Kumar, N; Orenstein, R; Uslan, DZ	1
Chappuis, F; Eperon, G; Loutan, L; Schmid, C	1
Bernhard, SC; Brun, R; Mäser, P; Nerima, B	1
De Koning, HP; Dogruel, M; Rodgers, J; Sanderson, L; Thomas, SA	1
Al-Salabi, MI; Barrett, MP; Collar, CJ; de Koning, HP; Stewart, ML; Wilson, WD	1
Blum, J; Brun, R; Burri, C; Chappuis, F	1
Schlitzer, M	1
Boelaert, M; Büscher, P; Lejon, V; Ngoyi, DM	1
Al-Salabi, MI; Augustyns, K; Berg, M; Castagna, V; Cos, P; de Koning, HP; Degano, M; Giannese, F; Grellier, P; Haemers, A; Joossens, J; Kohl, L; Maes, L; Steyaert, J; Van der Veken, P; Versées, W	1
Kennedy, A; Lutje, V; Seixas, J	2
Barrett, MP	1
Alsford, S; Baker, N; Berriman, M; Eckert, S; Field, MC; Glover, L; Horn, D; Leung, KF; Sanchez-Flores, A; Turner, DJ	1
Aguinaga Andrés, D; Baker, N; Barrett, MP; de Koning, HP; Glover, L; Horn, D; Munday, JC	1
Baker, N; de Koning, HP; Horn, D; Mäser, P	1
Boykin, DW; Braissant, O; Brun, R; Wang, MZ; Wenzler, T; Yang, S	1
Brun, R; Büscher, P; de Koning, HP; Graf, FE; Horn, D; Kaiser, M; Ludin, P; Mäser, P; Pyana, PP; Wenzler, T	1
Bucheton, B; Courtois, P; Cuny, G; Daulouède, S; Dethoua, M; Nzoumbou-Boko, R; Semballa, S; Truc, P; Vincendeau, P	1
Aguinaga Andrés, D; Baker, N; Barrett, MP; Burchmore, RJ; Clucas, C; De Koning, HP; Eze, AA; Glover, L; Graf, FE; Horn, D; Lee, RS; Ludin, P; MacLeod, A; Mäser, P; McDonald, J; Munday, JC; Natto, MJ; Tait, A; Teka, IA; Turner, CM	1
Boykin, DW; Braissant, O; Brun, R; Ismail, MA; Patrick, DA; Tidwell, RR; Wang, MZ; Wenzler, T; Yang, S	1
Büscher, P; Karhemere Bin Shamamba, S; Mumba Ngoyi, D; Ngay Lukusa, I; Pyana Pati, P; Van Reet, N	1
Alkhaldi, AA; Alzahrani, KJ; De Koning, HP; Eze, AA; Krezdorn, JA; McDonald, F; Munday, JC; Rojas López, KE; Settimo, L; Still, J; Tagoe, DN	1
Baker, N; de Koning, HP; Graf, FE; Horn, D; Mäser, P; Munday, JC	1
Adenan, MI; Amanah, A; Lim, KT; Zahari, Z; Zainuddin, Z	1
Arquint, C; Baker, N; Balmer, O; Caccone, A; de Koning, HP; Graf, FE; Horn, D; Krezdorn, J; Kunz Renggli, C; Ludin, P; Mäser, P; Munday, JC; Schaub, N; Schmidt, RS	1
Alsford, S; Baker, N; Dominicus, C; Glover, L; Horn, D; Hutchinson, S; Thomas, JA; Trenaman, A	1
Al-Salabi, MI; Alghamdi, AH; Anderson, LF; Boykin, DW; Campagnaro, GD; Carrington, M; Dardonville, C; De Koning, HP; Dimitriou, A; Eze, AA; Field, M; Gudin, S; Gurvic, D; Hulpia, F; Ibrahim, HM; Kelly, SPY; Kumar, A; Martin Abril, ME; Milić, P; Munday, JC; O'Neill, P; Okpara, CE; Paape, D; Quintana, J; Settimo, L; Smart, G; Sprenger, T; Svensson, F; Teka, IA; Tidwell, RR; Watson, L; Weyand, S; Wielinska, J; Woodley, CM; Zachariae, U	1
Auma, JE; Chemuliti, JK; Gitonga, PK; Kurgat, RK; Mdachi, RE; Murilla, GA; Ndung'u, K; Ngae, GN; Thuita, JK; Thungu, DK	1

Reviews

11 review(s) available for melarsoprol and pentamidine

Article	Year
Existing chemotherapy and its limitations. British medical bulletin, 1985, Volume: 41, Issue:2 Topics: Chagas Disease; Gentian Violet; Humans; Melarsoprol; Nifurtimox; Nitroimidazoles; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African	1985
Drugs for the treatment of parasitic infection. The Medical clinics of North America, 1982, Volume: 66, Issue:1 Topics: Antimony; Bithionol; Chloroquine; Diethylcarbamazine; Humans; Mebendazole; Melarsoprol; Metronidazole; Niclosamide; Niridazole; Oxamniquine; Parasitic Diseases; Pentamidine; Piperazines; Primaquine; Pyrantel Pamoate; Pyrimethamine; Suramin; Thiabendazole; Trichlorfon	1982
Human trypanosomiasis in the Ivory Coast: therapy and problems. Acta tropica, 1993, Volume: 54, Issue:3-4 Topics: Animals; Cote d'Ivoire; Eflornithine; Humans; Melarsoprol; Pentamidine; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African	1993
The treatment of human African trypanosomiasis. Advances in parasitology, 1994, Volume: 33 Topics: Animals; Diminazene; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	1994
Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis. Parasitology research, 2003, Volume: 90, Issue:1 Topics: Animals; Drug Resistance; HIV; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2003
Current chemotherapy of human African trypanosomiasis. Parasitology research, 2003, Volume: 90 Supp 1 Topics: Animals; Eflornithine; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African	2003
[Agents for the treatment of African sleeping sickness. Those developed in the last century]. Pharmazie in unserer Zeit, 2009, Volume: 38, Issue:6 Topics: Animals; Eflornithine; History, 20th Century; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African	2009
Chemotherapy for second-stage Human African trypanosomiasis. The Cochrane database of systematic reviews, 2010, Aug-04, Issue:8 Topics: Animals; Antiprotozoal Agents; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Prednisolone; Randomized Controlled Trials as Topic; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African	2010
Potential new drugs for human African trypanosomiasis: some progress at last. Current opinion in infectious diseases, 2010, Volume: 23, Issue:6 Topics: Animals; Benzamides; Boron Compounds; Drug Discovery; Drug Resistance; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2010
Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story. Trends in parasitology, 2013, Volume: 29, Issue:3 Topics: Animals; Aquaglyceroporins; Drug Resistance; Humans; Melarsoprol; Pentamidine; Phylogeny; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2013
Chemotherapy for second-stage human African trypanosomiasis. The Cochrane database of systematic reviews, 2013, Jun-28, Issue:6 Topics: Animals; Antiprotozoal Agents; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Prednisolone; Randomized Controlled Trials as Topic; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African	2013

Trials

3 trial(s) available for melarsoprol and pentamidine

Article	Year
Pharmacokinetics and adverse reactions after a single dose of pentamidine in patients with Trypanosoma gambiense sleeping sickness. British journal of clinical pharmacology, 1995, Volume: 39, Issue:3 Topics: Adult; Aged; Animals; Biomarkers; Blood Pressure; Drug Therapy, Combination; Female; Follow-Up Studies; Half-Life; Humans; Infusions, Intravenous; Male; Melarsoprol; Metabolic Clearance Rate; Pentamidine; Tissue Distribution; Trypanosoma brucei gambiense; Trypanosomiasis, African	1995
Neuro-inflammatory risk factors for treatment failure in "early second stage" sleeping sickness patients treated with pentamidine. Journal of neuroimmunology, 2003, Volume: 144, Issue:1-2 Topics: Adolescent; Adult; Animals; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Female; Humans; Immunoglobulin M; Latex Fixation Tests; Leukocyte Count; Male; Melarsoprol; Middle Aged; Pentamidine; Recurrence; Risk Factors; Treatment Failure; Trypanosoma brucei gambiense; Trypanosomiasis, African	2003
A CATT negative result after treatment for human African trypanosomiasis is no indication for cure. PLoS neglected tropical diseases, 2010, Jan-26, Volume: 4, Issue:1 Topics: Agglutination Tests; Antibodies, Protozoan; Eflornithine; Humans; Melarsoprol; Pentamidine; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African	2010

Other Studies

79 other study(ies) available for melarsoprol and pentamidine

Article	Year
Trypanocidal diarylheptanoids from Aframomum letestuianum. Journal of natural products, 2003, Volume: 66, Issue:3 Topics: Animals; Cameroon; Diarylheptanoids; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Seeds; Stereoisomerism; Trypanocidal Agents; Trypanosoma brucei brucei; Zingiberaceae	2003
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites. Journal of medicinal chemistry, 2005, Aug-25, Volume: 48, Issue:17 Topics: Animals; Cell Line; Female; Furaldehyde; Hydrazones; Leishmania donovani; Mice; Nitrofurans; Nucleoside Transport Proteins; Rats; Thiophenes; Triazines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Trypanosomiasis, African	2005
2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: Adenosine; Animals; Antimalarials; Dose-Response Relationship, Drug; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi	2007
Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations. Journal of medicinal chemistry, 2007, Nov-15, Volume: 50, Issue:23 Topics: Animals; Antimalarials; Benzofurans; Cations; Leishmania donovani; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei rhodesiense	2007
New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity. Journal of medicinal chemistry, 2008, Feb-28, Volume: 51, Issue:4 Topics: Animals; Antimalarials; Cell Line; DNA; Female; Guanidines; Hemeproteins; Hemin; Imidazolines; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Rats; Structure-Activity Relationship; Transition Temperature; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2008
Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Animals; Antiprotozoal Agents; Benzofurans; Cations; Disease Models, Animal; Leishmania; Mice; Molecular Structure; Structure-Activity Relationship; Trypanosoma; Trypanosomiasis	2008
Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. European journal of medicinal chemistry, 2009, Volume: 44, Issue:9 Topics: Animals; Antiprotozoal Agents; Benzene; Cell Survival; Leishmania donovani; Mice; Myoblasts; Naphthalenes; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2009
Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Animals; Antiprotozoal Agents; Female; Leishmania donovani; Mice; Pentamidine; Plasmodium falciparum; Pyridines; Rats; Structure-Activity Relationship	2009
New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:10 Topics: Animals; Benzamidines; Central Nervous System; Female; Furans; Mice; Molecular Structure; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2009
On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences. Journal of medicinal chemistry, 2009, Sep-24, Volume: 52, Issue:18 Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Cathepsin L; Cathepsins; Cattle; Combinatorial Chemistry Techniques; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diamide; Drug Evaluation, Preclinical; Fumarates; Humans; Peptide Library; Plasmodium falciparum	2009
Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles. Journal of medicinal chemistry, 2010, Jan-14, Volume: 53, Issue:1 Topics: Amidines; Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Disease Models, Animal; Female; Leishmania donovani; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Stereoisomerism; Structure-Activity Relationship; Triazoles; Trypanosoma brucei rhodesiense	2010
Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids. Journal of medicinal chemistry, 2010, Mar-11, Volume: 53, Issue:5 Topics: Antimalarials; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Plasmodium falciparum; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei	2010
Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi. Bioorganic & medicinal chemistry, 2010, Apr-01, Volume: 18, Issue:7 Topics: Acetylation; Animals; Aspergillus fumigatus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diketopiperazines; Drug Evaluation, Preclinical; Fungi; Geologic Sediments; Humans; Indicators and Reagents; Jurkat Cells; Magnetic Resonance Spectroscopy; Methylation; Piperazines; Spiro Compounds; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei	2010
QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids. European journal of medicinal chemistry, 2010, Volume: 45, Issue:11 Topics: Alkaloids; Animals; Antimalarials; Isoquinolines; Magnetic Resonance Spectroscopy; Models, Molecular; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared	2010
Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation. Bioorganic & medicinal chemistry, 2011, Jan-01, Volume: 19, Issue:1 Topics: Animals; Cyclization; Mice; Quinolines; Salts; Structure-Activity Relationship; Trypanocidal Agents	2011
Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic & medicinal chemistry, 2011, Mar-01, Volume: 19, Issue:5 Topics: Benzodiazepines; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Trypanocidal Agents; Trypanosoma brucei brucei	2011
Quinol derivatives as potential trypanocidal agents. Bioorganic & medicinal chemistry, 2012, Feb-15, Volume: 20, Issue:4 Topics: Benzamidines; Cell Line; Drug Delivery Systems; Humans; Hydroquinones; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Triazines; Trypanocidal Agents; Trypanosoma brucei brucei	2012
Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes. Journal of medicinal chemistry, 2012, Mar-22, Volume: 55, Issue:6 Topics: Carrier Proteins; Cell Line; Drug Resistance; Humans; Models, Molecular; Nucleoside Transport Proteins; Organophosphorus Compounds; Pentamidine; Quantitative Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense	2012
A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: Amides; Animals; HeLa Cells; Humans; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei	2013
Aminoalkyl derivatives of guanidine diaromatic minor groove binders with antiprotozoal activity. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: Animals; Antiprotozoal Agents; Guanidine; Nucleic Acid Denaturation; Plasmodium falciparum; Trypanosoma brucei rhodesiense	2013
Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. Journal of natural products, 2013, Apr-26, Volume: 76, Issue:4 Topics: Animals; Biological Products; Chagas Disease; Glycolysis; Humans; Leishmania donovani; Lipopeptides; Microbodies; Microscopy, Fluorescence; Trypanosoma brucei brucei; Zebrafish	2013
Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT). Journal of medicinal chemistry, 2013, Apr-11, Volume: 56, Issue:7 Topics: Animals; Benzamides; Cell Line; Drug Evaluation, Preclinical; Humans; Structure-Activity Relationship; Trypanosomiasis, African	2013
Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis. Journal of medicinal chemistry, 2013, May-23, Volume: 56, Issue:10 Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Survival; Coloring Agents; Drug Design; Drug Discovery; ErbB Receptors; Humans; Indicators and Reagents; Lapatinib; Morpholines; Neglected Diseases; Phosphotransferases; Quinazolines; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2013
Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives. Journal of medicinal chemistry, 2013, Jul-11, Volume: 56, Issue:13 Topics: Animals; Antiprotozoal Agents; Benzene; Chagas Disease; Female; Leishmania donovani; Mice; Mice, Inbred Strains; Models, Chemical; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyridines; Structure-Activity Relationship; Terphenyl Compounds; Trypanosoma cruzi	2013
Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives. European journal of medicinal chemistry, 2013, Volume: 67 Topics: Animals; Antiprotozoal Agents; Dose-Response Relationship, Drug; Leishmania donovani; Mice; Molecular Structure; Myoblasts; Parasitic Sensitivity Tests; Pentamidine; Phenyl Ethers; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosomiasis	2013
Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives. Journal of medicinal chemistry, 2013, Sep-26, Volume: 56, Issue:18 Topics: Antiprotozoal Agents; Biological Products; Chemistry Techniques, Synthetic; Chromans; Inhibitory Concentration 50; Structure-Activity Relationship	2013
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues. Bioorganic & medicinal chemistry, 2014, Jan-01, Volume: 22, Issue:1 Topics: Animals; Antiprotozoal Agents; Isoxazoles; Mice; Molecular Structure; Plasmodium falciparum; Prodrugs; Structure-Activity Relationship; Trypanosomiasis, African	2014
Synthesis and antiparasitic activity of new bis-arylimidamides: DB766 analogs modified in the terminal groups. European journal of medicinal chemistry, 2014, Aug-18, Volume: 83 Topics: Amides; Animals; Antiparasitic Agents; Cell Line; Chemistry Techniques, Synthetic; Leishmania; Plasmodium falciparum; Rats; Trypanosoma	2014
Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei. Journal of medicinal chemistry, 2014, Aug-14, Volume: 57, Issue:15 Topics: Animals; Benzamides; Cell Line; HEK293 Cells; Humans; Microsomes, Liver; Myoblasts; Pyridines; Rats; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense	2014
Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense. Bioorganic & medicinal chemistry, 2016, 06-01, Volume: 24, Issue:11 Topics: Amides; Amines; Animals; Antiprotozoal Agents; Cell Survival; Dose-Response Relationship, Drug; Humans; Mice; Microsomes, Liver; Molecular Structure; Myoblasts; Parasitic Sensitivity Tests; Rats; Structure-Activity Relationship; Thiazoles; Trypanosoma brucei rhodesiense; Urea	2016
Synthesis and antitrypanosomal activities of novel pyridylchalcones. European journal of medicinal chemistry, 2017, Mar-10, Volume: 128 Topics: Animals; Cells, Cultured; Chagas Disease; Chalcones; Humans; Leishmania donovani; Leishmaniasis, Visceral; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Propane; Pyridines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi	2017
2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design. Journal of medicinal chemistry, 2018, 04-26, Volume: 61, Issue:8 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Drug Design; Female; Humans; Leishmania donovani; Ligands; Mice; Microsomes, Liver; Molecular Structure; Nitriles; Plasmodium falciparum; Protozoan Proteins; Rats; Structure-Activity Relationship; Swine; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi	2018
Investigation of thiazolyl-benzothiophenamides as potential agents for African sleeping sickness. RSC medicinal chemistry, 2020, Dec-17, Volume: 11, Issue:12 Topics:	2020
Chemotherapy of sleeping sickness. The Central African journal of medicine, 1979, Volume: 25, Issue:11 Topics: Arsenicals; Humans; Melarsoprol; Pentamidine; Suramin; Trypanosomiasis, African	1979
Human trypanosomiasis in Southern Africa. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Apr-02, Volume: 51, Issue:14 Topics: Complement System Proteins; Humans; Immunoglobulin M; Immunoglobulins; Male; Melarsoprol; Military Medicine; Pentamidine; South Africa; Trypanosomiasis, African	1977
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Tryparsamide. Lancet (London, England), 1989, Sep-02, Volume: 2, Issue:8662 Topics: Drug Therapy, Combination; Humans; Melarsoprol; Nigeria; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African	1989
In vitro drug sensitivity of Trypanosoma gambiense isolates. Acta tropica, 1989, Volume: 46, Issue:5-6 Topics: Animals; Arsenicals; Cote d'Ivoire; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	1989
Drugs for protozoan infections. American family physician, 1987, Volume: 35, Issue:3 Topics: Antimalarials; Antimony Sodium Gluconate; Antiprotozoal Agents; Humans; Iodoquinol; Melarsoprol; Metronidazole; Nifurtimox; Pentamidine; Protozoan Infections; Suramin	1987
Flow cytofluorimetric analysis of drug accumulation by multidrug-resistant Trypanosoma brucei brucei and T. b. rhodesiense. Molecular and biochemical parasitology, 1987, Volume: 26, Issue:1-2 Topics: Acriflavine; Animals; Benzimidazoles; Diminazene; Drug Resistance; Ethidium; Flow Cytometry; Fluorescent Dyes; Humans; Indoles; Melarsoprol; Mice; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei	1987
Arsenic and old taxa: subspeciation and drug sensitivity in Trypanosoma brucei. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1984, Volume: 78, Issue:6 Topics: Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Isoenzymes; Male; Melarsoprol; Mice; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1984
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Endotoxin antibodies in African sleeping sickness. Parasitology, 1997, Volume: 114 ( Pt 4) Topics: Antibodies, Bacterial; Central Nervous System Diseases; Endotoxins; Gram-Negative Bacteria; Humans; Melarsoprol; Pentamidine; Trypanocidal Agents; Trypanosomiasis, African	1997
Trypanosoma brucei: lack of cross-resistance to melarsoprol in vitro by cymelarsan-resistant parasites. Experimental parasitology, 1997, Volume: 86, Issue:3 Topics: Adenine; Adenosine; Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Female; Inosine; Melarsoprol; Mice; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei	1997
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In vivo evaluation of sixteen plant extracts on mice inoculated with Trypanosoma brucei gambiense. Bulletin of the World Health Organization, 1997, Volume: 75, Issue:4 Topics: Administration, Oral; Animals; Cote d'Ivoire; Eflornithine; Infusions, Parenteral; Injections, Intraperitoneal; Medicine, Traditional; Melarsoprol; Mice; Pentamidine; Plant Extracts; Sodium Chloride; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	1997
[Current status of trypanosomiasis]. Medecine tropicale : revue du Corps de sante colonial, 1997, Volume: 57, Issue:3 Suppl Topics: Africa; Animals; Autoantibodies; Blood-Brain Barrier; Brain Diseases; Follow-Up Studies; Forecasting; Humans; Incidence; Melarsoprol; Nitroimidazoles; Pentamidine; Population Surveillance; Protozoan Vaccines; Recurrence; Social Problems; Socioeconomic Factors; Survival Rate; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African	1997
Anti-sleeping sickness drugs and cancer chemotherapy. Parasitology today (Personal ed.), 2000, Volume: 16, Issue:1 Topics: Animals; Antineoplastic Agents; Eflornithine; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2000
Treatment of human African trypanosomiasis. Bulletin of the World Health Organization, 2000, Volume: 78, Issue:12 Topics: Acetanilides; Africa; Humans; Melarsoprol; Nitroimidazoles; Pentamidine; Suramin; Thiadiazoles; Trypanocidal Agents; Trypanosomiasis, African	2000
[Human african trypanosomiasis: A history of its therapies and their failures]. Tropical medicine & international health : TM & IH, 2001, Volume: 6, Issue:11 Topics: Arsenicals; Drug Resistance; History, 20th Century; History, 21st Century; Humans; Melarsoprol; Pentamidine; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African	2001
Availability and affordability of treatment for Human African Trypanosomiasis. Tropical medicine & international health : TM & IH, 2001, Volume: 6, Issue:11 Topics: Eflornithine; Health Services Accessibility; Humans; Melarsoprol; Pentamidine; Research; Suramin; Trypanocidal Agents; Trypanosomiasis, African; World Health Organization	2001
Control of human African trypanosomiasis in the Quiçama focus, Angola. Bulletin of the World Health Organization, 2002, Volume: 80, Issue:9 Topics: Angola; Communicable Disease Control; Endemic Diseases; Humans; Melarsoprol; Pentamidine; Risk Factors; Seroepidemiologic Studies; Treatment Failure; Trypanocidal Agents; Trypanosomiasis	2002
[The return of sleeping sickness in an epidemic form: international action for drugs]. Nederlands tijdschrift voor geneeskunde, 2002, Dec-28, Volume: 146, Issue:52 Topics: Africa, Central; Animals; Disease Outbreaks; Eflornithine; Humans; International Cooperation; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	2002
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic cell, 2003, Volume: 2, Issue:5 Topics: Adenine; Adenosine; Animals; Arsenicals; Benzamidines; Cell Death; Cell Division; Diminazene; Drug Resistance; Female; Gene Silencing; Hypoxanthine; Inhibitory Concentration 50; Inosine; Melarsoprol; Mice; Mutation; Nucleoside Transport Proteins; Pentamidine; Stilbamidines; Trypanosoma brucei brucei	2003
Retaking sleeping sickness control in Angola. Tropical medicine & international health : TM & IH, 2004, Volume: 9, Issue:1 Topics: Adolescent; Adult; Age Distribution; Aged; Angola; Animals; Child; Child, Preschool; Disease Outbreaks; Eflornithine; Female; Humans; Infant; Insect Vectors; Male; Melarsoprol; Middle Aged; Pentamidine; Sex Distribution; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Tsetse Flies	2004
The elimination of Trypanosoma brucei gambiense sleeping sickness in the focus of Luba, Bioko Island, Equatorial Guinea. Tropical medicine & international health : TM & IH, 2006, Volume: 11, Issue:5 Topics: Agglutination Tests; Animals; Disease Outbreaks; Disease Vectors; Endemic Diseases; Equatorial Guinea; Fluorescent Antibody Technique, Indirect; Humans; Melarsoprol; Pentamidine; Population Surveillance; Prevalence; Recurrence; Rural Health; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	2006
A woman with fever and rash after African safari. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006, Sep-01, Volume: 43, Issue:5 Topics: Africa; Exanthema; Female; Fever; Humans; Melarsoprol; Middle Aged; Pentamidine; Suramin; Travel; Trypanocidal Agents; Trypanosomiasis, African	2006
Clinical presentation and treatment outcome of sleeping sickness in Sudanese pre-school children. Acta tropica, 2007, Volume: 101, Issue:1 Topics: Adolescent; Age Factors; Animals; Child; Child, Preschool; Humans; Infant; Infusions, Intravenous; Injections, Intramuscular; Melarsoprol; Pentamidine; Retrospective Studies; Sudan; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	2007
Melarsoprol- and pentamidine-resistant Trypanosoma brucei rhodesiense populations and their cross-resistance. International journal for parasitology, 2007, Volume: 37, Issue:13 Topics: Animals; Antifungal Agents; Benzamidines; Drug Resistance; Female; Melarsoprol; Mice; Parasitic Sensitivity Tests; Pentamidine; Trypanocidal Agents; Trypanosoma brucei rhodesiense	2007
Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:3 Topics: Adenine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Brain; Cerebrospinal Fluid; Disease Models, Animal; Drug Interactions; Eflornithine; Indomethacin; Male; Melarsoprol; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Knockout; Multidrug Resistance-Associated Proteins; Nifurtimox; Pentamidine; Perfusion; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African	2009
Predictive computational models of substrate binding by a nucleoside transporter. The Journal of biological chemistry, 2009, Dec-04, Volume: 284, Issue:49 Topics: Animals; Chemistry, Pharmaceutical; Computational Biology; Computers; Drug Design; Female; Kinetics; Melarsoprol; Nucleoside Transport Proteins; Pentamidine; Rats; Rats, Wistar; Software; Trypanocidal Agents; Trypanosoma brucei brucei	2009
Human African trypanosomiasis. Lancet (London, England), 2010, Jan-09, Volume: 375, Issue:9709 Topics: Africa; Animals; Biomedical Research; Communicable Disease Control; Eflornithine; Endemic Diseases; Humans; Incidence; Insect Bites and Stings; Insect Vectors; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Tsetse Flies; Variant Surface Glycoproteins, Trypanosoma	2010
Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:5 Topics: Adenosine; Animals; Antiprotozoal Agents; Carrier Proteins; Gene Knockdown Techniques; Melarsoprol; Mice; Models, Chemical; N-Glycosyl Hydrolases; Pentamidine; RNA, Small Interfering; Trypanosoma brucei brucei; Trypanosomiasis, African	2010
High-throughput decoding of antitrypanosomal drug efficacy and resistance. Nature, 2012, Jan-25, Volume: 482, Issue:7384 Topics: Aquaglyceroporins; Drug Resistance; Eflornithine; Endocytosis; Glycosylation; High-Throughput Screening Assays; Humans; Lysosomes; Melarsoprol; Nifurtimox; Pentamidine; RNA Interference; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2012
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 2012, Jul-03, Volume: 109, Issue:27 Topics: Animals; Aquaporin 2; Aquaporin 3; Cell Line; Drug Resistance; Flagella; High-Throughput Screening Assays; Humans; Melarsoprol; Molecular Sequence Data; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis; Tsetse Flies	2012
Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11 Topics: Amidines; Animals; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Humans; Injections, Intraperitoneal; Melarsoprol; Mice; Parasitic Sensitivity Tests; Pentamidine; Time Factors; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2013
Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol. PLoS neglected tropical diseases, 2013, Volume: 7, Issue:10 Topics: Aquaporin 2; DNA, Protozoan; Drug Resistance; Humans; Melarsoprol; Molecular Sequence Data; Mutation; Pentamidine; Protozoan Proteins; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	2013
Evaluation of trypanocidal drugs used for human African trypanosomosis against Trypanosoma lewisi. Parasite (Paris, France), 2013, Volume: 20 Topics: Animals; Eflornithine; Female; Humans; Immunocompromised Host; Inhibitory Concentration 50; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Parasitemia; Pentamidine; Rats; Rats, Wistar; Suramin; Trypanocidal Agents; Trypanosoma lewisi; Trypanosomiasis	2013
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:3 Topics: Alleles; Aquaglyceroporins; Biological Transport; Drug Resistance; Genes, Protozoan; Melarsoprol; Pentamidine; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma brucei brucei	2014
In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:8 Topics: Amidines; Animals; Dose-Response Relationship, Drug; Female; Humans; Melarsoprol; Mice; Pentamidine; Pyridines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2014
Melarsoprol sensitivity profile of Trypanosoma brucei gambiense isolates from cured and relapsed sleeping sickness patients from the Democratic Republic of the Congo. PLoS neglected tropical diseases, 2014, Volume: 8, Issue:10 Topics: Adult; Animals; Aquaglyceroporins; Base Sequence; Democratic Republic of the Congo; DNA, Protozoan; Drug Resistance; Female; Genotype; Humans; Melarsoprol; Mice; Molecular Sequence Data; Mutant Chimeric Proteins; Mutation; Pentamidine; Phenotype; Recurrence; Sequence Analysis, DNA; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	2014
Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein. Molecular microbiology, 2015, Volume: 96, Issue:4 Topics: Alleles; Diminazene; Drug Resistance, Multiple; Kinetics; Melarsoprol; Models, Molecular; Mutation; Nucleoside Transport Proteins; Parasitic Sensitivity Tests; Pentamidine; Polymorphism, Single Nucleotide; Protein Interaction Domains and Motifs; Trypanocidal Agents; Trypanosoma brucei brucei	2015
Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates. International journal for parasitology. Drugs and drug resistance, 2015, Volume: 5, Issue:2 Topics: Aquaporin 2; Aquaporin 3; Drug Resistance; Gene Expression Regulation; Melarsoprol; Pentamidine; Trypanocidal Agents; Trypanosoma brucei gambiense	2015
Development of resazurin-based assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei rhodesiense strain STIB 900 for the identification of potential anti-trypanosomal agents. Experimental parasitology, 2016, Volume: 162 Topics: Animals; Cell Line; Cell Survival; Cost-Benefit Analysis; Dose-Response Relationship, Drug; High-Throughput Screening Assays; Indicators and Reagents; Inhibitory Concentration 50; Melarsoprol; Muscle, Skeletal; Myoblasts; Oxazines; Pentamidine; Rats; Reproducibility of Results; Sensitivity and Specificity; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Xanthenes	2016
Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. Cellular and molecular life sciences : CMLS, 2016, Volume: 73, Issue:17 Topics: Amino Acid Sequence; Aquaporins; Comparative Genomic Hybridization; DNA, Protozoan; Drug Resistance; Genome, Protozoan; Heterozygote; Humans; Male; Melarsoprol; Nucleoside Transport Proteins; Parasitic Sensitivity Tests; Pentamidine; Phenotype; Polymorphism, Single Nucleotide; Protozoan Proteins; RNA-Binding Proteins; Sequence Alignment; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2016
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling. PLoS neglected tropical diseases, 2018, Volume: 12, Issue:11 Topics: Cell Biology; Humans; Lysosomes; Melarsoprol; Mitochondria; Mitochondrial Proteins; Mitosis; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2018
Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter eLife, 2020, 08-11, Volume: 9 Topics: Animals; Aquaporin 2; Aquaporins; Drug Resistance; Melarsoprol; Mutation; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2020
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model. PloS one, 2020, Volume: 15, Issue:11 Topics: Animals; Diminazene; Disease Models, Animal; Drug Resistance; Kenya; Male; Melarsoprol; Mice; Pentamidine; Suramin; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Uganda; Virulence	2020