melarsoprol has been researched along with nifurtimox in 37 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (5.41) | 18.7374 |
1990's | 3 (8.11) | 18.2507 |
2000's | 10 (27.03) | 29.6817 |
2010's | 22 (59.46) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Davioud-Charvet, E; Landry, V; Maes, L; Millet, R; Sergheraert, C | 1 |
Baliani, A; Barrett, MP; Brun, R; Bueno, GJ; Gilbert, IH; Stewart, ML; Yardley, V | 1 |
Caffrey, CR; Glaser, M; Hansell, E; Hoerr, V; Holzgrabe, U; McKerrow, JH; Moll, H; Ponte-Sucre, A; Schirmeister, T; Schultheis, M; Stich, A; Vicik, R | 1 |
Büchold, C; Gelhaus, C; Gut, J; Kisker, C; Leippe, M; Leyh, M; Machon, U; Rosenthal, PJ; Schirmeister, T; Schmuck, C; Stempka, M | 1 |
Hall, BS; Hu, L; Wilkinson, SR; Wu, X | 1 |
Breuning, A; Büchold, C; Degel, B; Gelhaus, C; Gut, J; Heppner, S; Kisker, C; Leippe, M; Leyh, M; Machon, U; Rath, J; Rosenthal, PJ; Schirmeister, T; Schmuck, C; Schulz, F; Stempka, M; Stich, A | 1 |
Bloomer, WD; Brun, R; Kaiser, M; McKenzie, C; Papadopoulou, MV; Prasittichai, C; Torreele, E; Trunz, BB; Wilkinson, SR | 1 |
Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; McKenzie, C; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
Rideau, E; Smith, TK; Stewart, G; Westwood, NJ; Zhou, L | 1 |
Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS | 1 |
Ariën, KK; Augustyns, K; Cos, P; Dirié, B; Heeres, J; Joossens, J; Lewi, PJ; Lyssens, S; Maes, L; Michiels, J; Van der Veken, P; Vanham, G; Venkatraj, M | 1 |
Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
Bloomer, WD; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS; Szular, J; Wilkinson, SR | 2 |
Augustyns, K; Caljon, G; Heeres, J; Joossens, J; Lewi, PJ; Maes, L; Salado, IG; Van der Veken, P; Venkatraj, M | 1 |
Brun, R; Diederich, F; Giroud, M; Haap, W; Kaiser, M; Kuhn, B; Kuratli, C; Martin, RE; Saint-Auret, S; Schirmeister, T; Schuler, F | 1 |
Van Nieuwenhove, S | 1 |
Lefrock, JL; Smith, BR | 1 |
Gutteridge, WE | 1 |
Milord, F; Pépin, J | 1 |
Brun, R; Iten, M; Kaminsky, R; Matovu, E | 1 |
Burri, C; Büscher, P; Gastellu-Etchegorry, M; Jannin, J; Legros, D; Ollivier, G; Paquet, C | 1 |
Bisser, S; Būscher, P; Lejon, V; Miaka Mia Bilenge, C; N'Siesi, FX; Preux, PM; Van Nieuwenhove, S | 1 |
Abel, PM; Krishna, S; Woodrow, CJ | 1 |
Chappuis, F | 1 |
De Koning, HP; Dogruel, M; Rodgers, J; Sanderson, L; Thomas, SA | 1 |
Schlitzer, M | 1 |
Kennedy, A; Lutje, V; Seixas, J | 2 |
Barrett, MP | 1 |
Alsford, S; Baker, N; Berriman, M; Eckert, S; Field, MC; Glover, L; Horn, D; Leung, KF; Sanchez-Flores, A; Turner, DJ | 1 |
Diarra, A; Franco, J; Jannin, J; Postigo, JA; Simarro, PP | 1 |
Bucheton, B; Courtois, P; Cuny, G; Daulouède, S; Dethoua, M; Nzoumbou-Boko, R; Semballa, S; Truc, P; Vincendeau, P | 1 |
Kaka, JT; Kazumba, LM; Ngoyi, DM; Tshala-Katumbay, D | 1 |
Alsford, S; Baker, N; Dominicus, C; Glover, L; Horn, D; Hutchinson, S; Thomas, JA; Trenaman, A | 1 |
8 review(s) available for melarsoprol and nifurtimox
Article | Year |
---|---|
Existing chemotherapy and its limitations.
Topics: Chagas Disease; Gentian Violet; Humans; Melarsoprol; Nifurtimox; Nitroimidazoles; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 1985 |
The treatment of human African trypanosomiasis.
Topics: Animals; Diminazene; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 1994 |
Treatment of human African trypanosomiasis--present situation and needs for research and development.
Topics: Africa South of the Sahara; Animals; Benzamidines; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurtimox; Thiadiazoles; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2002 |
[Agents for the treatment of African sleeping sickness. Those developed in the last century].
Topics: Animals; Eflornithine; History, 20th Century; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 2009 |
Chemotherapy for second-stage Human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Prednisolone; Randomized Controlled Trials as Topic; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2010 |
Potential new drugs for human African trypanosomiasis: some progress at last.
Topics: Animals; Benzamides; Boron Compounds; Drug Discovery; Drug Resistance; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis.
Topics: Animals; Drug Therapy, Combination; Eflornithine; Health Services Accessibility; Humans; Melarsoprol; Nifurtimox; Trypanocidal Agents; Trypanosomiasis, African | 2012 |
Chemotherapy for second-stage human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Prednisolone; Randomized Controlled Trials as Topic; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2013 |
1 trial(s) available for melarsoprol and nifurtimox
Article | Year |
---|---|
Equivalence trial of melarsoprol and nifurtimox monotherapy and combination therapy for the treatment of second-stage Trypanosoma brucei gambiense sleeping sickness.
Topics: Administration, Oral; Adult; Animals; Brain Diseases; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Male; Melarsoprol; Nifurtimox; Recurrence; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2007 |
28 other study(ies) available for melarsoprol and nifurtimox
Article | Year |
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Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.
Topics: Animals; Cell Survival; Humans; Hydrazines; Inhibitory Concentration 50; Leishmania infantum; Macrophages, Peritoneal; Mice; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Tumor Cells, Cultured | 2002 |
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.
Topics: Animals; Cell Line; Female; Furaldehyde; Hydrazones; Leishmania donovani; Mice; Nitrofurans; Nucleoside Transport Proteins; Rats; Thiophenes; Triazines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Trypanosomiasis, African | 2005 |
Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents.
Topics: Animals; Antiprotozoal Agents; Carboxylic Acids; Cysteine Proteinase Inhibitors; Trypanosoma brucei brucei | 2006 |
On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences.
Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Cathepsin L; Cathepsins; Cattle; Combinatorial Chemistry Techniques; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diamide; Drug Evaluation, Preclinical; Fumarates; Humans; Peptide Library; Plasmodium falciparum | 2009 |
Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.
Topics: Animals; Cell Line; Enzyme Activation; Humans; Nitroreductases; Oxidation-Reduction; Parasitic Sensitivity Tests; Phosphoramide Mustards; Structure-Activity Relationship; Substrate Specificity; Trypanocidal Agents; Trypanosoma brucei brucei | 2010 |
Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids.
Topics: Antimalarials; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Plasmodium falciparum; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei | 2010 |
Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents.
Topics: Amines; Animals; Cells, Cultured; Chagas Disease; Leishmania donovani; Mice; Nitro Compounds; Parasitic Sensitivity Tests; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2011 |
Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents.
Topics: Amides; Animals; Cell Line; Leishmania donovani; Nitro Compounds; Nitroreductases; Parasitic Sensitivity Tests; Prodrugs; Rats; Structure-Activity Relationship; Sulfonamides; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi | 2012 |
A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro.
Topics: Amides; Animals; HeLa Cells; Humans; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei | 2013 |
Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agents.
Topics: Animals; Benzothiazoles; Cell Line; Cell Survival; Leishmania donovani; Piperazines; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi | 2013 |
From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds.
Topics: Anti-HIV Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Structure; Parasitic Sensitivity Tests; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense | 2014 |
Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents.
Topics: Amides; Apoptosis; Blood Platelets; Cells, Cultured; Chagas Disease; Flow Cytometry; Heterocyclic Compounds; Humans; Imidazoles; In Vitro Techniques; Leishmania donovani; Leishmaniasis, Visceral; Molecular Structure; Monocytes; Platelet Activation; Sulfonamides; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.
Topics: Animals; Binding Sites; Cell Line; Chagas Disease; Disease Models, Animal; Leishmania donovani; Mice; Mice, Inbred BALB C; Nitroreductases; Parasitic Sensitivity Tests; Prodrugs; Protein Structure, Tertiary; Protozoan Proteins; Rats; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2015 |
3-Nitrotriazole-based piperazides as potent antitrypanosomal agents.
Topics: Animals; Cell Line; Chagas Disease; Dose-Response Relationship, Drug; Humans; Leishmania donovani; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Piperazines; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2015 |
Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds.
Topics: Amides; Antiprotozoal Agents; Cell Line; Chagas Disease; Humans; Leishmania; Parasitic Sensitivity Tests; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma | 2016 |
Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity.
Topics: Acetamides; Animals; Mice; Nitroreductases; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Trypanosomiasis, African | 2016 |
Novel triazine dimers with potent antitrypanosomal activity.
Topics: Animals; Antiprotozoal Agents; Cell Proliferation; Cell Survival; Dimerization; Dose-Response Relationship, Drug; Drug Discovery; Fibroblasts; Humans; Leishmania infantum; Male; Mice; Molecular Structure; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Triazines; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2018 |
2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Drug Design; Female; Humans; Leishmania donovani; Ligands; Mice; Microsomes, Liver; Molecular Structure; Nitriles; Plasmodium falciparum; Protozoan Proteins; Rats; Structure-Activity Relationship; Swine; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2018 |
Advances in sleeping sickness therapy.
Topics: Animals; Clinical Trials as Topic; Democratic Republic of the Congo; Eflornithine; Humans; Melarsoprol; Nifurtimox; Sudan; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1992 |
Drugs for protozoan infections.
Topics: Antimalarials; Antimony Sodium Gluconate; Antiprotozoal Agents; Humans; Iodoquinol; Melarsoprol; Metronidazole; Nifurtimox; Pentamidine; Protozoan Infections; Suramin | 1987 |
Innate lack of susceptibility of Ugandan Trypanosoma brucei rhodesiense to DL-alpha-difluoromethylornithine (DFMO).
Topics: Animals; Drug Resistance; Eflornithine; Female; Humans; Hypoxanthine; Hypoxanthines; Melarsoprol; Mice; Mice, Inbred ICR; Nifurtimox; Species Specificity; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Uganda | 1995 |
Randomized, controlled trial of treatments for second-stage sleeping sickness.
Topics: Animals; Drug Therapy, Combination; Humans; Melarsoprol; Nifurtimox; Randomized Controlled Trials as Topic; Recurrence; Treatment Failure; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2007 |
Melarsoprol-free drug combinations for second-stage Gambian sleeping sickness: the way to go.
Topics: Drug Resistance; Drug Therapy, Combination; Eflornithine; Gambia; Humans; Melarsoprol; Nifurtimox; Trypanocidal Agents; Trypanosomiasis, African | 2007 |
Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.
Topics: Adenine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Brain; Cerebrospinal Fluid; Disease Models, Animal; Drug Interactions; Eflornithine; Indomethacin; Male; Melarsoprol; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Knockout; Multidrug Resistance-Associated Proteins; Nifurtimox; Pentamidine; Perfusion; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African | 2009 |
High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Topics: Aquaglyceroporins; Drug Resistance; Eflornithine; Endocytosis; Glycosylation; High-Throughput Screening Assays; Humans; Lysosomes; Melarsoprol; Nifurtimox; Pentamidine; RNA Interference; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2012 |
Evaluation of trypanocidal drugs used for human African trypanosomosis against Trypanosoma lewisi.
Topics: Animals; Eflornithine; Female; Humans; Immunocompromised Host; Inhibitory Concentration 50; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Parasitemia; Pentamidine; Rats; Rats, Wistar; Suramin; Trypanocidal Agents; Trypanosoma lewisi; Trypanosomiasis | 2013 |
Mortality trends and risk factors in advanced stage-2 Human African Trypanosomiasis: A critical appraisal of 23 years of experience in the Democratic Republic of Congo.
Topics: Adolescent; Adult; Democratic Republic of the Congo; Disease Management; Drug Therapy, Combination; Eflornithine; Female; Hospital Records; Humans; Male; Melarsoprol; Middle Aged; Multivariate Analysis; Nifurtimox; Recurrence; Retrospective Studies; Risk Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Young Adult | 2018 |
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.
Topics: Cell Biology; Humans; Lysosomes; Melarsoprol; Mitochondria; Mitochondrial Proteins; Mitosis; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2018 |