Compounds > melarsoprol
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melarsoprol and melarsen oxide

melarsoprol has been researched along with melarsen oxide in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's4 (36.36)18.2507
2000's5 (45.45)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bacchi, CJ; Garofalo, J; Goldberg, B; Nathan, HC; Yarlett, N1
Coombs, GH; Mottram, JC1
Carter, NS; Fairlamb, AH1
Atouguia, JM; Jennings, FW; Murray, M1
Scott, AG; Tait, A; Turner, CM1
Barrett, MP; Cover, B; de Koning, HP; Jarvis, SM; MacLeod, A1
Burri, C; Ericsson, O; Keiser, J1
Barrett, MP; Brun, R; Burchmore, RJ; de Koning, HP; Enyaru, JC; Geiser, F; Kaminsky, R; Mäser, P; Matovu, E; Seebeck, T; Stewart, ML; Wallace, LJ1
Schweingruber, ME1
Alibu, VP; Brun, R; Clayton, C; Marti, G; Renggli, CK; Richter, C; Seebeck, T; Shahi, S; Voncken, F1
Baumann, A; Karst, U; Melles, D; Pfeifer, T1

Other Studies

11 other study(ies) available for melarsoprol and melarsen oxide

ArticleYear
Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals.
    Experimental parasitology, 1991, Volume: 72, Issue:2

    Topics: Animals; Arsenicals; Calcium; Calcium Channels; Drug Resistance; Female; Melarsoprol; Mice; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

1991
Leishmania mexicana: enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicals.
    Experimental parasitology, 1985, Volume: 59, Issue:2

    Topics: Animals; Antimony; Antimony Sodium Gluconate; Antiprotozoal Agents; Arsenicals; Citric Acid Cycle; Gluconates; Glycolysis; Hexokinase; Leishmania; Malate Dehydrogenase; Melarsoprol; Organometallic Compounds; Phosphoenolpyruvate Carboxykinase (GTP); Phosphofructokinase-1; Pyruvate Kinase; Triazines

1985
Arsenical-resistant trypanosomes lack an unusual adenosine transporter.
    Nature, 1993, Jan-14, Volume: 361, Issue:6408

    Topics: Adenine; Adenosine; Animals; Antiprotozoal Agents; Arsenicals; Biological Transport; Carrier Proteins; Drug Resistance; Inosine; Kinetics; Melarsoprol; Trypanosoma brucei brucei

1993
The importance of 2,3-dimercaptopropinol (British anti-lewisite, BAL) in the trypanocidal activity of topical melarsoprol.
    Acta tropica, 1996, Volume: 62, Issue:2

    Topics: Administration, Topical; Animals; Arsenicals; Dimercaprol; Drug Combinations; Female; Gels; Melarsoprol; Mice; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

1996
Trypanosoma brucei: lack of cross-resistance to melarsoprol in vitro by cymelarsan-resistant parasites.
    Experimental parasitology, 1997, Volume: 86, Issue:3

    Topics: Adenine; Adenosine; Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Female; Inosine; Melarsoprol; Mice; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei

1997
Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes.
    Molecular and biochemical parasitology, 2000, Feb-25, Volume: 106, Issue:1

    Topics: Animals; Antiprotozoal Agents; Arsenicals; Biological Transport, Active; Dose-Response Relationship, Drug; Drug Resistance; Melarsoprol; Mice; Mice, Inbred BALB C; Minisatellite Repeats; Purines; Trypanocidal Agents; Trypanosoma brucei brucei

2000
Investigations of the metabolites of the trypanocidal drug melarsoprol.
    Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:5

    Topics: Adult; Animals; Area Under Curve; Arsenic; Arsenicals; Biological Assay; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Interactions; Female; Humans; Male; Melarsoprol; Mice; Mice, Inbred Strains; Microsomes, Liver; Spectrophotometry, Atomic; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African

2000
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
    Eukaryotic cell, 2003, Volume: 2, Issue:5

    Topics: Adenine; Adenosine; Animals; Arsenicals; Benzamidines; Cell Death; Cell Division; Diminazene; Drug Resistance; Female; Gene Silencing; Hypoxanthine; Inhibitory Concentration 50; Inosine; Melarsoprol; Mice; Mutation; Nucleoside Transport Proteins; Pentamidine; Stilbamidines; Trypanosoma brucei brucei

2003
The melaminophenyl arsenicals melarsoprol and melarsen oxide interfere with thiamine metabolism in the fission yeast Schizosaccharomyces pombe.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:9

    Topics: Arsenicals; Culture Media; Melarsoprol; Mutation; Oxides; Pyrimidines; Schizosaccharomyces; Thiamine; Trypanocidal Agents

2004
The role of Trypanosoma brucei MRPA in melarsoprol susceptibility.
    Molecular and biochemical parasitology, 2006, Volume: 146, Issue:1

    Topics: Animals; Arsenicals; Blotting, Western; Cell Line; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression; Humans; Melarsoprol; Membrane Transport Proteins; Mice; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Protozoan Proteins; Reverse Transcriptase Polymerase Chain Reaction; Treatment Failure; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

2006
Investigation of the biotransformation of melarsoprol by electrochemistry coupled to complementary LC/ESI-MS and LC/ICP-MS analysis.
    Analytical and bioanalytical chemistry, 2013, Volume: 405, Issue:15

    Topics: Arsenicals; Chromatography, Liquid; Hemoglobins; Humans; Mass Spectrometry; Melarsoprol; Molecular Structure; Protein Binding; Serum Albumin; Trypanocidal Agents

2013