Page last updated: 2024-08-21

melarsoprol and eflornithine

melarsoprol has been researched along with eflornithine in 51 studies

Research

Studies (51)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (13.73)	18.7374
1990's	11 (21.57)	18.2507
2000's	17 (33.33)	29.6817
2010's	16 (31.37)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Büchold, C; Gelhaus, C; Gut, J; Kisker, C; Leippe, M; Leyh, M; Machon, U; Rosenthal, PJ; Schirmeister, T; Schmuck, C; Stempka, M	1
Breuning, A; Büchold, C; Degel, B; Gelhaus, C; Gut, J; Heppner, S; Kisker, C; Leippe, M; Leyh, M; Machon, U; Rath, J; Rosenthal, PJ; Schirmeister, T; Schmuck, C; Schulz, F; Stempka, M; Stich, A	1
Brun, R; Jędrysiak, R; Kaiser, M; Suwiński, J; Torreele, E; Trunz, BB; Tweats, D	1
Clayton, C; De Muylder, G; Gerwick, L; Helbig, C; Knudsen, GM; Linington, RG; Mackey, ZB; Mascuch, SM; McKerrow, JH; Sanchez, LM	1
Behera, R; Edwards, P; Guyett, PJ; Karver, CE; Mensa-Wilmot, K; Patel, G; Pollastri, MP; Roncal, NE; Sullenberger, C	1
Brun, R; Diederich, F; Giroud, M; Haap, W; Kaiser, M; Kuhn, B; Kuratli, C; Martin, RE; Saint-Auret, S; Schirmeister, T; Schuler, F	1
Van Nieuwenhove, S	1
Ormerod, WE; Raseroka, BH	1
Bales, JD; Harrison, SM; Mbwabi, DL; Schecter, PJ	1
Jennings, FW	2
Guern, C; Milord, F; Pepin, J; Schechter, PJ	1
Bouteille, B; Darde, ML; Pestre-Alexandre, M	1
Kazyumba, GL; Nkanga, N; Ruppol, JF; Tshefu, AK	1
Boa Yapo, F; Doua, F	1
Roberts, JF; Yunmbam, MK	1
Doua, F; Yapo, FB	1
Milord, F; Pépin, J	1
Kazadi, K; Kazumba, M; Mulumba, MP	1
Brun, R; Iten, M; Kaminsky, R; Matovu, E	1
Cattand, P; Jannin, J	1
Bamba, M; Coulibaly, S; Doua, F; Miezan, TB; Youan, BB	1
Gastellu, M; Pécoul, B	1
Barrett, MP; Barrett, SV	1
Bonkoungou, P; Millogo, A; Nacro, B; Sanou, M; Tall, F; Traoré, H; Traoré, S	1
Enyaru, JC; Kaminsky, R; Legros, D; Matovu, E; Schmid, C; Seebeck, T	1
Etchegorry, MG; Helenport, JP; Jannin, J; Legros, D; Pecoul, B	1
Burri, C; Büscher, P; Gastellu-Etchegorry, M; Jannin, J; Legros, D; Ollivier, G; Paquet, C	1
Mpia, B; Pépin, J	1
Kager, PA	1
Docampo, R; Moreno, SN	1
Abel, PM; Behrend, M; Fleischmann, H; Kiala, G; Krishna, S; Lôa, V; Musolf, J; Stich, A; Théophile, J	1
Bovier, PA; Chappuis, F; Meussen, A; Stietenroth, K; Udayraj, N	1
Balasegaram, M; Checchi, F; Ghorashian, S; Hamel, C; Harris, S; Karunakara, U	1
Chappuis, F	1
Blum, JA; Burri, C; Hatz, C; Kazumba, L; Mangoni, P; Zellweger, MJ	1
Boelaert, M; Josenando, T; Raguenaud, ME; Robays, J	1
Balasegaram, M; Chappuis, F; Checchi, F; Priotto, G; Raguenaud, ME; Young, H	1
De Koning, HP; Dogruel, M; Rodgers, J; Sanderson, L; Thomas, SA	1
Blum, J; Brun, R; Burri, C; Chappuis, F	1
Schlitzer, M	1
Boelaert, M; Büscher, P; Lejon, V; Ngoyi, DM	1
Kennedy, A; Lutje, V; Seixas, J	2
Barrett, MP	1
Jutzi, P; Roditi, I; Schumann Burkard, G	1
Alsford, S; Baker, N; Berriman, M; Eckert, S; Field, MC; Glover, L; Horn, D; Leung, KF; Sanchez-Flores, A; Turner, DJ	1
Diarra, A; Franco, J; Jannin, J; Postigo, JA; Simarro, PP	1
Bucheton, B; Courtois, P; Cuny, G; Daulouède, S; Dethoua, M; Nzoumbou-Boko, R; Semballa, S; Truc, P; Vincendeau, P	1
Rushworth, SA; Steverding, D	1
Kaka, JT; Kazumba, LM; Ngoyi, DM; Tshala-Katumbay, D	1

Reviews

9 review(s) available for melarsoprol and eflornithine

Article	Year
Human trypanosomiasis in the Ivory Coast: therapy and problems. Acta tropica, 1993, Volume: 54, Issue:3-4 Topics: Animals; Cote d'Ivoire; Eflornithine; Humans; Melarsoprol; Pentamidine; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African	1993
The treatment of human African trypanosomiasis. Advances in parasitology, 1994, Volume: 33 Topics: Animals; Diminazene; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	1994
Treatment of human African trypanosomiasis--present situation and needs for research and development. The Lancet. Infectious diseases, 2002, Volume: 2, Issue:7 Topics: Africa South of the Sahara; Animals; Benzamidines; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurtimox; Thiadiazoles; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2002
Current chemotherapy of human African trypanosomiasis. Parasitology research, 2003, Volume: 90 Supp 1 Topics: Animals; Eflornithine; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African	2003
[Agents for the treatment of African sleeping sickness. Those developed in the last century]. Pharmazie in unserer Zeit, 2009, Volume: 38, Issue:6 Topics: Animals; Eflornithine; History, 20th Century; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosomiasis, African	2009
Chemotherapy for second-stage Human African trypanosomiasis. The Cochrane database of systematic reviews, 2010, Aug-04, Issue:8 Topics: Animals; Antiprotozoal Agents; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Prednisolone; Randomized Controlled Trials as Topic; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African	2010
Potential new drugs for human African trypanosomiasis: some progress at last. Current opinion in infectious diseases, 2010, Volume: 23, Issue:6 Topics: Animals; Benzamides; Boron Compounds; Drug Discovery; Drug Resistance; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2010
Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis. Parasitology, 2012, Volume: 139, Issue:7 Topics: Animals; Drug Therapy, Combination; Eflornithine; Health Services Accessibility; Humans; Melarsoprol; Nifurtimox; Trypanocidal Agents; Trypanosomiasis, African	2012
Chemotherapy for second-stage human African trypanosomiasis. The Cochrane database of systematic reviews, 2013, Jun-28, Issue:6 Topics: Animals; Antiprotozoal Agents; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Prednisolone; Randomized Controlled Trials as Topic; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African	2013

Trials

3 trial(s) available for melarsoprol and eflornithine

Article	Year
Combination of eflornithine and melarsoprol for melarsoprol-resistant Gambian trypanosomiasis. Tropical medicine & international health : TM & IH, 2002, Volume: 7, Issue:9 Topics: Adolescent; Adult; Congo; Drug Administration Schedule; Drug Therapy, Combination; Eflornithine; Female; Humans; Injections, Intravenous; Male; Melarsoprol; Middle Aged; Recurrence; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis	2002
Sleeping hearts: the role of the heart in sleeping sickness (human African trypanosomiasis). Tropical medicine & international health : TM & IH, 2007, Volume: 12, Issue:12 Topics: Adult; Animals; Eflornithine; Electrocardiography; Female; Heart Diseases; Humans; Male; Melarsoprol; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	2007
A CATT negative result after treatment for human African trypanosomiasis is no indication for cure. PLoS neglected tropical diseases, 2010, Jan-26, Volume: 4, Issue:1 Topics: Agglutination Tests; Antibodies, Protozoan; Eflornithine; Humans; Melarsoprol; Pentamidine; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African	2010

Other Studies

39 other study(ies) available for melarsoprol and eflornithine

Article	Year
On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences. Journal of medicinal chemistry, 2009, Sep-24, Volume: 52, Issue:18 Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Cathepsin L; Cathepsins; Cattle; Combinatorial Chemistry Techniques; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diamide; Drug Evaluation, Preclinical; Fumarates; Humans; Peptide Library; Plasmodium falciparum	2009
Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids. Journal of medicinal chemistry, 2010, Mar-11, Volume: 53, Issue:5 Topics: Antimalarials; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Plasmodium falciparum; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei	2010
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis. European journal of medicinal chemistry, 2011, Volume: 46, Issue:5 Topics: Animals; Antiprotozoal Agents; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Leukocytes, Mononuclear; Mice; Molecular Structure; Mutagenicity Tests; Nitroimidazoles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Trypanosomiasis, African	2011
Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. Journal of natural products, 2013, Apr-26, Volume: 76, Issue:4 Topics: Animals; Biological Products; Chagas Disease; Glycolysis; Humans; Leishmania donovani; Lipopeptides; Microbodies; Microscopy, Fluorescence; Trypanosoma brucei brucei; Zebrafish	2013
Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis. Journal of medicinal chemistry, 2013, May-23, Volume: 56, Issue:10 Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Survival; Coloring Agents; Drug Design; Drug Discovery; ErbB Receptors; Humans; Indicators and Reagents; Lapatinib; Morpholines; Neglected Diseases; Phosphotransferases; Quinazolines; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2013
2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design. Journal of medicinal chemistry, 2018, 04-26, Volume: 61, Issue:8 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Drug Design; Female; Humans; Leishmania donovani; Ligands; Mice; Microsomes, Liver; Molecular Structure; Nitriles; Plasmodium falciparum; Protozoan Proteins; Rats; Structure-Activity Relationship; Swine; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi	2018
Advances in sleeping sickness therapy. Annales de la Societe belge de medecine tropicale, 1992, Volume: 72 Suppl 1 Topics: Animals; Clinical Trials as Topic; Democratic Republic of the Congo; Eflornithine; Humans; Melarsoprol; Nifurtimox; Sudan; Trypanosoma brucei gambiense; Trypanosomiasis, African	1992
Screening compounds for sleeping sickness therapy without relapse. Bulletin de la Societe de pathologie exotique et de ses filiales, 1988, Volume: 81, Issue:3 Pt 2 Topics: Animals; Bleomycin; Drug Evaluation, Preclinical; Eflornithine; Melarsoprol; Metronidazole; Mice; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1988
Treatment of arsenical refractory Rhodesian sleeping sickness in Kenya. Annals of tropical medicine and parasitology, 1989, Volume: 83 Suppl 1 Topics: Adult; Animals; Arsenicals; Drug Therapy, Combination; Eflornithine; Female; Humans; Kenya; Male; Melarsoprol; Middle Aged; Recurrence; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African	1989
The potentiation of arsenicals with difluoromethylornithine (DFMO): experimental studies in murine trypanosomiasis. Bulletin de la Societe de pathologie exotique et de ses filiales, 1988, Volume: 81, Issue:3 Pt 2 Topics: Animals; Antimony Sodium Gluconate; Arsenicals; Drug Synergism; Drug Therapy, Combination; Eflornithine; Melarsoprol; Mice; Mitoguazone; Trypanosoma brucei brucei; Trypanosomiasis, African	1988
Difluoromethylornithine for arseno-resistant Trypanosoma brucei gambiense sleeping sickness. Lancet (London, England), 1987, Dec-19, Volume: 2, Issue:8573 Topics: Administration, Oral; Adolescent; Animals; Arsenicals; Child; Child, Preschool; Diarrhea; Drug Resistance; Eflornithine; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Male; Melarsoprol; Recurrence; Trypanosoma brucei gambiense; Trypanosomiasis, African	1987
[Action of drugs tested in an acellular medium and in mice infected with Trypanosoma brucei brucei]. Bulletin de la Societe de pathologie exotique et de ses filiales, 1988, Volume: 81, Issue:3 Pt 2 Topics: Acetanilides; Animals; Culture Media; Cyclosporins; Eflornithine; In Vitro Techniques; Melarsoprol; Mice; Mitoguazone; Nitroimidazoles; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1988
[Arsenical resistance and difluoromethylornithine in the treatment of human African trypanosomiasis]. Bulletin de la Societe de pathologie exotique et de ses filiales, 1988, Volume: 81, Issue:3 Pt 2 Topics: Arsenicals; Drug Resistance; Eflornithine; Humans; Melarsoprol; Trypanosomiasis, African	1988
Chemotherapy of trypanosomiasis: the potentiation of melarsoprol by concurrent difluoromethylornithine (DFMO) treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:4 Topics: Animals; Arsenicals; Chagas Disease; Drug Synergism; Drug Therapy, Combination; Eflornithine; Melarsoprol; Mice; Trypanosoma brucei brucei	1988
[Current therapy of trypanosomiasis]. Bulletin de la Societe de pathologie exotique (1990), 1994, Volume: 87, Issue:5 Topics: Adenosylmethionine Decarboxylase; Animals; Arsenicals; Deoxyadenosines; Drug Resistance; Eflornithine; Enzyme Inhibitors; Hospitalization; Humans; Melarsoprol; Pentamidine; Randomized Controlled Trials as Topic; Recurrence; Suramin; Triazines; Trypanocidal Agents; Trypanosomiasis, African	1994
In vivo evaluation of reuterin and its combinations with suramin, melarsoprol, DL-alpha-difluoromethylornithine and bleomycin in mice infected with Trypanosoma brucei brucei. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1993, Volume: 105, Issue:3 Topics: Aldehydes; Animals; Anti-Bacterial Agents; Bleomycin; Drug Therapy, Combination; Eflornithine; Female; Glyceraldehyde; Lethal Dose 50; Melarsoprol; Mice; Propane; Suramin; Trypanosomiasis, African	1993
[Characteristics of trypanosomiasis in children. Apropos of 19 case reports at the CNPP (Neuro-Psycho-Pathology Center), University Hospitals of Kinshasa, Zaire]. Annales de la Societe belge de medecine tropicale, 1993, Volume: 73, Issue:4 Topics: Adolescent; Child; Child, Preschool; Democratic Republic of the Congo; Drug Therapy, Combination; Eflornithine; Follow-Up Studies; Humans; Melarsoprol; Trypanosomiasis, African	1993
Innate lack of susceptibility of Ugandan Trypanosoma brucei rhodesiense to DL-alpha-difluoromethylornithine (DFMO). Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1995, Volume: 46, Issue:3 Topics: Animals; Drug Resistance; Eflornithine; Female; Humans; Hypoxanthine; Hypoxanthines; Melarsoprol; Mice; Mice, Inbred ICR; Nifurtimox; Species Specificity; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Uganda	1995
[Correspondence of the World Health Organization relative to the editorial by T. Ancelle (Med. Trop. 1996; 56: 347-348)]. Medecine tropicale : revue du Corps de sante colonial, 1997, Volume: 57, Issue:1 Topics: Africa; Eflornithine; France; Global Health; Humans; International Cooperation; Melarsoprol; Pentamidine; Trypanocidal Agents; Trypanosomiasis, African; World Health Organization	1997
In vivo evaluation of sixteen plant extracts on mice inoculated with Trypanosoma brucei gambiense. Bulletin of the World Health Organization, 1997, Volume: 75, Issue:4 Topics: Administration, Oral; Animals; Cote d'Ivoire; Eflornithine; Infusions, Parenteral; Injections, Intraperitoneal; Medicine, Traditional; Melarsoprol; Mice; Pentamidine; Plant Extracts; Sodium Chloride; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	1997
Production of sleeping-sickness treatment. Lancet (London, England), 1999, Sep-11, Volume: 354, Issue:9182 Topics: Cost-Benefit Analysis; Drug Compounding; Eflornithine; Humans; Melarsoprol; Sudan; Trypanocidal Agents; Trypanosomiasis, African; Uganda	1999
Anti-sleeping sickness drugs and cancer chemotherapy. Parasitology today (Personal ed.), 2000, Volume: 16, Issue:1 Topics: Animals; Antineoplastic Agents; Eflornithine; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2000
[Sleeping sickness in children at Bobo-Dioulasso Hospital Center: apropos of 3 cases]. Bulletin de la Societe de pathologie exotique (1990), 1999, Volume: 92, Issue:5 Topics: Adolescent; Burkina Faso; Child, Preschool; Cote d'Ivoire; Eflornithine; Female; Humans; Male; Melarsoprol; Trypanocidal Agents; Trypanosomiasis, African	1999
Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda. Tropical medicine & international health : TM & IH, 2001, Volume: 6, Issue:5 Topics: Animals; DNA, Protozoan; Drug Resistance; Eflornithine; Humans; Melarsoprol; Microbial Sensitivity Tests; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Recurrence; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Uganda	2001
Availability and affordability of treatment for Human African Trypanosomiasis. Tropical medicine & international health : TM & IH, 2001, Volume: 6, Issue:11 Topics: Eflornithine; Health Services Accessibility; Humans; Melarsoprol; Pentamidine; Research; Suramin; Trypanocidal Agents; Trypanosomiasis, African; World Health Organization	2001
[The return of sleeping sickness in an epidemic form: international action for drugs]. Nederlands tijdschrift voor geneeskunde, 2002, Dec-28, Volume: 146, Issue:52 Topics: Africa, Central; Animals; Disease Outbreaks; Eflornithine; Humans; International Cooperation; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	2002
Retaking sleeping sickness control in Angola. Tropical medicine & international health : TM & IH, 2004, Volume: 9, Issue:1 Topics: Adolescent; Adult; Age Distribution; Aged; Angola; Animals; Child; Child, Preschool; Disease Outbreaks; Eflornithine; Female; Humans; Infant; Insect Vectors; Male; Melarsoprol; Middle Aged; Pentamidine; Sex Distribution; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Tsetse Flies	2004
Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005, Sep-01, Volume: 41, Issue:5 Topics: Adolescent; Adult; Child; Eflornithine; Female; Humans; Male; Melarsoprol; Sudan; Trypanocidal Agents; Trypanosomiasis, African	2005
Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo. Bulletin of the World Health Organization, 2006, Volume: 84, Issue:10 Topics: Adolescent; Adult; Animals; Child; Democratic Republic of the Congo; Disease Progression; Eflornithine; Female; Humans; Male; Melarsoprol; Retrospective Studies; Risk Assessment; Risk Factors; Secondary Prevention; Treatment Failure; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	2006
Melarsoprol-free drug combinations for second-stage Gambian sleeping sickness: the way to go. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007, Dec-01, Volume: 45, Issue:11 Topics: Drug Resistance; Drug Therapy, Combination; Eflornithine; Gambia; Humans; Melarsoprol; Nifurtimox; Trypanocidal Agents; Trypanosomiasis, African	2007
Eflornithine is a cost-effective alternative to melarsoprol for the treatment of second-stage human West African trypanosomiasis in Caxito, Angola. Tropical medicine & international health : TM & IH, 2008, Volume: 13, Issue:2 Topics: Angola; Animals; Cost of Illness; Cost-Benefit Analysis; Eflornithine; Humans; Melarsoprol; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African	2008
Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes. Transactions of the Royal Society of Tropical Medicine and Hygiene, 2009, Volume: 103, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angola; Animals; Child; Developing Countries; Eflornithine; Female; Humans; International Agencies; Male; Melarsoprol; Middle Aged; Statistics as Topic; Sudan; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Uganda; Voluntary Health Agencies; Young Adult	2009
Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:3 Topics: Adenine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Brain; Cerebrospinal Fluid; Disease Models, Animal; Drug Interactions; Eflornithine; Indomethacin; Male; Melarsoprol; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Knockout; Multidrug Resistance-Associated Proteins; Nifurtimox; Pentamidine; Perfusion; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African	2009
Human African trypanosomiasis. Lancet (London, England), 2010, Jan-09, Volume: 375, Issue:9709 Topics: Africa; Animals; Biomedical Research; Communicable Disease Control; Eflornithine; Endemic Diseases; Humans; Incidence; Insect Bites and Stings; Insect Vectors; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Tsetse Flies; Variant Surface Glycoproteins, Trypanosoma	2010
Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters. Molecular and biochemical parasitology, 2011, Volume: 175, Issue:1 Topics: Antiprotozoal Agents; Blood; Eflornithine; Gene Knockdown Techniques; Gene Silencing; Melarsoprol; Membrane Transport Proteins; Protozoan Proteins; Transfection; Trypanosoma brucei brucei	2011
High-throughput decoding of antitrypanosomal drug efficacy and resistance. Nature, 2012, Jan-25, Volume: 482, Issue:7384 Topics: Aquaglyceroporins; Drug Resistance; Eflornithine; Endocytosis; Glycosylation; High-Throughput Screening Assays; Humans; Lysosomes; Melarsoprol; Nifurtimox; Pentamidine; RNA Interference; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2012
Evaluation of trypanocidal drugs used for human African trypanosomosis against Trypanosoma lewisi. Parasite (Paris, France), 2013, Volume: 20 Topics: Animals; Eflornithine; Female; Humans; Immunocompromised Host; Inhibitory Concentration 50; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Parasitemia; Pentamidine; Rats; Rats, Wistar; Suramin; Trypanocidal Agents; Trypanosoma lewisi; Trypanosomiasis	2013
Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine. Experimental parasitology, 2017, Volume: 178 Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Therapy, Combination; Eflornithine; Glioblastoma; HL-60 Cells; Humans; Melarsoprol; Temozolomide; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2017
Mortality trends and risk factors in advanced stage-2 Human African Trypanosomiasis: A critical appraisal of 23 years of experience in the Democratic Republic of Congo. PLoS neglected tropical diseases, 2018, Volume: 12, Issue:6 Topics: Adolescent; Adult; Democratic Republic of the Congo; Disease Management; Drug Therapy, Combination; Eflornithine; Female; Hospital Records; Humans; Male; Melarsoprol; Middle Aged; Multivariate Analysis; Nifurtimox; Recurrence; Retrospective Studies; Risk Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African; Young Adult	2018