melarsomine dihydrochloride has been researched along with suramin in 10 studies
| Studies (melarsomine dihydrochloride) | Trials (melarsomine dihydrochloride) | Recent Studies (post-2010) (melarsomine dihydrochloride) | Studies (suramin) | Trials (suramin) | Recent Studies (post-2010) (suramin) |
|---|---|---|---|---|---|
| 53 | 3 | 6 | 3,023 | 92 | 431 |
| Protein | Taxonomy | melarsomine dihydrochloride (IC50) | suramin (IC50) |
|---|---|---|---|
| ATP-dependent 6-phosphofructokinase | Trypanosoma brucei brucei | 3 | |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | 9.76 | |
| P2X purinoceptor 2 | Rattus norvegicus (Norway rat) | 4 | |
| DNA-dependent protein kinase catalytic subunit | Homo sapiens (human) | 1.7 | |
| DNA primase | Mycobacterium tuberculosis CDC1551 | 8.2 | |
| RmtA | Aspergillus nidulans | 5.9 | |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | 9.4 | |
| NAD-dependent protein deacetylase sirtuin-2 | Homo sapiens (human) | 1.15 | |
| NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens (human) | 1.5667 | |
| Protein arginine N-methyltransferase 1 | Homo sapiens (human) | 5.33 | |
| NAD-dependent protein deacylase sirtuin-5, mitochondrial | Homo sapiens (human) | 2.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (90.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kamar, K; Mutugi, M; Njogu, AR; Otsyula, M | 1 |
| Baltz, T; Giroud, C; Zhang, ZQ | 2 |
| Jennings, FW | 1 |
| Kinabo, LD | 1 |
| Kaminsky, R; Moloo, SK; Zweygarth, E | 1 |
| Jones, TW; Partoutomo, S; Payne, RC; Sukanto, IP | 1 |
| Barns, AM; Ross, CA; Sutherland, DV | 1 |
| Scott, AG; Tait, A; Turner, CM | 1 |
| Arafa, RK; Boykin, DW; Brun, R; Gillingwater, K; Ismail, MA; Kumar, A; Stephens, CE; Tidwell, RR | 1 |
1 review(s) available for melarsomine dihydrochloride and suramin
| Article | Year |
|---|---|
Pharmacology of existing drugs for animal trypanosomiasis.
Topics: Animals; Arsenicals; Diminazene; Ethidium; Phenanthridines; Quinolinium Compounds; Suramin; Trypanocidal Agents; Trypanosomiasis, African | 1993 |
1 trial(s) available for melarsomine dihydrochloride and suramin
| Article | Year |
|---|---|
Preliminary efficacy trial of Cymelarsan, a novel trypanocide, in camels naturally infected with Trypanosoma evansi in Kenya.
Topics: Animals; Arsenicals; Camelus; Dose-Response Relationship, Drug; Injections, Subcutaneous; Kenya; Suramin; Trypanocidal Agents; Trypanosomiasis | 1992 |
8 other study(ies) available for melarsomine dihydrochloride and suramin
| Article | Year |
|---|---|
In vivo and in vitro sensitivity of Trypanosoma evansi and T. equiperdum to diminazene, suramin, MelCy, quinapyramine and isometamidium.
Topics: Animals; Arsenicals; Diminazene; Female; Mice; Phenanthridines; Quinolinium Compounds; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosomiasis | 1991 |
Chemotherapy of CNS-trypanosomiasis: combination chemotherapy with a 5-nitroimidazole (MK 436), an arsenical (Cymelarsan) and suramin.
Topics: Animals; Arsenicals; Brain Diseases; Disease Models, Animal; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1991 |
Trypanosoma simiae: in vitro studies on drug susceptibility.
Topics: Animals; Arsenicals; Diminazene; Drug Resistance; Eflornithine; Parasitology; Quinolinium Compounds; Species Specificity; Suramin; Trypanocidal Agents; Trypanosoma | 1993 |
Efficacy of Cymelarsan treatment of suramin resistant Trypanosoma evansi in cattle.
Topics: Animals; Arsenicals; Cattle; Drug Resistance; Injections, Subcutaneous; Recurrence; Suramin; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, Bovine | 1994 |
Trypanosoma evansi: in vivo and in vitro determination of trypanocide resistance profiles.
Topics: Animals; Arsenicals; Diminazene; Drug Resistance; Phenanthridines; Quinolinium Compounds; Suramin; Trypanocidal Agents; Trypanosoma | 1993 |
Trypanosoma evansi: measurement of pyruvate production as an indicator of the drug sensitivity of isolates in vitro.
Topics: Animals; Arsenic Poisoning; Arsenicals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Pyruvates; Quinolinium Compounds; Suramin; Trypanocidal Agents; Trypanosoma | 1995 |
Characterisation of cloned lines of Trypanosoma brucei expressing stable resistance to MelCy and suramin.
Topics: Animals; Arsenicals; Biological Assay; Cells, Cultured; Clone Cells; Drug Resistance; Female; Male; Melarsoprol; Mice; Mice, Inbred BALB C; Phenotype; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei | 1996 |
In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi.
Topics: Amidines; Animals; Arsenicals; Cells, Cultured; Diminazene; Drug Resistance; Female; Inhibitory Concentration 50; Mice; Pentamidine; Quinolinium Compounds; Rats; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosomiasis | 2010 |