Compounds > melarsomine dihydrochloride
Page last updated: 2024-09-03

melarsomine dihydrochloride and pentamidine

melarsomine dihydrochloride has been researched along with pentamidine in 6 studies

Compound Research Comparison

Studies
(melarsomine dihydrochloride)		Trials
(melarsomine dihydrochloride)		Recent Studies (post-2010)
(melarsomine dihydrochloride)		Studies
(pentamidine)		Trials
(pentamidine)		Recent Studies (post-2010) (pentamidine)
53362,411136477

Protein Interaction Comparison

ProteinTaxonomymelarsomine dihydrochloride (IC50)pentamidine (IC50)
Solute carrier family 22 member 2Homo sapiens (human)1.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)3.278
Protein tyrosine phosphatase type IVA 3Homo sapiens (human)0.3
Solute carrier family 22 member 3Homo sapiens (human)9.5
PlasminogenHomo sapiens (human)7.3333
Urokinase-type plasminogen activatorHomo sapiens (human)10
Trypsin-1Homo sapiens (human)10
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.214
Muscarinic acetylcholine receptor M2Homo sapiens (human)1.425
Muscarinic acetylcholine receptor M4Homo sapiens (human)1.58
Muscarinic acetylcholine receptor M5Homo sapiens (human)2.885
Alpha-2A adrenergic receptorHomo sapiens (human)1.375
Cytochrome P450 2D6Homo sapiens (human)10
Amine oxidase [flavin-containing] AHomo sapiens (human)0.793
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.214
5-hydroxytryptamine receptor 2AHomo sapiens (human)1.639
5-hydroxytryptamine receptor 2CHomo sapiens (human)3.278
D(3) dopamine receptorHomo sapiens (human)3.998
Sodium-dependent dopamine transporter Homo sapiens (human)3.159
Glutamate receptor ionotropic, NMDA 1Homo sapiens (human)0.72
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)10
Glutamate receptor ionotropic, NMDA 2AHomo sapiens (human)0.72
Protein tyrosine phosphatase type IVA 2Homo sapiens (human)0.3
Multidrug and toxin extrusion protein 2Homo sapiens (human)2.7
Protein tyrosine phosphatase type IVA 1Homo sapiens (human)0.3
Multidrug and toxin extrusion protein 1Homo sapiens (human)1.7033

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (50.00)18.2507
2000's1 (16.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Al-Salabi, MI; Ali, JA; de Koning, HP; El-Sabbagh, N; Ho, W; Ibrahim, HM; Koomen, GJ; Rodenko, B; Teka, IA; Wanner, MJ1
Jennings, FW1
Baltz, T; Barrett, MP; Denise, H; Giroud, C; Zhang, ZQ1
Scott, AG; Tait, A; Turner, CM1
Barrett, MP; Brun, R; Burchmore, RJ; de Koning, HP; Enyaru, JC; Geiser, F; Kaminsky, R; Mäser, P; Matovu, E; Seebeck, T; Stewart, ML; Wallace, LJ1
Arafa, RK; Boykin, DW; Brun, R; Gillingwater, K; Ismail, MA; Kumar, A; Stephens, CE; Tidwell, RR1

Other Studies

6 other study(ies) available for melarsomine dihydrochloride and pentamidine

ArticleYear
Synthesis of marine-derived 3-alkylpyridinium alkaloids with potent antiprotozoal activity.
    ACS medicinal chemistry letters, 2011, Dec-08, Volume: 2, Issue:12

    Topics:

2011
Chemotherapy of CNS-trypanosomiasis: the combined use of diminazene aceturate or pentamidine with DL-alpha-difluoromethylornithine (DFMO).
    Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1992, Volume: 43, Issue:2

    Topics: Animals; Arsenicals; Central Nervous System Diseases; Diminazene; Drug Administration Schedule; Drug Therapy, Combination; Eflornithine; Female; Mice; Pentamidine; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

1992
A diamidine-resistant Trypanosoma equiperdum clone contains a P2 purine transporter with reduced substrate affinity.
    Molecular and biochemical parasitology, 1995, Volume: 73, Issue:1-2

    Topics: Adenosine; Animals; Arsenicals; Biological Transport, Active; Carrier Proteins; Diminazene; Drug Resistance; Kinetics; Pentamidine; Receptors, Purinergic P2; Trypanocidal Agents; Trypanosoma

1995
Trypanosoma brucei: lack of cross-resistance to melarsoprol in vitro by cymelarsan-resistant parasites.
    Experimental parasitology, 1997, Volume: 86, Issue:3

    Topics: Adenine; Adenosine; Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Female; Inosine; Melarsoprol; Mice; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei

1997
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
    Eukaryotic cell, 2003, Volume: 2, Issue:5

    Topics: Adenine; Adenosine; Animals; Arsenicals; Benzamidines; Cell Death; Cell Division; Diminazene; Drug Resistance; Female; Gene Silencing; Hypoxanthine; Inhibitory Concentration 50; Inosine; Melarsoprol; Mice; Mutation; Nucleoside Transport Proteins; Pentamidine; Stilbamidines; Trypanosoma brucei brucei

2003
In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi.
    Veterinary parasitology, 2010, May-11, Volume: 169, Issue:3-4

    Topics: Amidines; Animals; Arsenicals; Cells, Cultured; Diminazene; Drug Resistance; Female; Inhibitory Concentration 50; Mice; Pentamidine; Quinolinium Compounds; Rats; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosomiasis

2010