Page last updated: 2024-09-03

melarsomine dihydrochloride and diminazene

melarsomine dihydrochloride has been researched along with diminazene in 18 studies

Compound Research Comparison

Studies (melarsomine dihydrochloride)	Trials (melarsomine dihydrochloride)	Recent Studies (post-2010) (melarsomine dihydrochloride)	Studies (diminazene)	Trials (diminazene)	Recent Studies (post-2010) (diminazene)
53	3	6	758	24	244

Research

Studies (18)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (55.56)	18.2507
2000's	4 (22.22)	29.6817
2010's	4 (22.22)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Holmes, PH; Jennings, FW; Osman, AS	1
Adams, JH; Hunter, CA; Jennings, FW; Kennedy, PG; Murray, M	1
Jennings, FW	1
Huang, D; Huang, YT; Liang, JX; Lun, ZR; Min, ZP; Yang, XF	1
Baltz, T; Giroud, C; Zhang, ZQ	2
Kinabo, LD	1
Kaminsky, R; Moloo, SK; Zweygarth, E	1
Baltz, T; Barrett, MP; Denise, H; Giroud, C; Zhang, ZQ	1
Scott, AG; Tait, A; Turner, CM	1
Martin, RJ; Ross, CA; Suswam, EA; Taylor, DW	1
Barrett, MP; Brun, R; Burchmore, RJ; de Koning, HP; Enyaru, JC; Geiser, F; Kaminsky, R; Mäser, P; Matovu, E; Seebeck, T; Stewart, ML; Wallace, LJ	1
Martin, RJ; Ross, CA; Suswam, EA	1
Aliyu, MM; Ibrahim, UI; Mbaya, AW; Nwosu, CO; Taiwo, VO	1
Arafa, RK; Boykin, DW; Brun, R; Gillingwater, K; Ismail, MA; Kumar, A; Stephens, CE; Tidwell, RR	1
Alemu, T; Claes, F; Feseha, G; Fikru, R; Goddeeris, BM; Hagos, A; Yacob, HT; Yilkal, K	1
Kumshe, HA; Mbaya, AW; Nwosu, CO	1
Birhanu, H; Büscher, P; Kidane, W; Mekonnen, G; Mohammed, EF; Nesibu, A; Van Reet, N; Yohannes, H	1

Reviews

1 review(s) available for melarsomine dihydrochloride and diminazene

Article	Year
Pharmacology of existing drugs for animal trypanosomiasis. Acta tropica, 1993, Volume: 54, Issue:3-4 Topics: Animals; Arsenicals; Diminazene; Ethidium; Phenanthridines; Quinolinium Compounds; Suramin; Trypanocidal Agents; Trypanosomiasis, African	1993

Trials

2 trial(s) available for melarsomine dihydrochloride and diminazene

Article	Year
Effects of melarsamine hydrochloride (Cymelarsan) and diminazene aceturate (Berenil) on the pathology of experimental Trypanosoma brucei infection in red fronted gazelles (Gazella rufifrons). Veterinary parasitology, 2009, Jul-07, Volume: 163, Issue:1-2 Topics: Animals; Antelopes; Arsenicals; Diminazene; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2009
Efficacy of Cymelarsan and Diminasan against Trypanosoma equiperdum infections in mice and horses. Veterinary parasitology, 2010, Aug-04, Volume: 171, Issue:3-4 Topics: Animals; Arsenicals; Diminazene; Female; Horse Diseases; Horses; Mice; Parasitemia; Time Factors; Trypanocidal Agents; Trypanosoma; Trypanosomiasis	2010

Other Studies

15 other study(ies) available for melarsomine dihydrochloride and diminazene

Article	Year
The rapid development of drug-resistance by Trypanosoma evansi in immunosuppressed mice. Acta tropica, 1992, Volume: 50, Issue:3 Topics: Animals; Arsenicals; Diminazene; Drug Resistance; Immunosuppression Therapy; Mice; Phenanthridines; Trypanocidal Agents; Trypanosoma; Trypanosomiasis	1992
Subcurative chemotherapy and fatal post-treatment reactive encephalopathies in African trypanosomiasis. Lancet (London, England), 1992, Apr-18, Volume: 339, Issue:8799 Topics: Adolescent; Adult; Animals; Arsenicals; Brain; Brain Diseases; Child; Child, Preschool; Diminazene; Female; Humans; Male; Mice; Nitroimidazoles; Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1992
Chemotherapy of CNS-trypanosomiasis: the combined use of diminazene aceturate or pentamidine with DL-alpha-difluoromethylornithine (DFMO). Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1992, Volume: 43, Issue:2 Topics: Animals; Arsenicals; Central Nervous System Diseases; Diminazene; Drug Administration Schedule; Drug Therapy, Combination; Eflornithine; Female; Mice; Pentamidine; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1992
Cymelarsan in the treatment of buffaloes naturally infected with Trypanosoma evansi in south China. Acta tropica, 1991, Volume: 49, Issue:3 Topics: Animals; Arsenicals; Buffaloes; Diminazene; Female; Injections, Intramuscular; Male; Muscles; Necrosis; Recurrence; Skin; Trypanocidal Agents; Trypanosomiasis	1991
In vivo and in vitro sensitivity of Trypanosoma evansi and T. equiperdum to diminazene, suramin, MelCy, quinapyramine and isometamidium. Acta tropica, 1991, Volume: 50, Issue:2 Topics: Animals; Arsenicals; Diminazene; Female; Mice; Phenanthridines; Quinolinium Compounds; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosomiasis	1991
Trypanosoma simiae: in vitro studies on drug susceptibility. Acta tropica, 1993, Volume: 54, Issue:3-4 Topics: Animals; Arsenicals; Diminazene; Drug Resistance; Eflornithine; Parasitology; Quinolinium Compounds; Species Specificity; Suramin; Trypanocidal Agents; Trypanosoma	1993
Trypanosoma evansi: in vivo and in vitro determination of trypanocide resistance profiles. Experimental parasitology, 1993, Volume: 77, Issue:4 Topics: Animals; Arsenicals; Diminazene; Drug Resistance; Phenanthridines; Quinolinium Compounds; Suramin; Trypanocidal Agents; Trypanosoma	1993
A diamidine-resistant Trypanosoma equiperdum clone contains a P2 purine transporter with reduced substrate affinity. Molecular and biochemical parasitology, 1995, Volume: 73, Issue:1-2 Topics: Adenosine; Animals; Arsenicals; Biological Transport, Active; Carrier Proteins; Diminazene; Drug Resistance; Kinetics; Pentamidine; Receptors, Purinergic P2; Trypanocidal Agents; Trypanosoma	1995
Trypanosoma brucei: lack of cross-resistance to melarsoprol in vitro by cymelarsan-resistant parasites. Experimental parasitology, 1997, Volume: 86, Issue:3 Topics: Adenine; Adenosine; Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Female; Inosine; Melarsoprol; Mice; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei	1997
Changes in properties of adenosine transporters in Trypanosoma evansi and modes of selection of resistance to the melaminophenyl arsenical drug, Mel Cy. Veterinary parasitology, 2001, Dec-13, Volume: 102, Issue:3 Topics: Adenine; Adenosine; Animals; Arsenicals; Biological Transport; Biomarkers; Carrier Proteins; Diminazene; Dose-Response Relationship, Drug; Drug Resistance; Inosine; Membrane Transport Proteins; Nucleoside Transport Proteins; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma	2001
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic cell, 2003, Volume: 2, Issue:5 Topics: Adenine; Adenosine; Animals; Arsenicals; Benzamidines; Cell Death; Cell Division; Diminazene; Drug Resistance; Female; Gene Silencing; Hypoxanthine; Inhibitory Concentration 50; Inosine; Melarsoprol; Mice; Mutation; Nucleoside Transport Proteins; Pentamidine; Stilbamidines; Trypanosoma brucei brucei	2003
Changes in adenosine transport associated with melaminophenyl arsenical (Mel CY) resistance in Trypanosoma evansi: down-regulation and affinity changes of the P2 transporter. Parasitology, 2003, Volume: 127, Issue:Pt 6 Topics: Adenine; Adenosine; Animals; Arsenicals; Diminazene; Down-Regulation; Drug Resistance; Inosine; Kinetics; Nucleoside Transport Proteins; Trypanocidal Agents; Trypanosoma	2003
In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi. Veterinary parasitology, 2010, May-11, Volume: 169, Issue:3-4 Topics: Amidines; Animals; Arsenicals; Cells, Cultured; Diminazene; Drug Resistance; Female; Inhibitory Concentration 50; Mice; Pentamidine; Quinolinium Compounds; Rats; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosomiasis	2010
Genital lesions in male red fronted gazelles (Gazella rufifrons) experimentally infected with Trypanosoma brucei and the effect of melarsamine hydrochloride (Cymelarsan®) and diminazene aceturate (Berenil®) in its treatment. Theriogenology, 2011, Sep-01, Volume: 76, Issue:4 Topics: Animals; Antelopes; Arsenicals; Body Temperature; Diminazene; Genital Diseases, Male; Hematocrit; Histocytochemistry; Male; Parasitemia; Semen; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2011
Isometamidium chloride and homidium chloride fail to cure mice infected with Ethiopian Trypanosoma evansi type A and B. PLoS neglected tropical diseases, 2018, Volume: 12, Issue:9 Topics: Animals; Arsenicals; Diminazene; Disease Models, Animal; Ethiopia; Female; Injections; Mice; Phenanthridines; Recurrence; Treatment Outcome; Trypanocidal Agents; Trypanosoma; Trypanosomiasis	2018