melarsen oxide has been researched along with arsenic in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (30.30) | 18.7374 |
| 1990's | 11 (33.33) | 18.2507 |
| 2000's | 10 (30.30) | 29.6817 |
| 2010's | 2 (6.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bacchi, CJ; Garofalo, J; Goldberg, B; Nathan, HC; Yarlett, N | 1 |
| Aba, L; Camara, P; Doua, F; Hamon, JF; Seri, B | 1 |
| Cerami, A; Fairlamb, AH; Henderson, GB | 1 |
| Coombs, GH; Mottram, JC | 1 |
| Hers, HG; Opperdoes, FR; Van Schaftingen, E | 1 |
| Fairlamb, AH; Müller, S; Walter, RD | 1 |
| Cunningham, ML; Fairlamb, AH; Zvelebil, MJ | 1 |
| Carter, NS; Fairlamb, AH | 1 |
| Atouguia, JM; Jennings, FW; Murray, M | 1 |
| Scott, AG; Tait, A; Turner, CM | 1 |
| Bacchi, CJ; Goldberg, B; Lloyd, D; Rattendi, D; Sufrin, JR | 1 |
| Cowgill, C; Glocker, MO; Happersberger, HP; Stapleton, J | 1 |
| Glocker, MO; Happersberger, HP; Przybylski, M | 1 |
| Kaminsky, R; Kralli, A; Mäser, P; Sütterlin, C | 1 |
| Ariyanayagam, MR; Clayton, C; Fairlamb, AH; Krauth-Siegel, RL; Krieger, S; Schwarz, W | 1 |
| Barrett, MP; Cover, B; de Koning, HP; Jarvis, SM; MacLeod, A | 1 |
| Burri, C; Ericsson, O; Keiser, J | 1 |
| Loiseau, PM; Lubert, P; Wolf, JG | 1 |
| Eggleston, IM; Fairlamb, AH; Hamilton, CJ; Saravanamuthu, A | 1 |
| APTED, FI | 1 |
| BAKER, JR | 1 |
| Barrett, MP; Brun, R; Burchmore, RJ; de Koning, HP; Enyaru, JC; Geiser, F; Kaminsky, R; Mäser, P; Matovu, E; Seebeck, T; Stewart, ML; Wallace, LJ | 1 |
| Schweingruber, ME | 1 |
| Alibu, VP; Brun, R; Clayton, C; Marti, G; Renggli, CK; Richter, C; Seebeck, T; Shahi, S; Voncken, F | 1 |
| de Koning, HP; Mäser, P; Rodenko, B; Schweingruber, AM; Schweingruber, ME; Stoffel, SA | 1 |
| Bridges, DJ; Burchmore, RJ; de Koning, HP; Gould, MK; Mäser, P; Nerima, B | 1 |
| FRIEDHEIM, EA | 1 |
| LOURIE, EM; WILLIAMSON, J | 1 |
| BALTHAZAR, E; BEZERRA, DA; PAYNE, EH | 1 |
| BALTHAZAR, E; FERNANDES, JS; PAYNE, EH | 1 |
| Abdeen, Z; Azmi, K; Baneth, G; Berlin, D; Ereqat, S; Nasereddin, A | 1 |
| WEINMAN, D | 1 |
| Baumann, A; Karst, U; Melles, D; Pfeifer, T | 1 |
33 other study(ies) available for melarsen oxide and arsenic
| Article | Year |
|---|---|
Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals.
Topics: Animals; Arsenicals; Calcium; Calcium Channels; Drug Resistance; Female; Melarsoprol; Mice; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1991 |
Effects of Mel B arsobal and alpha-difluoromethylornithine on the awakening electroencephalogram of humans with gambiense trypanosomiasis disease: preliminary report.
Topics: Adolescent; Adult; Arsenicals; Dimercaprol; Drug Combinations; Eflornithine; Electroencephalography; Female; Humans; Male; Middle Aged; Trypanosomiasis, African | 1990 |
Trypanothione is the primary target for arsenical drugs against African trypanosomes.
Topics: Animals; Arsenic Poisoning; Arsenicals; Chromatography, High Pressure Liquid; Glutathione; Kinetics; NADH, NADPH Oxidoreductases; Spermidine; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma brucei brucei | 1989 |
Leishmania mexicana: enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicals.
Topics: Animals; Antimony; Antimony Sodium Gluconate; Antiprotozoal Agents; Arsenicals; Citric Acid Cycle; Gluconates; Glycolysis; Hexokinase; Leishmania; Malate Dehydrogenase; Melarsoprol; Organometallic Compounds; Phosphoenolpyruvate Carboxykinase (GTP); Phosphofructokinase-1; Pyruvate Kinase; Triazines | 1985 |
Effects of various metabolic conditions and of the trivalent arsenical melarsen oxide on the intracellular levels of fructose 2,6-bisphosphate and of glycolytic intermediates in Trypanosoma brucei.
Topics: Animals; Arsenicals; Fructosediphosphates; Glycolysis; Hexosediphosphates; Kinetics; Phosphofructokinase-2; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Pyruvate Kinase; Salicylamides; Subcellular Fractions; Trypanosoma brucei brucei | 1987 |
Differential susceptibility of filarial and human erythrocyte glutathione reductase to inhibition by the trivalent organic arsenical melarsen oxide.
Topics: Animals; Arsenicals; Binding Sites; Cattle; Enzyme Inhibitors; Erythrocytes; Glutathione Reductase; Humans; In Vitro Techniques; Kinetics; Molecular Weight; Onchocerca; Setaria Nematode; Species Specificity | 1995 |
Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals.
Topics: Animals; Arsenicals; Binding Sites; Binding, Competitive; Crithidia fasciculata; Disulfides; Erythrocytes; Glutathione; Glutathione Reductase; Humans; Kinetics; Models, Molecular; NADH, NADPH Oxidoreductases; NADP; Structure-Activity Relationship; Trypanocidal Agents | 1994 |
Arsenical-resistant trypanosomes lack an unusual adenosine transporter.
Topics: Adenine; Adenosine; Animals; Antiprotozoal Agents; Arsenicals; Biological Transport; Carrier Proteins; Drug Resistance; Inosine; Kinetics; Melarsoprol; Trypanosoma brucei brucei | 1993 |
The importance of 2,3-dimercaptopropinol (British anti-lewisite, BAL) in the trypanocidal activity of topical melarsoprol.
Topics: Administration, Topical; Animals; Arsenicals; Dimercaprol; Drug Combinations; Female; Gels; Melarsoprol; Mice; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1996 |
Trypanosoma brucei: lack of cross-resistance to melarsoprol in vitro by cymelarsan-resistant parasites.
Topics: Adenine; Adenosine; Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Female; Inosine; Melarsoprol; Mice; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei | 1997 |
Effects of intermediates of methionine metabolism and nucleoside analogs on S-adenosylmethionine transport by Trypanosoma brucei brucei and a drug-resistant Trypanosoma brucei rhodesiense.
Topics: Adenosine; Animals; Arsenicals; Drug Resistance; Methionine; Polyamines; Purine Nucleosides; S-Adenosylmethionine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense | 1998 |
Characterization of the folding pathway of recombinant human macrophage-colony stimulating-factor beta (rhM-CSF beta) by bis-cysteinyl modification and mass spectrometry.
Topics: Arsenicals; Cysteine; Fluorescence; Humans; Macrophage Colony-Stimulating Factor; Mass Spectrometry; Oxidation-Reduction; Protein Folding; Protein Structure, Tertiary; Recombinant Proteins; Tryptophan | 1998 |
Selective bridging of bis-cysteinyl residues by arsonous acid derivatives as an approach to the characterization of protein tertiary structures and folding pathways by mass spectrometry.
Topics: Amino Acid Sequence; Animals; Aprotinin; Arginine Vasopressin; Arsenicals; Cattle; Chromatography, High Pressure Liquid; Cysteine; Disulfides; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Molecular Weight; Oxytocin; Peptide Mapping; Peptides; Protein Folding; Protein Structure, Tertiary; Reducing Agents; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin | 1998 |
A nucleoside transporter from Trypanosoma brucei involved in drug resistance.
Topics: Adenosine; Amino Acid Sequence; Animals; Arsenicals; Biological Transport; Carrier Proteins; Cloning, Molecular; Drug Resistance; Genes, Protozoan; Membrane Proteins; Molecular Sequence Data; Mutation; Nucleoside Transport Proteins; Nucleosides; Purines; Saccharomyces cerevisiae; Substrate Specificity; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1999 |
Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress.
Topics: Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Arsenicals; Cell Cycle; Cell Division; Doxycycline; Enzyme Inhibitors; Mice; Mice, Inbred BALB C; Mutation; NADH, NADPH Oxidoreductases; Oxidative Stress; Promoter Regions, Genetic; Sulfhydryl Compounds; Tetracycline; Trypanosoma brucei brucei; Trypanosomiasis, African; Virulence | 2000 |
Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes.
Topics: Animals; Antiprotozoal Agents; Arsenicals; Biological Transport, Active; Dose-Response Relationship, Drug; Drug Resistance; Melarsoprol; Mice; Mice, Inbred BALB C; Minisatellite Repeats; Purines; Trypanocidal Agents; Trypanosoma brucei brucei | 2000 |
Investigations of the metabolites of the trypanocidal drug melarsoprol.
Topics: Adult; Animals; Area Under Curve; Arsenic; Arsenicals; Biological Assay; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Interactions; Female; Humans; Male; Melarsoprol; Mice; Mice, Inbred Strains; Microsomes, Liver; Spectrophotometry, Atomic; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2000 |
Contribution of dithiol ligands to in vitro and in vivo trypanocidal activities of dithiaarsanes and investigation of ligand exchange in an aqueous solution.
Topics: Animals; Arsenicals; Cysteamine; Dansyl Compounds; Disease Models, Animal; Female; Mice; Parasitic Sensitivity Tests; Structure-Activity Relationship; Sulfhydryl Compounds; Thioctic Acid; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2000 |
Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase.
Topics: Arsenicals; Biochemistry; Dimethyl Sulfoxide; Dithionitrobenzoic Acid; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glutathione; Hydrogen-Ion Concentration; Linear Models; NADH, NADPH Oxidoreductases; Spermidine; Time Factors; Xanthenes | 2003 |
Four years' experience of melarsen oxide/BAL in the treatment of late-stage Rhodesian sleeping sickness.
Topics: Animals; Arsenicals; Black People; Humans; Trypanosomiasis; Trypanosomiasis, African | 1957 |
The curative power of 4-(2:6-diaminopyrimidin-4-ylamino) phenylarsine oxide (compound 12,065) in infections of Trypanosoma rhodesiense in laboratory animals.
Topics: Animals; Animals, Laboratory; Arsenicals; Humans; Mice; Rats; Trypanosoma brucei rhodesiense; Trypanosomiasis; Trypanosomiasis, African; Tsetse Flies | 1958 |
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
Topics: Adenine; Adenosine; Animals; Arsenicals; Benzamidines; Cell Death; Cell Division; Diminazene; Drug Resistance; Female; Gene Silencing; Hypoxanthine; Inhibitory Concentration 50; Inosine; Melarsoprol; Mice; Mutation; Nucleoside Transport Proteins; Pentamidine; Stilbamidines; Trypanosoma brucei brucei | 2003 |
The melaminophenyl arsenicals melarsoprol and melarsen oxide interfere with thiamine metabolism in the fission yeast Schizosaccharomyces pombe.
Topics: Arsenicals; Culture Media; Melarsoprol; Mutation; Oxides; Pyrimidines; Schizosaccharomyces; Thiamine; Trypanocidal Agents | 2004 |
The role of Trypanosoma brucei MRPA in melarsoprol susceptibility.
Topics: Animals; Arsenicals; Blotting, Western; Cell Line; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression; Humans; Melarsoprol; Membrane Transport Proteins; Mice; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Protozoan Proteins; Reverse Transcriptase Polymerase Chain Reaction; Treatment Failure; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2006 |
Biosynthesis and uptake of thiamine (vitamin B1) in bloodstream form Trypanosoma brucei brucei and interference of the vitamin with melarsen oxide activity.
Topics: Animals; Arsenicals; Humans; Microbial Sensitivity Tests; Parasitemia; Thiamine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis; Vitamin B 6 | 2006 |
Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes.
Topics: Animals; Arsenicals; Carrier Proteins; Drug Resistance; Female; Nucleoside Transport Proteins; Pentamidine; Protozoan Proteins; Rats; Rats, Wistar; Trypanocidal Agents; Trypanosoma; Trypanosomiasis | 2007 |
Melarsen oxide in the treatment of human trypanosomiasis.
Topics: Arsenicals; Trypanosomiasis | 1948 |
Melarsen and melarsen oxide.
Topics: Anthelmintics; Arsenic; Arsenicals | 1948 |
Preliminary observations on the use of melarsen oxide in malaria.
Topics: Arsenicals; Malaria | 1946 |
Further experience with melarsen oxide (a new arsenical) in the treatment of tropical disease.
Topics: Arsenic; Arsenicals; Tropical Medicine | 1946 |
Longitudinal study of an outbreak of Trypanosoma evansi infection in equids and dromedary camels in Israel.
Topics: Animals; Arsenicals; Camelus; Disease Outbreaks; Equidae; Female; Israel; Longitudinal Studies; Male; Species Specificity; Trypanocidal Agents; Trypanosomiasis | 2010 |
The treatment of African sleeping sickness with two new trivalent arsenical preparations (melarsen oxide and 70A).
Topics: Animals; Arsenicals; Humans; Trypanosomiasis; Trypanosomiasis, African | 1946 |
Investigation of the biotransformation of melarsoprol by electrochemistry coupled to complementary LC/ESI-MS and LC/ICP-MS analysis.
Topics: Arsenicals; Chromatography, Liquid; Hemoglobins; Humans; Mass Spectrometry; Melarsoprol; Molecular Structure; Protein Binding; Serum Albumin; Trypanocidal Agents | 2013 |