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melarsen oxide and arsenic

melarsen oxide has been researched along with arsenic in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199010 (30.30)18.7374
1990's11 (33.33)18.2507
2000's10 (30.30)29.6817
2010's2 (6.06)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bacchi, CJ; Garofalo, J; Goldberg, B; Nathan, HC; Yarlett, N1
Aba, L; Camara, P; Doua, F; Hamon, JF; Seri, B1
Cerami, A; Fairlamb, AH; Henderson, GB1
Coombs, GH; Mottram, JC1
Hers, HG; Opperdoes, FR; Van Schaftingen, E1
Fairlamb, AH; Müller, S; Walter, RD1
Cunningham, ML; Fairlamb, AH; Zvelebil, MJ1
Carter, NS; Fairlamb, AH1
Atouguia, JM; Jennings, FW; Murray, M1
Scott, AG; Tait, A; Turner, CM1
Bacchi, CJ; Goldberg, B; Lloyd, D; Rattendi, D; Sufrin, JR1
Cowgill, C; Glocker, MO; Happersberger, HP; Stapleton, J1
Glocker, MO; Happersberger, HP; Przybylski, M1
Kaminsky, R; Kralli, A; Mäser, P; Sütterlin, C1
Ariyanayagam, MR; Clayton, C; Fairlamb, AH; Krauth-Siegel, RL; Krieger, S; Schwarz, W1
Barrett, MP; Cover, B; de Koning, HP; Jarvis, SM; MacLeod, A1
Burri, C; Ericsson, O; Keiser, J1
Loiseau, PM; Lubert, P; Wolf, JG1
Eggleston, IM; Fairlamb, AH; Hamilton, CJ; Saravanamuthu, A1
APTED, FI1
BAKER, JR1
Barrett, MP; Brun, R; Burchmore, RJ; de Koning, HP; Enyaru, JC; Geiser, F; Kaminsky, R; Mäser, P; Matovu, E; Seebeck, T; Stewart, ML; Wallace, LJ1
Schweingruber, ME1
Alibu, VP; Brun, R; Clayton, C; Marti, G; Renggli, CK; Richter, C; Seebeck, T; Shahi, S; Voncken, F1
de Koning, HP; Mäser, P; Rodenko, B; Schweingruber, AM; Schweingruber, ME; Stoffel, SA1
Bridges, DJ; Burchmore, RJ; de Koning, HP; Gould, MK; Mäser, P; Nerima, B1
FRIEDHEIM, EA1
LOURIE, EM; WILLIAMSON, J1
BALTHAZAR, E; BEZERRA, DA; PAYNE, EH1
BALTHAZAR, E; FERNANDES, JS; PAYNE, EH1
Abdeen, Z; Azmi, K; Baneth, G; Berlin, D; Ereqat, S; Nasereddin, A1
WEINMAN, D1
Baumann, A; Karst, U; Melles, D; Pfeifer, T1

Other Studies

33 other study(ies) available for melarsen oxide and arsenic

ArticleYear
Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals.
    Experimental parasitology, 1991, Volume: 72, Issue:2

    Topics: Animals; Arsenicals; Calcium; Calcium Channels; Drug Resistance; Female; Melarsoprol; Mice; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

1991
Effects of Mel B arsobal and alpha-difluoromethylornithine on the awakening electroencephalogram of humans with gambiense trypanosomiasis disease: preliminary report.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Arsenicals; Dimercaprol; Drug Combinations; Eflornithine; Electroencephalography; Female; Humans; Male; Middle Aged; Trypanosomiasis, African

1990
Trypanothione is the primary target for arsenical drugs against African trypanosomes.
    Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:8

    Topics: Animals; Arsenic Poisoning; Arsenicals; Chromatography, High Pressure Liquid; Glutathione; Kinetics; NADH, NADPH Oxidoreductases; Spermidine; Sulfhydryl Compounds; Trypanocidal Agents; Trypanosoma brucei brucei

1989
Leishmania mexicana: enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicals.
    Experimental parasitology, 1985, Volume: 59, Issue:2

    Topics: Animals; Antimony; Antimony Sodium Gluconate; Antiprotozoal Agents; Arsenicals; Citric Acid Cycle; Gluconates; Glycolysis; Hexokinase; Leishmania; Malate Dehydrogenase; Melarsoprol; Organometallic Compounds; Phosphoenolpyruvate Carboxykinase (GTP); Phosphofructokinase-1; Pyruvate Kinase; Triazines

1985
Effects of various metabolic conditions and of the trivalent arsenical melarsen oxide on the intracellular levels of fructose 2,6-bisphosphate and of glycolytic intermediates in Trypanosoma brucei.
    European journal of biochemistry, 1987, Aug-03, Volume: 166, Issue:3

    Topics: Animals; Arsenicals; Fructosediphosphates; Glycolysis; Hexosediphosphates; Kinetics; Phosphofructokinase-2; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Pyruvate Kinase; Salicylamides; Subcellular Fractions; Trypanosoma brucei brucei

1987
Differential susceptibility of filarial and human erythrocyte glutathione reductase to inhibition by the trivalent organic arsenical melarsen oxide.
    Molecular and biochemical parasitology, 1995, Volume: 71, Issue:2

    Topics: Animals; Arsenicals; Binding Sites; Cattle; Enzyme Inhibitors; Erythrocytes; Glutathione Reductase; Humans; In Vitro Techniques; Kinetics; Molecular Weight; Onchocerca; Setaria Nematode; Species Specificity

1995
Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals.
    European journal of biochemistry, 1994, Apr-01, Volume: 221, Issue:1

    Topics: Animals; Arsenicals; Binding Sites; Binding, Competitive; Crithidia fasciculata; Disulfides; Erythrocytes; Glutathione; Glutathione Reductase; Humans; Kinetics; Models, Molecular; NADH, NADPH Oxidoreductases; NADP; Structure-Activity Relationship; Trypanocidal Agents

1994
Arsenical-resistant trypanosomes lack an unusual adenosine transporter.
    Nature, 1993, Jan-14, Volume: 361, Issue:6408

    Topics: Adenine; Adenosine; Animals; Antiprotozoal Agents; Arsenicals; Biological Transport; Carrier Proteins; Drug Resistance; Inosine; Kinetics; Melarsoprol; Trypanosoma brucei brucei

1993
The importance of 2,3-dimercaptopropinol (British anti-lewisite, BAL) in the trypanocidal activity of topical melarsoprol.
    Acta tropica, 1996, Volume: 62, Issue:2

    Topics: Administration, Topical; Animals; Arsenicals; Dimercaprol; Drug Combinations; Female; Gels; Melarsoprol; Mice; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

1996
Trypanosoma brucei: lack of cross-resistance to melarsoprol in vitro by cymelarsan-resistant parasites.
    Experimental parasitology, 1997, Volume: 86, Issue:3

    Topics: Adenine; Adenosine; Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Female; Inosine; Melarsoprol; Mice; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei

1997
Effects of intermediates of methionine metabolism and nucleoside analogs on S-adenosylmethionine transport by Trypanosoma brucei brucei and a drug-resistant Trypanosoma brucei rhodesiense.
    Biochemical pharmacology, 1998, Jul-01, Volume: 56, Issue:1

    Topics: Adenosine; Animals; Arsenicals; Drug Resistance; Methionine; Polyamines; Purine Nucleosides; S-Adenosylmethionine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense

1998
Characterization of the folding pathway of recombinant human macrophage-colony stimulating-factor beta (rhM-CSF beta) by bis-cysteinyl modification and mass spectrometry.
    Proteins, 1998, Volume: Suppl 2

    Topics: Arsenicals; Cysteine; Fluorescence; Humans; Macrophage Colony-Stimulating Factor; Mass Spectrometry; Oxidation-Reduction; Protein Folding; Protein Structure, Tertiary; Recombinant Proteins; Tryptophan

1998
Selective bridging of bis-cysteinyl residues by arsonous acid derivatives as an approach to the characterization of protein tertiary structures and folding pathways by mass spectrometry.
    Analytical biochemistry, 1998, Nov-15, Volume: 264, Issue:2

    Topics: Amino Acid Sequence; Animals; Aprotinin; Arginine Vasopressin; Arsenicals; Cattle; Chromatography, High Pressure Liquid; Cysteine; Disulfides; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Molecular Weight; Oxytocin; Peptide Mapping; Peptides; Protein Folding; Protein Structure, Tertiary; Reducing Agents; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin

1998
A nucleoside transporter from Trypanosoma brucei involved in drug resistance.
    Science (New York, N.Y.), 1999, Jul-09, Volume: 285, Issue:5425

    Topics: Adenosine; Amino Acid Sequence; Animals; Arsenicals; Biological Transport; Carrier Proteins; Cloning, Molecular; Drug Resistance; Genes, Protozoan; Membrane Proteins; Molecular Sequence Data; Mutation; Nucleoside Transport Proteins; Nucleosides; Purines; Saccharomyces cerevisiae; Substrate Specificity; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

1999
Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress.
    Molecular microbiology, 2000, Volume: 35, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Arsenicals; Cell Cycle; Cell Division; Doxycycline; Enzyme Inhibitors; Mice; Mice, Inbred BALB C; Mutation; NADH, NADPH Oxidoreductases; Oxidative Stress; Promoter Regions, Genetic; Sulfhydryl Compounds; Tetracycline; Trypanosoma brucei brucei; Trypanosomiasis, African; Virulence

2000
Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes.
    Molecular and biochemical parasitology, 2000, Feb-25, Volume: 106, Issue:1

    Topics: Animals; Antiprotozoal Agents; Arsenicals; Biological Transport, Active; Dose-Response Relationship, Drug; Drug Resistance; Melarsoprol; Mice; Mice, Inbred BALB C; Minisatellite Repeats; Purines; Trypanocidal Agents; Trypanosoma brucei brucei

2000
Investigations of the metabolites of the trypanocidal drug melarsoprol.
    Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:5

    Topics: Adult; Animals; Area Under Curve; Arsenic; Arsenicals; Biological Assay; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Interactions; Female; Humans; Male; Melarsoprol; Mice; Mice, Inbred Strains; Microsomes, Liver; Spectrophotometry, Atomic; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African

2000
Contribution of dithiol ligands to in vitro and in vivo trypanocidal activities of dithiaarsanes and investigation of ligand exchange in an aqueous solution.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:11

    Topics: Animals; Arsenicals; Cysteamine; Dansyl Compounds; Disease Models, Animal; Female; Mice; Parasitic Sensitivity Tests; Structure-Activity Relationship; Sulfhydryl Compounds; Thioctic Acid; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

2000
Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase.
    The Biochemical journal, 2003, Feb-01, Volume: 369, Issue:Pt 3

    Topics: Arsenicals; Biochemistry; Dimethyl Sulfoxide; Dithionitrobenzoic Acid; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glutathione; Hydrogen-Ion Concentration; Linear Models; NADH, NADPH Oxidoreductases; Spermidine; Time Factors; Xanthenes

2003
Four years' experience of melarsen oxide/BAL in the treatment of late-stage Rhodesian sleeping sickness.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1957, Volume: 51, Issue:1

    Topics: Animals; Arsenicals; Black People; Humans; Trypanosomiasis; Trypanosomiasis, African

1957
The curative power of 4-(2:6-diaminopyrimidin-4-ylamino) phenylarsine oxide (compound 12,065) in infections of Trypanosoma rhodesiense in laboratory animals.
    British journal of pharmacology and chemotherapy, 1958, Volume: 13, Issue:4

    Topics: Animals; Animals, Laboratory; Arsenicals; Humans; Mice; Rats; Trypanosoma brucei rhodesiense; Trypanosomiasis; Trypanosomiasis, African; Tsetse Flies

1958
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
    Eukaryotic cell, 2003, Volume: 2, Issue:5

    Topics: Adenine; Adenosine; Animals; Arsenicals; Benzamidines; Cell Death; Cell Division; Diminazene; Drug Resistance; Female; Gene Silencing; Hypoxanthine; Inhibitory Concentration 50; Inosine; Melarsoprol; Mice; Mutation; Nucleoside Transport Proteins; Pentamidine; Stilbamidines; Trypanosoma brucei brucei

2003
The melaminophenyl arsenicals melarsoprol and melarsen oxide interfere with thiamine metabolism in the fission yeast Schizosaccharomyces pombe.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:9

    Topics: Arsenicals; Culture Media; Melarsoprol; Mutation; Oxides; Pyrimidines; Schizosaccharomyces; Thiamine; Trypanocidal Agents

2004
The role of Trypanosoma brucei MRPA in melarsoprol susceptibility.
    Molecular and biochemical parasitology, 2006, Volume: 146, Issue:1

    Topics: Animals; Arsenicals; Blotting, Western; Cell Line; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression; Humans; Melarsoprol; Membrane Transport Proteins; Mice; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Protozoan Proteins; Reverse Transcriptase Polymerase Chain Reaction; Treatment Failure; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

2006
Biosynthesis and uptake of thiamine (vitamin B1) in bloodstream form Trypanosoma brucei brucei and interference of the vitamin with melarsen oxide activity.
    International journal for parasitology, 2006, Volume: 36, Issue:2

    Topics: Animals; Arsenicals; Humans; Microbial Sensitivity Tests; Parasitemia; Thiamine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis; Vitamin B 6

2006
Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes.
    Molecular pharmacology, 2007, Volume: 71, Issue:4

    Topics: Animals; Arsenicals; Carrier Proteins; Drug Resistance; Female; Nucleoside Transport Proteins; Pentamidine; Protozoan Proteins; Rats; Rats, Wistar; Trypanocidal Agents; Trypanosoma; Trypanosomiasis

2007
Melarsen oxide in the treatment of human trypanosomiasis.
    Annals of tropical medicine and parasitology, 1948, Volume: 42, Issue:3-4

    Topics: Arsenicals; Trypanosomiasis

1948
Melarsen and melarsen oxide.
    Nature, 1948, Jan-17, Volume: 161, Issue:4081

    Topics: Anthelmintics; Arsenic; Arsenicals

1948
Preliminary observations on the use of melarsen oxide in malaria.
    Southern medical journal, 1946, Volume: 39, Issue:12

    Topics: Arsenicals; Malaria

1946
Further experience with melarsen oxide (a new arsenical) in the treatment of tropical disease.
    Southern medical journal, 1946, Volume: 39, Issue:12

    Topics: Arsenic; Arsenicals; Tropical Medicine

1946
Longitudinal study of an outbreak of Trypanosoma evansi infection in equids and dromedary camels in Israel.
    Veterinary parasitology, 2010, Dec-15, Volume: 174, Issue:3-4

    Topics: Animals; Arsenicals; Camelus; Disease Outbreaks; Equidae; Female; Israel; Longitudinal Studies; Male; Species Specificity; Trypanocidal Agents; Trypanosomiasis

2010
The treatment of African sleeping sickness with two new trivalent arsenical preparations (melarsen oxide and 70A).
    The American journal of tropical medicine and hygiene, 1946, Volume: 26, Issue:Suppl 5

    Topics: Animals; Arsenicals; Humans; Trypanosomiasis; Trypanosomiasis, African

1946
Investigation of the biotransformation of melarsoprol by electrochemistry coupled to complementary LC/ESI-MS and LC/ICP-MS analysis.
    Analytical and bioanalytical chemistry, 2013, Volume: 405, Issue:15

    Topics: Arsenicals; Chromatography, Liquid; Hemoglobins; Humans; Mass Spectrometry; Melarsoprol; Molecular Structure; Protein Binding; Serum Albumin; Trypanocidal Agents

2013