Page last updated: 2024-08-26

melanotan-ii and shu 9119

melanotan-ii has been researched along with shu 9119 in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.00)18.2507
2000's12 (60.00)29.6817
2010's6 (30.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Adan, RA; Brakkee, JH; Gispen, WH; Meloen, RH; Nijenhuis, WA; Oosterom, J; Schaaper, WM; Szklarczyk, AW1
Bednarek, MA; Chen, AS; Chen, HY; Fong, TM; Goulet, MT; Guan, X; Howard, AD; MacIntyre, ED; MacNeil, DJ; MacNeil, T; Marsh, DJ; Nargund, RP; Rosenblum, CI; Shen, CP; Strack, AM; Tota, M; Van der Ploeg, LH; Weinberg, DH1
Doering, SR; Haskell-Luevano, C; Todorovic, A1
Ballet, S; Cone, RD; Gimenez, LE; Gonzalez, S; Hollanders, C; Jing, Y; Lamouroux, A; Martin, C; Previti, S; Stevens, RC; Tourwé, D; Van der Poorten, O; Van Holsbeeck, K; Williams, SY; Wu, Y; Zhao, S1
Davis, H; Kurowski, S; Parker, E; Salisbury, B; Vemulapalli, R1
Buntin, JD; Schiöth, HB; Strader, AD1
Baile, CA; Choi, YH; Della-Fera, MA; Hartzell, DL; Li, C; Lin, J; Page, K; Westby, A1
Balse-Srinivasan, P; Grieco, P; Han, G; Hruby, VJ; MacNeil, T; Van der Ploeg, LH; Weinberg, D1
Baile, CA; Choi, YH; Della-Fera, MA; Hartzell, DL; Li, C; Lin, J1
Ebling, FJ; Hastings, MH; Horan, TL; Mercer, JG; Morgan, PJ; Schuhler, S1
Christian, HC; D'Amico, M; Di Filippo, C; Getting, SJ; Lam, CW; Perretti, M; Rossi, F1
Al-Qassab, H; Ashford, ML; Heffron, H; Hisadome, K; Smith, MA; Withers, DJ1
Cai, M; Hruby, VJ; Mayorov, A; Perry, JW; Stankova, M; Trivedi, D; Varga, EV; Yamamura, HI1
Cai, M; Campiglia, P; Grieco, P; Han, G; Hruby, VJ; Novellino, E; Trivedi, D1
Fujino, Y; Lee, S; Minokoshi, Y; Okamoto, S; Shiuchi, T; Suzuki, A; Toda, C; Yamato-Esaki, M1
Li, DP; Ye, ZY1
Cui, BP; Li, P; Liu, TY; Sun, HJ; Zhang, LL; Zhu, GQ1
Mäkelä, S; Rinne, P; Savontaus, E; Streng, T; Tikka, S1
da Silva, AA; do Carmo, JM; Hall, JE; Pace, B; Rushing, JS1
Leng, G; Ludwig, M; Paiva, L; Sabatier, N1

Reviews

1 review(s) available for melanotan-ii and shu 9119

ArticleYear
The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.
    European journal of pharmacology, 2002, Apr-12, Volume: 440, Issue:2-3

    Topics: Animals; Anti-Obesity Agents; Body Weight; Gene Expression; Humans; Melanocyte-Stimulating Hormones; Obesity; Receptors, Corticotropin; Receptors, Melanocortin

2002

Other Studies

19 other study(ies) available for melanotan-ii and shu 9119

ArticleYear
Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.
    European journal of pharmacology, 1999, Aug-13, Volume: 378, Issue:3

    Topics: alpha-Galactosidase; alpha-MSH; Amino Acid Sequence; Animals; Binding, Competitive; Catheterization; Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Grooming; Humans; Injections, Intravenous; Injections, Intraventricular; Ligands; Melanocyte-Stimulating Hormones; Molecular Sequence Data; Peptide Fragments; Radioligand Assay; Rats; Rats, Wistar; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4; Receptors, Corticotropin; Receptors, Melanocortin; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Time Factors

1999
Melanocortin antagonist tetrapeptides with minimal agonist activity at the mouse melanocortin-3 receptor.
    ACS medicinal chemistry letters, 2015, Feb-12, Volume: 6, Issue:2

    Topics:

2015
Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure†.
    Journal of medicinal chemistry, 2021, 01-14, Volume: 64, Issue:1

    Topics: Crystallography, X-Ray; Humans; Ligands; Molecular Structure; Receptor, Melanocortin, Type 4

2021
Activation of central melanocortin receptors by MT-II increases cavernosal pressure in rabbits by the neuronal release of NO.
    British journal of pharmacology, 2001, Volume: 134, Issue:8

    Topics: alpha-MSH; Alprostadil; Anesthesia; Animals; Blood Pressure; Culture Techniques; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Injections, Intravenous; Isometric Contraction; Male; Melanocyte-Stimulating Hormones; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Papaverine; Penis; Peptides, Cyclic; Phentolamine; Rabbits; Receptors, Corticotropin; Receptors, Melanocortin

2001
The role of the melanocortin system and the melanocortin-4 receptor in ring dove (Streptopelia risoria) feeding behavior.
    Brain research, 2003, Jan-17, Volume: 960, Issue:1-2

    Topics: Agouti-Related Protein; alpha-MSH; Animals; Body Weight; Columbidae; Eating; Energy Metabolism; Feeding Behavior; Food Deprivation; Hypothalamus; Immunohistochemistry; Injections, Intraventricular; Intercellular Signaling Peptides and Proteins; Male; Melanocyte-Stimulating Hormones; Microinjections; Neurons; Peptides, Cyclic; Proteins; Receptor, Melanocortin, Type 4; Receptors, Corticotropin

2003
Melanocortin receptors mediate leptin effects on feeding and body weight but not adipose apoptosis.
    Physiology & behavior, 2003, Volume: 79, Issue:4-5

    Topics: Adipose Tissue; alpha-MSH; Animals; Apoptosis; Body Composition; Body Weight; Feeding Behavior; Injections, Intraventricular; Leptin; Male; Melanocyte-Stimulating Hormones; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Melanocortin; Signal Transduction

2003
Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.
    The journal of peptide research : official journal of the American Peptide Society, 2003, Volume: 62, Issue:5

    Topics: alpha-MSH; Animals; Cell Membrane; CHO Cells; Cricetinae; Drug Design; Histidine; Humans; Inhibitory Concentration 50; Lactams; Melanocyte-Stimulating Hormones; Peptides, Cyclic; Proline; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4; Receptors, Corticotropin; Receptors, Melanocortin; Structure-Activity Relationship

2003
CNS melanocortin and leptin effects on stearoyl-CoA desaturase-1 and resistin expression.
    Biochemical and biophysical research communications, 2003, Nov-14, Volume: 311, Issue:2

    Topics: Adipose Tissue; alpha-MSH; Animals; Central Nervous System; Cerebral Ventricles; Hormones, Ectopic; Leptin; Liver; Male; Melanocyte-Stimulating Hormones; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Melanocortin; Recombinant Proteins; Resistin; Stearoyl-CoA Desaturase

2003
Feeding and behavioural effects of central administration of the melanocortin 3/4-R antagonist SHU9119 in obese and lean Siberian hamsters.
    Behavioural brain research, 2004, Jul-09, Volume: 152, Issue:2

    Topics: alpha-MSH; Analysis of Variance; Animals; Body Weight; Cricetinae; Dose-Response Relationship, Drug; Drug Interactions; Eating; Feeding Behavior; Grooming; Injections, Intraventricular; Male; Melanocyte-Stimulating Hormones; Motor Activity; Obesity; Peptides, Cyclic; Photoperiod; Receptors, Corticotropin; Time Factors

2004
MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct.
    Journal of leukocyte biology, 2004, Volume: 76, Issue:4

    Topics: Acute Disease; alpha-MSH; Animals; Fibroblasts; Interleukin-1; Macrophages; Melanocyte-Stimulating Hormones; Mice; Mutation; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Peptides, Cyclic; Peroxidase; Rats; Receptor, Melanocortin, Type 3; Receptors, Corticotropin

2004
Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances.
    The Journal of physiology, 2007, Jan-15, Volume: 578, Issue:Pt 2

    Topics: 4-Aminopyridine; Action Potentials; Adenylyl Cyclase Inhibitors; Agouti-Related Protein; alpha-MSH; Animals; Arcuate Nucleus of Hypothalamus; Barium; Green Fluorescent Proteins; Integrases; Intercellular Signaling Peptides and Proteins; Melanocortins; Melanocyte-Stimulating Hormones; Mice; Mice, Transgenic; Neurons; Patch-Clamp Techniques; Peptides, Cyclic; Potassium Channel Blockers; Potassium Channels; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4; Synaptic Transmission

2007
Cell signaling and trafficking of human melanocortin receptors in real time using two-photon fluorescence and confocal laser microscopy: differentiation of agonists and antagonists.
    Chemical biology & drug design, 2006, Volume: 68, Issue:4

    Topics: alpha-MSH; Arrestins; beta-Arrestin 2; beta-Arrestins; Binding, Competitive; Biological Transport; Caveolae; Cell Line; Clathrin-Coated Vesicles; Colforsin; Cyclic AMP-Dependent Protein Kinases; Green Fluorescent Proteins; Humans; Isoquinolines; Kinetics; Melanocyte-Stimulating Hormones; Microscopy, Confocal; Microscopy, Fluorescence, Multiphoton; Models, Molecular; Peptides, Cyclic; Receptors, Melanocortin; Rhodamines; Signal Transduction; Sulfonamides; Transfection

2006
Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.
    Peptides, 2007, Volume: 28, Issue:6

    Topics: alpha-MSH; Humans; Lactams; Melanocyte-Stimulating Hormones; Molecular Structure; Peptides, Cyclic; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4; Receptors, Corticotropin; Receptors, Melanocortin; Structure-Activity Relationship

2007
Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues.
    Diabetes, 2009, Volume: 58, Issue:12

    Topics: Adipose Tissue, Brown; alpha-MSH; Animals; Cerebral Ventricles; Glucose; Hypothalamus, Middle; Immunoblotting; Injections; Leptin; Melanocyte-Stimulating Hormones; Mice; Mice, Inbred Strains; Muscle, Skeletal; Myocardium; Peptides, Cyclic; Receptors, Melanocortin; Reverse Transcriptase Polymerase Chain Reaction; Tritium; Ventromedial Hypothalamic Nucleus

2009
Activation of the melanocortin-4 receptor causes enhanced excitation in presympathetic paraventricular neurons in obese Zucker rats.
    Regulatory peptides, 2011, Jan-17, Volume: 166, Issue:1-3

    Topics: alpha-MSH; Animals; Bicuculline; Guanosine Diphosphate; Kynurenic Acid; Male; Melanocyte-Stimulating Hormones; Neurons; Obesity; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Peptides, Cyclic; Rats; Rats, Zucker; Receptor, Melanocortin, Type 4; Thionucleotides

2011
Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure.
    Experimental physiology, 2013, Volume: 98, Issue:2

    Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Agouti-Related Protein; alpha-MSH; Animals; Arterial Pressure; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Kidney; Male; Melanocyte-Stimulating Hormones; Microinjections; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Peptides, Cyclic; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4; Receptors, Melanocortin; Second Messenger Systems; Sympathetic Nervous System; Thionucleotides; Time Factors

2013
Hemodynamic actions and mechanisms of systemically administered α-MSH analogs in mice.
    Peptides, 2012, Volume: 38, Issue:1

    Topics: alpha-MSH; Anesthetics; Animals; Blood Pressure; Consciousness; Dose-Response Relationship, Drug; Heart Rate; Hexamethonium; Male; Melanocyte-Stimulating Hormones; Metoprolol; Mice; Mice, Inbred C57BL; Peptides, Cyclic; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4; Receptors, Corticotropin

2012
Differential control of metabolic and cardiovascular functions by melanocortin-4 receptors in proopiomelanocortin neurons.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2013, Aug-15, Volume: 305, Issue:4

    Topics: Adipose Tissue, Brown; Adiposity; alpha-MSH; Animals; Blood Glucose; Blood Pressure; Body Temperature; Brain; Eating; Energy Metabolism; Glucose Tolerance Test; Green Fluorescent Proteins; Heart Rate; Hemodynamics; Infusions, Intraventricular; Integrases; Intra-Abdominal Fat; Ion Channels; Male; Melanocyte-Stimulating Hormones; Mice; Mice, Knockout; Mice, Transgenic; Mitochondrial Proteins; Monitoring, Ambulatory; Neurons; Oxygen Consumption; Peptides, Cyclic; Pro-Opiomelanocortin; Receptor, Melanocortin, Type 4; Recombinant Fusion Proteins; Stress, Physiological; Telemetry; Time Factors; Uncoupling Protein 1; Weight Gain

2013
Effect of Melanotan-II on Brain Fos Immunoreactivity and Oxytocin Neuronal Activity and Secretion in Rats.
    Journal of neuroendocrinology, 2017, Volume: 29, Issue:2

    Topics: Administration, Intranasal; Administration, Intravenous; alpha-MSH; Animals; Infusions, Intraventricular; Male; Melanocyte-Stimulating Hormones; Neurons; Oxytocin; Paraventricular Hypothalamic Nucleus; Peptides, Cyclic; Proto-Oncogene Proteins c-fos; Rats; Supraoptic Nucleus

2017