Compounds > melagatran

Page last updated: 2024-09-05

melagatran and warfarin

melagatran has been researched along with warfarin in 11 studies

Compound Research Comparison

Studies (melagatran)	Trials (melagatran)	Recent Studies (post-2010) (melagatran)	Studies (warfarin)	Trials (warfarin)	Recent Studies (post-2010) (warfarin)
185	32	19	36,573	2,143	14,728

Protein Interaction Comparison

Protein	Taxonomy	melagatran (IC50)	warfarin (IC50)
Vitamin K epoxide reductase complex subunit 1	Homo sapiens (human)		0.0088

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (90.91)	29.6817
2010's	1 (9.09)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Bode, C; Darius, H; Diehm, C; Encke, A; Gulba, DC; Haas, S; Hacke, W; Puhl, W; Quante, M; Riess, H; Scharf, R; Schellong, S; Schrör, T; Schulte, KL; Tebbe, U; Van Aken, H	1
Lassila, R	1
Braunwald, E; Giugliano, RP	1
Evans, HC; Faulds, D; Perry, CM	1
Eikelboom, JW; Hankey, GJ	1
Bereznicki, LR; Jackson, SL; Peterson, GM	1
Carlsson, S; Elg, M	1

Reviews

3 review(s) available for melagatran and warfarin

Article	Year
Anticoagulation: the present and future. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2001, Volume: 7, Issue:3 Topics: Administration, Oral; Amino Acid Chloromethyl Ketones; Anticoagulants; Arginine; Azetidines; Benzylamines; Binding Sites; Biological Availability; Blood Coagulation; Comorbidity; Coumarins; Drug Design; Embolism; Female; Forecasting; Glycine; Guanidines; Heart Diseases; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Hirudin Therapy; Humans; Neoplasms; Pipecolic Acids; Pregnancy; Pregnancy Complications, Hematologic; Prodrugs; Safety; Serine; Stroke; Sulfonamides; Thrombin; Thrombophilia; Thrombosis	2001
[Thrombosis in spite of warfarin--what should be done?]. Duodecim; laaketieteellinen aikakauskirja, 2001, Volume: 117, Issue:24 Topics: Anticoagulants; Antiphospholipid Syndrome; Azetidines; Benzylamines; Blood Coagulation; Glycine; Heparin, Low-Molecular-Weight; Humans; International Normalized Ratio; Neoplasms; Recurrence; Thrombin; Thrombosis; Treatment Failure; Warfarin	2001
Ximelagatran/Melagatran: a review of its use in the prevention of venous thromboembolism in orthopaedic surgery. Drugs, 2004, Volume: 64, Issue:6 Topics: Anticoagulants; Azetidines; Benzylamines; Drug Interactions; Drug Therapy, Combination; Enoxaparin; Glycine; Humans; Orthopedic Procedures; Randomized Controlled Trials as Topic; Thrombin; Thromboembolism; Venous Thrombosis; Warfarin	2004

Other Studies

8 other study(ies) available for melagatran and warfarin

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Improving antithrombotic treatment in patients after myocardial infarction. Lancet (London, England), 2003, Sep-06, Volume: 362, Issue:9386 Topics: Azetidines; Benzylamines; Clopidogrel; Fibrinolytic Agents; Glycine; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome; Warfarin	2003
The beginning of the end of warfarin? The Medical journal of Australia, 2004, Jun-07, Volume: 180, Issue:11 Topics: Anticoagulants; Aspirin; Azetidines; Benzylamines; Glycine; Humans; Platelet Aggregation Inhibitors; Prodrugs; Thrombin; Warfarin	2004
The direct thrombin inhibitor melagatran/ximelagatran. The Medical journal of Australia, 2005, Mar-07, Volume: 182, Issue:5 Topics: Anticoagulants; Atrial Fibrillation; Azetidines; Benzylamines; Cost-Benefit Analysis; Drug Costs; Humans; Safety; Thrombin; Thromboembolism; Warfarin	2005
The effects of ximelagatran and warfarin on the prophylaxis of a caval vein thrombosis and bleeding in the anaesthetized rat. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2005, Volume: 16, Issue:4 Topics: Animals; Azetidines; Benzylamines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glycine; Hemorrhage; Male; Rats; Rats, Sprague-Dawley; Venae Cavae; Venous Thrombosis; Warfarin	2005