Compounds > melagatran
Page last updated: 2024-09-05

melagatran and sildenafil

melagatran has been researched along with sildenafil in 3 studies

Compound Research Comparison

Studies
(melagatran)		Trials
(melagatran)		Recent Studies (post-2010)
(melagatran)		Studies
(sildenafil)		Trials
(sildenafil)		Recent Studies (post-2010) (sildenafil)
1853219134060

Protein Interaction Comparison

ProteinTaxonomymelagatran (IC50)sildenafil (IC50)
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)20
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)20
Chain A, cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)20
Chain A, cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)20
Chain A, cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.0024
Chain A, cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.0024
Phosphodiesterase Bos taurus (cattle)9.2
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)2.881
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit deltaHomo sapiens (human)0.0187
cGMP-specific 3',5'-cyclic phosphodiesteraseRattus norvegicus (Norway rat)0.0012
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)2.881
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.2626
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AHomo sapiens (human)4.2
cGMP-specific 3',5'-cyclic phosphodiesteraseCanis lupus familiaris (dog)0.0024
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaBos taurus (cattle)0.0374
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus8.247
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 28.247
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alphaBos taurus (cattle)0.0545
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Bos taurus (cattle)0.78
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Rattus norvegicus (Norway rat)4.6
cAMP-specific 3',5'-cyclic phosphodiesterase 4CRattus norvegicus (Norway rat)4.6
cAMP-specific 3',5'-cyclic phosphodiesterase 4BRattus norvegicus (Norway rat)4.6
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alphaHomo sapiens (human)0.0187
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'Bos taurus (cattle)0.0366
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaHomo sapiens (human)0.0187
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaBos taurus (cattle)0.0374
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit betaBos taurus (cattle)0.0374
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)7.9333
Adenosine receptor A2aHomo sapiens (human)0.253
Adenosine receptor A1Homo sapiens (human)1.493
Delta-type opioid receptorRattus norvegicus (Norway rat)0.04
Prostaglandin G/H synthase 2Homo sapiens (human)0.003
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit betaHomo sapiens (human)0.0187
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'Homo sapiens (human)0.0418
cAMP-specific 3',5'-cyclic phosphodiesterase 4ARattus norvegicus (Norway rat)4.6
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)0.7199
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaCanis lupus familiaris (dog)0.0182
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BBos taurus (cattle)0.78
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)1.8841
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BRattus norvegicus (Norway rat)0.3
Synaptic vesicular amine transporterRattus norvegicus (Norway rat)0.01
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)6.3336
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)8.52
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)5.7005
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)3.3075
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)4.7337
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7AHomo sapiens (human)4.69
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaHomo sapiens (human)0.0187
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)0.7398
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)4.6677
cGMP-specific 3',5'-cyclic phosphodiesteraseBos taurus (cattle)0.557
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CRattus norvegicus (Norway rat)0.3
Indoleamine 2,3-dioxygenase 2Mus musculus (house mouse)4.5
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit deltaBos taurus (cattle)0.0374
Phosphodiesterase Rattus norvegicus (Norway rat)0.3
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AHomo sapiens (human)4.1584
cAMP-specific 3',5'-cyclic phosphodiesterase 7BHomo sapiens (human)3.6006
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)4.2432

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1

Other Studies

3 other study(ies) available for melagatran and sildenafil

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010