melagatran has been researched along with promethazine in 3 studies
| Studies (melagatran) | Trials (melagatran) | Recent Studies (post-2010) (melagatran) | Studies (promethazine) | Trials (promethazine) | Recent Studies (post-2010) (promethazine) |
|---|---|---|---|---|---|
| 185 | 32 | 19 | 3,110 | 299 | 235 |
| Protein | Taxonomy | melagatran (IC50) | promethazine (IC50) |
|---|---|---|---|
| Spike glycoprotein | Betacoronavirus England 1 | 5.86 | |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | 5.86 | |
| Transmembrane protease serine 2 | Homo sapiens (human) | 5.86 | |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.012 | |
| Procathepsin L | Homo sapiens (human) | 5.86 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 4.238 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.035 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.0076 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.0046 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.681 | |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | 5.86 | |
| Replicase polyprotein 1ab | Human coronavirus 229E | 5.86 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | 5.86 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | 5.86 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.014 | |
| D(2) dopamine receptor | Homo sapiens (human) | 0.4395 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.053 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 2.431 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 2.596 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.02 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 2.744 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 4.238 | |
| Histamine H2 receptor | Homo sapiens (human) | 1.165 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.183 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.045 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.012 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 2.596 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 5.8 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.0041 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.559 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.068 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 2.429 | |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | 5.86 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.287 | |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | 5.86 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
3 other study(ies) available for melagatran and promethazine
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |