melagatran has been researched along with inogatran in 10 studies
| Studies (melagatran) | Trials (melagatran) | Recent Studies (post-2010) (melagatran) | Studies (inogatran) | Trials (inogatran) | Recent Studies (post-2010) (inogatran) |
|---|---|---|---|---|---|
| 185 | 32 | 19 | 44 | 12 | 2 |
| Protein | Taxonomy | melagatran (IC50) | inogatran (IC50) |
|---|---|---|---|
| Prothrombin | Homo sapiens (human) | 0.6585 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 7 (70.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abbenante, G; Fairlie, DP; Leung, D | 1 |
| Brånalt, J; Kvarnström, I; Linschoten, M; Musil, D; Nöteberg, D; Nyström, JE; Samuelsson, B; Zuccarello, G | 1 |
| Dullweber, F; Klebe, G; Musil, D; Stubbs, MT; Stürzebecher, J | 1 |
| Deinum, J; Elg, M; Gustafsson, D | 1 |
| Carlsson, S; Eriksson, BI; Halvarsson, M; Mattsson, C; Risberg, B | 1 |
| Deinum, J; Nilsson, T; Sjöling-Ericksson, A | 1 |
| Elg, M; Gustafsson, D; Mikulski, A | 1 |
| Frebelius, S; Jansson, K; Linder, R; Swedenborg, J | 1 |
| Mattsson, C; Nylander, S | 1 |
| Frebelius, S; Grip, L; Linder, R; Swedenborg, J | 1 |
1 review(s) available for melagatran and inogatran
| Article | Year |
|---|---|
Protease inhibitors: current status and future prospects.
Topics: Animals; Aspartic Acid Endopeptidases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Metalloendopeptidases; Models, Molecular; Protease Inhibitors; Serine Endopeptidases; Serine Proteinase Inhibitors | 2000 |
9 other study(ies) available for melagatran and inogatran
| Article | Year |
|---|---|
New proline mimetics: synthesis of thrombin inhibitors incorporating cyclopentane- and cyclopentenedicarboxylic acid templates in the P2 position. Binding conformation investigated by X-ray crystallography.
Topics: Anticoagulants; Blood Coagulation; Crystallography, X-Ray; Cyclopentanes; Humans; In Vitro Techniques; Indicators and Reagents; Magnetic Resonance Spectroscopy; Models, Molecular; Proline; Protein Binding; Protein Conformation; Stereoisomerism; Structure-Activity Relationship; Templates, Genetic; Thrombin | 2000 |
Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
Topics: Animals; Calorimetry; Cattle; Crystallography, X-Ray; Drug Design; Entropy; Hot Temperature; Humans; Hydrogen Bonding; Kinetics; Ligands; Models, Molecular; Molecular Structure; Molecular Weight; Osmolar Concentration; Protein Binding; Protein Conformation; Protons; Serine Proteinase Inhibitors; Sodium; Solvents; Thrombin; Titrimetry; Trypsin; Trypsin Inhibitors | 2001 |
The importance of enzyme inhibition kinetics for the effect of thrombin inhibitors in a rat model of arterial thrombosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Arginine; Azetidines; Benzylamines; Carotid Artery Thrombosis; Dose-Response Relationship, Drug; Fibrinolytic Agents; Glycine; Hemodynamics; Heparin; Hirudin Therapy; Hirudins; Kinetics; Male; Oligopeptides; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time | 1997 |
Antithrombotic effect of two low molecular weight thrombin inhibitors and a low-molecular weight heparin in a caval vein thrombosis model in the rat.
Topics: Animals; Azetidines; Benzylamines; Dalteparin; Disease Models, Animal; Fibrinolytic Agents; Glycine; Heparin, Low-Molecular-Weight; Infusions, Intravenous; Injections, Intravenous; Male; Piperidines; Rats; Rats, Wistar; Thrombin; Thrombophlebitis; Vena Cava, Inferior | 1997 |
The mechanism of binding of low-molecular-weight active site inhibitors to human alpha-thrombin.
Topics: Antithrombins; Area Under Curve; Arginine; Azetidines; Benzylamines; Binding Sites; Dipeptides; Fluorescence; Glycine; Humans; Kinetics; Molecular Weight; Pipecolic Acids; Piperidines; Spectrometry, Fluorescence; Spectrophotometry; Sulfonamides; Thrombin | 1998 |
The effects of oral and intravenous direct thrombin inhibitors on the size of photochemically induced cortical infarction in rats.
Topics: Administration, Oral; Animals; Antithrombins; Azetidines; Benzylamines; Brain Infarction; Cerebral Cortex; Drug Evaluation, Preclinical; Glycine; Hypertension; Injections, Intravenous; Light; Male; Photochemistry; Piperidines; Rats; Rats, Inbred SHR | 2001 |
Inhibition of endothelial cell-mediated generation of activated protein C by direct and antithrombin-dependent thrombin inhibitors.
Topics: Antithrombins; Azetidines; Benzylamines; Dose-Response Relationship, Drug; Endothelium, Vascular; Flow Cytometry; Glycine; Heparin; Hirudins; Humans; Piperidines; Protein C; Thrombin; Thrombomodulin | 2003 |
Thrombin-induced platelet activation and its inhibition by anticoagulants with different modes of action.
Topics: Adult; Anticoagulants; Azetidines; Benzylamines; Dalteparin; Dose-Response Relationship, Drug; Flow Cytometry; Glycine; Heparin; Hirudins; Humans; Male; P-Selectin; Piperidines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Receptor, PAR-1; Receptors, Thrombin; Statistics as Topic; Thrombin | 2003 |
The influence of direct and antithrombin-dependent thrombin inhibitors on the procoagulant and anticoagulant effects of thrombin.
Topics: Amino Acid Chloromethyl Ketones; Anticoagulants; Azetidines; Benzylamines; Clinical Trials as Topic; Coagulants; Coronary Artery Disease; Fibrinopeptide A; Glycine; Hirudins; Humans; Peptide Fragments; Piperidines; Protein C; Thrombin | 2003 |