Page last updated: 2024-09-05

melagatran and hirudin

melagatran has been researched along with hirudin in 20 studies

Compound Research Comparison

Studies
(melagatran)
Trials
(melagatran)
Recent Studies (post-2010)
(melagatran)
Studies
(hirudin)
Trials
(hirudin)
Recent Studies (post-2010) (hirudin)
18532193,658378995

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.00)18.2507
2000's18 (90.00)29.6817
2010's1 (5.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Deinum, J; Elg, M; Gustafsson, D1
Hauptmann, J; Steinmetzer, T; Sturzebecher, J1
Fleischer, K; Gulba, DC; Lankes, W1
Fenyvesi, T; Harenberg, J; Jörg, I1
Fenyvesi, T; Harenberg, J; Jörg, I; Piazolo, L; Zokai, K1
Fenyvesi, T; Harenberg, J; Joerg, I1
Carlsson, S; Elg, M; Mattsson, C1
Frebelius, S; Jansson, K; Linder, R; Swedenborg, J1
Mattsson, C; Nylander, S1
Adams, TE; Everse, SJ; Mann, KG1
Carlsson, S; Johnston, M; Klement, P; Liao, P; Rak, J; Stafford, A; Vlasin, M; Weitz, JI1
Frebelius, S; Grip, L; Linder, R; Swedenborg, J1
Elalamy, I; Lebrazi, J; Samama, MM1
Fenyvesi, T; Harenberg, J; Jörg, I; Weiss, C2
Meyer Samama, M1
Craven, S; Dewar, L; Greinacher, A; Ofosu, FA; Sheppard, JA; Warkentin, TE1
Caronia, A; Montalto, S; Novo, S; Puccio, D; Valerio, MC; Ventimiglia, A1
Kalb, ML; Kozek-Langenecker, SA; Potura, L; Scharbert, G1
Danielson, UH; Deinum, J; Geschwindner, S; Gustavsson, L; Musil, D; Winquist, J; Xue, Y1

Reviews

4 review(s) available for melagatran and hirudin

ArticleYear
Advances in the development of thrombin inhibitors.
    Expert opinion on investigational drugs, 2001, Volume: 10, Issue:5

    Topics: Arginine; Azetidines; Benzylamines; Clinical Trials as Topic; Glycine; Hirudin Therapy; Hirudins; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin

2001
[Direct thrombin antagonists].
    Herz, 2001, Volume: 26 Suppl 1

    Topics: Acute Disease; Angina, Unstable; Angioplasty, Balloon, Coronary; Animals; Anticoagulants; Antithrombins; Arginine; Azetidines; Benzylamines; Fibrinolytic Agents; Glycine; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Rabbits; Recombinant Proteins; Sulfonamides; Syndrome; Thrombin; Thromboembolism; Thrombosis; Time Factors

2001
[The new antithrombotic agents].
    Presse medicale (Paris, France : 1983), 2005, Oct-22, Volume: 34, Issue:18

    Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Azetidines; Benzylamines; Clopidogrel; Fibrinolytic Agents; Glycine; Hirudins; Humans; Injections, Subcutaneous; Platelet Aggregation Inhibitors; Polysaccharides; Prodrugs; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine; Time Factors; Venous Thrombosis

2005
[Clinical use of a new class of anticoagulant drugs: the direct thrombin inhibitors].
    Giornale italiano di cardiologia (2006), 2006, Volume: 7, Issue:11

    Topics: Anticoagulants; Antithrombins; Azetidines; Benzylamines; Clinical Trials as Topic; Drug Therapy, Combination; Fibrinolytic Agents; Hirudins; Humans; Peptide Fragments; Recombinant Proteins; Thromboembolism; Treatment Outcome

2006

Other Studies

16 other study(ies) available for melagatran and hirudin

ArticleYear
The importance of enzyme inhibition kinetics for the effect of thrombin inhibitors in a rat model of arterial thrombosis.
    Thrombosis and haemostasis, 1997, Volume: 78, Issue:4

    Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Arginine; Azetidines; Benzylamines; Carotid Artery Thrombosis; Dose-Response Relationship, Drug; Fibrinolytic Agents; Glycine; Hemodynamics; Heparin; Hirudin Therapy; Hirudins; Kinetics; Male; Oligopeptides; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides; Thrombin; Thrombin Time

1997
Monitoring of anticoagulant effects of direct thrombin inhibitors.
    Seminars in thrombosis and hemostasis, 2002, Volume: 28, Issue:4

    Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Blood Coagulation Tests; Drug Monitoring; Glycine; Heparin; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sensitivity and Specificity; Sulfonamides; Thrombin

2002
Comparative antithrombotic potencies of direct thrombin inhibitors and low-molecular-weight heparins in an ex vivo human experimental thrombosis model.
    Seminars in thrombosis and hemostasis, 2002, Volume: 28, Issue:4

    Topics: Antithrombin III; Azetidines; Benzylamines; Fibrin; Fibrinolytic Agents; Glycine; Heparin, Low-Molecular-Weight; Hirudins; Humans; Models, Cardiovascular; Peptide Hydrolases; Platelet Activation; Platelet Factor 4; Thrombin; Thrombosis

2002
Influence of lepirudin, argatroban, and melagatran on prothrombin time and additional effect of oral anticoagulation.
    Clinical chemistry, 2002, Volume: 48, Issue:10

    Topics: Administration, Oral; Anticoagulants; Arginine; Azetidines; Benzylamines; Drug Synergism; Glycine; Hirudins; Humans; Phenprocoumon; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Sulfonamides

2002
Effects of ximelagatran, the oral form of melagatran, in the treatment of caval vein thrombosis in conscious rats.
    Thrombosis research, 2002, Aug-15, Volume: 107, Issue:3-4

    Topics: Administration, Oral; Animals; Anticoagulants; Azetidines; Benzylamines; Dalteparin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glycine; Hirudins; Male; Prodrugs; Rats; Rats, Sprague-Dawley; Thrombosis; Venae Cavae

2002
Inhibition of endothelial cell-mediated generation of activated protein C by direct and antithrombin-dependent thrombin inhibitors.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2003, Volume: 14, Issue:2

    Topics: Antithrombins; Azetidines; Benzylamines; Dose-Response Relationship, Drug; Endothelium, Vascular; Flow Cytometry; Glycine; Heparin; Hirudins; Humans; Piperidines; Protein C; Thrombin; Thrombomodulin

2003
Thrombin-induced platelet activation and its inhibition by anticoagulants with different modes of action.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2003, Volume: 14, Issue:2

    Topics: Adult; Anticoagulants; Azetidines; Benzylamines; Dalteparin; Dose-Response Relationship, Drug; Flow Cytometry; Glycine; Heparin; Hirudins; Humans; Male; P-Selectin; Piperidines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Receptor, PAR-1; Receptors, Thrombin; Statistics as Topic; Thrombin

2003
Predicting the pharmacology of thrombin inhibitors.
    Journal of thrombosis and haemostasis : JTH, 2003, Volume: 1, Issue:5

    Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Blood Coagulation; Computer Simulation; Dose-Response Relationship, Drug; Glycine; Hirudins; Humans; Kinetics; Models, Cardiovascular; Oligopeptides; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin

2003
The benefit-to-risk profile of melagatran is superior to that of hirudin in a rabbit arterial thrombosis prevention and bleeding model.
    Journal of thrombosis and haemostasis : JTH, 2003, Volume: 1, Issue:3

    Topics: Animals; Arteries; Azetidines; Benzylamines; Dose-Response Relationship, Drug; Fibrin; Fibrinolytic Agents; Glycine; Hemorrhage; Hirudin Therapy; Hirudins; Male; Rabbits; Risk Assessment; Thrombin; Thrombosis

2003
The influence of direct and antithrombin-dependent thrombin inhibitors on the procoagulant and anticoagulant effects of thrombin.
    Thrombosis research, 2003, Jun-01, Volume: 110, Issue:4

    Topics: Amino Acid Chloromethyl Ketones; Anticoagulants; Azetidines; Benzylamines; Clinical Trials as Topic; Coagulants; Coronary Artery Disease; Fibrinopeptide A; Glycine; Hirudins; Humans; Peptide Fragments; Piperidines; Protein C; Thrombin

2003
In vitro effect of melagatran and lepirudin on clot-bound thrombin.
    Thrombosis research, 2003, Jun-01, Volume: 110, Issue:4

    Topics: Anticoagulants; Azetidines; Benzylamines; Glycine; Hirudins; Humans; In Vitro Techniques; Recombinant Proteins; Thrombin; Thrombosis

2003
Effects of lepirudin, argatroban and melagatran and additional influence of phenprocoumon on ecarin clotting time.
    Thrombosis research, 2003, Volume: 111, Issue:1-2

    Topics: Anticoagulants; Azetidines; Benzylamines; Blood Coagulation; Blood Coagulation Tests; Fibrinolytic Agents; Glycine; Hirudins; Humans; Kinetics; Outpatients; Phenprocoumon; Recombinant Proteins; Reference Values

2003
Comparison of two different ecarin clotting time methods.
    Journal of thrombosis and thrombolysis, 2005, Volume: 20, Issue:1

    Topics: Antithrombins; Azetidines; Benzylamines; Blood Coagulation; Endopeptidases; Glycine; Hirudins; Humans; In Vitro Techniques; Recombinant Proteins; Viper Venoms

2005
Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation.
    Thrombosis and haemostasis, 2005, Volume: 94, Issue:5

    Topics: Animals; Anticoagulants; Arginine; Azetidines; Benzylamines; Blood Coagulation; Cattle; Dose-Response Relationship, Drug; Factor Xa; Factor Xa Inhibitors; Glycine; Hirudins; Humans; In Vitro Techniques; Partial Thromboplastin Time; Peptide Fragments; Pipecolic Acids; Prothrombin Time; Recombinant Proteins; Species Specificity; Sulfonamides; Thrombin; Thrombin Time; Thromboplastin

2005
The effect of ex vivo anticoagulants on whole blood platelet aggregation.
    Platelets, 2009, Volume: 20, Issue:1

    Topics: Adenosine Diphosphate; Anticoagulants; Arachidonic Acid; Arginine; Azetidines; Benzylamines; Blood Platelets; Citric Acid; Collagen; Female; Heparin; Hirudins; Humans; Male; Peptide Fragments; Pipecolic Acids; Platelet Aggregation; Platelet Function Tests; Recombinant Proteins; Ristocetin; Sulfonamides; Time Factors

2009
Identification of structural-kinetic and structural-thermodynamic relationships for thrombin inhibitors.
    Biochemistry, 2013, Jan-29, Volume: 52, Issue:4

    Topics: Antithrombins; Azetidines; Benzylamines; Catalytic Domain; Crystallography, X-Ray; Drug Discovery; Hirudins; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Kinetics; Models, Molecular; Protein Binding; Surface Properties; Thermodynamics; Thrombin

2013