meiogynin-a has been researched along with 2-cyclohexen-1-one* in 1 studies
1 other study(ies) available for meiogynin-a and 2-cyclohexen-1-one
| Article | Year |
|---|---|
Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins.
The synthesis, on a large scale, with very good yield and er via an efficient strategy, of a chiral 4-substituted 2-cyclohexenone intermediate, was a milestone in the synthesis of seven analogues of meiogynin A, a natural sesquiterpenoid dimer. These compounds were elaborated in ten linear steps. Their binding affinities for Bcl-xL and Mcl-1, two proteins of the Bcl-2 family, overexpressed in various types of cancers, were evaluated. This enabled to further SAR studies en route to the elaboration of potent dual inhibitors of anti-apoptotic proteins of the Bcl-2 family. Topics: Aldehydes; bcl-2 Homologous Antagonist-Killer Protein; bcl-X Protein; BH3 Interacting Domain Death Agonist Protein; Chromatography, High Pressure Liquid; Cyclohexanones; Ligands; Myeloid Cell Leukemia Sequence 1 Protein; Naphthalenes; Sesquiterpenes | 2015 |