megestrol has been researched along with nomegestrol acetate in 128 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (3.91) | 18.7374 |
| 1990's | 36 (28.13) | 18.2507 |
| 2000's | 28 (21.88) | 29.6817 |
| 2010's | 48 (37.50) | 24.3611 |
| 2020's | 11 (8.59) | 2.80 |
| Authors | Studies |
|---|---|
| Basdevant, A; Conard, J; Degrelle, H; Guyene, TT; Pelissier, C; Thomas, JL | 1 |
| Botella, J; Delansorne, R; Duc, I; Paris, J | 1 |
| Chretien, FC; Dubois, R | 1 |
| Botella, J; Delansorne, R; Duc, I; Lahlou, B; Paris, J | 1 |
| Fraser, DI; Padwick, ML; Pryse-Davies, J; Ryder, TA; White, J; Whitehead, MI | 1 |
| Botella, J; Lahlou, B; Paris, J | 2 |
| Bazin, B; Bursaux, C; Paris, J; Thevenot, R | 1 |
| Bonnet, P; Granero, M; Paris, J; Thévenot, R | 1 |
| Catherino, WH; Jordan, VC | 1 |
| Jamin, C | 1 |
| Berrod, JL; Frileux, P; Loc'h, P; Moulin, G; Parc, Y | 1 |
| Basdevant, A; Conard, J; Degrelle, H; Denis, C; Guyene, TT; Ochsenbein, E; Thomas, JL | 1 |
| de Ziegler, D; Linh, CG; Micheletti, MC; Schaerer, E; Zartarian, M | 1 |
| Bonnet, P; Botella, J; Delansorne, R; Duc, I; Fraboul, F; Paris, J | 1 |
| Coutinho, EM; Ladipo, O | 1 |
| Botella, J; Cognet, AM; Delansorne, R; Duc, I; Duranti, E; Paris, J | 1 |
| Coutinho, EM | 1 |
| Athayde, C; Barbosa, I; Coutinho, E; Ladipo, OA; Olsson, SE; Ulmsten, U | 1 |
| Barbosa, I; Coutinho, E; Hirsch, C; Ladipo, O; Olsson, SE; Ulmsten, U | 1 |
| Athayde, C; Barbosa, IC; Coutinho, EM; Ladipo, OA; Olsson, SE; Ulmsten, U | 1 |
| Adekunle, AO; Affandi, B; Alvarez, F; Athayde, C; Barbosa, IC; Brache, V; Coutinho, EM; de Acosta, OM; de Souza, JC; Devoto, L; Emuveyan, EE; Gu, ZP; Ladipo, OA; Mati, J; Salem, HT; Shaaban, MM | 1 |
| Botella, J; Chetrite, G; Paris, J; Pasqualini, JR | 1 |
| Barbosa, IC; Coutinho, E; Hirsch, C; Ladipo, OA; Olsson, SE; Ulmsten, U | 1 |
| Brailly, S; Chanson, P; Couzinet, B; Schaison, G; Thomas, JL; Young, J | 1 |
| Barnhart, KT; Coutinho, E; Devoto, L; Furman, I; Pommer, R | 1 |
| Barnhart, K; Coutinho, E; Devoto, L; Pommer, R; Robinovic, J; Sir-Pettermann, T | 1 |
| Béliard, A; Bergeron, C; Bernard, AM; Foidart, JM; Hedon, B; Ochsenbein, E; Thomas, JL | 1 |
| Alba, F; Barnhart, K; Coutinho, E; Devoto, L; Kohen, P; Pommer, R; Retamales, I | 1 |
| Lombardi, PA; Lombardi, PL; Persiani, P; Radici, E | 1 |
| Cabrol, D; Carbonne, B; Clerget, MS; Germain, G | 1 |
| Cefalu, WT; Greaves, KA; Thomas, MJ; Wagner, JD; Williams, JK; Zhang, L | 1 |
| Dewailly, D; Gauthier, A; Micheletti, MC; Torres, C; Zartarian, M | 1 |
| Delansorne, R; Paris, J; Williams, JK | 1 |
| Coutinho, EM; Ladipo, OA; Nascimento, Mde L | 1 |
| Cline, JM; Delansorne, R; Honoré, EK; Paris, J; Williams, JK | 1 |
| Croxatto, HB; Fuentealba, B; Massai, R; Salvatierra, AM | 1 |
| Chevallier, T; Jamin, C; Leber, C; Micheletti, MC; Zartarian, M | 1 |
| De Leo, V; la Marca, A; Lanzetta, D; Morgante, G | 1 |
| Brailly, S; Chanson, P; Couzinet, B; Kujas, M; Meduri, G; Schaison, G; Thomas, JL; Young, J | 1 |
| Cobellis, L; Colacurci, N; De Franciscis , P; De Placido , G; Nazzaro, G | 1 |
| Assouline, PS; Dulmet, E; Levasseur, P; Oliviero, G; Tebboune, D; Zeggane, A | 1 |
| Chen, Y; Guo, WJ; He, KL; Li, J; Xia, P; Xu, LZ; Zheng, YH | 1 |
| Athayde, C; Barbosa, IC; Coutinho, E; Hirsch, C; Ladipo, OA; Lopes, R; Matias, B; Nascimento, ML | 1 |
| Colacurci, N; De Franciscis, P; del Vecchio, W; Fornaro, F; Mele, D; Palermo, M | 1 |
| Colacurci, N; De Franciscis, P; del Vecchio, W; Fornaro, F; Palermo, M | 1 |
| He, K; Li, J; Xu, L | 1 |
| Cao, L; Gu, ZP; Leng, Y; Qian, LH; Yang, B | 1 |
| Guo, W; He, K; Li, J; Xia, P; Xu, L; Zheng, Y; Zhu, X | 1 |
| Batallan, A; Jamin, C; Madelenat, P | 1 |
| Colau, JC; Jamin, C; Pélissier, C | 1 |
| Boubli, L; Carpentier-Meunier, S; Charpin, C; Dales, JP; Garcia, S; Illouz, S; Lavaut, MN; Sferlazzo, K | 1 |
| Adekunle, AO; Arinola, O; Arowojolu, AO; Okunlola, MA; Salimonu, LS | 1 |
| Chevallier, T; Collette, J; Dethor, M; Foidart, JM; Micheletti, MC; Reginster, JY; Viethel, P | 1 |
| Bonnet, P; Delansorne, R; Duc, I; Duranti, E; Paris, J; Puccio, F; Shields-Botella, J | 1 |
| Shields-Botella, J | 1 |
| Alessandrini, C; Arangino, S; Baldassari, F; Cagnacci, A; Landi, S; Volpe, A | 1 |
| Chetrite, G; Meschi, S; Pasqualini, JR; Shields-Botella, J | 1 |
| André, G | 1 |
| Akan, P; Dogan, E; Gol, M; Karas, C; Posaci, C; Saygili, U | 1 |
| Bergougnoux, L; Delmas, PD; Drapier-Faure, E; Garnero, P; Nguyên-Pascal, ML; Thomas, JL | 1 |
| Baldacci, C; Caruso, A; Fornari, L; Fu, XD; Garibaldi, S; Genazzani, AR; Giretti, MS; Mannella, P; Scorticati, C; Simoncini, T | 1 |
| Barbosa, IC; Botto, A; Coutinho, E; Lopes, AC; Lopes, R; Maia, H; Noronha, C | 1 |
| D'Agosta, S; Lombardo, G; Savoca, S | 1 |
| Chevallier, T; Micheletti, MC | 1 |
| Begliuomini, S; Casarosa, E; Centofanti, M; Freschi, L; Genazzani, AR; Lenzi, E; Luisi, M; Luisi, S; Ninni, F; Pluchino, N; Valentino, V | 1 |
| Boesch, C; Bronner, C; Hecker, M; Jourdain, M; Schini-Kerth, VB; Zerr-Fouineau, M | 1 |
| Barbosa, IC; Coutinho, EM; Lopes, AC; Lopes, RC; Mota, RL; Noronha, CF; Oladapo, L | 1 |
| Lello, S | 2 |
| Angioni, S; Bruni, L; Calzolari, S; Florio, P; Franchini, M; Gabbanini, M; Imperatore, A; Litta, P; Petraglia, F | 1 |
| Duijkers, IJ; Grob, P; Klipping, C; Korver, T | 1 |
| Leitner, H | 1 |
| Aiach, M; Alhenc-Gelas, M; Ali, FD; Bachelot-Loza, C; Gaussem, P; Remones, V; Scarabin, PY; Thomas, JL | 1 |
| Chabbert-Buffet, N; Chassard, D; Christin-Maitre, S; Ochsenbein, E; Thomas, JL | 1 |
| Mueck, AO; Sitruk-Ware, R | 1 |
| Chabbert-Buffet, N; Chassard, D; Christin-Maitre, S; Ochsenbein, E; Serfaty, D; Thomas, JL | 1 |
| Ågren, UM; Anttila, M; Mäenpää-Liukko, K; Mommers, E; Rantala, ML; Rautiainen, H; Sommer, WF | 2 |
| Korver, T; Mansour, D; Melis, GB; Sommer, W; Sundström-Poromaa, I; Taneepanichskul, S; Verhoeven, C; Weisberg, E | 1 |
| Cahill, MA; Chen, R; Fehm, T; Mueck, AO; Neubauer, H; Ruan, X; Schneck, H; Schultz, S; Seeger, H; Yu, Q | 1 |
| Bahamondes, L; Darney, P; Kaunitz, AM; Korver, T; Sommer, W; Verhoeven, C; Westhoff, C | 1 |
| Gaspard, U; Nisolle, M; Pintiaux, A | 1 |
| Debski, R; Kotarski, J; Paszkowski, T; Pawelczyk, L; Poreba, R; Skrzypulec-Plinta, V; Tomaszewski, J | 1 |
| Grob, P; Sørdal, T; Verhoeven, C | 1 |
| Gerrits, MG; Peeters, PA; Post, TM; Schnabel, PG | 1 |
| Plosker, GL; Yang, LP | 1 |
| van Diepen, HA | 1 |
| Bricaire, L; Christin-Maitre, S; Laroche, E | 1 |
| Shulman, LP | 1 |
| Schindler, AE | 1 |
| Berretta, M; Cavaliere, C; Del Pup, L; Di Francia, R; Di Napoli, M; Facchini, G; Fiorica, F; Mileto, M; Schindler, AE | 1 |
| de Kam, PJ; Lillin, O; Post, T; Thomsen, T; van Kuijk, J | 1 |
| Banco, R; Barbati, G; Conversano, E; De Leo, R; De Seta, F; Lello, S; Maso, G; Restaino, S; Tonon, M | 1 |
| Cao, L; Chen, X; Huang, Q; Riviere, JE; Zhu, Y | 1 |
| Chen, Q; Guo, X; Hao, S; Huang, Y; Li, Z; Xie, S; Zhang, J; Zhou, J; Zhou, X; Zhu, Y | 1 |
| Creinin, MD; Korver, T; Martin Nguyen, A; Sundström-Poromaa, I; Witjes, H | 1 |
| Cagnacci, A; Di Carlo, C; Grandi, G; Napolitano, A; Tirelli, A; Xholli, A | 1 |
| de Greef, R; Gerrits, M; Kerbusch, T; Post, TM | 1 |
| Nelson, AL | 1 |
| Cagnacci, A; Grandi, G; Napolitano, A | 1 |
| Africander, D; Louw-du Toit, R; Perkins, MS; Snoep, JL; Storbeck, KH | 1 |
| Cibarelli, F; Di Carlo, C; Gallo, A; Guida, M; Martini, E; Nappi, RE; Tiranini, L; Troisi, J | 1 |
| Kher, U; Korver, T; Mansour, D; Westhoff, C | 1 |
| Cariola, M; Caruso, S; Cianci, A; Cianci, S; Di Pasqua, S; Fava, V | 1 |
| Corda, V; Malune, ME; Melis, GB; Neri, M; Orani, MP; Paoletti, AM; Pilloni, M; Piras, B; Vallerino, V; Zedda, P | 1 |
| Ma, AY; Xie, SW; Zhou, JY; Zhu, Y | 1 |
| Baumgart, J; Bengtsdotter, H; Bixo, M; Brynhildsen, J; Gemzell Danielsson, K; Lindh, I; Lundin, C; Malmborg, A; Marions, L; Sundström Poromaa, I | 1 |
| Arana, MR; Domínguez, CJ; Mottino, AD; Rigalli, JP; Ruiz, ML; Tocchetti, GN; Villanueva, SSM; Weiss, J; Zecchinati, F | 2 |
| Cruz, SM; Fox, MC; Frenkl, TL; Klipping, C; Korver, T; Nguyen, AM; Wang, Y | 1 |
| Bastianelli, C; Benedetto, C; Borrelli, G; Cagnacci, A; Calanni, L; Cianci, A; Cicinelli, E; De Leo, V; Neri, M; Vignali, M; Volpe, A | 1 |
| Huang, YS; Song, SY; Sun, YT; Xie, BC; Xie, XY; Xu, DH; Zhang, XY | 1 |
| Champagne, PO; Froelich, S; Passeri, T | 1 |
| Bernat, AL; Champagne, PO; Froelich, S; Hanakita, S; Mandonnet, E; Passeri, T; Salle, H | 1 |
| Cipriani, S; Di Stasi, V; Maggi, M; Magini, A; Maseroli, E; Scavello, I; Verde, N; Vignozzi, L | 1 |
| Cao, C; Gong, YJ; Guo, XJ; Li, GT; Li, Z; Shao, HH; Xie, SW; Yang, WJ; Zhong, RH; Zhou, JY; Zhu, Y | 1 |
| Derntl, B; Lundin, C; Pletzer, B; Scheuringer, A; Sundström Poromaa, I | 1 |
| Angsuwathana, S; Chotrungrote, B; Jirakittidul, P; Neungton, C; Rattanachaiyanont, M; Thiampong, T | 1 |
| Baulieu, EE; Berger, E; Bossard, N; Brassat, D; Castelnovo, G; Clavelou, P; Cornu, C; Cotton, F; De Seze, J; Debouverie, M; Durand-Dubief, F; Durelli, L; El-Etr, M; Gignoux, L; Hautecoeur, P; Heinzlef, O; Ionescu, I; Laplaud, DA; Le Page, E; Lebrun-Frenay, C; Marignier, R; Moreau, T; Patti, F; Pelletier, J; Remontet, L; Trojano, M; Vukusic, S | 1 |
| Biglia, N; Casula, E; Fuso, L; Mancarella, M; Mariani, LL; Novara, L | 1 |
| Aboukais, R; Bourgeois, P; Caron, S; De Witte, O; Devalckeneer, A; Lejeune, JP; Maurage, CA; Perbet, R; Racape, J | 1 |
| Karimi, L; Kulkarni, J; Robertson, E; Thew, C; Thomas, N | 1 |
| Bauerfeind, A; Becker, K; DiBello, J; Franke, C; Heinemann, K; Koro, C; Reed, S | 2 |
| Caruso, G; Caruso, S; Cianci, A; Cianci, S; Iraci Sareri, M; Panella, M | 1 |
| Esposito, G; La Vecchia, C; Parazzini, F; Santucci, C; Vercellini, P | 1 |
18 review(s) available for megestrol and nomegestrol acetate
| Article | Year |
|---|---|
Insulin sensitivity and cardiovascular risk factors in ovariectomized monkeys with estradiol alone or combined with nomegestrol acetate.
Topics: Administration, Oral; Animals; Aorta, Thoracic; Cardiovascular Diseases; Cholesterol; Dinoprost; Drug Combinations; Estradiol; Female; Insulin Resistance; Macaca fascicularis; Megestrol; Norpregnadienes; Ovariectomy; Risk Factors | 1998 |
[Antigonadotropic effects of a 19-nor-progesterone derivative: the example of nomegestrol acetate].
Topics: Adult; Estradiol; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Gonadotropins; Humans; Luteinizing Hormone; Megestrol; Menopause; Middle Aged; Norpregnadienes; Ovulation; Periodicity; Progesterone; Progestins | 2003 |
[Effects of a 19-norprogesterone derivative, the fourth decade nomegestrol acetate, on lipids].
Topics: Adult; Apolipoprotein A-I; Apolipoproteins B; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Estrogen Replacement Therapy; Female; Humans; Lipids; Lipoprotein(a); Megestrol; Middle Aged; Norpregnadienes; Postmenopause | 2003 |
An overview of nomegestrol acetate selective receptor binding and lack of estrogenic action on hormone-dependent cancer cells.
Topics: Animals; Cell Line, Tumor; Estradiol; Estrogens; Female; Humans; Male; Megestrol; Neoplasms, Hormone-Dependent; Norpregnadienes; Progestins; Receptors, Steroid; Structure-Activity Relationship | 2003 |
Effect of nomegestrol acetate on estrogen biosynthesis and transformation in MCF-7 and T47-D breast cancer cells.
Topics: 17-Hydroxysteroid Dehydrogenases; Aromatase; Biotransformation; Breast Neoplasms; Cell Line, Tumor; Estradiol; Estrogens; Estrone; Female; Humans; Megestrol; Neoplasms, Hormone-Dependent; Norpregnadienes; Progesterone Congeners; Progestins; Sulfatases; Sulfotransferases | 2005 |
[Actions of a 19-norprogesterone derivative on mammary gland: nomegestrol acetate].
Topics: Apoptosis; Breast Diseases; Cell Division; Cells, Cultured; Female; Humans; Mammary Glands, Human; Megestrol; Norpregnadienes; Radiography; Receptors, Estrogen; Receptors, Steroid | 2005 |
[Nomegestrol acetate: clinical pharmacology].
Topics: Biological Availability; Breast Diseases; Drug Therapy, Combination; Estradiol; Female; Hormone Replacement Therapy; Humans; Hypothalamo-Hypophyseal System; Inactivation, Metabolic; Megestrol; Menopause; Menstruation Disturbances; Molecular Structure; Norpregnadienes; Ovulation Inhibition; Protein Binding | 2009 |
Nomegestrol acetate: pharmacology, safety profile and therapeutic efficacy.
Topics: Animals; Bone Remodeling; Breast Neoplasms; Cardiovascular Diseases; Contraceptives, Oral, Hormonal; Endometrial Hyperplasia; Female; Hormone Replacement Therapy; Humans; Megestrol; Norpregnadienes; Progesterone Congeners; Risk Assessment; Risk Factors; Thromboembolism; Treatment Outcome | 2010 |
Nomegestrol acetate, a novel progestogen for oral contraception.
Topics: Contraceptives, Oral, Synthetic; Endometrium; Estrogens; Female; Humans; Megestrol; Norpregnadienes; Ovulation; Progesterone Congeners; Receptors, Steroid; Venous Thromboembolism | 2011 |
[Zoely, a combined oral contraceptive, monophasic pill containing estradiol and nomegestrol acetate].
Topics: Animals; Contraception; Contraceptives, Oral, Combined; Drug Design; Estradiol; Humans; Megestrol; Norpregnadienes; Tablets | 2012 |
Preclinical pharmacological profile of nomegestrol acetate, a synthetic 19-nor-progesterone derivative.
Topics: Androgens; Animals; Bone Density; Carbohydrate Metabolism; Cell Proliferation; CHO Cells; Contraceptives, Oral, Combined; Cricetinae; Dogs; Drug Evaluation, Preclinical; Estrogens; Female; Hemodynamics; Humans; Lipid Metabolism; Macaca fascicularis; Male; Megestrol; Norpregnadienes; Ovulation; Progesterone Congeners; Rats; Tumor Cells, Cultured; Uterus | 2012 |
A new contraceptive pill containing 17β-estradiol and nomegestrol acetate.
Topics: Contraceptives, Oral, Combined; Estradiol; Estrogens; Ethinyl Estradiol; Female; Humans; Megestrol; Menstrual Cycle; Norpregnadienes; Progestins; Women's Health | 2013 |
Changing convention in combination oral contraceptives: estradiol and nomegestrol acetate in a monophasic 24/4 regimen.
Topics: Contraceptives, Oral, Combined; Estradiol; Estrogens; Female; Humans; Megestrol; Norpregnadienes | 2013 |
The "newer" progestogens and postmenopausal hormone therapy (HRT).
Topics: Androstenes; Estradiol; Female; Humans; Megestrol; Nandrolone; Norpregnadienes; Postmenopause; Progestins | 2014 |
Nomegestrol acetate/estradiol hormonal oral contraceptive and breast cancer risk.
Topics: Breast; Breast Neoplasms; Cell Proliferation; Contraceptives, Oral, Hormonal; Estradiol; Female; Humans; Megestrol; Membrane Proteins; Neoplasms, Hormone-Dependent; Norpregnadienes; Receptors, Progesterone; Risk | 2014 |
Zoely: a new combined oral contraceptive.
Topics: Contraceptives, Oral, Combined; Drug Approval; Estradiol; Female; Humans; Megestrol; Norpregnadienes; United Kingdom | 2014 |
An update on new orally administered contraceptives for women.
Topics: Clinical Trials as Topic; Contraceptives, Oral; Estradiol; Estrogens; Ethinyl Estradiol; Female; Humans; Megestrol; Nandrolone; Norpregnadienes; Progestins | 2015 |
Metabolic impact of combined hormonal contraceptives containing estradiol.
Topics: Blood Pressure; Contraceptives, Oral, Combined; Contraceptives, Oral, Hormonal; Estradiol; Ethinyl Estradiol; Hemostasis; Humans; Lipid Metabolism; Megestrol; Nandrolone; Norpregnadienes | 2016 |
42 trial(s) available for megestrol and nomegestrol acetate
| Article | Year |
|---|---|
The effects of the addition of nomegestrol acetate to post-menopausal oestrogen therapy.
Topics: Adult; DNA; Dose-Response Relationship, Drug; Double-Blind Method; Endometrium; Estradiol; Estradiol Dehydrogenases; Female; Humans; Isocitrate Dehydrogenase; Megestrol; Menopause; Middle Aged; Norpregnadienes; Prospective Studies; Random Allocation; Receptors, Estradiol; Substance Withdrawal Syndrome; Uterine Hemorrhage | 1989 |
[High-dose progestational contraception: advantages].
Topics: Administration, Cutaneous; Adult; Chlormadinone Acetate; Contraceptives, Oral, Combined; Estradiol; Female; Humans; Incidence; Megestrol; Menstruation Disturbances; Norpregnadienes; Progesterone Congeners; Promegestone | 1993 |
Cardiovascular risk factors and combined estrogen-progestin replacement therapy: a placebo-controlled study with nomegestrol acetate and estradiol.
Topics: Apoproteins; Blood Glucose; Blood Pressure; Cardiovascular Diseases; Cholesterol; Double-Blind Method; Drug Combinations; Estradiol; Estrogen Replacement Therapy; Female; Fibrinogen; Follicle Stimulating Hormone; Humans; Lipoproteins; Megestrol; Middle Aged; Norpregnadienes; Plasminogen; Progesterone Congeners; Prospective Studies; Renin; Risk Factors; Triglycerides | 1995 |
[The cyclic administration of nomegestrol acetate does not alter the vasodilating effects of estradiol on the uterine artery].
Topics: Arteries; Blood Flow Velocity; Drug Administration Schedule; Estradiol; Estrogen Replacement Therapy; Female; Humans; Megestrol; Middle Aged; Norpregnadienes; Progesterone Congeners; Pulsatile Flow; Ultrasonography, Doppler, Pulsed; Uterus; Vasodilation | 1994 |
One year contraception with a single subdermal implant containing nomegestrol acetate (Uniplant).
Topics: Adult; Blood Pressure; Body Weight; Drug Implants; Female; Humans; Megestrol; Menstruation; Norpregnadienes; Progesterone Congeners | 1993 |
Effects of a single contraceptive Silastic implant containing nomegestrol acetate on ovarian function and cervical mucus production during 2 years.
Topics: Adolescent; Adult; Cervix Mucus; Contraceptive Agents, Female; Drug Implants; Estradiol; Female; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Megestrol; Menstrual Cycle; Norpregnadienes; Ovary; Progesterone; Progesterone Congeners; Sex Hormone-Binding Globulin; Silicone Elastomers; Time Factors | 1996 |
Multicenter clinical trial on the efficacy and acceptability of a single contraceptive implant of nomegestrol acetate, Uniplant.
Topics: Adult; Contraceptive Agents, Female; Drug Implants; Female; Humans; Megestrol; Norpregnadienes; Pregnancy; Progesterone Congeners; Uterine Hemorrhage | 1996 |
The antigonadotropic activity of progestins (19-nortestosterone and 19-norprogesterone derivatives) is not mediated through the androgen receptor.
Topics: Cholesterol, HDL; Cross-Over Studies; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Luteinizing Hormone; Megestrol; Middle Aged; Norethindrone; Norethindrone Acetate; Norpregnadienes; Postmenopause; Progesterone Congeners; Receptors, Androgen | 1996 |
Changes in the menstrual bleeding of users of a subdermal contraceptive implant of nomegestrol acetate (Uniplant) do not influence sexual frequency, sexual desire, or sexual enjoyment.
Topics: Adolescent; Adult; Child; Coitus; Drug Implants; Female; Health Status; Humans; Male; Megestrol; Menstruation; Norpregnadienes; Patient Satisfaction; Periodicity; Prospective Studies; Self Concept; Sexual Behavior | 1997 |
Impact of percutaneous oestradiol gels in postmenopausal hormone replacement therapy on clinical symptoms and endometrium.
Topics: Administration, Cutaneous; Adult; Climacteric; Drug Therapy, Combination; Endometrial Hyperplasia; Estradiol; Estrogen Replacement Therapy; Female; Gels; Humans; Megestrol; Menstrual Cycle; Middle Aged; Norpregnadienes; Patient Compliance; Progesterone Congeners | 1997 |
Hormonal profile, endometrial histology and ovarian ultrasound assessment during 1 year of nomegestrol acetate implant (Uniplant).
Topics: Adult; Biopsy; Contraceptive Agents, Female; Drug Implants; Endometrium; Evaluation Studies as Topic; Female; Hormones; Humans; Longitudinal Studies; Luteal Phase; Megestrol; Norpregnadienes; Ovarian Follicle; Ovary; Ovulation; Progesterone Congeners; Reference Values; Ultrasonography | 1997 |
[Use of nomegestrol acetate in the treatment of menstruation disorders. Our experience in 56 cases].
Topics: Adult; Amenorrhea; Female; Humans; Megestrol; Menstrual Cycle; Menstruation Disturbances; Norpregnadienes; Oligomenorrhea; Premenstrual Syndrome; Progesterone; Progesterone Congeners | 1997 |
[Effects of nomegestrol acetate administered alone or with cutaneous 17 beta estradiol in inversed sequence on cycle quality and hot flashes in periomenopausal women].
Topics: Adult; Climacteric; Contraceptives, Oral, Combined; Contraceptives, Oral, Sequential; Estradiol; Estrogen Replacement Therapy; Female; Humans; Megestrol; Menstruation Disturbances; Middle Aged; Norpregnadienes; Prospective Studies | 1998 |
Contraceptive potential of a mifepristone-nomegestrol acetate sequential regimen in women.
Topics: Adult; Contraceptives, Oral, Combined; Estradiol; Female; Humans; Luteinizing Hormone; Megestrol; Menstruation-Inducing Agents; Mifepristone; Norpregnadienes; Ovulation; Progesterone; Progesterone Congeners; Sterilization, Reproductive | 1998 |
Effects of a short-term suspension of hormone replacement therapy on mammographic density.
Topics: Administration, Cutaneous; Bone Density; Drug Combinations; Estradiol; Estrogen Replacement Therapy; Follicle Stimulating Hormone; Humans; Hysterectomy; Mammography; Megestrol; Menopause; Middle Aged; Norpregnadienes; Parity; Postmenopause; Prospective Studies; Time Factors | 2001 |
Effects of different types of hormone replacement therapy on mammographic density.
Topics: Administration, Cutaneous; Breast; Estradiol; Female; Hormone Replacement Therapy; Humans; Mammography; Megestrol; Middle Aged; Norpregnadienes; Norpregnenes; Postmenopause; Prospective Studies; Treatment Outcome | 2001 |
[Comparison of changes in biochemical markers of bone turnover after 6 months of hormone replacement therapy with either transdermal 17 beta-estradiol or equine conjugated estrogen plus nomegestrol acetate].
Topics: Administration, Cutaneous; Administration, Oral; Alkaline Phosphatase; Biomarkers; Bone and Bones; Bone Remodeling; Estradiol; Estrogens; Female; Hormone Replacement Therapy; Humans; Megestrol; Middle Aged; Norpregnadienes; Postmenopause; Predictive Value of Tests | 2003 |
A comparison of the central effects of different progestins used in hormone replacement therapy.
Topics: Administration, Cutaneous; Anxiety; Body Temperature; Depression; Double-Blind Method; Estradiol; Female; Follow-Up Studies; Hormone Replacement Therapy; Hot Flashes; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Megestrol; Middle Aged; Norethindrone; Norethindrone Acetate; Norpregnadienes; Placebos; Postmenopause; Progestins; Time Factors | 2004 |
Effects of estrogen, raloxifene, and hormone replacement therapy on serum C-reactive protein and homocysteine levels.
Topics: Adult; Aged; C-Reactive Protein; Drug Combinations; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Homocysteine; Humans; Medroxyprogesterone Acetate; Megestrol; Middle Aged; Norpregnadienes; Postmenopause; Prospective Studies; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Treatment Outcome | 2006 |
Nomegestrol acetate may enhance the skeletal effects of estradiol on biochemical markers of bone turnover in menopausal women after a 12-week treatment period.
Topics: Alkaline Phosphatase; Biomarkers; Bone and Bones; Bone Density; Bone Remodeling; Collagen; Collagen Type I; Double-Blind Method; Estradiol; Estrogen Replacement Therapy; Female; Humans; Megestrol; Menopause; Middle Aged; Norpregnadienes; Osteocalcin; Peptides; Progesterone Congeners; Quality of Life; Surveys and Questionnaires; Treatment Outcome | 2005 |
Effects of a single Silastic contraceptive implant containing nomegestrol acetate (Uniplant) on endometrial morphology and ovarian function for 1 year.
Topics: Adolescent; Adult; Dimethylpolysiloxanes; Drug Implants; Endometrium; Female; Humans; Hysteroscopy; Megestrol; Menstrual Cycle; Norpregnadienes; Ovarian Follicle; Progesterone Congeners; Silicones; Ultrasonography | 2006 |
An open-label study of subdermal implants of estradiol-only versus subdermal implants of estradiol plus nomegestrol acetate: effects on symptom control, lipid profile and tolerability.
Topics: Dermis; Dimethylpolysiloxanes; Drug Implants; Drug Therapy, Combination; Dyspareunia; Estradiol; Estrogen Replacement Therapy; Female; Hot Flashes; Humans; Lipids; Megestrol; Menstruation; Middle Aged; Norpregnadienes; Vaginal Diseases; Weight Gain | 2009 |
The use of nomegestrol acetate in rapid preparation of endometrium before operative hysteroscopy in pre-menopausal women.
Topics: Administration, Oral; Adult; Endometrium; Female; Humans; Hysteroscopy; Megestrol; Norpregnadienes; Polyps; Premenopause; Time Factors | 2010 |
Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17 beta-oestradiol on ovarian function in comparison to a monophasic combined oral contraceptive containing drospirenone and ethinylestradiol.
Topics: Adolescent; Adult; Androstenes; Contraceptives, Oral, Combined; Estradiol; Estrogens; Ethinyl Estradiol; Female; Follicle Stimulating Hormone; Humans; Megestrol; Menstrual Cycle; Mineralocorticoid Receptor Antagonists; Norpregnadienes; Ovulation; Progesterone; Young Adult | 2010 |
Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17β-estradiol, compared with those of levonorgestrel/ethinyl estradiol. A double-blind, randomised study.
Topics: Adolescent; Adult; Contraceptives, Oral, Combined; Double-Blind Method; Estradiol; Ethinyl Estradiol; Female; Fibrinolysis; Hemostasis; Humans; Levonorgestrel; Megestrol; Norpregnadienes; Placebos; Thrombosis; Treatment Outcome | 2011 |
Inhibition of ovulation by NOMAC/E2, a novel monophasic oral contraceptive combining nomegestrol acetate and 17β-oestradiol: a double-blind, randomised, dose-finding pilot study.
Topics: Adult; Contraceptives, Oral, Combined; Dose-Response Relationship, Drug; Double-Blind Method; Estradiol; Estrogens; Female; Humans; Megestrol; Menstrual Cycle; Norpregnadienes; Ovulation; Pilot Projects; Young Adult | 2011 |
Comparison of a 24-day and a 21-day pill regimen for the novel combined oral contraceptive, nomegestrol acetate and 17β-estradiol (NOMAC/E2): a double-blind, randomized study.
Topics: Contraceptives, Oral, Combined; Double-Blind Method; Estradiol; Humans; Megestrol; Norpregnadienes | 2011 |
Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in comparison to one containing levonorgestrel and ethinylestradiol on markers of endocrine function.
Topics: Adolescent; Adult; Contraceptives, Oral, Combined; Contraceptives, Oral, Synthetic; Estradiol; Estrogens; Ethinyl Estradiol; Female; Humans; Hydrocortisone; Levonorgestrel; Megestrol; Middle Aged; Norpregnadienes; Sex Hormone-Binding Globulin; Testosterone Congeners; Thyroxine-Binding Globulin; Transcortin; Young Adult | 2011 |
Efficacy and tolerability of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in a 24/4 regimen, in comparison to an oral contraceptive containing ethinylestradiol and drospirenone in a 21/7 regimen.
Topics: Acne Vulgaris; Adolescent; Adult; Androstenes; Contraceptives, Oral, Combined; Contraceptives, Oral, Synthetic; Estradiol; Estrogens; Ethinyl Estradiol; Female; Humans; Megestrol; Menstrual Cycle; Metrorrhagia; Middle Aged; Mineralocorticoid Receptor Antagonists; Norpregnadienes; Pregnancy; Pregnancy Rate; Substance Withdrawal Syndrome; Young Adult | 2011 |
Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol compared with one containing levonorgestrel and ethinylestradiol on haemostasis, lipids and carbohydrate metabolism.
Topics: Adolescent; Adult; C-Reactive Protein; Carbohydrate Metabolism; Cholesterol, HDL; Cholesterol, LDL; Contraceptives, Oral, Combined; Contraceptives, Oral, Synthetic; Estradiol; Estrogens; Ethinyl Estradiol; Female; Hemostasis; Humans; Levonorgestrel; Megestrol; Middle Aged; Norpregnadienes; Sex Hormone-Binding Globulin; Triglycerides; Young Adult | 2011 |
Efficacy, safety, and tolerability of a monophasic oral contraceptive containing nomegestrol acetate and 17β-estradiol: a randomized controlled trial.
Topics: Adolescent; Adult; Androstenes; Contraceptives, Oral, Combined; Drug Administration Schedule; Estradiol; Ethinyl Estradiol; Female; Humans; Kaplan-Meier Estimate; Megestrol; Middle Aged; Norpregnadienes; Pregnancy; Proportional Hazards Models; Young Adult | 2012 |
Effects on bone mineral density of a monophasic combined oral contraceptive containing nomegestrol acetate/17β-estradiol in comparison to levonorgestrel/ethinylestradiol.
Topics: Absorptiometry, Photon; Adult; Bone Density; Contraceptives, Oral, Combined; Contraceptives, Oral, Synthetic; Estradiol; Estrogens; Ethinyl Estradiol; Female; Humans; Levonorgestrel; Megestrol; Norpregnadienes; Progesterone Congeners; Prospective Studies; Young Adult | 2012 |
The effect of therapeutic and supratherapeutic oral doses of nomegestrol acetate (NOMAC)/17β-estradiol (E2) on QTcF intervals in healthy women: results from a randomized, double-blind, placebo- and positive-controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Contraceptives, Oral, Combined; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Estradiol; Female; Fluoroquinolones; Humans; Long QT Syndrome; Megestrol; Middle Aged; Moxifloxacin; Norpregnadienes; Time Factors; Young Adult | 2014 |
Comparative analysis of the effects of nomegestrol acetate/17 β-estradiol and drospirenone/ethinylestradiol on premenstrual and menstrual symptoms and dysmenorrhea.
Topics: Adult; Androstenes; Dysmenorrhea; Estradiol; Ethinyl Estradiol; Female; Humans; Longitudinal Studies; Megestrol; Menstrual Cycle; Middle Aged; Norpregnadienes; Premenstrual Syndrome; Reproductive Control Agents; Surveys and Questionnaires; Young Adult | 2015 |
Prediction of nomegestrol acetate pharmacokinetics in healthy female adolescents and adults by whole-body physiology-based pharmacokinetic modelling and clinical validation.
Topics: Adolescent; Adult; Age Factors; Contraceptives, Oral, Combined; Estradiol; Estrone; Female; Half-Life; Humans; Megestrol; Middle Aged; Models, Biological; Norpregnadienes; Progesterone Congeners; Young Adult | 2016 |
Pooled analysis of two randomized, open-label studies comparing the effects of nomegestrol acetate/17β-estradiol and drospirenone/ethinyl estradiol on bleeding patterns in healthy women.
Topics: Adolescent; Adult; Amenorrhea; Androstenes; Contraceptives, Oral, Combined; Estradiol; Estrogens; Ethinyl Estradiol; Female; Humans; Megestrol; Menstrual Cycle; Metrorrhagia; Middle Aged; Norpregnadienes; Young Adult | 2017 |
Ongoing or previous mental disorders predispose to adverse mood reporting during combined oral contraceptive use.
Topics: Adolescent; Adult; Affect; Alcohol Drinking; Anxiety Disorders; Contraceptives, Oral, Combined; Double-Blind Method; Estradiol; Estrogens; Feeding and Eating Disorders; Female; Humans; Megestrol; Mental Disorders; Mood Disorders; Norpregnadienes; Progesterone Congeners; Psychiatric Status Rating Scales; Psychological Tests; Risk Factors; Severity of Illness Index; Sweden; Young Adult | 2018 |
A phase 2b multicenter, randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of vaginal rings containing nomegestrol acetate or etonogestrel and 17β-estradiol in the treatment of women with primary dysmenorrhea.
Topics: Adult; Contraceptive Agents, Hormonal; Contraceptive Devices, Female; Desogestrel; Double-Blind Method; Dysmenorrhea; Estradiol; Female; Humans; Megestrol; Norpregnadienes; Progesterone Congeners; Treatment Outcome; Young Adult | 2019 |
Use of an estradiol-based combined oral contraceptives has no influence on attentional bias or depressive symptoms in healthy women.
Topics: Adult; Affect; Affective Symptoms; Anxiety; Anxiety Disorders; Attentional Bias; Contraceptives, Oral, Combined; Depression; Estradiol; Estrogens; Female; Humans; Megestrol; Mood Disorders; Norpregnadienes; Prospective Studies | 2020 |
The effectiveness of quick starting oral contraception containing nomegestrol acetate and 17-β estradiol on ovulation inhibition: A randomized controlled trial.
Topics: Adult; Contraceptives, Oral, Combined; Drug Combinations; Estradiol; Ethinyl Estradiol; Female; Healthy Volunteers; Humans; Megestrol; Menstrual Cycle; Norpregnadienes; Norpregnenes; Ovulation Inhibition; Treatment Outcome; Young Adult | 2020 |
Oral nomegestrol acetate and transdermal 17-beta-estradiol for preventing post-partum relapses in multiple sclerosis: The POPARTMUS study.
Topics: Estradiol; Female; Humans; Megestrol; Multiple Sclerosis; Norpregnadienes; Postpartum Period; Pregnancy; Recurrence | 2021 |
Randomized study on the effectiveness of nomegestrol acetate plus 17β-estradiol oral contraceptive versus dienogest oral pill in women with suspected endometriosis‑associated chronic pelvic pain.
Topics: Chronic Pain; Contraceptives, Oral, Combined; Endometriosis; Estradiol; Female; Humans; Male; Megestrol; Nandrolone; Norpregnadienes; Pelvic Pain; Quality of Life | 2022 |
68 other study(ies) available for megestrol and nomegestrol acetate
| Article | Year |
|---|---|
Effects of nomegestrol acetate (5 mg/d) on hormonal, metabolic and hemostatic parameters in premenopausal women.
Topics: Adolescent; Adult; Antithrombin III; Apolipoproteins; Blood Glucose; Blood Pressure; Body Weight; Cervix Mucus; Cholesterol; Estradiol; Female; Fibrinogen; Hemostatics; Humans; Insulin; Megestrol; Middle Aged; Norpregnadienes; Ovulation; Plasminogen; Progesterone | 1991 |
Interaction of [3H]nomegestrol acetate with cytosolic progesterone receptors from the rat uterus.
Topics: Animals; Binding, Competitive; Cytosol; Female; Kinetics; Megestrol; Norpregnadienes; Progesterone Congeners; Rats; Receptors, Progesterone; Uterus | 1991 |
Effect of nomegestrol acetate on spinability, ferning and mesh dimension of midcycle cervical mucus.
Topics: Adult; Cervix Mucus; Crystallization; Female; Glycoproteins; Humans; Male; Megestrol; Menstrual Cycle; Microscopy, Electron; Norpregnadienes; Progesterone Congeners; Spermatozoa | 1991 |
Kinetic analysis of the binding of nomegestrol acetate to the progesterone receptors in rat uterus by competition studies.
Topics: Animals; Binding, Competitive; Cytosol; Female; Kinetics; Megestrol; Norpregnadienes; Pregnenediones; Progesterone Congeners; Rats; Receptors, Progesterone; Uterus | 1990 |
Steroid regulation of Na+/K+-ATPase activity in the rat kidney: effect of a new 19-nor-progestagen.
Topics: Adrenalectomy; Animals; Chemical Phenomena; Chemistry; Depression, Chemical; Kidney; Male; Megestrol; Mice; Mice, Inbred Strains; Norpregnadienes; Rats; Sodium-Potassium-Exchanging ATPase | 1986 |
Effect of nomegestrol acetate, a new 19-nor-progesterone derivative, on pituitary-ovarian function in women.
Topics: Adult; Dose-Response Relationship, Drug; Estradiol; Female; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Megestrol; Norpregnadienes; Ovary; Ovulation; Pituitary Gland; Progesterone; Progesterone Congeners | 1987 |
The cellular mechanism of the antiandrogenic action of nomegestrol acetate, a new 19-nor progestagen, on the rat prostate.
Topics: Androgen Antagonists; Animals; Cell Nucleus; Cytosol; Male; Megestrol; Norpregnadienes; Orchiectomy; Progesterone; Progestins; Prostate; Rats; Rats, Inbred Strains; Receptors, Androgen; Testosterone | 1987 |
The pharmacological profile of TX 066 (17 alpha-acetoxy-6-methyl-19-nor-4,6-pregna-diene-3,20-dione), a new oral progestative.
Topics: Adrenal Glands; Androgen Antagonists; Androgens; Animals; Anti-Inflammatory Agents; Estrogens; Female; Fetus; Gonadotropins; Megestrol; Mice; Norpregnadienes; Ovulation; Pregnancy; Progesterone Congeners; Rats; Time Factors; Water-Electrolyte Balance | 1983 |
Nomegestrol acetate, a clinically useful 19-norprogesterone derivative which lacks estrogenic activity.
Topics: Animals; Base Sequence; Binding Sites; Breast Neoplasms; Cell Division; Cell Line; Estradiol; Estradiol Congeners; Estrogen Antagonists; Estrogens; Female; Fulvestrant; Humans; Luciferases; Megestrol; Molecular Sequence Data; Norpregnadienes; Oligodeoxyribonucleotides; Progesterone Congeners; Recombinant Proteins; Structure-Activity Relationship; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Vitellogenins; Xenopus | 1995 |
[Pseudotumoral rectal endometriosis].
Topics: Adult; Barium Sulfate; Combined Modality Therapy; Contrast Media; Endometriosis; Enema; Female; Humans; Megestrol; Norpregnadienes; Radiography; Rectal Diseases; Time Factors | 1995 |
Antiandrogenic properties of nomegestrol acetate.
Topics: Androgen Antagonists; Animals; Cyproterone Acetate; Cytosol; Dose-Response Relationship, Drug; Genitalia, Male; Male; Megestrol; Norethindrone; Norpregnadienes; Organ Size; Progesterone Congeners; Prostate; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Testosterone; Weight Gain | 1995 |
Contraceptive implants.
Topics: Adolescent; Adult; Consumer Behavior; Consumer Product Safety; Contraceptive Agents; Desogestrel; Drug Implants; Female; Humans; Levonorgestrel; Megestrol; Menstruation Disturbances; Norpregnadienes | 1994 |
Inhibition by nomegestrol acetate and other synthetic progestins on proliferation and progesterone receptor content of T47-D human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Humans; Megestrol; Norpregnadienes; Pregnenediones; Progesterone Congeners; Promegestone; Receptors, Progesterone; Tumor Cells, Cultured | 1994 |
Androgen levels in women using a single implant of nomegestrol acetate.
Topics: Acne Vulgaris; Adult; Androgens; Androstenedione; Blood Pressure; Body Weight; Brazil; Drug Implants; Female; Humans; Incidence; Megestrol; Norpregnadienes; Progesterone Congeners; Sex Hormone-Binding Globulin; Testosterone | 1996 |
Effects of an implant of nomegestrol acetate, a 19-nor-progesterone derivative, on thyroid function.
Topics: Adult; Contraceptive Agents, Female; Drug Implants; Female; Humans; Megestrol; Norpregnadienes; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1995 |
Effect of nomegestrol acetate on estrone-sulfatase and 17beta-hydroxysteroid dehydrogenase activities in human breast cancer cells.
Topics: Breast Neoplasms; Female; Humans; Hydroxysteroid Dehydrogenases; Megestrol; Norpregnadienes; Sulfatases; Tumor Cells, Cultured | 1996 |
Temporal relationship between Uniplant insertion and changes in cervical mucus.
Topics: Adult; Capsules; Cervix Mucus; Drug Implants; Estradiol; Female; Humans; Luteinizing Hormone; Male; Megestrol; Norpregnadienes; Ovarian Follicle; Progesterone; Progesterone Congeners; Spermatozoa; Time Factors | 1996 |
Neuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant).
Topics: Adult; Drug Implants; Endocrine Glands; Estradiol; Female; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Megestrol; Neurosecretory Systems; Norpregnadienes; Ovarian Follicle; Ovulation; Time Factors | 1997 |
Effects of nomegestrol acetate on spontaneous and sulprostone-induced uterine contractions in pregnant cynomolgus monkeys monitored by telemetry.
Topics: Abortifacient Agents, Nonsteroidal; Animals; Circadian Rhythm; Dinoprostone; Female; Macaca fascicularis; Megestrol; Norpregnadienes; Pregnancy; Pregnancy, Animal; Progesterone Congeners; Telemetry; Time Factors; Uterine Contraction | 1998 |
Estrogens, progestins, and coronary artery reactivity in atherosclerotic monkeys.
Topics: Acetylcholine; Animals; Coronary Artery Disease; Estrogens; Female; Macaca fascicularis; Male; Medroxyprogesterone Acetate; Megestrol; Norpregnadienes; Premenopause; Progestins; Sex Characteristics; Vasodilation; Vasodilator Agents | 1998 |
Nomegestrol acetate contraceptive implant use by women with sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Biomarkers; Female; Humans; Megestrol; Norpregnadienes; Progesterone Congeners; Prospective Studies | 1998 |
Coadministration of nomegestrol acetate does not diminish the beneficial effects of estradiol on coronary artery dilator responses in nonhuman primates (Macaca fascicularis).
Topics: Acetylcholine; Animals; Blood Flow Velocity; Coronary Angiography; Coronary Circulation; Coronary Vessels; Drug Combinations; Estradiol; Female; Macaca fascicularis; Megestrol; Norpregnadienes; Ovariectomy; Prospective Studies; Ultrasonography; Vasoconstriction; Vasodilation; Vasodilator Agents | 1998 |
[Biological and clinical safety of nomegestrol acetate administered alone then associated in inverse sequence with transdermal 17 beta estradiol, in women at risk of dyslipoproteinemia type IIa].
Topics: Administration, Cutaneous; Adolescent; Adult; Blood Pressure; Contraceptives, Oral, Sequential; Estradiol; Female; Humans; Hyperlipoproteinemia Type II; Megestrol; Middle Aged; Norpregnadienes; Progesterone Congeners | 1998 |
Comparison of two HRT regimens with bimonthly and monthly progestin administration in postmenopause.
Topics: Administration, Cutaneous; Administration, Oral; Cholesterol; Drug Administration Schedule; Endometrium; Estradiol; Estrogen Replacement Therapy; Female; Humans; Megestrol; Middle Aged; Norpregnadienes; Progesterone Congeners; Triglycerides; Ultrasonography; Uterine Hemorrhage | 1999 |
The antigonadotropic activity of a 19-nor-progesterone derivative is exerted both at the hypothalamic and pituitary levels in women.
Topics: Adolescent; Adult; Amenorrhea; Estradiol; Female; Fibrous Dysplasia, Polyostotic; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Humans; Hypothalamus; Luteinizing Hormone; Megestrol; Norpregnadienes; Ovary; Periodicity; Pituitary Gland; Progesterone; Progesterone Congeners; Receptors, Progesterone | 1999 |
Effects of hormone replacement therapy on postmenopausal uterine myoma.
Topics: Estradiol; Female; Hormone Replacement Therapy; Humans; Leiomyoma; Megestrol; Middle Aged; Norpregnadienes; Postmenopause; Prospective Studies; Regional Blood Flow; Ultrasonography; Uterine Neoplasms; Uterus | 2000 |
[Pulmonary lymphangioleiomyomatosis in a menopaused woman].
Topics: Androgen Antagonists; Biopsy; Chylothorax; Cyproterone; Estradiol; Estrogen Replacement Therapy; Female; Follow-Up Studies; Humans; Lung; Lung Neoplasms; Lymphangioleiomyomatosis; Megestrol; Menopause; Middle Aged; Norpregnadienes; Progesterone Congeners; Radiography, Thoracic; Time Factors; Tomography, X-Ray Computed | 2000 |
Reversal effects of nomegestrol acetate on multidrug resistance in adriamycin-resistant MCF7 breast cancer cell line.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Cycle; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Glutathione Transferase; Humans; Megestrol; Norpregnadienes; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2001 |
Carbohydrate metabolism in sickle cell patients using a subdermal implant containing nomegestrol acetate (Uniplant).
Topics: Adult; Anemia, Sickle Cell; Area Under Curve; Blood Glucose; Drug Implants; Female; Glucose; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Insulin; Megestrol; Norpregnadienes; Progesterone Congeners | 2001 |
[Modulation of multiple drug resistance by nomegestrol acetate and droloxifene in K562/A02].
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; DNA Topoisomerases, Type II; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Estrogen Antagonists; Gene Expression; Genes, MDR; Glutathione Transferase; Humans; K562 Cells; Megestrol; Norpregnadienes; RNA, Messenger; Tamoxifen | 1999 |
Inhibitory effect of nomegestrol acetate on steroidogenesis of cultured granulosa cells from rat ovary in vitro.
Topics: Animals; Cell Survival; Cells, Cultured; Estrogens; Female; Follicle Stimulating Hormone; Granulosa Cells; Megestrol; Norpregnadienes; Progesterone; Progesterone Congeners; Rats; Rats, Sprague-Dawley | 2001 |
[Reversal of nomegestrol acetate on multidrug resistance in drug-resistant human breast cancer cell line MCF7/ADR].
Topics: Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Survival; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Immunohistochemistry; Inhibitory Concentration 50; Isoenzymes; Megestrol; Multidrug Resistance-Associated Proteins; Norpregnadienes; Progesterone Congeners; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Verapamil | 2002 |
Effects of progestins of human proliferative endometrium: an in vitro model of potential clinical relevance.
Topics: Adult; Antineoplastic Agents, Hormonal; Biopsy; Cell Division; Cells, Cultured; Endometrium; Female; Glycogen; Humans; Immunohistochemistry; Medroxyprogesterone Acetate; Megestrol; Middle Aged; Norethindrone; Norethindrone Acetate; Norpregnadienes; Progesterone Congeners; Progestins; Receptors, Estradiol; Receptors, Progesterone; Time Factors | 2003 |
Serum immunoglobulins, total protein and albumin levels during UniplantR use by Nigerian women.
Topics: Adult; Blood Proteins; Contraceptive Agents, Female; Drug Implants; Female; Humans; Immunoglobulins; Megestrol; Nigeria; Norpregnadienes; Progesterone Congeners; Serum Albumin; Time Factors | 2001 |
Nomegestrol acetate: a progestin that deserves recognition.
Topics: Breast Neoplasms; Cell Line, Tumor; Humans; Megestrol; Norpregnadienes; Progesterone Congeners | 2004 |
Activation of nitric oxide synthesis in human endothelial cells using nomegestrol acetate.
Topics: Cells, Cultured; Contraceptive Agents, Female; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelial Cells; Estradiol; Humans; Medroxyprogesterone Acetate; Megestrol; Mifepristone; Nitric Oxide; Nitric Oxide Synthase; Norpregnadienes; Progesterone; Progesterone Congeners; Signal Transduction | 2006 |
[Evaluation of the climacteric symptomatology modifications and clinical-instrumental parameters in women in physiological menopause treated with hormone replacement therapy with nomegestrol acetate and in surgical menopause treated with estrogen replacem
Topics: Adult; Climacteric; Drug Therapy, Combination; Endometrium; Estradiol; Estrogen Replacement Therapy; Female; Follow-Up Studies; Humans; Megestrol; Menopause; Middle Aged; Norpregnadienes; Quality of Life; Treatment Outcome | 2007 |
Letter by Micheletti and Chevallier regarding article, "Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER Study".
Topics: Aged; Clinical Trials as Topic; Confidence Intervals; Estrogen Replacement Therapy; Estrogens; Female; Humans; Megestrol; Middle Aged; Norpregnadienes; Norpregnanes; Odds Ratio; Postmenopause; Progestins; Thromboembolism; Venous Thrombosis | 2007 |
Effects of nomegestrol acetate administration on central and peripheral beta-endorphin and allopregnanolone in ovx rats.
Topics: Animals; beta-Endorphin; Brain; Estradiol; Female; Hippocampus; Hypothalamus; Megestrol; Norpregnadienes; Ovariectomy; Pituitary Gland, Anterior; Pregnanolone; Rats; Rats, Wistar | 2008 |
Certain progestins prevent the enhancing effect of 17beta-estradiol on NO-mediated inhibition of platelet aggregation by endothelial cells.
Topics: Blood Platelets; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Estradiol; GTP Cyclohydrolase; Hormone Antagonists; Humans; Levonorgestrel; Medroxyprogesterone Acetate; Megestrol; Mifepristone; Nitric Oxide; Nitric Oxide Synthase Type III; Norpregnadienes; Platelet Aggregation; Progesterone; Progesterone Congeners; Pterins; Receptors, Glucocorticoid; Receptors, Progesterone; RNA, Messenger; Thrombosis; Time Factors | 2009 |
Multiple sclerosis and progestins: a comment to POPART'MUS.
Topics: Humans; Megestrol; Multiple Sclerosis; Norpregnadienes; Postpartum Period; Progesterone Congeners; Secondary Prevention | 2011 |
Nomegestrol acetate sequentially or continuously combined to estradiol did not negatively affect membrane-receptor associated progestogenic effects in human breast cancer cells.
Topics: Breast; Breast Neoplasms; Cell Proliferation; Contraceptives, Oral, Hormonal; Female; Humans; MCF-7 Cells; Megestrol; Membrane Proteins; Norpregnadienes; Receptors, Progesterone; Steroids | 2012 |
[Oral combined hormonal contraception containing nomegestrol acetate and 17beta-oestradiol--the statement of Polish Gynecological Society Experts Group].
Topics: Adult; Contraceptives, Oral, Combined; Contraceptives, Oral, Synthetic; Estradiol; Female; Gynecology; Humans; Inservice Training; Megestrol; National Health Programs; Norpregnadienes; Obstetrics; Ovulation; Poland; Practice Guidelines as Topic; Young Adult | 2012 |
Pharmacokinetic profile of nomegestrol acetate and 17β-estradiol after multiple and single dosing in healthy women.
Topics: Adolescent; Adult; Biological Availability; Contraceptives, Oral, Combined; Estradiol; Estrone; Female; Humans; Megestrol; Middle Aged; Norpregnadienes | 2013 |
Nomegestrol acetate/estradiol: in oral contraception.
Topics: Acne Vulgaris; Adolescent; Adult; Androstenes; Contraceptives, Oral, Combined; Drug Therapy, Combination; Estradiol; Estrogens; Ethinyl Estradiol; Female; Humans; Megestrol; Menstrual Cycle; Middle Aged; Norpregnadienes; Pregnancy; Progesterone Congeners; Randomized Controlled Trials as Topic; Young Adult | 2012 |
Effects of estroprogestins containing natural estrogen on vaginal flora.
Topics: Adolescent; Adult; Drug Combinations; Estradiol; Female; Humans; Megestrol; Middle Aged; Nandrolone; Norpregnadienes; Prospective Studies; Vagina; Young Adult | 2014 |
Pharmacokinetics, tissue distribution, and excretion of nomegestrol acetate in female rats.
Topics: Animals; Bile; Feces; Female; Liver; Megestrol; Norpregnadienes; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2015 |
Evaluation of biodegradable microspheres containing nomegestrol acetate in a rat model of endometriosis.
Topics: Alanine Transaminase; Animals; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Disease Models, Animal; Endometriosis; Estradiol; Estrogen Receptor alpha; Female; Glutamyl Aminopeptidase; Liver Function Tests; Megestrol; Microspheres; Norpregnadienes; Progesterone; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Triiodothyronine | 2014 |
Effect of oral contraceptives containing estradiol and nomegestrol acetate or ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea.
Topics: Adult; Chlormadinone Acetate; Contraceptives, Oral, Hormonal; Drug Combinations; Dysmenorrhea; Estradiol; Ethinyl Estradiol; Female; Humans; Megestrol; Norpregnadienes; Prospective Studies; Quality of Life; Treatment Outcome; Young Adult | 2015 |
Fourth-Generation Progestins Inhibit 3β-Hydroxysteroid Dehydrogenase Type 2 and Modulate the Biosynthesis of Endogenous Steroids.
Topics: 17-Hydroxysteroid Dehydrogenases; Androstenes; Animals; Cell Line, Tumor; Cell Survival; Chlorocebus aethiops; Chromatography, Liquid; COS Cells; Gene Expression Regulation, Enzymologic; Humans; Megestrol; Norpregnadienes; Norprogesterones; Progestins; Steroids; Tandem Mass Spectrometry | 2016 |
The sexuological impact of hormonal contraceptives based on their route of administration.
Topics: Adult; Clitoris; Contraceptive Agents, Female; Contraceptive Devices, Female; Contraceptives, Oral, Combined; Contraceptives, Oral, Hormonal; Delayed-Action Preparations; Desogestrel; Dose-Response Relationship, Drug; Drug Implants; Estrogens; Female; Humans; Italy; Megestrol; Norpregnadienes; Orgasm; Progestins; Regional Blood Flow; Self Report; Sexual Behavior; Ultrasonography, Doppler; Young Adult | 2017 |
Improvement of Low Sexual Desire Due to Antiandrogenic Combined Oral Contraceptives After Switching to an Oral Contraceptive Containing 17β-Estradiol.
Topics: Adult; Androgen Antagonists; Contraceptives, Oral, Combined; Contraceptives, Oral, Synthetic; Estradiol; Ethinyl Estradiol; Female; Humans; Libido; Megestrol; Norpregnadienes; Prospective Studies; Sex Hormone-Binding Globulin; Sexual Dysfunction, Physiological; Surveys and Questionnaires; Testosterone; Treatment Outcome; Young Adult | 2017 |
Body composition and psychological improvement in healthy premenopausal women assuming the oral contraceptive containing micronized estradiol (E2) and nomegestrol acetate (NOMAC).
Topics: Adolescent; Adult; Anthropometry; Body Composition; Contraceptives, Oral, Hormonal; Dysmenorrhea; Emotions; Estradiol; Female; Humans; Megestrol; Norpregnadienes; Psychometrics; Young Adult | 2017 |
Nomegestrol Acetate Suppresses Human Endometrial Cancer RL95-2 Cells Proliferation In Vitro and In Vivo Possibly Related to Upregulating Expression of SUFU and Wnt7a.
Topics: Animals; Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; Endometrium; Female; Gene Expression Regulation, Neoplastic; Humans; Megestrol; Mice, Inbred BALB C; Mice, Nude; Norpregnadienes; Repressor Proteins; Up-Regulation; Wnt Proteins | 2017 |
Biphasic modulation of cAMP levels by the contraceptive nomegestrol acetate. Impact on P-glycoprotein expression and activity in hepatic cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Contraceptive Agents; Cyclic AMP; Dose-Response Relationship, Drug; Gene Expression; Hep G2 Cells; Hepatocytes; Humans; Megestrol; Norpregnadienes | 2018 |
Inhibition of multidrug resistance-associated protein 2 (MRP2) activity by the contraceptive nomegestrol acetate in HepG2 and Caco-2 cells.
Topics: Caco-2 Cells; Cell Survival; Contraceptive Agents; Hep G2 Cells; Humans; Megestrol; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Norpregnadienes | 2018 |
Treatment continuation and satisfaction in women using combined oral contraception with nomegestrol acetate and oestradiol: a multicentre, prospective cohort study (BOLERO).
Topics: Adolescent; Adult; Contraception Behavior; Contraceptives, Oral, Combined; Estradiol; Female; Humans; Megestrol; Menstrual Cycle; Middle Aged; Norpregnadienes; Patient Satisfaction; Prospective Studies; Treatment Adherence and Compliance; Young Adult | 2018 |
Isolation, synthesis, and cytotoxicity evaluation of two impurities in nomegestrol acetate.
Topics: Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Survival; Drug Contamination; Drug Discovery; Humans; Megestrol; Molecular Structure; Norpregnadienes; Progesterone Congeners | 2019 |
Combined hormonal influence of cyproterone acetate and nomegestrol acetate on meningioma: a case report.
Topics: Cyproterone Acetate; Female; Humans; Megestrol; Meningeal Neoplasms; Meningioma; Middle Aged; Norpregnadienes | 2019 |
Spontaneous regression of meningiomas after interruption of nomegestrol acetate: a series of three patients.
Topics: Adult; Aged; Female; Humans; Magnetic Resonance Imaging; Megestrol; Meningeal Neoplasms; Meningioma; Middle Aged; Norpregnadienes; Retrospective Studies; Withholding Treatment | 2019 |
Nomegestrol acetate/17beta-estradiol does not negatively alter the vascular resistance of clitoral arteries: a prospective, exploratory study.
Topics: Adult; Clitoris; Contraceptives, Oral, Hormonal; Estradiol; Female; Humans; Italy; Linear Models; Megestrol; Norpregnadienes; Pilot Projects; Prospective Studies; Ultrasonography, Doppler, Color; Uterine Artery; Vascular Resistance; Young Adult | 2020 |
Metformin Enhances Nomegestrol Acetate Suppressing Growth of Endometrial Cancer Cells and May Correlate to Downregulating mTOR Activity In Vitro and In Vivo.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Endometrial Neoplasms; Estrogen Receptor alpha; Eukaryotic Initiation Factor-4G; Female; Humans; Megestrol; Metformin; Mice, Nude; Norpregnadienes; Phosphorylation; Receptors, Progesterone; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2019 |
Estradiol/nomegestrol acetate as a first-line and rescue therapy for the treatment of ovarian and deep infiltrating endometriosis.
Topics: Adult; Cohort Studies; Contraceptives, Oral, Combined; Drug Combinations; Endometriosis; Estradiol; Estrogens; Female; Humans; Megestrol; Middle Aged; Norpregnadienes; Ovarian Diseases; Pain Measurement; Pelvic Pain; Progesterone Congeners; Retrospective Studies; Ultrasonography; Young Adult | 2021 |
Preliminary report of patients with meningiomas exposed to Cyproterone Acetate, Nomegestrol Acetate and Chlormadinone Acetate - Monocentric ongoing study on progestin related meningiomas.
Topics: Adult; Aged; Chlormadinone Acetate; Cyproterone Acetate; Female; Humans; Magnetic Resonance Imaging; Male; Megestrol; Meningeal Neoplasms; Meningioma; Middle Aged; Norpregnadienes; Retrospective Studies | 2021 |
Pilot Data on the Feasibility And Clinical Outcomes of a Nomegestrol Acetate Oral Contraceptive Pill in Women With Premenstrual Dysphoric Disorder.
Topics: Administration, Oral; Adult; Australia; Contraceptives, Oral, Combined; Feasibility Studies; Female; Follow-Up Studies; Humans; Megestrol; Middle Aged; Mood Disorders; Norpregnadienes; Pilot Projects; Premenstrual Dysphoric Disorder; Prognosis | 2021 |
Prospective controlled cohort study on the safety of a monophasic oral contraceptive containing nomegestrol acetate (2.5mg) and 17β-oestradiol (1.5mg) (PRO-E2 study): risk of venous and arterial thromboembolism.
Topics: Adult; Cohort Studies; Contraceptives, Oral, Combined; Estradiol; Ethinyl Estradiol; Female; Humans; Megestrol; Norpregnadienes; Prospective Studies; Venous Thromboembolism; Young Adult | 2021 |
Unintended pregnancy in users of nomegestrol acetate and 17β-oestradiol (NOMAC-E2) compared with levonorgestrel-containing combined oral contraceptives: final results from the PRO-E2 study.
Topics: Contraceptives, Oral, Combined; Estradiol; Ethinyl Estradiol; Female; Humans; Levonorgestrel; Megestrol; Norpregnadienes; Pregnancy; Pregnancy, Unplanned | 2021 |
Nomegestrol acetate for symptomatic endometriosis and meningioma risk: understandable statistics for decision-making.
Topics: Endometriosis; Female; Humans; Megestrol; Meningeal Neoplasms; Meningioma; Norpregnadienes | 2023 |