mefloquine-sulfadoxine-pyrimethamine has been researched along with pyrimethamine in 39 studies
| Studies (mefloquine-sulfadoxine-pyrimethamine) | Trials (mefloquine-sulfadoxine-pyrimethamine) | Recent Studies (post-2010) (mefloquine-sulfadoxine-pyrimethamine) | Studies (pyrimethamine) | Trials (pyrimethamine) | Recent Studies (post-2010) (pyrimethamine) |
|---|---|---|---|---|---|
| 43 | 20 | 0 | 5,088 | 738 | 1,047 |
| Protein | Taxonomy | mefloquine-sulfadoxine-pyrimethamine (IC50) | pyrimethamine (IC50) |
|---|---|---|---|
| Dihydrofolate reductase | Homo sapiens (human) | 3.1057 | |
| Dihydrofolate reductase | Bos taurus (cattle) | 0.1007 | |
| Beta-hexosaminidase subunit alpha | Homo sapiens (human) | 6.8333 | |
| Beta-hexosaminidase subunit beta | Homo sapiens (human) | 6.4 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 4.3 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | 0.0609 | |
| Dihydrofolate reductase | Pneumocystis carinii | 3.25 | |
| Dihydrofolate reductase | Candida albicans | 5 | |
| Low molecular weight phosphotyrosine protein phosphatase | Homo sapiens (human) | 15.615 | |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | 0.39 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | 0.3217 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum 3D7 | 2.48 | |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | 2.0727 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (46.15) | 18.7374 |
| 1990's | 19 (48.72) | 18.2507 |
| 2000's | 2 (5.13) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bunnag, D; Chindanond, D; Chittamas, S; Fernex, M; Harinasuta, T; Kristiansen, S; Malikul, S; Mittelholzer, ML; Sturchler, D | 1 |
| Adio, RA; Dickschat, U; Mittelholzer, ML; Reber-Liske, R; Salako, LA; Sowunmi, A; Stürchler, D; Walker, O | 1 |
| Bunnag, D; Chitamas, S; Harinasuta, T; Karbwang, J; Viravan, C | 1 |
| Chongsuphajaisiddhi, T; Frejacques, L; Luxemburger, C; Nosten, F; ter Kuiile, F; White, NJ | 1 |
| Holdener, F; Nurminen, L; Steffen, R; Wyss, R | 1 |
| Chongsuphajaisiddhi, T; Edstein, MD; Lika, ID; Sabchareon, A; Webster, HK | 1 |
| Malikul, S; Pinichpongse, S; Rooney, W; Tansophalaks, S; Thimasarn, K | 1 |
| Eberlé, F; Gazin, P; Gelas, H; Hengy, C; Jambou, R; Kouka-Bemba, D | 1 |
| Karbwang, J; White, NJ | 1 |
| Cappelletti, G; Guenzi, A; Scala, A; Zanetti, M | 1 |
| Prociv, P | 1 |
| Aina Adio, R; Fadeke Aderounmu, A; Laoye, AJ; Modupe Makinde, J; Salako, LA | 1 |
| Kollaritsch, H; Kollaritsch, R; Kremsner, P; Leimer, R; Mailer, H; Stemberger, H; Wiedermann, G | 1 |
| Hlaing, N; Lasserre, R; Tin, F; Tun, T; Win, S | 1 |
| Kharazmi, A; Nielsen, H | 1 |
| Fernex, M | 1 |
| Beeching, NJ; Eales, M; Ellis-Pegler, RB; Fraser, AG; Wells, AU | 1 |
| Aderounmu, AF; Adio, RA; Laoye, JO; Makinde, JM; Salako, LA | 1 |
| Arnold, K; Chen, PQ; Fu, LC; Guo, XB; Li, GQ | 1 |
| Asthana, OP; Nityanand, S; Tangri, AN | 1 |
| de Souza, JM; Doberstyn, EB; Sheth, UK; Trigg, PI; Wernsdorfer, WH | 1 |
| Bunnag, D; Charoenlarp, P; Chitamas, S; Harinasuta, T; Sheth, UK; Suntharasmai, P; Vanijanond, S; Wernsdorfer, WH | 1 |
| Ekue, JM; Mukunyandela, M; Phiri, DE; Sheth, UK | 1 |
| Heizmann, P; Mimica, I; Portmann, R; Schwartz, DE; Weidekamm, E | 1 |
| Dubach, UC; Schwartz, DE; Weber, B; Weidekamm, E | 1 |
| Danis, M; Félix, H; Rosenheim, M | 1 |
| Cavalcante, EQ; de Oliveira, RM; de Souza, JM; Gomes, AT; Sheth, UK | 1 |
| Duong, TH; Igwangou, P; Kombila, M; Ngou-Milama, E; Ozouaki, P | 1 |
| Chatnugrob, P; Eamsila, C; Lasserre, R; Mittelholzer, ML; Nopavong Na Ayuthya, A; Singharaj, P; Stürchler, D; Webster, HK; Yooyen, P | 1 |
| Bangchang, KN; Bunnag, D; Harinasuta, T; Karbwang, J; Rooney, W; Thimasarn, K | 1 |
| Banmairuroi, V; Bunnag, D; Harinasuta, T; Karbwang, J; Na Bangchang, K | 1 |
| Mittelholzer, ML; Stürchler, D | 1 |
| Schubarth, P | 1 |
| Laomiphol, A; Palananth, C; Rooney, W; Sirichaisinthop, J; Tansophalaks, S; Tháithong, S; Thamewat, U; Thimasarn, K; Vijaykadga, S; Yamokgul, P | 1 |
| Coppel, RL; Marshall, VM; Tieqiao, W | 1 |
| Alaribe, AA; Chukwuani, CM; Ekanem, OJ; Ezedinachi, EN; Haller, L; Meremikwu, MM; Ojar, EA; Umotong, AB | 1 |
| Granier, H; Laborde, JP; Martin, J; Nicolas, X; Talarmin, F | 1 |
| Shen, WJ; Thiero, M | 1 |
3 review(s) available for mefloquine-sulfadoxine-pyrimethamine and pyrimethamine
| Article | Year |
|---|---|
Clinical pharmacokinetics of mefloquine.
Topics: Animals; Antimalarials; Drug Combinations; Drug Interactions; Humans; Malaria; Mefloquine; Plasmodium falciparum; Pyrimethamine; Sulfadoxine | 1990 |
[Malaria in Switzerland].
Topics: Animals; Antimalarials; Drug Combinations; Drug Resistance; Humans; Malaria; Mefloquine; Plasmodium falciparum; Pyrimethamine; Quinolines; Sulfadoxine; Switzerland | 1988 |
[Malaria: the most important emergency in subjects returning from the tropics].
Topics: Animals; Antimalarials; Chloroquine; Drug Combinations; Emergencies; Humans; Malaria; Malaria, Falciparum; Mefloquine; Plasmodium; Pyrimethamine; Quinidine; Quinine; Sulfadoxine | 1993 |
17 trial(s) available for mefloquine-sulfadoxine-pyrimethamine and pyrimethamine
| Article | Year |
|---|---|
Fansimef for prophylaxis of malaria: a double-blind randomized placebo controlled trial.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Double-Blind Method; Drug Combinations; Humans; Incidence; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Pyrimethamine; Sulfadoxine; Treatment Outcome | 1992 |
Mefloquine-sulphadoxine-pyrimethamine (Fansimef, Roche) in the prophylaxis of Plasmodium falciparum malaria: a double-blind, comparative, placebo-controlled study.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Double-Blind Method; Drug Combinations; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Pyrimethamine; Sulfadoxine | 1992 |
Clinical trials of mefloquine with tetracycline.
Topics: Acute Disease; Adolescent; Adult; Chloroquine; Drug Combinations; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Prospective Studies; Pyrimethamine; Sulfadoxine; Tetracycline | 1992 |
Phase III double-blind comparative study of Fansimef and Lariam for the curative treatment of Plasmodium falciparum infections in Thailand.
Topics: Adult; Animals; Antimalarials; Double-Blind Method; Drug Combinations; Drug Resistance; Female; Follow-Up Studies; Humans; Malaria; Male; Mefloquine; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Thailand | 1990 |
Comparison of the susceptibility of falciparum malaria to mefloquine-sulphadoxine-pyrimethamine and chloroquine in Nigeria.
Topics: Animals; Antimalarials; Child; Chloroquine; Clinical Trials as Topic; Drug Administration Schedule; Drug Combinations; Drug Resistance; Female; Humans; Malaria; Male; Mefloquine; Nigeria; Plasmodium falciparum; Pyrimethamine; Quinolines; Random Allocation; Sulfadoxine; Sulfanilamides | 1988 |
Tolerability of long-term malaria prophylaxis with the combination mefloquine + sulfadoxine + pyrimethamine (Fansimef): results of a double blind field trial versus chloroquine in Nigeria.
Topics: Adolescent; Adult; Animals; Antimalarials; Aspartate Aminotransferases; Blood Cell Count; Child; Chloroquine; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; gamma-Glutamyltransferase; Humans; Malaria; Male; Mefloquine; Middle Aged; Nigeria; Plasmodium falciparum; Pyrimethamine; Quinolines; Random Allocation; Sulfadoxine; Sulfanilamides | 1988 |
Sensitivity of Plasmodium falciparum to mefloquine-sulphadoxine-pyrimethamine (Fansimef) in vivo and to mefloquine alone in vitro in Nigeria.
Topics: Animals; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Evaluation; Drug Resistance; Female; Humans; Malaria; Male; Mefloquine; Nigeria; Plasmodium falciparum; Pyrimethamine; Quinolines; Random Allocation; Sulfadoxine; Sulfanilamides | 1988 |
Double-blind dose finding study of mefloquine-sulfadoxine-pyrimethamine in children with acute falciparum malaria.
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Humans; Malaria; Male; Mefloquine; Plasmodium falciparum; Pyrimethamine; Quinolines; Sulfadoxine; Sulfanilamides | 1988 |
Clinical trial of fansimef in Indian patients of P. falciparum malaria.
Topics: Adolescent; Adult; Animals; Antimalarials; Clinical Trials as Topic; Drug Combinations; Humans; Malaria; Male; Mefloquine; Middle Aged; Plasmodium falciparum; Prospective Studies; Pyrimethamine; Sulfadoxine; Sulfanilamides | 1988 |
A phase II/III double-blind, dose-finding clinical trial of a combination of mefloquine, sulfadoxine, and pyrimethamine (Fansimef) in falciparum malaria.
Topics: Administration, Oral; Adolescent; Adult; Animals; Antimalarials; Brazil; Double-Blind Method; Drug Combinations; Drug Evaluation; Humans; Malaria; Male; Mefloquine; Middle Aged; Plasmodium falciparum; Pyrimethamine; Quinolines; Random Allocation; Sulfadoxine; Sulfanilamides | 1987 |
Mefloquine, sulfadoxine, and pyrimethamine in the treatment of symptomatic falciparum malaria: a double-blind trial for determining the most effective dose.
Topics: Administration, Oral; Adolescent; Adult; Animals; Antimalarials; Double-Blind Method; Drug Combinations; Humans; Malaria; Male; Mefloquine; Plasmodium falciparum; Pyrimethamine; Quinolines; Random Allocation; Sulfadoxine; Sulfanilamides; Thailand | 1987 |
A double-blind trial of a fixed combination of mefloquine plus sulfadoxine-pyrimethamine compared with sulfadoxine-pyrimethamine alone in symptomatic falciparum malaria.
Topics: Administration, Oral; Adolescent; Adult; Animals; Antimalarials; Child; Double-Blind Method; Drug Combinations; Humans; Malaria; Male; Mefloquine; Middle Aged; Plasmodium falciparum; Pyrimethamine; Quinolines; Random Allocation; Sulfadoxine; Sulfanilamides | 1987 |
A phase I clinical trial of Fansimef (mefloquine plus sulfadoxine-pyrimethamine) in Brazilian male subjects.
Topics: Adult; Brazil; Double-Blind Method; Drug Combinations; Drug Evaluation; Humans; Malaria; Male; Mefloquine; Plasmodium falciparum; Pyrimethamine; Quinolines; Random Allocation; Sulfadoxine; Sulfanilamides | 1985 |
Prevention of Plasmodium falciparum malaria by Fansimef and Lariam in the northeastern part of Thailand.
Topics: Adult; Animals; Antibodies, Protozoan; Blood; Chloroquine; Drug Combinations; Humans; Malaria, Falciparum; Male; Mefloquine; Military Personnel; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Thailand | 1993 |
Mefloquine monitoring in acute uncomplicated malaria treated with Fansimef and Lariam.
Topics: Acute Disease; Adolescent; Adult; Antimalarials; Drug Combinations; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Pyrimethamine; Sulfadoxine | 1993 |
In vivo study of the response of Plasmodium falciparum to standard mefloquine/sulfadoxine/pyrimethamine (MSP) treatment among gem miners returning from Cambodia.
Topics: Adult; Animals; Antimalarials; Cambodia; Chi-Square Distribution; Drug Combinations; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Mining; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Thailand; Transients and Migrants | 1995 |
[Coartem and fansimef in the treatment of falciparum malaria].
Topics: Abdominal Pain; Adolescent; Artemether, Lumefantrine Drug Combination; Artemisinins; Child; Child, Preschool; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Female; Fever; Fluorenes; Humans; Malaria, Falciparum; Male; Mali; Mefloquine; Nausea; Pyrimethamine; Skin; Sulfadoxine; Time Factors; Treatment Outcome | 2006 |
19 other study(ies) available for mefloquine-sulfadoxine-pyrimethamine and pyrimethamine
| Article | Year |
|---|---|
Mefloquine plus sulfadoxine and pyrimethamine.
Topics: Animals; Drug Combinations; Drug Resistance; Humans; Malaria; Mefloquine; Plasmodium falciparum; Pyrimethamine; Sulfadoxine | 1991 |
Mefloquine for multidrug-resistant malaria.
Topics: Animals; Antimalarials; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Plasmodium falciparum; Psychoses, Substance-Induced; Pyrimethamine; Refugees; Sulfadoxine | 1991 |
Malaria prophylaxis and self-therapy in airline crews.
Topics: Aerospace Medicine; Africa; Animals; Antimalarials; Culicidae; Drug Combinations; Drug Resistance; Emergencies; Humans; Incidence; Insect Bites and Stings; Malaria; Mefloquine; Patient Compliance; Protective Clothing; Pyrimethamine; Self Medication; Sulfadoxine | 1990 |
Quantitation of Fansimef components (mefloquine + sulfadoxine + pyrimethamine) in human plasma by two high-performance liquid chromatographic methods.
Topics: Antimalarials; Child; Chromatography, High Pressure Liquid; Drug Combinations; Humans; Male; Mefloquine; Pyrimethamine; Sulfadoxine | 1991 |
[Uncomplicated malaria attack in an area with high resistance to chloroquine. 3. The use of second-choice oral drug treatment].
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Female; Humans; Infant; Malaria; Male; Mefloquine; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Sulfanilamides | 1990 |
Simultaneous determination of pyrimethamine and mefloquine in human plasma by high-performance liquid chromatography with ultraviolet detection.
Topics: Antimalarials; Chromatography, High Pressure Liquid; Drug Combinations; Humans; Mefloquine; Pyrimethamine; Spectrophotometry, Ultraviolet; Sulfadoxine | 1989 |
Fansimef in the treatment of malaria.
Topics: Animals; Antimalarials; Drug Combinations; Humans; Malaria; Mefloquine; Plasmodium vivax; Pyrimethamine; Quinolines; Sulfadoxine; Sulfanilamides | 1989 |
Falciparum malaria treated with a fixed combination of mefloquine, sulfadoxine and pyrimethamine: a field study in adults in Burma.
Topics: Adolescent; Adult; Drug Combinations; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Mefloquine; Middle Aged; Myanmar; Plasmodium falciparum; Pyrimethamine; Quinolines; Sulfadoxine; Sulfanilamides | 1985 |
In vitro effect of fansimef on human neutrophil and monocyte function.
Topics: Blood Bactericidal Activity; Chemotaxis; Drug Combinations; Humans; In Vitro Techniques; Luminescent Measurements; Mefloquine; Monocytes; Neutrophils; Nitroblue Tetrazolium; Oxidation-Reduction; Phagocytosis; Pyrimethamine; Quinolines; Sulfadoxine; Sulfanilamides; Superoxides | 1986 |
Fansimef [Fansidar plus mefloquine] is effective treatment for imported malaria in New Zealand.
Topics: Adolescent; Adult; Animals; Child; Drug Combinations; Female; Humans; Malaria; Male; Mefloquine; Plasmodium falciparum; Plasmodium vivax; Pyrimethamine; Quinolines; Sulfadoxine; Sulfanilamides | 1988 |
Multiple-dose pharmacokinetics of the antimalarial drug Fansimef (pyrimethamine + sulfadoxine + mefloquine) in healthy subjects.
Topics: Adult; Antimalarials; Drug Combinations; Female; Half-Life; Humans; Kinetics; Male; Mefloquine; Metabolic Clearance Rate; Middle Aged; Pyrimethamine; Quinolines; Sulfadoxine; Sulfanilamides | 1987 |
Single-dose investigation of possible interactions between the components of the antimalarial combination Fansimef.
Topics: Adult; Antimalarials; Biological Availability; Blood Proteins; Drug Combinations; Drug Interactions; Erythrocytes; Half-Life; Humans; Kinetics; Male; Mefloquine; Middle Aged; Protein Binding; Pyrimethamine; Quinolines; Sulfadoxine; Sulfanilamides | 1987 |
[Making good use of mefloquine].
Topics: Adult; Antimalarials; Child; Drug Combinations; Drug Resistance, Microbial; Humans; Malaria; Mefloquine; Pyrimethamine; Quinolines; Sulfadoxine | 1985 |
[Variation of cholostase enzymes (5'-nucleotidase and alkaline phosphatase) during a specific treatment for malaria in the Gabonese child].
Topics: 5'-Nucleotidase; Alkaline Phosphatase; Antimalarials; Child; Child, Preschool; Drug Combinations; Gabon; Humans; Infant; Malaria; Mefloquine; Phenanthrenes; Pyrimethamine; Reference Values; Sulfadoxine | 1995 |
Mefloquine level monitoring in patients with multidrug resistant Plasmodium falciparum on the Thai Myanmar border.
Topics: Administration, Oral; Adolescent; Adult; Antimalarials; Cambodia; Chromatography, High Pressure Liquid; Drug Combinations; Drug Monitoring; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Primaquine; Pyrimethamine; Sulfadoxine; Thailand; Treatment Outcome | 1993 |
[Emergency treatment of malaria during travel].
Topics: Antimalarials; Drug Combinations; Emergencies; Humans; Malaria; Mefloquine; Patient Education as Topic; Pyrimethamine; Sulfadoxine; Travel | 1993 |
Close linkage of three merozoite surface protein genes on chromosome 2 of Plasmodium falciparum.
Topics: Amino Acid Sequence; Animals; Antibodies, Protozoan; Antigens, Protozoan; Antimalarials; Base Sequence; Chromosomes; DNA, Complementary; DNA, Protozoan; Drug Combinations; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique, Indirect; Genes, Protozoan; Immunoblotting; Mefloquine; Membrane Proteins; Molecular Sequence Data; Plasmodium falciparum; Polymerase Chain Reaction; Protozoan Proteins; Pyrimethamine; Rabbits; Sulfadoxine | 1998 |
Efficacy and tolerability of a low-dose mefloquine-sulfadoxine-pyrimethamine combination compared with chloroquine in the treatment of acute malaria infection in a population with multiple drug-resistant Plasmodium falciparum.
Topics: Adolescent; Adult; Animals; Antimalarials; Blood; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance, Multiple; Female; Humans; Infant; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Nigeria; Plasmodium falciparum; Prospective Studies; Pyrimethamine; Random Allocation; Sulfadoxine | 1999 |
[Danger of malaria self-treatment. Acute neurologic toxicity of mefloquine and its combination with pyrimethamine-sulfadoxine].
Topics: Adult; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Female; Humans; Malaria; Male; Mefloquine; Pyrimethamine; Self Medication; Sulfadoxine | 2001 |