mefloquine hydrochloride and chloroquine

mefloquine hydrochloride has been researched along with chloroquine in 101 studies

Research

Studies (101)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.99)	18.7374
1990's	12 (11.88)	18.2507
2000's	55 (54.46)	29.6817
2010's	30 (29.70)	24.3611
2020's	3 (2.97)	2.80

Authors

Authors	Studies
Adrián, F; Anderson, P; Brinker, A; Caldwell, JS; Chatterjee, A; Gray, NS; Henson, K; Janes, J; Kato, N; Kuhen, K; Matzen, JT; McNamara, C; Nagle, A; Nam, TG; Plouffe, D; Schultz, PG; Trager, R; Winzeler, EA; Yan, SF; Zhou, Y	1
Agnamey, P; Azas, N; Cohen, A; Damiani, C; Dassonville-Klimpt, A; Dormoi, J; Guillon, J; Marchivie, M; Mullié, C; Pradines, B; Schneider, J; Sonnet, P; Taudon, N; Tisnerat, C; Totet, A	1
Angerhofer, CK; König, GM; Pezzuto, JM; Sticher, O; Wright, AD	1
Brossi, A; Buchs, P; Dominguez Gerpe, L; Flippen-Anderson, JL; Luo, XD; Milhous, W; Peters, W; Venugopalan, B; Yeh, HJ	1
Angerhofer, CK; Chai, H; Cordell, GA; Hu, SF; Lin, J; Lin, LZ; Pezzuto, JM; Zaw, K; Zheng, DM	1
Denny, WA; Figgitt, DP; Gamage, SA; Ralph, RK; Tepsiri, N; Wilairat, P; Wojcik, SJ	1
Angerhofer, CK; Chai, H; Cordell, GA; Likhitwitayawuid, K; Pezzuto, JM; Ruangrungsi, N	2
Cabral, JA; McChesney, JD; Milhous, WK	1
Angerhofer, CK; Cordell, GA; Likhitwitayawuid, K; Pezzuto, JM; Ruangrungsi, N	1
Angerhofer, CK; Desqueyroux-Faúndez, R; Greenidge, P; König, GM; Linden, A; Wright, AD	1
Angerhofer, CK; Böhlke, M; Farnsworth, NR; Guinaudeau, H; Mora, GA; Poveda, LJ; Soejarto, DD; Wongpanich, V	1
Angerhofer, C; Arnason, JT; Durst, T; Gbeassor, M; MacKinnon, S; Pezzuto, J; Poveda, LJ; Sanchez-Vindas, PE	1
Cimanga, K; De Bruyne, T; Pieters, L; Turger, CA; Vlietinck, AJ	1
Angerhofer, CK; Cordell, GA; Guinaudeau, H; Pezzuto, JM; Wongpanich, V	1
Berecibar, A; Davioud-Charvet, E; Debreu, MA; Girault, S; Grellier, P; Lemière, P; Maes, L; Mouray, E; Sergheraert, C	1
Angenot, L; Brandt, V; De Pauw, M; DeMol, P; Frédérich, M; Hayette, M; Penelle, J; Prosperi, C; Tits, M	1
Jomaa, H; Mitsch, A; Schlitzer, M; Wiesner, J; Wissner, P	1
Bosisio, E; Cabalion, P; Dell'Agli, M; Giolito, A; Guerrini, M; Verotta, L	1
Ayad, F; Deady, LW; Tilley, L	1
Angerhofer, CK; Cordell, GA; Han, J; Kim, SU; Lee, JG; Min, SS; Park, SH	1
Kyle, DE; Milhous, WK; Riel, MA	1
Gerena, L; Milhous, WK; Opsenica, D; Pocsfalvi, G; Solaja, BA; Terzić, N; Tinant, B	1
Ager, A; Alvim-Gaston, M; Avery, MA; Charman, W; Peters, W; Robinson, BL; Vroman, JA; Wu, B	1
Avery, MA; Bandyopadhyaya, AK; Desai, PV; Furtado, MM; Muraleedharan, KM; Tekwani, BL	1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD	1
Bhattacharjee, AK; Geyer, JA; Kathcart, AK; Li, Z; Mott, BT; Nichols, DA; Prigge, ST; Waters, NC; Woodard, CL	1
Brun, R; El-Idreesy, TT; Griesbeck, AG; Höinck, LO; Lex, J	1
Bauer, KD; Bendale, P; Buckner, FS; Chakrabarti, D; Floyd, D; Gelb, MH; Hamilton, A; Hornéy, CP; Lombardo, LJ; Nallan, L; Pendyala, PR; Rivas, K; Sebti, S; Van Voorhis, WC; Weber, PC; Williams, DK; Windsor, WT; Yokoyama, K	1
Ager, A; Ellis, W; Guan, J; Kyle, D; Lin, AJ; Milhous, W; Sacci, J; Zhang, Q	1
Bohle, DS; Fotie, J; Georges, E; Leimanis, ML; Nkengfack, AE; Rukunga, G	1
Malik, H; Puri, SK; Singh, C	1
Angelovski, G; Diaz, DS; Doković, D; Eilbracht, P; Juranić, Z; Lehnig, M; Milhous, WK; Opsenica, D; Opsenica, I; Smith, KS; Smith, PL; Solaja, BA; Terzić, N; Tinant, B; Yang, YS	1
Berger, H; Brun, R; Kaiser, M; Saf, R; Seebacher, W; Weis, R	2
Angerhofer, CK; de Nys, R; Gurrath, M; Pezzuto, JM; Wright, AD	1
Andrews, KT; Gardiner, DL; McCarthy, J; Melville, L; Skinner-Adams, TS	1
Harada, S; Huy, NT; Kamei, K; Maeda, A; Oida, T; Trang, DT; Uyen, DT	1
Fukuda, M; Jongsakul, K; Knirsch, C; Krudsood, S; Leowattana, W; Looareesuwan, S; Miller, RS; Noedl, H; Ohrt, C; Sriwichai, S; Tangpukdee, N; Thanachartwet, W; Yingyuen, K	1
Baniecki, ML; Clardy, J; Wirth, DF	1
Dennull, RA; Gerena, L; Johnson, JD; Lopez-Sanchez, M; Roncal, NE; Waters, NC	1
Adagu, IS; Fivelman, QL; Warhurst, DC	1
Brun, R; Kaiser, M; Saf, R; Schlapper, C; Seebacher, W; Weis, R	1
Brun, R; de Koning, HP; Gould, M; Kaiser, M; Koomen, GJ; Rodenko, B; van der Burg, AM; Wanner, MJ	1
Milhous, WK; Milić, D; Opsenica, D; Smith, KS; Solaja, BA; Terzić, N; Tinant, B	1
Dodean, RA; Gard, GL; Kelly, JX; Peyton, D; Riscoe, MK; Winter, RW	1
Anstey, NM; Brockman, A; Chalfein, F; Cheng, Q; Kenangalem, E; Piera, K; Prasetyorini, B; Prayoga, P; Price, RN; Russell, B; Sugiarto, P; Suwanarusk, R; Tjitra, E	1
Becker, K; Davioud-Charvet, E; Friebolin, W; Furrer, J; Jannack, B; Lanzer, M; Oeser, T; Sanchez, CP; Wenzel, N; Yardley, V	1
Fitos, I; Mády, G; Visy, J; Zsila, F	1
Egan, TJ; Hoppe, HC; Joiner, KA; Roberts, L	1
Milhous, WK; Opsenica, D; Opsenica, I; Smith, KS; Solaja, BA	1
Andrews, KT; Anstey, NM; Boonma, P; Gardiner, DL; Lek-Uthai, U; Machunter, B; McCarthy, JS; Nosten, F; Piera, KA; Price, RN; Ruengweerayut, R; Russell, B; Skinner-Adams, TS; Suwanarusk, R	1
Billadeau, DD; Chen, Y; Dow, GS; Kozikowski, AP; Lopez-Sanchez, M; Savoy, DN	1
Anova, L; Opsenica, DM; Smith, KS; Smith, PL; Solaja, BA; Terzić, N; Yang, Y	1
Bavari, S; Burnett, JC; Gussio, R; Milhous, WK; Nuss, J; Opsenica, D; Opsenica, I; Smith, KS; Solaja, BA; Terzić, N	1
Castanys, S; Castanys-Muñoz, E; Gamarro, F; Pérez-Victoria, JM	1
Andrews, KT; Caridha, D; Chen, Y; Dow, GS; Gerena, L; Gettayacamin, M; Johnson, J; Kozikowski, AP; Li, Q; Melendez, V; Obaldia, N; Tran, TN	1
Anova, L; Lanteri, CA; Milhous, WK; Opsenica, D; Opsenica, I; Smith, KS; Solaja, BA	1
Anstey, NM; Chalfien, F; Hasugian, AR; Kenangalem, E; Marfurt, J; Penttinen, PM; Piera, KA; Price, RN; Purba, HL; Ratcliff, A; Russell, B; Siswantoro, H; Tjitra, E; Wuwung, RM	1
Borne, RF; Khan, MO; Khan, SI; Kimura, E; Levi, MS; Tekwani, BL	1
Bambal, RB; Bates, M; Berry, N; Biagini, GA; Bonar-Law, R; Bray, PG; Brigandi, RA; Davis, CB; Gargallo, DV; Gibbons, P; Gomez-delas-Heras, FM; Gresham, SL; Hart, TK; Hindley, S; Lawrence, RM; Maggs, JL; Mukhtar, A; O'Neill, PM; Park, BK; Roberts, P; Shone, AE; Stocks, PA; Ward, SA; Winstanley, PA	1
Bacon, DJ; Escalante, AA; Griffing, SM; Haley, R; Lucas, C; McCollum, AM; Salas, C; Santolalla, M; Soberon, V; Tsukayama, P; Udhayakumar, V	1
Asadollahy, E; Bambal, RB; Bates, M; Berry, N; Biagini, G; Bray, PG; Brigandi, RA; Davies, J; Davis, CB; Gargallo, DV; Gomez-de-Las-Heras, FM; Gresham, SL; Hall, C; Hindley, S; Lander, H; Maggs, JL; Nixon, G; O'Neill, PM; Parapini, S; Park, BK; Rimmer, K; Roberts, P; Shone, AE; Stanford, D; Stocks, PA; Taramelli, D; Vivas, L; Ward, SA; Winstanley, PA	1
Baniecki, ML; Clardy, J; Cortese, JF; Mazitschek, R; Rush, MA; Wiegand, R; Wirth, DF	1
Almeras, L; Amalvict, R; Baret, E; Briolant, S; Fusaï, T; Henry, M; Parquet, V; Pradines, B; Rogier, C; Torrentino-Madamet, M	1
Masseno, V; Muriithi, S; Nzila, A	1
Fuehrer, HP; Haque, R; Hofecker, V; Khan, WA; Ley, B; Noedl, H; Siedl, A; Starzengruber, P; Thriemer, K; Wernsdorfer, WH	1
Grimberg, BT; Hough, LB; Jaworska, MM; Phillips, JG; Zimmerman, PA	1
Andrianaranjaka, V; Andriantsoanirina, V; Bouchier, C; Durand, R; Jahevitra, M; Ménard, D; Mercereau-Puijalon, O; Rabarijaona, LP; Rabearimanana, S; Radrianjafy, R; Randriantsoa, T; Rason, MA; Ratsimbasoa, A; Tichit, M	1
Brun, R; Charman, SA; Charman, WN; Chollet, J; Creek, DJ; Dong, Y; Dorn, A; Koltun, M; Matile, H; Morizzi, J; Padmanilayam, M; Santo Tomas, J; Scheurer, C; Snyder, C; Sriraghavan, K; Tang, Y; Urwyler, H; Vennerstrom, JL; Wang, X; Wittlin, S	1
Charman, SA; Charman, WN; Chiu, FC; Chollet, J; Dong, Y; Dorn, A; Johnson, LM; Matile, H; Morizzi, J; Scheurer, C; Snyder, C; Tang, Y; Tomas, JS; Urwyler, H; Vennerstrom, JL; Wittlin, S; Zhou, L	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Connelly, MC; Guiguemde, WA; Guy, RK; Nwaka, S; Sigal, M; Zhang, Y; Zhu, F	1
Datti, A; Liang, M; Pillai, DR; Shahinas, D	1
Brun, R; Chitnumsub, P; Dartois, V; Diagana, TT; Goh, A; Kamchonwongpaisan, S; Keller, TH; Kiara, SM; Lakshminarayana, SB; Ma, NL; Maneeruttanarungroj, C; Nzila, A; Rottmann, M; Taweechai, S; Weaver, M; Wittlin, S; Wong, J; Yeung, BK; Yuthavong, Y; Zou, B	1
Biagini, GA; Chandramohanadas, R; Darling, C; DeGrado, WF; Diamond, SL; Fisher, N; Greenbaum, DC; Jing, H; Jo, H; Lucumi, E; Napper, AD; Shone, AE; Ward, SA	1
Beck, HP; Brun, R; Cohen, SB; Dartois, V; Dharia, NV; Diagana, TT; Fidock, DA; Goh, A; González-Páez, GE; Jegla, T; Keller, TH; Lakshminarayana, SB; Lee, MC; McNamara, C; Nosten, F; Plouffe, DM; Renia, L; Rottmann, M; Russell, B; Schmitt, EK; Seitz, P; Spencer, KR; Suwanarusk, R; Tan, J; Winzeler, EA; Yeung, BK; Zou, B	1
Anstey, NM; Chalfein, F; Kenangalem, E; Marfurt, J; Piera, KA; Price, RN; Russell, B; Tjitra, E	1
Anstey, NM; Chalfein, F; Ebsworth, EP; Kenangalem, E; Marfurt, J; Piera, KA; Prasetyorini, B; Price, RN; Ratcliff, A; Russell, B; Siswantoro, H; Tjitra, E; Wuwung, M	1
Haiech, J; Hibert, M; Kellenberger, E; Kuhn, I; Lobstein, A; Muller-Steffner, H; Rognan, D; Said-Hassane, F; Schuber, F; Villa, P	1
Andrews, KT; Anstey, NM; Chalfein, F; Fairlie, DP; Kenangalem, E; Marfurt, J; Piera, KA; Prayoga, P; Price, RN; Tjitra, E; Wabiser, F	1
Bhattacharjee, AK; Gerena, L; Gutteridge, CE; Hoffman, MM; Milhous, WK	1
Sen, S; Sinha, N	1
Carvalho, L; Castanys, S; Gamarro, F; Manzano, JI; Pérez-Victoria, JM	1
Basilico, N; Bavari, S; Burnett, JC; Gettayacamin, M; Gussio, R; Lanteri, CA; Nuss, JE; Opsenica, D; Opsenica, I; Panchal, RG; Sciotti, RJ; Solaja, BA; Taramelli, D; Todorović, N; Wanner, L	1
Bathurst, I; Buckner, FS; Burrows, J; Charman, SA; Charman, WN; Creason, S; Deng, X; El Mazouni, F; Floyd, DM; Gujjar, R; Matthews, D; Phillips, MA; Rathod, PK; Shackleford, DM; White, J; White, KL	1
Charman, SA; Chibale, K; Fakorede, F; Gessner, RK; Gitari, PW; Hudson, A; Kaiser, M; Ndakala, AJ; October, N; Shackleford, DM; White, KL; Yeates, C	1
Ang, HQ; Borboa, R; Brun, R; Caldwell, C; Chang, J; Chatterjee, AK; Chen, Z; Dartois, V; Diagana, T; Ek, J; Fischli, C; Francek, C; Gagaring, K; Glynne, R; Goh, A; Hollenbeck, T; Isbell, J; Kang, ML; Keller, T; Kuhen, K; Lakshminarayana, SB; Li, C; Lin, X; Liu, F; Nagle, A; Plouffe, D; Rottmann, M; Skolnik, S; Tan, M; Tan, W; Tully, DC; Tuntland, T; Wang, J; Winzeler, E; Wu, J; Wu, T; Ye, N; Zeng, P	1
Auschwitz, J; Bathurst, I; Caridha, D; Dow, G; Gardner, S; Gerena, L; Gettayacamin, M; Grauer, K; Johnson, J; Kozar, M; Lee, P; Leed, S; Li, Q; McCalmont, W; Melendez, V; Milner, E; Moon, J; Roncal, N; Sciotti, R; Smith, B; Sousa, J; Tungtaeng, A; Wipf, P	1
de Azevedo, WF; de Menezes, MN; Krettli, AU; Ribeiro dos Santos, R; Ribeiro, IM; Sá, MS; Soares, MB; Tomassini, TC	1
Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y	1
Chandrashekar, G; Chatterji, D; Meng, L; Robinson, K; Zhu, S	1
Akala, HM; Alao, JP; Ekberg, A; Endale, M; Erdélyi, M; Sunnerhagen, P; Yenesew, A	1
Campbell, M; Charman, SA; Gilbert, IH; Hudson, A; Kaiser, M; Katneni, K; Mital, A; Morizzi, J; Murugesan, D; Shackleford, DM; Yeates, C	1
Akala, H; Manguro, LA; Ochieng, CO; Owuor, PO	1
de Dios, A; Gorka, AP; Roepe, PD	1
Caridha, D; Gerena, L; Korotchenko, V; Kreishman-Deitrick, M; Li, Q; Lin, AJ; Sathunuru, R; Smith, PL	1
Aroonkit, P; Krajangsri, S; Mungthin, M; Ruchirawat, S; Thongsornkleeb, C; Tummatorn, J	1
Djurković-Djaković, O; Opsenica, IM; Pybus, BS; Sciotti, RJ; Slavić, K; Šolaja, BA; Tot, M; Verbić, TŽ	1
Byun, SY; Choi, I; Jeon, S; Kim, S; Ko, M; Lee, J; Park, S; Shum, D	1
Easwaran, M; Manickam, M; Pillaiyar, T; Wendt, LL	1

Reviews

3 review(s) available for mefloquine hydrochloride and chloroquine

Article	Year
Antimalarial activity: the search for marine-derived natural products with selective antimalarial activity. Journal of natural products, 1996, Volume: 59, Issue:7 Topics: Animals; Antimalarials; Magnetic Resonance Spectroscopy; Marine Toxins; Plants; Plasmodium; Porifera; Rhodophyta; Structure-Activity Relationship	1996
Quinoline drug-heme interactions and implications for antimalarial cytostatic versus cytocidal activities. Journal of medicinal chemistry, 2013, Jul-11, Volume: 56, Issue:13 Topics: Antimalarials; Crystallization; Drug Resistance; Heme; Hemeproteins; Humans; Malaria, Falciparum; Molecular Structure; Plasmodium falciparum; Quinolines	2013
The recent outbreaks of human coronaviruses: A medicinal chemistry perspective. Medicinal research reviews, 2021, Volume: 41, Issue:1 Topics: Antiviral Agents; Chemistry, Pharmaceutical; COVID-19; Disease Outbreaks; Drug Repositioning; Humans; Virus Internalization	2021

Other Studies

98 other study(ies) available for mefloquine hydrochloride and chloroquine

Article	Year
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proceedings of the National Academy of Sciences of the United States of America, 2008, Jul-01, Volume: 105, Issue:26 Topics: Animals; Antimalarials; Cluster Analysis; Computational Biology; Drug Evaluation, Preclinical; Drug Resistance; Folic Acid Antagonists; Malaria; Models, Molecular; Parasites; Plasmodium falciparum; Reproducibility of Results; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase	2008
Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity. European journal of medicinal chemistry, 2022, Jan-15, Volume: 228 Topics: Amino Alcohols; Animals; Antimalarials; Cell Line; Cricetulus; Dose-Response Relationship, Drug; Drug Design; Ether-A-Go-Go Potassium Channels; Female; Humans; Malaria; Mice; Mice, Inbred BALB C; Microsomes, Liver; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Structure-Activity Relationship	2022
Antimalarial activity of sesquiterpenes from the marine sponge Acanthella klethra. Journal of natural products, 1992, Volume: 55, Issue:12 Topics: Animals; Antimalarials; Cell Survival; Humans; KB Cells; Plasmodium falciparum; Porifera; Sesquiterpenes	1992
Arteether, a new antimalarial drug: synthesis and antimalarial properties. Journal of medicinal chemistry, 1988, Volume: 31, Issue:3 Topics: Animals; Antimalarials; Artemisinins; Magnetic Resonance Spectroscopy; Malaria; Mice; Models, Molecular; Plasmodium berghei; Plasmodium falciparum; Sesquiterpenes	1988
Thalifaberidine, a cytotoxic aporphine-benzylisoquinoline alkaloid from Thalictrum faberi. Journal of natural products, 1994, Volume: 57, Issue:10 Topics: Alkaloids; Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Aporphines; Drugs, Chinese Herbal; HIV; Humans; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Mice; Reverse Transcriptase Inhibitors; Tumor Cells, Cultured	1994
Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum. Journal of medicinal chemistry, 1994, May-13, Volume: 37, Issue:10 Topics: Aminoacridines; Animals; Antimalarials; Cell Division; Cells, Cultured; Drug Resistance; Erythrocytes; Humans; Plasmodium falciparum; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tumor Cells, Cultured	1994
Cytotoxic and antimalarial alkaloids from the bulbs of Crinum amabile. Journal of natural products, 1993, Volume: 56, Issue:8 Topics: Alkaloids; Amaryllidaceae Alkaloids; Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Magnetic Resonance Spectroscopy; Phenanthridines; Plants, Medicinal; Plasmodium falciparum; Spectrophotometry, Ultraviolet	1993
Cytotoxic and antimalarial alkaloids from the tubers of Stephania pierrei. Journal of natural products, 1993, Volume: 56, Issue:9 Topics: Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Aporphines; Drug Screening Assays, Antitumor; Glucosides; Isoquinolines; Magnetic Resonance Spectroscopy; Molecular Weight; Plants, Medicinal; Plasmodium falciparum; Species Specificity	1993
A new antimalarial quassinoid from Simaba guianensis. Journal of natural products, 1993, Volume: 56, Issue:11 Topics: Animals; Antimalarials; Brazil; Bridged Bicyclo Compounds; Chromatography, Thin Layer; Glaucarubin; Magnetic Resonance Spectroscopy; Plant Extracts; Plants, Medicinal; Plasmodium falciparum; Quassins; Spectrophotometry, Ultraviolet	1993
Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Stephania erecta. Journal of natural products, 1993, Volume: 56, Issue:1 Topics: Alkaloids; Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Benzylisoquinolines; Cell Survival; Drug Screening Assays, Antitumor; Erythrocytes; Female; Humans; In Vitro Techniques; Male; Mice; Plants, Medicinal; Plasmodium falciparum; Thailand; Tumor Cells, Cultured	1993
Costaricine, a new antiplasmodial bisbenzylisoquinoline alkaloid from Nectandra salicifolia trunk bark. Journal of natural products, 1996, Volume: 59, Issue:6 Topics: Alkaloids; Animals; Antimalarials; Chromatography, Thin Layer; Costa Rica; Mass Spectrometry; Plants, Medicinal; Plasmodium falciparum	1996
Antimalarial activity of tropical Meliaceae extracts and gedunin derivatives. Journal of natural products, 1997, Volume: 60, Issue:4 Topics: Animals; Antimalarials; Cell Survival; Chloroquine; Drug Resistance; Humans; KB Cells; Limonins; Malaria, Falciparum; Mice; Plant Extracts; Plants, Medicinal; Plasmodium falciparum; Rats; Secosteroids; Structure-Activity Relationship	1997
In vitro and in vivo antiplasmodial activity of cryptolepine and related alkaloids from Cryptolepis sanguinolenta. Journal of natural products, 1997, Volume: 60, Issue:7 Topics: Alkaloids; Animals; Antimalarials; Humans; In Vitro Techniques; Indole Alkaloids; Indoles; Mice; Microbial Sensitivity Tests; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Quinolines; Spectrum Analysis	1997
Antiplasmodial and cytotoxic activity of natural bisbenzylisoquinoline alkaloids. Journal of natural products, 1999, Volume: 62, Issue:1 Topics: Alkaloids; Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship; Tumor Cells, Cultured	1999
Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino-6-chloro-2-methoxyacridines): influence of the linker. Journal of medicinal chemistry, 2000, Jul-13, Volume: 43, Issue:14 Topics: Acridines; Animals; Antimalarials; Cell Line; Leishmania infantum; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi	2000
Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja. Journal of natural products, 2001, Volume: 64, Issue:1 Topics: Alkaloids; Animals; Antimalarials; HeLa Cells; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plasmodium falciparum; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Strychnine	2001
Structure-activity relationships of novel anti-malarial agents. Part 2: cinnamic acid derivatives. Bioorganic & medicinal chemistry letters, 2001, Feb-12, Volume: 11, Issue:3 Topics: Animals; Antimalarials; Cinnamates; Combinatorial Chemistry Techniques; Inhibitory Concentration 50; Microbial Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship	2001
In vitro antiplasmodial activity of extracts of Tristaniopsis species and identification of the active constituents: ellagic acid and 3,4,5-trimethoxyphenyl-(6'-O-galloyl)-O-beta-D-glucopyranoside. Journal of natural products, 2001, Volume: 64, Issue:5 Topics: Animals; Antimalarials; Ellagic Acid; Glucosides; Humans; Magnetic Resonance Spectroscopy; New Caledonia; Plant Epidermis; Plant Extracts; Plants, Medicinal; Plasmodium; Tumor Cells, Cultured	2001
Synthesis, antimalarial activity and inhibition of haem detoxification of novel bisquinolines. Bioorganic & medicinal chemistry letters, 2001, Aug-20, Volume: 11, Issue:16 Topics: Animals; Antimalarials; Chloroquine; Inactivation, Metabolic; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines	2001
Synthesis of new artemisinin analogues from artemisinic acid modified at C-3 and C-13 and their antimalarial activity. Journal of natural products, 2001, Volume: 64, Issue:9 Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Chromatography, Thin Layer; Drug Resistance, Microbial; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; KB Cells; Magnetic Resonance Spectroscopy; Molecular Structure; Plasmodium falciparum; Sesquiterpenes; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Structure-Activity Relationship	2001
Efficacy of scopadulcic acid A against Plasmodium falciparum in vitro. Journal of natural products, 2002, Volume: 65, Issue:4 Topics: Animals; Antimalarials; Chloroquine; Diterpenes; Drug Resistance; Humans; In Vitro Techniques; Inhibitory Concentration 50; Mefloquine; Plants, Medicinal; Plasmodium falciparum; Scrophulariaceae	2002
Mixed steroidal 1,2,4,5-tetraoxanes: antimalarial and antimycobacterial activity. Journal of medicinal chemistry, 2002, Aug-01, Volume: 45, Issue:16 Topics: Animals; Anti-Bacterial Agents; Antimalarials; Chlorocebus aethiops; Crystallography, X-Ray; Inhibitory Concentration 50; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Plasmodium falciparum; Spectrometry, Mass, Electrospray Ionization; Spiro Compounds; Steroids; Structure-Activity Relationship; Vero Cells	2002
Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates. Journal of medicinal chemistry, 2002, Sep-12, Volume: 45, Issue:19 Topics: Administration, Oral; Animals; Antimalarials; Artemisinins; Drug Evaluation, Preclinical; Drug Resistance; Injections, Intravenous; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Stereoisomerism; Structure-Activity Relationship	2002
Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria. Journal of medicinal chemistry, 2003, Sep-25, Volume: 46, Issue:20 Topics: Animals; Antimalarials; Antiprotozoal Agents; Artemisinins; Clone Cells; Drug Design; Inhibitory Concentration 50; L-Lactate Dehydrogenase; Leishmania donovani; Malaria, Falciparum; Models, Molecular; Molecular Conformation; Plasmodium falciparum; Sesquiterpenes; Static Electricity; Stereoisomerism; Structure-Activity Relationship	2003
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18 Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2004
A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. Journal of medicinal chemistry, 2004, Oct-21, Volume: 47, Issue:22 Topics: Adenosine Triphosphate; Animals; Antimalarials; Binding Sites; Cyclin-Dependent Kinases; Databases, Factual; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Plasmodium falciparum; Protein Kinases; Protozoan Proteins; Quantitative Structure-Activity Relationship	2004
Novel spiroanellated 1,2,4-trioxanes with high in vitro antimalarial activities. Bioorganic & medicinal chemistry letters, 2005, Feb-01, Volume: 15, Issue:3 Topics: Adamantane; Animals; Antimalarials; Cell Death; Cell Line; Heterocyclic Compounds; Humans; Inhibitory Concentration 50; Molecular Structure; Plasmodium falciparum; Spiro Compounds; Structure-Activity Relationship	2005
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. Journal of medicinal chemistry, 2005, Jun-02, Volume: 48, Issue:11 Topics: Alkyl and Aryl Transferases; Animals; Antimalarials; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Farnesyltranstransferase; Female; Humans; Malaria; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Plasmodium berghei; Plasmodium falciparum; Protein Prenylation; Quinolones; Rats; Structure-Activity Relationship	2005
Unambiguous synthesis and prophylactic antimalarial activities of imidazolidinedione derivatives. Journal of medicinal chemistry, 2005, Oct-06, Volume: 48, Issue:20 Topics: Administration, Oral; Animals; Antimalarials; Carbamates; Guanidines; Imidazoles; Imidazolidines; Malaria; Male; Mice; Plasmodium falciparum; Plasmodium yoelii; Structure-Activity Relationship	2005
Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda. Journal of natural products, 2006, Volume: 69, Issue:1 Topics: Animals; Antimalarials; Cameroon; Erythrocytes; Fatty Acids; Holarrhena; Molecular Structure; Pentacyclic Triterpenes; Plant Bark; Plants, Medicinal; Plasmodium falciparum; Structure-Activity Relationship; Triterpenes	2006
Orally active 1,2,4-trioxanes: synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxaspiro[5.5]undecanes against multi-drug-resistant plasmodium yoelii nigeriensis in mice. Journal of medicinal chemistry, 2006, May-04, Volume: 49, Issue:9 Topics: Administration, Oral; Amination; Animals; Antimalarials; Artemisinins; Drug Resistance, Multiple; Heterocyclic Compounds; Malaria; Mice; Molecular Structure; Plasmodium yoelii; Structure-Activity Relationship; Survival Rate	2006
Tetraoxane antimalarials and their reaction with Fe(II). Journal of medicinal chemistry, 2006, Jun-29, Volume: 49, Issue:13 Topics: Animals; Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Electron Spin Resonance Spectroscopy; Ferrous Compounds; Free Radicals; Humans; In Vitro Techniques; Mice; Microsomes, Liver; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship; Tetraoxanes	2006
Antiprotozoal activities of new bis-chlorophenyl derivatives of bicyclic octanes and aza-nonanes. Bioorganic & medicinal chemistry letters, 2006, Oct-15, Volume: 16, Issue:20 Topics: Animals; Antiprotozoal Agents; Bridged Bicyclo Compounds, Heterocyclic; In Vitro Techniques; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Stereoisomerism; Structure-Activity Relationship; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense	2006
Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products. Journal of natural products, 2006, Volume: 69, Issue:8 Topics: Anti-Infective Agents; Antimalarials; Antineoplastic Agents; Antitubercular Agents; Furans; HIV Reverse Transcriptase; Hydrocarbons, Halogenated; Interleukin-1; Models, Molecular; Molecular Conformation; Molecular Structure; Protein Kinase C; Protein-Tyrosine Kinases; Quantitative Structure-Activity Relationship; Rhodophyta	2006
Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2 Topics: Animals; Antimalarials; Chloroquine; Drug Synergism; HIV Protease Inhibitors; Humans; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Plasmodium falciparum; Ritonavir; Saquinavir	2007
Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:1 Topics: Animals; Antimalarials; Colorimetry; Crystallization; Drug Evaluation, Preclinical; Heme; Hemeproteins; Plasmodium falciparum; Polysorbates; Reproducibility of Results	2007
In vitro antimalarial activity of azithromycin, artesunate, and quinine in combination and correlation with clinical outcome. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Azithromycin; Clinical Trials, Phase II as Topic; Drug Evaluation; Drug Interactions; Drug Therapy, Combination; Humans; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinine; Sesquiterpenes	2007
High-throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2 Topics: Animals; Biological Assay; Child, Preschool; DNA, Protozoan; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Female; Humans; Indoles; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Pregnancy	2007
Assessment and continued validation of the malaria SYBR green I-based fluorescence assay for use in malaria drug screening. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Animals; Antimalarials; Benzothiazoles; Diamines; Drug Evaluation, Preclinical; Erythrocytes; Fluorescent Dyes; Humans; Hypoxanthine; Organic Chemicals; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Reproducibility of Results; Sensitivity and Specificity	2007
Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Antagonism; Drug Combinations; Drug Interactions; Drug Resistance; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines; Sesquiterpenes; Tritium	2007
Bicyclo[2.2.2]octyl esters of dialkylamino acids as antiprotozoals. Bioorganic & medicinal chemistry, 2007, Aug-15, Volume: 15, Issue:16 Topics: Alkylation; Amino Acids; Animals; Antiprotozoal Agents; Bridged Bicyclo Compounds; Esters; Inhibitory Concentration 50; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship; Trypanosoma brucei rhodesiense	2007
2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: Adenosine; Animals; Antimalarials; Dose-Response Relationship, Drug; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi	2007
Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives(1). Journal of medicinal chemistry, 2007, Oct-18, Volume: 50, Issue:21 Topics: Animals; Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Cyclohexanes; Deoxycholic Acid; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Malaria; Mice; Microsomes; Plasmodium berghei; Plasmodium falciparum; Stereoisomerism; Structure-Activity Relationship; Tetraoxanes	2007
Synthesis and heme-binding correlation with antimalarial activity of 3,6-bis-(omega-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone. Bioorganic & medicinal chemistry, 2008, Feb-01, Volume: 16, Issue:3 Topics: Animals; Antimalarials; Fluorine; Heme; Magnetic Resonance Spectroscopy; Molecular Structure; Plasmodium falciparum; Spectrophotometry; Structure-Activity Relationship; Xanthones	2008
Determinants of in vitro drug susceptibility testing of Plasmodium vivax. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:3 Topics: Animals; Antimalarials; Chloroquine; Humans; Inhibitory Concentration 50; Life Cycle Stages; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodium vivax; Schizonts; Time Factors	2008
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5 Topics: Animals; Antimalarials; Biological Transport; Cell Line, Tumor; Chloroquine; Drug Resistance; Drug Therapy, Combination; Glutathione Reductase; Humans; In Vitro Techniques; Malaria; Mice; Mice, Inbred BALB C; Naphthalenes; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship	2008
Selective plasma protein binding of antimalarial drugs to alpha1-acid glycoprotein. Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7 Topics: Antimalarials; Binding Sites; Chromatography, Affinity; Circular Dichroism; Humans; Molecular Structure; Orosomucoid; Protein Binding; Serum Albumin; Spectrophotometry; Stereoisomerism; Structure-Activity Relationship	2008
Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5 Topics: Amodiaquine; Animals; Antimalarials; Blotting, Western; Chloroquine; Endocytosis; Erythrocytes; Hemoglobins; Humans; Mefloquine; Peroxidase; Phenanthrenes; Plasmodium falciparum; Protein Binding; Protozoan Proteins; Quinolines	2008
Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials. Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7 Topics: Animals; Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Parasitic Sensitivity Tests; Peroxides; Plasmodium falciparum; Stereoisomerism; Structure-Activity Relationship; Tetraoxanes	2008
Stronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:7 Topics: Animals; Antimalarials; Drug Resistance, Multiple; Gene Dosage; Genes, MDR; Genes, Protozoan; HIV Infections; HIV Protease Inhibitors; Humans; In Vitro Techniques; Malaria, Falciparum; Malaria, Vivax; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodium vivax; Ritonavir; Saquinavir	2008
A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum. Journal of medicinal chemistry, 2008, Jun-26, Volume: 51, Issue:12 Topics: Animals; Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Isoenzymes; Pancreatic Neoplasms; Parasitic Sensitivity Tests; Plasmodium falciparum; Triazoles	2008
Novel azabicyclo[3.2.2]nonane derivatives and their activities against Plasmodium falciparum K1 and Trypanosoma brucei rhodesiense. Bioorganic & medicinal chemistry, 2008, Jun-15, Volume: 16, Issue:12 Topics: Animals; Antimalarials; Azabicyclo Compounds; Plasmodium falciparum; Trypanocidal Agents; Trypanosoma brucei brucei	2008
Mixed tetraoxanes containing the acetone subunit as antimalarials. Bioorganic & medicinal chemistry, 2008, Jul-15, Volume: 16, Issue:14 Topics: Acetone; Animals; Antimalarials; Artemisinins; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Mefloquine; Mice; Plasmodium falciparum; Tetraoxanes	2008
Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A. Journal of medicinal chemistry, 2008, Aug-14, Volume: 51, Issue:15 Topics: Aminoquinolines; Animals; Botulinum Toxins, Type A; Chloroquine; Drug Resistance; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship	2008
Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10 Topics: Aminoquinolines; Animals; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Base Sequence; Biological Transport, Active; Chloroquine; DNA, Protozoan; Drug Resistance; Fluorescent Dyes; Genes, Protozoan; Humans; Leishmania infantum; Leishmaniasis, Visceral; Lipid Bilayers; Phosphorylcholine; Protozoan Proteins; Recombinant Proteins; Transformation, Genetic	2008
Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10 Topics: Animals; Antimalarials; Aotidae; Drug Resistance; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Hydroxamic Acids; In Vitro Techniques; Malaria; Malaria, Falciparum; Male; Mice; Mice, Inbred ICR; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship; Thiazoles	2008
New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Aminoquinolines; Animals; Antimalarials; Binding Sites; Disease Models, Animal; Dose-Response Relationship, Drug; Malaria; Maximum Tolerated Dose; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Stereoisomerism; Structure-Activity Relationship; Tetraoxanes	2008
In vivo and in vitro efficacy of amodiaquine monotherapy for treatment of infection by chloroquine-resistant Plasmodium vivax. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3 Topics: Adolescent; Age Distribution; Amodiaquine; Animals; Antimalarials; Chloroquine; Confidence Intervals; Drug Resistance; Drug Tolerance; Female; Follow-Up Studies; Humans; Inhibitory Concentration 50; Male; Outpatients; Parasitemia; Plasmodium vivax; Prospective Studies; Recurrence; Rural Health; Time Factors; Treatment Failure; Treatment Outcome	2009
Synthesis and antimalarial activities of cyclen 4-aminoquinoline analogs. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:4 Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Cyclams; Hemeproteins; Heterocyclic Compounds; Malaria; Male; Mice; Plasmodium berghei	2009
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5 Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Benzylamines; Cytochrome P-450 Enzyme Inhibitors; Dogs; Drug Evaluation, Preclinical; Drug Resistance; Female; Haplorhini; Heme; Humans; Malaria; Mice; Models, Molecular; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Rats; Structure-Activity Relationship	2009
Dynamics of malaria drug resistance patterns in the Amazon basin region following changes in Peruvian national treatment policy for uncomplicated malaria. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5 Topics: Animals; Antimalarials; Drug Resistance; Genotype; Haplotypes; Health Policy; Humans; Malaria, Falciparum; Microsatellite Repeats; Mutation; Parasitic Sensitivity Tests; Peru; Plasmodium falciparum; Protozoan Proteins	2009
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine. Journal of medicinal chemistry, 2009, Apr-09, Volume: 52, Issue:7 Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Cell Survival; Chloroquine; Dogs; Drug Resistance; Female; Haplorhini; Hepatocytes; Humans; In Vitro Techniques; Malaria; Male; Mice; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Rats; Rats, Wistar; Structure-Activity Relationship	2009
Colorimetric high-throughput screen for detection of heme crystallization inhibitors. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:6 Topics: Animals; Antimalarials; Colorimetry; Crystallization; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Heme; Hemeproteins; Plasmodium falciparum	2009
Atorvastatin is a promising partner for antimalarial drugs in treatment of Plasmodium falciparum malaria. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:6 Topics: Animals; Antimalarials; Atorvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Plasmodium falciparum; Pyrroles	2009
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7 Topics: Adjuvants, Pharmaceutic; Animals; Antimalarials; Parasitic Sensitivity Tests; Plasmodium falciparum; Probenecid; Verapamil	2009
Antimalarial activity of tigecycline, a novel glycylcycline antibiotic. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:9 Topics: Animals; Anti-Bacterial Agents; Antimalarials; Doxycycline; Inhibitory Concentration 50; Minocycline; Parasitic Sensitivity Tests; Plasmodium falciparum; Tetracycline; Tetracyclines; Tigecycline	2009
Addressing the malaria drug resistance challenge using flow cytometry to discover new antimalarials. Bioorganic & medicinal chemistry letters, 2009, Sep-15, Volume: 19, Issue:18 Topics: Animals; Antimalarials; DNA, Protozoan; Drug Discovery; Drug Resistance; Erythrocytes; Flow Cytometry; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; RNA, Protozoan; Structure-Activity Relationship	2009
Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:11 Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Dihydropteroate Synthase; Drug Combinations; Drug Resistance; Haplotypes; Madagascar; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase	2009
The structure-activity relationship of the antimalarial ozonide arterolane (OZ277). Journal of medicinal chemistry, 2010, Jan-14, Volume: 53, Issue:1 Topics: Animals; Antimalarials; Heterocyclic Compounds, 1-Ring; Malaria, Falciparum; Mice; Molecular Conformation; Parasitic Sensitivity Tests; Peroxides; Plasmodium falciparum; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship	2010
The comparative antimalarial properties of weak base and neutral synthetic ozonides. Bioorganic & medicinal chemistry letters, 2010, Jan-15, Volume: 20, Issue:2 Topics: Animals; Antimalarials; Heterocyclic Compounds; Mice; Plasmodium falciparum; Rats	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones. Bioorganic & medicinal chemistry, 2010, Apr-01, Volume: 18, Issue:7 Topics: Animals; Antimalarials; Cell Line; Cell Survival; Drug Resistance; Erythrocytes; Escherichia coli; Humans; Indicators and Reagents; Mefloquine; Membranes, Artificial; Permeability; Plasmodium falciparum; Quinolones; Solubility; Structure-Activity Relationship	2010
A repurposing strategy identifies novel synergistic inhibitors of Plasmodium falciparum heat shock protein 90. Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Adenosine Triphosphate; Antimalarials; Binding Sites; Binding, Competitive; Drug Evaluation, Preclinical; Drug Synergism; HSP90 Heat-Shock Proteins; Humans; Parasitic Sensitivity Tests; Plasmodium falciparum; Small Molecule Libraries; Substrate Specificity	2010
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:6 Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Drug Resistance; Female; Folic Acid Antagonists; Humans; In Vitro Techniques; Malaria; Malaria, Falciparum; Male; Mice; Models, Molecular; Mutation; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Pyrimethamine; Quinazolines; Rats; Rats, Wistar; Tetrahydrofolate Dehydrogenase	2010
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9 Topics: Animals; Antimalarials; Drug Resistance, Multiple; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum	2010
Spiroindolones, a potent compound class for the treatment of malaria. Science (New York, N.Y.), 2010, Sep-03, Volume: 329, Issue:5996 Topics: Adenosine Triphosphatases; Animals; Antimalarials; Cell Line; Drug Discovery; Drug Resistance; Erythrocytes; Female; Genes, Protozoan; Humans; Indoles; Malaria; Male; Mice; Models, Molecular; Mutant Proteins; Mutation; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Plasmodium vivax; Protein Synthesis Inhibitors; Protozoan Proteins; Rats; Rats, Wistar; Spiro Compounds	2010
In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12 Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Inhibitory Concentration 50; Naphthyridines; Plasmodium falciparum; Plasmodium vivax	2010
In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:1 Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chloroquine; Female; Humans; Indonesia; Malaria; Male; Middle Aged; Plasmodium malariae; Plasmodium ovale; Treatment Outcome; Young Adult	2011
Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme. Bioorganic & medicinal chemistry, 2010, Nov-15, Volume: 18, Issue:22 Topics: ADP-ribosyl Cyclase 1; Animals; Binding Sites; Catalytic Domain; Computer Simulation; Enzyme Inhibitors; Flavonoids; High-Throughput Screening Assays; Humans; NAD+ Nucleosidase; Schistosoma mansoni; Schistosomicides; Structure-Activity Relationship	2010
Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:3 Topics: Drug Resistance, Multiple, Bacterial; Histone Deacetylase Inhibitors; Hydroxamic Acids; Microbial Sensitivity Tests; Plasmodium falciparum; Plasmodium vivax; Vorinostat	2011
In vitro efficacy of 7-benzylamino-1-isoquinolinamines against Plasmodium falciparum related to the efficacy of chalcones. Bioorganic & medicinal chemistry letters, 2011, Jan-15, Volume: 21, Issue:2 Topics: Aminoquinolines; Antimalarials; Chalcones; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Models, Molecular; Plasmodium falciparum; Structure-Activity Relationship	2011
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:3 Topics: Adenosine Triphosphate; Aminoquinolines; Antiprotozoal Agents; Drug Resistance; Glycolysis; Leishmania major; Pyruvate Kinase	2011
A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus. Journal of medicinal chemistry, 2011, Mar-10, Volume: 54, Issue:5 Topics: Animals; Anopheles; Anti-Bacterial Agents; Antimalarials; Antiviral Agents; Botulinum Toxins, Type A; Cell Line; Chlorocebus aethiops; Chrysenes; Ebolavirus; Hemeproteins; Malaria; Mice; Models, Molecular; Plasmodium berghei; Plasmodium falciparum; Quinolines; Rats; Stereoisomerism; Structure-Activity Relationship	2011
Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. Journal of medicinal chemistry, 2011, Jun-09, Volume: 54, Issue:11 Topics: Animals; Antimalarials; Dihydroorotate Dehydrogenase; Disease Models, Animal; Drug Design; Drug Discovery; Enzyme Inhibitors; Humans; Malaria; Mice; Microsomes, Liver; Molecular Structure; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium berghei; Plasmodium falciparum; Protein Binding; Pyrimidines; Solubility; Structure-Activity Relationship; Triazoles	2011
Antimalarial pyrido[1,2-a]benzimidazoles. Journal of medicinal chemistry, 2011, Jul-14, Volume: 54, Issue:13 Topics: Administration, Oral; Animals; Antimalarials; Benzimidazoles; Drug Resistance, Multiple; Humans; In Vitro Techniques; Injections, Intraperitoneal; L Cells; Malaria; Male; Mice; Microsomes, Liver; Plasmodium berghei; Plasmodium falciparum; Pyridines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	2011
Imidazolopiperazines: hit to lead optimization of new antimalarial agents. Journal of medicinal chemistry, 2011, Jul-28, Volume: 54, Issue:14 Topics: Amino Acids; Aniline Compounds; Animals; Antimalarials; Benzene Derivatives; Cell Line; Drug Resistance; Female; Humans; Imidazoles; Inhibitory Concentration 50; Malaria; Mice; Mice, Inbred BALB C; Piperazines; Plasmodium berghei; Plasmodium falciparum; Rats; Structure-Activity Relationship	2011
Structure-activity relationships of 4-position diamine quinoline methanols as intermittent preventative treatment (IPT) against Plasmodium falciparum. Journal of medicinal chemistry, 2011, Sep-22, Volume: 54, Issue:18 Topics: Animals; Antimalarials; Cell Line; Cell Membrane Permeability; Dimerization; Dogs; Drug Resistance; Ethanolamines; Ethylenediamines; Malaria; Mefloquine; Methanol; Mice; Plasmodium berghei; Plasmodium falciparum; Quinolines; Stereoisomerism; Structure-Activity Relationship	2011
Antimalarial activity of physalins B, D, F, and G. Journal of natural products, 2011, Oct-28, Volume: 74, Issue:10 Topics: Animals; Antimalarials; Immunosuppressive Agents; Malaria; Mice; Mice, Inbred BALB C; Parasitemia; Physalis; Plasmodium berghei; Plasmodium falciparum; Secosteroids	2011
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (New York, N.Y.), 2011, Dec-09, Volume: 334, Issue:6061 Topics: Animals; Antimalarials; Cell Line, Tumor; Drug Discovery; Drug Evaluation, Preclinical; Drug Resistance; Erythrocytes; Humans; Imidazoles; Liver; Malaria; Mice; Mice, Inbred BALB C; Molecular Structure; Piperazines; Plasmodium; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Polymorphism, Single Nucleotide; Protozoan Proteins; Random Allocation; Small Molecule Libraries; Sporozoites	2011
Febrifugine analogue compounds: synthesis and antimalarial evaluation. Bioorganic & medicinal chemistry, 2012, Jan-15, Volume: 20, Issue:2 Topics: Animals; Antimalarials; Aotus trivirgatus; Drug Evaluation, Preclinical; Malaria; Piperidines; Plasmodium falciparum; Quinazolines	2012
Busseihydroquinones A-D from the roots of Pentas bussei. Journal of natural products, 2012, Jul-27, Volume: 75, Issue:7 Topics: Antimalarials; Chloroquine; Crystallography, X-Ray; Hydroquinones; Kenya; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Plasmodium falciparum; Rubiaceae	2012
Discovery and structure-activity relationships of pyrrolone antimalarials. Journal of medicinal chemistry, 2013, Apr-11, Volume: 56, Issue:7 Topics: Animals; Antimalarials; Cell Line; Drug Discovery; Magnetic Resonance Spectroscopy; Mass Spectrometry; Plasmodium falciparum; Pyrroles; Rats; Structure-Activity Relationship	2013
Voulkensin C-E, new 11-oxocassane-type diterpenoids and a steroid glycoside from Caesalpinia volkensii stem bark and their antiplasmodial activities. Bioorganic & medicinal chemistry letters, 2013, May-15, Volume: 23, Issue:10 Topics: Antimalarials; Caesalpinia; Diterpenes; Dose-Response Relationship, Drug; Glycosides; Models, Molecular; Molecular Conformation; Parasitic Sensitivity Tests; Plant Bark; Plant Stems; Plasmodium falciparum; Steroids; Structure-Activity Relationship	2013
Antimalarial activity of 4-amidinoquinoline and 10-amidinobenzonaphthyridine derivatives. Journal of medicinal chemistry, 2015, Apr-23, Volume: 58, Issue:8 Topics: Animals; Antimalarials; Hep G2 Cells; Humans; Malaria; Malaria, Falciparum; Male; Mice; Naphthyridines; Plasmodium berghei; Plasmodium falciparum; Quinolines	2015
Synthesis of isocryptolepine analogues and their structure-activity relationship studies as antiplasmodial and antiproliferative agents. European journal of medicinal chemistry, 2015, Apr-13, Volume: 94 Topics: Antimalarials; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Chemistry Techniques, Synthetic; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Humans; Indole Alkaloids; Plasmodium falciparum; Quinolines; Structure-Activity Relationship	2015
Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice. Bioorganic & medicinal chemistry, 2015, May-01, Volume: 23, Issue:9 Topics: Aminoquinolines; Animals; Antimalarials; Cell Proliferation; Dose-Response Relationship, Drug; Furans; Hep G2 Cells; Humans; Macrophages; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium berghei; Structure-Activity Relationship; Thiophenes	2015
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs. Antimicrobial agents and chemotherapy, 2020, 06-23, Volume: 64, Issue:7 Topics: Animals; Anti-Inflammatory Agents; Antiviral Agents; Betacoronavirus; Cell Line; Chlorocebus aethiops; Coronavirus Infections; COVID-19; Drug Evaluation, Preclinical; Drug Repositioning; Humans; Niclosamide; Pandemics; Pneumonia, Viral; Pregnenediones; SARS-CoV-2; Vero Cells	2020